Publications

Publications from OUS - Genetics (Lothe)

141 publications found

Publications 2020

  1. Bruun J, Kryeziu K, Eide PW, Moosavi SH, Eilertsen IA, Langerud J, Røsok B, Totland MZ, Brunsell TH, Pellinen T, Saarela J, Bergsland CH, Palmer HG, Brudvik KW, Guren T, Dienstmann R, Guren MG, Nesbakken A, Bjørnbeth BA, Sveen A, Lothe RA (2020)
    Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity
    Clin Cancer Res, 26 (15), 4107-4119
    DOI 10.1158/1078-0432.CCR-19-3637, PubMed 32299813
  2. Hoff AM, Kraggerud SM, Alagaratnam S, Berg KCG, Johannessen B, Høland M, Nilsen G, Lingjærde OC, Andrews PW, Lothe RA, Skotheim RI (2020)
    Frequent copy number gains of SLC2A3 and ETV1 in testicular embryonal carcinomas
    Endocr Relat Cancer, 27 (9), 457-468
    DOI 10.1530/ERC-20-0064, PubMed 32580154
  3. Jeanmougin M, Håvik AB, Cekaite L, Brandal P, Sveen A, Meling TR, Ågesen TH, Scheie D, Heim S, Lothe RA, Lind GE (2020)
    Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment
    Mol Oncol, 14 (5), 1016-1027
    DOI 10.1002/1878-0261.12668, PubMed 32171051
  4. Lopes N, Bergsland C, Bruun J, Bjørnslett M, Vieira AF, Mesquita P, Pinto R, Gomes R, Cavadas B, Bennett E, Pereira L, Lothe RA, Almeida R, David L (2020)
    A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis
    Gastric Cancer, 23 (5), 811-823
    DOI 10.1007/s10120-020-01064-6, PubMed 32215766
  5. Smeby J, Kryeziu K, Berg KCG, Eilertsen IA, Eide PW, Johannessen B, Guren MG, Nesbakken A, Bruun J, Lothe RA, Sveen A (2020)
    Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity
    EBioMedicine, 59, 102923
    DOI 10.1016/j.ebiom.2020.102923, PubMed 32799124
  6. Wise JF, Nakken S, Steen CB, Vodák D, Trøen G, Johannessen B, Lingjærde OC, Hilden V, Blaker YN, Bai B, Aasheim LB, Pasanen A, Lorenz S, Sveen A, Lothe RA, Myklebost O, Leppä S, Meza-Zepeda LA, Beiske K, Lawrence MS, Hovig E, Myklebust JH, Smeland EB, Holte H (2020)
    Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
    Blood Adv, 4 (9), 1859-1866
    DOI 10.1182/bloodadvances.2019001325, PubMed 32374878

