Our main research program involves translational studies of primary and metastatic colorectal cancers (CRC), using genomics, drug screening, digital pathology and functional analyses. We are also the core lab of a European multicenter research study on MPNST (malignant peripheral nerve sheath tumor), an orphan disease. To gain knowledge of the complex dynamics of cancer development we combine large-scale and detailed biology research using in vitro models and patient samples. The main goal is to translate biological discoveries into improved patient stratification and treatment.

The group includes three project groups in "Cell signaling" led by Dr. E. Leithe, "Computational oncology" led by Assoc. prof. A. Sveen and "Functional oncology" led by Dr. K. Kryeziu.

Diseases

• Colorectal cancer
• MPNST
• Other solid tumours: prostate, ovarian, testis

Projects

• Biomarkers of colorectal cancer
• Tumor heterogeneity
• Precision medicine of colorectal cancer
• Cancer genomics
• E3 ubiquitin ligases in intercellular communication and carcinogenesis

Department of Molecular Oncology, Institute for Cancer Research
Oslo University Hospital HE - Norwegian Radium Hospital
Mail address: P. O. Box 4953 Nydalen, NO-0424 Oslo, Norway
Street address: Norwegian Radium Hospital, Montebello
Phone: +47 2278 1728, Switchboard: +47 2293 4000, Fax: +47 2278 1745
E-mail: ragnhild.a.lothe@rr-research.no