Publications 2019

  1. Berg KCG, Sveen A, Høland M, Alagaratnam S, Berg M, Danielsen SA, Nesbakken A, Søreide K, Lothe RA (2019)
    Gene expression profiles of CMS2-epithelial/canonical colorectal cancers are largely driven by DNA copy number gains
    Oncogene, 38 (33), 6109-6122
    DOI 10.1038/s41388-019-0868-5, PubMed 31308487
  2. Brunsell TH, Cengija V, Sveen A, Bjørnbeth BA, Røsok BI, Brudvik KW, Guren MG, Lothe RA, Abildgaard A, Nesbakken A (2019)
    Heterogeneous radiological response to neoadjuvant therapy is associated with poor prognosis after resection of colorectal liver metastases
    Eur J Surg Oncol, 45 (12), 2340-2346
    DOI 10.1016/j.ejso.2019.07.017, PubMed 31350075
  3. Brunsell TH, Sveen A, Bjørnbeth BA, Røsok BI, Danielsen SA, Brudvik KW, Berg KCG, Johannessen B, Cengija V, Abildgaard A, Guren MG, Nesbakken A, Lothe RA (2019)
    High Concordance and Negative Prognostic Impact of RAS/BRAF/PIK3CA Mutations in Multiple Resected Colorectal Liver Metastases
    Clin Colorectal Cancer, 19 (1), e26-e47
    DOI 10.1016/j.clcc.2019.09.003, PubMed 31982351
  4. Burocziova M, Burdova K, Martinikova AS, Kasparek P, Kleiblova P, Danielsen SA, Borecka M, Jenikova G, Janečková L, Pavel J, Zemankova P, Schneiderova M, Schwarzova L, Ticha I, Sun XF, Jiraskova K, Liska V, Vodickova L, Vodicka P, Sedlacek R, Kleibl Z, Lothe RA, Korinek V, Macurek L (2019)
    Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon
    Cell Death Dis, 10 (11), 818
    DOI 10.1038/s41419-019-2057-4, PubMed 31659152
  5. Carm KT, Hoff AM, Bakken AC, Axcrona U, Axcrona K, Lothe RA, Skotheim RI, Løvf M (2019)
    Interfocal heterogeneity challenges the clinical usefulness of molecular classification of primary prostate cancer
    Sci Rep, 9 (1), 13579
    DOI 10.1038/s41598-019-49964-7, PubMed 31537872
  6. Dienstmann R, Villacampa G, Sveen A, Mason MJ, Niedzwiecki D, Nesbakken A, Moreno V, Warren RS, Lothe RA, Guinney J (2019)
    Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer
    Ann Oncol, 30 (10), 1622-1629
    DOI 10.1093/annonc/mdz287, PubMed 31504112
  7. Eide PW, Eilertsen IA, Sveen A, Lothe RA (2019)
    Long noncoding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell-intrinsic properties
    Int J Cancer, 144 (11), 2843-2853
    DOI 10.1002/ijc.31998, PubMed 30447009
  8. Eilertsen IA, Moosavi SH, Strømme JM, Nesbakken A, Johannessen B, Lothe RA, Sveen A (2019)
    Technical differences between sequencing and microarray platforms impact transcriptomic subtyping of colorectal cancer
    Cancer Lett, 469, 246-255
    DOI 10.1016/j.canlet.2019.10.040, PubMed 31678167
  9. Glaire MA, Domingo E, Sveen A, Bruun J, Nesbakken A, Nicholson G, Novelli M, Lawson K, Oukrif D, Kildal W, Danielsen HE, Kerr R, Kerr D, Tomlinson I, Lothe RA, Church DN (2019)
    Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
    Br J Cancer, 121 (6), 474-482
    DOI 10.1038/s41416-019-0540-4, PubMed 31388185
  10. Glaire MA, Domingo E, Sveen A, Bruun J, Nesbakken A, Nicholson G, Novelli M, Lawson K, Oukrif D, Kildal W, Danielsen HE, Kerr R, Kerr D, Tomlinson I, Lothe RA, Church DN (2019)
    Correction: Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
    Br J Cancer, 121 (9), 807
    DOI 10.1038/s41416-019-0590-7, PubMed 31548598
  11. Kryeziu K, Bruun J, Guren TK, Sveen A, Lothe RA (2019)
    Combination therapies with HSP90 inhibitors against colorectal cancer
    Biochim Biophys Acta Rev Cancer, 1871 (2), 240-247
    DOI 10.1016/j.bbcan.2019.01.002, PubMed 30708039
  12. Lopes N, Bergsland CH, Bjørnslett M, Pellinen T, Svindland A, Nesbakken A, Almeida R, Lothe RA, David L, Bruun J (2019)
    Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2
    Lab Invest, 100 (1), 120-134
    DOI 10.1038/s41374-019-0336-4, PubMed 31641225
  13. Miranda A, Hamilton PT, Zhang AW, Pattnaik S, Becht E, Mezheyeuski A, Bruun J, Micke P, de Reynies A, Nelson BH (2019)
    Cancer stemness, intratumoral heterogeneity, and immune response across cancers
    Proc Natl Acad Sci U S A, 116 (18), 9020-9029
    DOI 10.1073/pnas.1818210116, PubMed 30996127
  14. Røsok BI, Høst-Brunsell T, Brudvik KW, Carling U, Dorenberg E, Björnsson B, Lothe RA, Bjørnbeth BA, Sandström P (2019)
    Characterization of early recurrences following liver resection by ALPPS and two stage hepatectomy in patients with colorectal liver-metastases and small future liver remnants; a translational substudy of the LIGRO-RCT
    HPB (Oxford), 21 (8), 1017-1023
    DOI 10.1016/j.hpb.2018.12.003, PubMed 30765198
  15. Smeby J, Sveen A, Bergsland CH, Eilertsen IA, Danielsen SA, Eide PW, Hektoen M, Guren MG, Nesbakken A, Bruun J, Lothe RA (2019)
    Exploratory analyses of consensus molecular subtype-dependent associations of TP53 mutations with immunomodulation and prognosis in colorectal cancer
    ESMO Open, 4 (3), e000523
    DOI 10.1136/esmoopen-2019-000523, PubMed 31321083
  16. Smeby J, Sveen A, Eilertsen IA, Danielsen SA, Hoff AM, Eide PW, Johannessen B, Hektoen M, Skotheim RI, Guren MG, Nesbakken A, Lothe RA (2019)
    Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer
    Oncogenesis, 8 (6), 35
    DOI 10.1038/s41389-019-0141-3, PubMed 31092812
  17. Sveen A, Cremolini C, Dienstmann R (2019)
    Predictive modeling in colorectal cancer: time to move beyond consensus molecular subtypes
    Ann Oncol, 30 (11), 1682-1685
    DOI 10.1093/annonc/mdz412, PubMed 31868904
  18. Sveen A, Kopetz S, Lothe RA (2019)
    Biomarker-guided therapy for colorectal cancer: strength in complexity
    Nat Rev Clin Oncol, 17 (1), 11-32
    DOI 10.1038/s41571-019-0241-1, PubMed 31289352
  19. Totland MZ, Rasmussen NL, Knudsen LM, Leithe E (2019)
    Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications
    Cell Mol Life Sci, 77 (4), 573-591
    DOI 10.1007/s00018-019-03285-0, PubMed 31501970
  20. Aasen T, Leithe E, Graham SV, Kameritsch P, Mayán MD, Mesnil M, Pogoda K, Tabernero A (2019)
    Connexins in cancer: bridging the gap to the clinic
    Oncogene, 38 (23), 4429-4451
    DOI 10.1038/s41388-019-0741-6, PubMed 30814684

Publications 2018

  1. Bruun J, Sveen A, Barros R, Eide PW, Eilertsen I, Kolberg M, Pellinen T, David L, Svindland A, Kallioniemi O, Guren MG, Nesbakken A, Almeida R, Lothe RA (2018)
    Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer
    Mol Oncol, 12 (9), 1639-1655
    DOI 10.1002/1878-0261.12347, PubMed 29900672
  2. Danielsen HE, Hveem TS, Domingo E, Pradhan M, Kleppe A, Syvertsen RA, Kostolomov I, Nesheim JA, Askautrud HA, Nesbakken A, Lothe RA, Svindland A, Shepherd N, Novelli M, Johnstone E, Tomlinson I, Kerr R, Kerr DJ (2018)
    Prognostic markers for colorectal cancer: estimating ploidy and stroma
    Ann Oncol, 29 (3), 616-623
    DOI 10.1093/annonc/mdx794, PubMed 29293881
  3. Eilertsen IA, Sveen A, Strømme JM, Skotheim RI, Nesbakken A, Lothe RA (2018)
    Alternative splicing expands the prognostic impact of KRAS in microsatellite stable primary colorectal cancer
    Int J Cancer, 144 (4), 841-847
    DOI 10.1002/ijc.31809, PubMed 30121958
  4. Høland M, Kolberg M, Danielsen SA, Bjerkehagen B, Eilertsen IA, Hektoen M, Mandahl N, van den Berg E, Smeland S, Mertens F, Sundby Hall K, Picci P, Sveen A, Lothe RA (2018)
    Inferior survival for patients with malignant peripheral nerve sheath tumors defined by aberrant TP53
    Mod Pathol, 31 (11), 1694-1707
    DOI 10.1038/s41379-018-0074-y, PubMed 29946184
  5. Lønning PE, Berge EO, Bjørnslett M, Minsaas L, Chrisanthar R, Høberg-Vetti H, Dulary C, Busato F, Bjørneklett S, Eriksen C, Kopperud R, Axcrona U, Davidson B, Bjørge L, Evans G, Howell A, Salvesen HB, Janszky I, Hveem K, Romundstad PR, Vatten LJ, Tost J, Dørum A, Knappskog S (2018)
    White Blood Cell BRCA1 Promoter Methylation Status and Ovarian Cancer Risk
    Ann Intern Med, 168 (5), 326-334
    DOI 10.7326/M17-0101, PubMed 29335712
  6. Løvf M, Zhao S, Axcrona U, Johannessen B, Bakken AC, Carm KT, Hoff AM, Myklebost O, Meza-Zepeda LA, Lie AK, Axcrona K, Lothe RA, Skotheim RI (2018)
    Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity
    Eur Urol, 75 (3), 498-505
    DOI 10.1016/j.eururo.2018.08.009, PubMed 30181068
  7. Mezheyeuski A, Bergsland CH, Backman M, Djureinovic D, Sjöblom T, Bruun J, Micke P (2018)
    Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients
    J Pathol, 244 (4), 421-431
    DOI 10.1002/path.5026, PubMed 29282718
  8. Oltedal S, Kørner H, Aasprong OG, Hussain I, Tjensvoll K, Smaaland R, Søreide JA, Søreide K, Lothe RA, Heikkilä R, Gilje B, Nordgård O (2018)
    The Prognostic Relevance of Sentinel Lymph Node Metastases Assessed by PHGR1 mRNA Quantification in Stage I to III Colon Cancer
    Transl Oncol, 11 (2), 436-443
    DOI 10.1016/j.tranon.2018.01.015, PubMed 29475140
  9. Pharo HD, Andresen K, Berg KCG, Lothe RA, Jeanmougin M, Lind GE (2018)
    A robust internal control for high-precision DNA methylation analyses by droplet digital PCR
    Clin Epigenetics, 10, 24
    DOI 10.1186/s13148-018-0456-5, PubMed 29484034
  10. Pinto D, Pinto C, Guerra J, Pinheiro M, Santos R, Vedeld HM, Yohannes Z, Peixoto A, Santos C, Pinto P, Lopes P, Lothe R, Lind GE, Henrique R, Teixeira MR (2018)
    Contribution of MLH1 constitutional methylation for Lynch syndrome diagnosis in patients with tumor MLH1 downregulation
    Cancer Med, 7 (2), 433-444
    DOI 10.1002/cam4.1285, PubMed 29341452
  11. Smeby J, Sveen A, Merok MA, Danielsen SA, Eilertsen IA, Guren MG, Dienstmann R, Nesbakken A, Lothe RA (2018)
    CMS-dependent prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer
    Ann Oncol, 29 (5), 1227-1234
    DOI 10.1093/annonc/mdy085, PubMed 29518181
  12. Vedeld HM, Nesbakken A, Lothe RA, Lind GE (2018)
    Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer
    Clin Epigenetics, 10, 70
    DOI 10.1186/s13148-018-0503-2, PubMed 29854011

Publications 2017

  1. Berg KCG, Eide PW, Eilertsen IA, Johannessen B, Bruun J, Danielsen SA, Bjørnslett M, Meza-Zepeda LA, Eknæs M, Lind GE, Myklebost O, Skotheim RI, Sveen A, Lothe RA (2017)
    Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
    Mol Cancer, 16 (1), 116
    DOI 10.1186/s12943-017-0691-y, PubMed 28683746
  2. Dienstmann R, Mason MJ, Sinicrope FA, Phipps AI, Tejpar S, Nesbakken A, Danielsen SA, Sveen A, Buchanan DD, Clendenning M, Rosty C, Bot B, Alberts SR, Milburn Jessup J, Lothe RA, Delorenzi M, Newcomb PA, Sargent D, Guinney J (2017)
    Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study
    Ann Oncol, 28 (5), 1023-1031
    DOI 10.1093/annonc/mdx052, PubMed 28453697
  3. Dukic AR, Haugen LH, Pidoux G, Leithe E, Bakke O, Taskén K (2017)
    A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells
    Cell Signal, 32, 1-11
    DOI 10.1016/j.cellsig.2017.01.008, PubMed 28077322
  4. Eide PW, Bruun J, Lothe RA, Sveen A (2017)
    CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models
    Sci Rep, 7 (1), 16618
    DOI 10.1038/s41598-017-16747-x, PubMed 29192179
  5. Gansmo LB, Bjørnslett M, Halle MK, Salvesen HB, Romundstad P, Hveem K, Vatten L, Dørum A, Lønning PE, Knappskog S (2017)
    MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk
    BMC Cancer, 17 (1), 97
    DOI 10.1186/s12885-017-3094-y, PubMed 28158999
  6. Kolberg M, Bruun J, Murumägi A, Mpindi JP, Bergsland CH, Høland M, Eilertsen IA, Danielsen SA, Kallioniemi O, Lothe RA (2017)
    Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors
    Mol Oncol, 11 (9), 1156-1171
    DOI 10.1002/1878-0261.12086, PubMed 28556483
  7. Landskron J, Kraggerud SM, Wik E, Dørum A, Bjørnslett M, Melum E, Helland Ø, Bjørge L, Lothe RA, Salvesen HB, Taskén K (2017)
    C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease
    PLoS One, 12 (7), e0182030
    DOI 10.1371/journal.pone.0182030, PubMed 28759630
  8. Leithe E, Mesnil M, Aasen T (2017)
    The connexin 43 C-terminus: A tail of many tales
    Biochim Biophys Acta Biomembr, 1860 (1), 48-64
    DOI 10.1016/j.bbamem.2017.05.008, PubMed 28526583
  9. Lind GE, Guriby M, Ahlquist T, Hussain I, Jeanmougin M, Søreide K, Kørner H, Lothe RA, Nordgård O (2017)
    Prognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients
    Clin Epigenetics, 9, 97
    DOI 10.1186/s13148-017-0397-4, PubMed 28878843
  10. Mesnil M, Aasen T, Boucher J, Chépied A, Cronier L, Defamie N, Kameritsch P, Laird DW, Lampe PD, Lathia JD, Leithe E, Mehta PP, Monvoisin A, Pogoda K, Sin WC, Tabernero A, Yamasaki H, Yeh ES, Dagli MLZ, Naus CC (2017)
    An update on minding the gap in cancer
    Biochim Biophys Acta Biomembr, 1860 (1), 237-243
    DOI 10.1016/j.bbamem.2017.06.015, PubMed 28655619
  11. Solheim O, Førsund M, Tropé CG, Kraggerud SM, Nesland JM, Davidson B (2017)
    Epithelial-mesenchymal transition markers in malignant ovarian germ cell tumors
    APMIS, 125 (9), 781-786
    DOI 10.1111/apm.12715, PubMed 28585395
  12. Sveen A, Bruun J, Eide PW, Eilertsen IA, Ramirez L, Murumägi A, Arjama M, Danielsen SA, Kryeziu K, Elez E, Tabernero J, Guinney J, Palmer HG, Nesbakken A, Kallioniemi O, Dienstmann R, Lothe RA (2017)
    Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies
    Clin Cancer Res, 24 (4), 794-806
    DOI 10.1158/1078-0432.CCR-17-1234, PubMed 29242316
  13. Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA (2017)
    Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1
    Genome Med, 9 (1), 46
    DOI 10.1186/s13073-017-0434-0, PubMed 28539123
  14. Totland MZ, Bergsland CH, Fykerud TA, Knudsen LM, Rasmussen NL, Eide PW, Yohannes Z, Sørensen V, Brech A, Lothe RA, Leithe E (2017)
    The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions
    J Cell Sci, 130 (17), 2867-2882
    DOI 10.1242/jcs.202408, PubMed 28733455
  15. Vedeld HM, Merok M, Jeanmougin M, Danielsen SA, Honne H, Presthus GK, Svindland A, Sjo OH, Hektoen M, Eknaes M, Nesbakken A, Lothe RA, Lind GE (2017)
    CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers
    Int J Cancer, 141 (5), 967-976
    DOI 10.1002/ijc.30796, PubMed 28542846

Publications 2016

  1. Cekaite L, Eide PW, Lind GE, Skotheim RI, Lothe RA (2016)
    MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer
    Oncotarget, 7 (6), 6476-505
    DOI 10.18632/oncotarget.6390, PubMed 26623728
  2. Domingo E, Freeman-Mills L, Rayner E, Glaire M, Briggs S, Vermeulen L, Fessler E, Medema JP, Boot A, Morreau H, van Wezel T, Liefers GJ, Lothe RA, Danielsen SA, Sveen A, Nesbakken A, Zlobec I, Lugli A, Koelzer VH, Berger MD, Castellví-Bel S, Muñoz J, Epicolon consortium, de Bruyn M, Nijman HW et al. (2016)
    Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study
    Lancet Gastroenterol Hepatol, 1 (3), 207-216
    DOI 10.1016/S2468-1253(16)30014-0, PubMed 28404093
  3. Fykerud TA, Knudsen LM, Totland MZ, Sørensen V, Dahal-Koirala S, Lothe RA, Brech A, Leithe E (2016)
    Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding
    Cell Cycle, 15 (21), 2943-2957
    DOI 10.1080/15384101.2016.1231280, PubMed 27625181
  4. Gansmo LB, Bjørnslett M, Halle MK, Salvesen HB, Dørum A, Birkeland E, Hveem K, Romundstad P, Vatten L, Lønning PE, Knappskog S (2016)
    The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer
    Tumour Biol, 37 (8), 10697-702
    DOI 10.1007/s13277-016-4940-2, PubMed 26867771
  5. Leithe E (2016)
    Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer
    Biochim Biophys Acta, 1865 (2), 133-46
    DOI 10.1016/j.bbcan.2016.02.001, PubMed 26855059
  6. Lorenz S, Barøy T, Sun J, Nome T, Vodák D, Bryne JC, Håkelien AM, Fernandez-Cuesta L, Möhlendick B, Rieder H, Szuhai K, Zaikova O, Ahlquist TC, Thomassen GO, Skotheim RI, Lothe RA, Tarpey PS, Campbell P, Flanagan A, Myklebost O, Meza-Zepeda LA (2016)
    Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations
    Oncotarget, 7 (5), 5273-88
    DOI 10.18632/oncotarget.6567, PubMed 26672768
  7. Moen LV, Ramberg H, Zhao S, Grytli HH, Sveen A, Berge V, Skotheim RI, Taskén KA, Skålhegg BS (2016)
    Observed correlation between the expression levels of catalytic subunit, Cβ2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness
    Urol Oncol, 35 (3), 111.e1-111.e8
    DOI 10.1016/j.urolonc.2016.10.002, PubMed 27838142
  8. Ramalho-Carvalho J, Martins JB, Cekaite L, Sveen A, Torres-Ferreira J, Graça I, Costa-Pinheiro P, Eilertsen IA, Antunes L, Oliveira J, Lothe RA, Henrique R, Jerónimo C (2016)
    Epigenetic disruption of miR-130a promotes prostate cancer by targeting SEC23B and DEPDC1
    Cancer Lett, 385, 150-159
    DOI 10.1016/j.canlet.2016.10.028, PubMed 27984115
  9. Sveen A, Løes IM, Alagaratnam S, Nilsen G, Høland M, Lingjærde OC, Sorbye H, Berg KC, Horn A, Angelsen JH, Knappskog S, Lønning PE, Lothe RA (2016)
    Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver Resection
    PLoS Genet, 12 (7), e1006225
    DOI 10.1371/journal.pgen.1006225, PubMed 27472274

Publications 2015

  1. Bjørnslett M, Dahl AA, Sørebø Ø, Dørum A (2015)
    Psychological distress related to BRCA testing in ovarian cancer patients
    Fam Cancer, 14 (4), 495-504
    DOI 10.1007/s10689-015-9811-2, PubMed 25980896
  2. Brabrand S, Johannessen B, Axcrona U, Kraggerud SM, Berg KG, Bakken AC, Bruun J, Fosså SD, Lothe RA, Lehne G, Skotheim RI (2015)
    Exome sequencing of bilateral testicular germ cell tumors suggests independent development lineages
    Neoplasia, 17 (2), 167-74
    DOI 10.1016/j.neo.2014.12.005, PubMed 25748235
  3. Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA (2015)
    Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
    Clin Cancer Res, 21 (16), 3759-70
    DOI 10.1158/1078-0432.CCR-14-3294, PubMed 25910952
  4. Hoff AM, Alagaratnam S, Zhao S, Bruun J, Andrews PW, Lothe RA, Skotheim RI (2015)
    Identification of Novel Fusion Genes in Testicular Germ Cell Tumors
    Cancer Res, 76 (1), 108-16
    DOI 10.1158/0008-5472.CAN-15-1790, PubMed 26659575
  5. Hoff AM, Johannessen B, Alagaratnam S, Zhao S, Nome T, Løvf M, Bakken AC, Hektoen M, Sveen A, Lothe RA, Skotheim RI (2015)
    Novel RNA variants in colorectal cancers
    Oncotarget, 6 (34), 36587-602
    DOI 10.18632/oncotarget.5500, PubMed 26474385
  6. Johannessen B, Sveen A, Skotheim RI (2015)
    TIN: An R Package for Transcriptome Instability Analysis
    Cancer Inform, 14, 109-12
    DOI 10.4137/CIN.S31363, PubMed 26448683
  7. Kolberg M, Høland M, Lind GE, Ågesen TH, Skotheim RI, Hall KS, Mandahl N, Smeland S, Mertens F, Davidson B, Lothe RA (2015)
    Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection
    Mol Oncol, 9 (6), 1129-39
    DOI 10.1016/j.molonc.2015.02.005, PubMed 25769404
  8. Mesquita D, Barros-Silva JD, Santos J, Skotheim RI, Lothe RA, Paulo P, Teixeira MR (2015)
    Specific and redundant activities of ETV1 and ETV4 in prostate cancer aggressiveness revealed by co-overexpression cellular contexts
    Oncotarget, 6 (7), 5217-36
    DOI 10.18632/oncotarget.2847, PubMed 25595908
  9. Seglen PO, Luhr M, Mills IG, Sætre F, Szalai P, Engedal N (2015)
    Macroautophagic cargo sequestration assays
    Methods, 75, 25-36
    DOI 10.1016/j.ymeth.2014.12.021, PubMed 25576638
  10. Sveen A, Kilpinen S, Ruusulehto A, Lothe RA, Skotheim RI (2015)
    Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
    Oncogene, 35 (19), 2413-27
    DOI 10.1038/onc.2015.318, PubMed 26300000

Publications 2014

  1. Bruun J, Kolberg M, Nesland JM, Svindland A, Nesbakken A, Lothe RA (2014)
    Prognostic Significance of β-Catenin, E-Cadherin, and SOX9 in Colorectal Cancer: Results from a Large Population-Representative Series
    Front Oncol, 4, 118
    DOI 10.3389/fonc.2014.00118, PubMed 24904831
  2. Danielsen SA, Eide PW, Nesbakken A, Guren T, Leithe E, Lothe RA (2014)
    Portrait of the PI3K/AKT pathway in colorectal cancer
    Biochim Biophys Acta, 1855 (1), 104-21
    DOI 10.1016/j.bbcan.2014.09.008, PubMed 25450577
  3. Danielsen SA, Lind GE, Kolberg M, Høland M, Bjerkehagen B, Sundby Hall K, van den Berg E, Mertens F, Smeland S, Picci P, Lothe RA (2014)
    Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis
    Neuro Oncol, 17 (1), 63-9
    DOI 10.1093/neuonc/nou140, PubMed 25038505
  4. Hveem TS, Merok MA, Pretorius ME, Novelli M, Bævre MS, Sjo OH, Clinch N, Liestøl K, Svindland A, Lothe RA, Nesbakken A, Danielsen HE (2014)
    Prognostic impact of genomic instability in colorectal cancer
    Br J Cancer, 110 (8), 2159-64
    DOI 10.1038/bjc.2014.133, PubMed 24642618
  5. Sirnes S, Lind GE, Bruun J, Fykerud TA, Mesnil M, Lothe RA, Rivedal E, Kolberg M, Leithe E (2014)
    Connexins in colorectal cancer pathogenesis
    Int J Cancer, 137 (1), 1-11
    DOI 10.1002/ijc.28911, PubMed 24752574
  6. Vedeld HM, Andresen K, Eilertsen IA, Nesbakken A, Seruca R, Gladhaug IP, Thiis-Evensen E, Rognum TO, Boberg KM, Lind GE (2014)
    The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers
    Int J Cancer, 136 (4), 844-53
    DOI 10.1002/ijc.29039, PubMed 24948044
  7. Vedeld HM, Skotheim RI, Lothe RA, Lind GE (2014)
    The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer
    Epigenetics, 9 (3), 346-50
    DOI 10.4161/epi.27582, PubMed 24384857

Publications 2013

  1. Ahmed D, Eide PW, Eilertsen IA, Danielsen SA, Eknæs M, Hektoen M, Lind GE, Lothe RA (2013)
    Epigenetic and genetic features of 24 colon cancer cell lines
    Oncogenesis, 2, e71
    DOI 10.1038/oncsis.2013.35, PubMed 24042735
  2. Alagaratnam S, Harrison N, Bakken AC, Hoff AM, Jones M, Sveen A, Moore HD, Andrews PW, Lothe RA, Skotheim RI (2013)
    Transforming pluripotency: an exon-level study of malignancy-specific transcripts in human embryonal carcinoma and embryonic stem cells
    Stem Cells Dev, 22 (7), 1136-46
    DOI 10.1089/scd.2012.0369, PubMed 23137282
  3. Berg M, Guriby M, Nordgård O, Nedrebø BS, Ahlquist TC, Smaaland R, Oltedal S, Søreide JA, Kørner H, Lothe RA, Søreide K (2013)
    Influence of microsatellite instability and KRAS and BRAF mutations on lymph node harvest in stage I-III colon cancers
    Mol Med, 19, 286-93
    DOI 10.2119/molmed.2013.00049, PubMed 23979710
  4. Bethge N, Lothe RA, Honne H, Andresen K, Trøen G, Eknæs M, Liestøl K, Holte H, Delabie J, Smeland EB, Lind GE (2013)
    Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma
    Epigenetics, 9 (3), 428-36
    DOI 10.4161/epi.27554, PubMed 24362313
  5. Kraggerud SM, Hoei-Hansen CE, Alagaratnam S, Skotheim RI, Abeler VM, Rajpert-De Meyts E, Lothe RA (2013)
    Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis
    Endocr Rev, 34 (3), 339-76
    DOI 10.1210/er.2012-1045, PubMed 23575763

Publications 2012

  1. Agesen TH, Sveen A, Merok MA, Lind GE, Nesbakken A, Skotheim RI, Lothe RA (2012)
    ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis
    Gut, 61 (11), 1560-7
    DOI 10.1136/gutjnl-2011-301179, PubMed 22213796
  2. Ahmed D, Danielsen SA, Aagesen TH, Bretthauer M, Thiis-Evensen E, Hoff G, Rognum TO, Nesbakken A, Lothe RA, Lind GE (2012)
    A tissue-based comparative effectiveness analysis of biomarkers for early detection of colorectal tumors
    Clin Transl Gastroenterol, 3, e27
    DOI 10.1038/ctg.2012.21, PubMed 23324654
  3. Cekaite L, Rantala JK, Bruun J, Guriby M, Agesen TH, Danielsen SA, Lind GE, Nesbakken A, Kallioniemi O, Lothe RA, Skotheim RI (2012)
    MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer
    Neoplasia, 14 (9), 868-79
    DOI 10.1593/neo.121094, PubMed 23019418
  4. Eide PW, Cekaite L, Danielsen SA, Eilertsen IA, Kjenseth A, Fykerud TA, Ågesen TH, Bruun J, Rivedal E, Lothe RA, Leithe E (2012)
    NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway
    Cell Signal, 25 (1), 12-8
    DOI 10.1016/j.cellsig.2012.08.012, PubMed 22974840
  5. Fykerud TA, Kjenseth A, Schink KO, Sirnes S, Bruun J, Omori Y, Brech A, Rivedal E, Leithe E (2012)
    Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43
    J Cell Sci, 125 (Pt 17), 3966-76
    DOI 10.1242/jcs.093500, PubMed 22623726
  6. Håvik AB, Brandal P, Honne H, Dahlback HS, Scheie D, Hektoen M, Meling TR, Helseth E, Heim S, Lothe RA, Lind GE (2012)
    MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR
    J Transl Med, 10, 36
    DOI 10.1186/1479-5876-10-36, PubMed 22390413
  7. Kjenseth A, Fykerud TA, Sirnes S, Bruun J, Yohannes Z, Kolberg M, Omori Y, Rivedal E, Leithe E (2012)
    The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation
    J Biol Chem, 287 (19), 15851-61
    DOI 10.1074/jbc.M111.281832, PubMed 22411987
  8. Kolberg M, Høland M, Agesen TH, Brekke HR, Liestøl K, Hall KS, Mertens F, Picci P, Smeland S, Lothe RA (2012)
    Survival meta-analyses for >1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1
    Neuro Oncol, 15 (2), 135-47
    DOI 10.1093/neuonc/nos287, PubMed 23161774
  9. Lind GE, Ahmed D, Lothe RA (2012)
    Vimentin in upper gastrointestinal pathologies--letter
    Cancer Epidemiol Biomarkers Prev, 21 (10), 1889; author reply 1890
    DOI 10.1158/1055-9965.EPI-12-0894, PubMed 22929079
  10. Lobert VH, Bruun J, Abrahamsen H, Lothe RA, Stenmark H, Kolberg M, Campsteijn C (2012)
    Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin
    EMBO Rep, 14 (1), 10-1
    DOI 10.1038/embor.2012.188, PubMed 23229585
  11. Paulo P, Ribeiro FR, Santos J, Mesquita D, Almeida M, Barros-Silva JD, Itkonen H, Henrique R, Jerónimo C, Sveen A, Mills IG, Skotheim RI, Lothe RA, Teixeira MR (2012)
    Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements
    Neoplasia, 14 (7), 600-11
    DOI 10.1593/neo.12600, PubMed 22904677

Publications 2011

  1. Ahmed D, Lothe RA, Rivedal E, Lind GE (2011)
    Quantitative validation of GJC1 promoter hypermethylation in benign and malignant colorectal tumors
    Endocr Relat Cancer, 18 (6), C31-4
    DOI 10.1530/ERC-11-0204, PubMed 21868474
  2. Alagaratnam S, Lind GE, Kraggerud SM, Lothe RA, Skotheim RI (2011)
    The testicular germ cell tumour transcriptome
    Int J Androl, 34 (4 Pt 2), e133-50; discussion e150-1
    DOI 10.1111/j.1365-2605.2011.01169.x, PubMed 21651573
  3. Danielsen SA, Cekaite L, Ågesen TH, Sveen A, Nesbakken A, Thiis-Evensen E, Skotheim RI, Lind GE, Lothe RA (2011)
    Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome
    PLoS One, 6 (9), e24419
    DOI 10.1371/journal.pone.0024419, PubMed 21909432
  4. Leithe E, Sirnes S, Fykerud T, Kjenseth A, Rivedal E (2011)
    Endocytosis and post-endocytic sorting of connexins
    Biochim Biophys Acta, 1818 (8), 1870-9
    DOI 10.1016/j.bbamem.2011.09.029, PubMed 21996040
  5. Lind GE, Danielsen SA, Ahlquist T, Merok MA, Andresen K, Skotheim RI, Hektoen M, Rognum TO, Meling GI, Hoff G, Bretthauer M, Thiis-Evensen E, Nesbakken A, Lothe RA (2011)
    Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas
    Mol Cancer, 10, 85
    DOI 10.1186/1476-4598-10-85, PubMed 21777459
  6. Lind GE, Raiborg C, Danielsen SA, Rognum TO, Thiis-Evensen E, Hoff G, Nesbakken A, Stenmark H, Lothe RA (2011)
    SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis
    Oncogene, 30 (37), 3967-78
    DOI 10.1038/onc.2011.109, PubMed 21499309
  7. Paulo P, Barros-Silva JD, Ribeiro FR, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR (2011)
    FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer
    Genes Chromosomes Cancer, 51 (3), 240-9
    DOI 10.1002/gcc.20948, PubMed 22081504
  8. Sirnes S, Bruun J, Kolberg M, Kjenseth A, Lind GE, Svindland A, Brech A, Nesbakken A, Lothe RA, Leithe E, Rivedal E (2011)
    Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome
    Int J Cancer, 131 (3), 570-81
    DOI 10.1002/ijc.26392, PubMed 21866551
  9. Sirnes S, Honne H, Ahmed D, Danielsen SA, Rognum TO, Meling GI, Leithe E, Rivedal E, Lothe RA, Lind GE (2011)
    DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer
    Epigenetics, 6 (5), 602-9
    DOI 10.4161/epi.6.5.15237, PubMed 21406965
  10. Ågesen TH, Berg M, Clancy T, Thiis-Evensen E, Cekaite L, Lind GE, Nesland JM, Bakka A, Mala T, Hauss HJ, Fetveit T, Vatn MH, Hovig E, Nesbakken A, Lothe RA, Skotheim RI (2011)
    CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer
    Genes Immun, 12 (8), 653-62
    DOI 10.1038/gene.2011.43, PubMed 21716316

Publications 2010

  1. Berg M, Agesen TH, Thiis-Evensen E, INFAC-study group, Merok MA, Teixeira MR, Vatn MH, Nesbakken A, Skotheim RI, Lothe RA (2010)
    Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
    Mol Cancer, 9, 100
    DOI 10.1186/1476-4598-9-100, PubMed 20459617
  2. Berg M, Danielsen SA, Ahlquist T, Merok MA, Ågesen TH, Vatn MH, Mala T, Sjo OH, Bakka A, Moberg I, Fetveit T, Mathisen Ø, Husby A, Sandvik O, Nesbakken A, Thiis-Evensen E, Lothe RA (2010)
    DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset
    PLoS One, 5 (11), e13978
    DOI 10.1371/journal.pone.0013978, PubMed 21103049
  3. Brekke HR, Ribeiro FR, Kolberg M, Agesen TH, Lind GE, Eknaes M, Hall KS, Bjerkehagen B, van den Berg E, Teixeira MR, Mandahl N, Smeland S, Mertens F, Skotheim RI, Lothe RA (2010)
    Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
    J Clin Oncol, 28 (9), 1573-82
    DOI 10.1200/JCO.2009.24.8989, PubMed 20159821
  4. Cekaite L, Clancy T, Sioud M (2010)
    Increased miR-21 expression during human monocyte differentiation into DCs
    Front Biosci (Elite Ed), 2, 818-28
    DOI 10.2741/e143, PubMed 20515755
  5. Kjenseth A, Fykerud T, Rivedal E, Leithe E (2010)
    Regulation of gap junction intercellular communication by the ubiquitin system
    Cell Signal, 22 (9), 1267-73
    DOI 10.1016/j.cellsig.2010.03.005, PubMed 20206687
  6. Leithe E, Kjenseth A, Bruun J, Sirnes S, Rivedal E (2010)
    Inhibition of connexin 43 gap junction channels by the endocrine disruptor ioxynil
    Toxicol Appl Pharmacol, 247 (1), 10-7
    DOI 10.1016/j.taap.2010.05.006, PubMed 20510257

Publications 2009

  1. Brekke HR, Kolberg M, Skotheim RI, Hall KS, Bjerkehagen B, Risberg B, Domanski HA, Mandahl N, Liestøl K, Smeland S, Danielsen HE, Mertens F, Lothe RA (2009)
    Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
    Neuro Oncol, 11 (5), 514-28
    DOI 10.1215/15228517-2008-127, PubMed 19182148
  2. Danielsen SA, Lind GE, Biornslett M, Meling GI, Rognum TO, Heim S, Lothe RA (2009)
    Novel Mutations of the Suppressor Gene PTEN in Colorectal Carcinomas Stratified by Microsatellite Instability- and TP53 Mutation- Status (vol 29, pg E252, 2008)
    Hum. Mutat., 30 (6), 1023
  3. Kraggerud SM, Oldenburg J, Alnaes GI, Berg M, Kristensen VN, Fossa SD, Lothe RA (2009)
    Functional glutathione S-transferase genotypes among testicular germ cell tumor survivors: associations with primary and post-chemotherapy tumor histology
    Pharmacogenet Genomics, 19 (10), 751-9
    DOI 10.1097/FPC.0b013e3283304253, PubMed 19741569
  4. Leithe E, Kjenseth A, Sirnes S, Stenmark H, Brech A, Rivedal E (2009)
    Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101
    J Cell Sci, 122 (Pt 21), 3883-93
    DOI 10.1242/jcs.053801, PubMed 19808888
  5. Pretorius ME, Waehre H, Abeler VM, Davidson B, Vlatkovic L, Lothe RA, Giercksky KE, Danielsen HE (2009)
    Large scale genomic instability as an additive prognostic marker in early prostate cancer
    Cell Oncol, 31 (4), 251-9
    DOI 10.3233/CLO-2009-0463, PubMed 19633362
  6. Sirnes S, Kjenseth A, Leithe E, Rivedal E (2009)
    Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication
    Biochem Biophys Res Commun, 382 (1), 41-5
    DOI 10.1016/j.bbrc.2009.02.141, PubMed 19258009

Publications 2008

  1. Ahlquist T, Bottillo I, Danielsen SA, Meling GI, Rognum TO, Lind GE, Dallapiccola B, Lothe RA (2008)
    RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A
    Neoplasia, 10 (7), 680-6, 2 p following 686
    DOI 10.1593/neo.08312, PubMed 18592002
  2. Ahlquist T, Lind GE, Costa VL, Meling GI, Vatn M, Hoff GS, Rognum TO, Skotheim RI, Thiis-Evensen E, Lothe RA (2008)
    Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers
    Mol Cancer, 7, 94
    DOI 10.1186/1476-4598-7-94, PubMed 19117505
  3. Danielsen SA, Lind GE, Bjørnslett M, Meling GI, Rognum TO, Heim S, Lothe RA (2008)
    Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status
    Hum Mutat, 29 (11), E252-62
    DOI 10.1002/humu.20860, PubMed 18781614
  4. Lind GE, Ahlquist T, Kolberg M, Berg M, Eknaes M, Alonso MA, Kallioniemi A, Meling GI, Skotheim RI, Rognum TO, Thiis-Evensen E, Lothe RA (2008)
    Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
    J Transl Med, 6, 13
    DOI 10.1186/1479-5876-6-13, PubMed 18346269
  5. Sirnes S, Leithe E, Rivedal E (2008)
    The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis
    Biochem Biophys Res Commun, 373 (4), 597-601
    DOI 10.1016/j.bbrc.2008.06.095, PubMed 18601906

Publications 2007

  1. Leithe E, Rivedal E (2007)
    Ubiquitination of gap junction proteins
    J Membr Biol, 217 (1-3), 43-51
    DOI 10.1007/s00232-007-9050-z, PubMed 17657522
  2. Lind GE, Ahlquist T, Lothe RA (2007)
    DNA hypermethylation of MAL: a promising diagnostic biomarker for colorectal tumors
    Gastroenterology, 132 (4), 1631-2; author reply 1632
    DOI 10.1053/j.gastro.2007.03.003, PubMed 17408629
  3. Lind GE, Skotheim RI, Lothe RA (2007)
    The epigenome of testicular germ cell tumors
    APMIS, 115 (10), 1147-60
    DOI 10.1111/j.1600-0463.2007.apm_660.xml.x, PubMed 18042148

Publications 2006

  1. Johnson MD, Tengs T, Oldach D, Stoecker DK (2006)
    Sequestration, performance, and functional control of cryptophyte plastids in the ciliate Myrionecta rubra (Ciliophora)
    J. Phycol., 42 (6), 1235-1246
  2. Leithe E, Brech A, Rivedal E (2006)
    Endocytic processing of connexin43 gap junctions: a morphological study
    Biochem J, 393 (Pt 1), 59-67
    DOI 10.1042/BJ20050674, PubMed 16162097
  3. Leithe E, Sirnes S, Omori Y, Rivedal E (2006)
    Downregulation of gap junctions in cancer cells
    Crit Rev Oncog, 12 (3-4), 225-56
    DOI 10.1615/critrevoncog.v12.i3-4.30, PubMed 17425504
  4. Lind GE, Kleivi K, Meling GI, Teixeira MR, Thiis-Evensen E, Rognum TO, Lothe RA (2006)
    ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis
    Cell. Oncol., 28 (5-6), 259-272
  5. Lind GE, Kleivi K, Meling GI, Teixeira MR, Thiis-Evensen E, Rognum TO, Lothe RA (2006)
    ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis
    Cell Oncol, 28 (5-6), 259-72
    DOI 10.1155/2006/949506, PubMed 17167179
  6. Lind GE, Skotheim RI, Fraga MF, Abeler VM, Esteller M, Lothe RA (2006)
    Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1)
    J Pathol, 210 (4), 441-9
    DOI 10.1002/path.2064, PubMed 17029216
  7. Lothe RA, Skotheim RI, Kallioniemi O, Esteller M (2006)
    To the Readers and Future Authors of Critical Reviews in Oncogenesis
    Critical Reviews in Oncogenesis, 12 (1-2), 1-2
    PublikaID 27

Publications 2004

  1. Cekaite L, Hovig E, Hauge HH (2004)
    Double-sided silicon strip detectors: new applications within genomics and proteomics
    Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc. Equip., 527 (1-2), 68-72

Publications 2003

  1. Thorstensen L, Holm R, Lothe RA, Tropé C, Carvalho B, Sobrinho-Simoes M, Seruca R (2003)
    WNT-inducible signaling pathway protein 3, WISP-3, is mutated in microsatellite unstable gastrointestinal carcinomas but not in endometrial carcinomas
    Gastroenterology, 124 (1), 270-1
    DOI 10.1053/gast.2003.50034, PubMed 12512062

Publications 2001

  1. Duval A, Iacopetta B, Thorstensen L, Meling GI, Lothe RA, Thuille B, Suraweera N, Thomas G, Hamelin R (2001)
    Gender difference for mismatch repair deficiency in human colorectal cancer
    Gastroenterology, 121 (4), 1026-7
    DOI 10.1053/gast.2001.28585, PubMed 11665694
  2. Thorstensen L, Qvist H, Nesland JM, Giercksky KE, Lothe RA (2001)
    Identification of two potential suppressor gene regions on chromosome arm 14q that are commonly lost in advanced colorectal carcinomas
    Scand J Gastroenterol, 36 (12), 1327-31
    DOI 10.1080/003655201317097209, PubMed 11761025

Publications 1995

  1. Kraggerud SM, Sandvik JA, Pettersen EO (1995)
    Regulation of protein synthesis in human cells exposed to extreme hypoxia
    Anticancer Res, 15 (3), 683-6
    PubMed 7645943

Publications 1989

  1. Gedde-Dahl T, Heim S, Lothe R, Bye R, Geitvik GA, Kyrkjebø HT, Hognestad J, Nygaard K, Bergan A, Olaisen B (1989)
    [The polyposis project]
    Nord Med, 104 (1), 12-5
    PubMed 2536147

Publications 1988

  1. Gedde-Dahl T, Heim S, Lothe R, Bye R, Brevik K, Geitvik GA, Kyrkjebø HT, Hognestad J, Nygaard K, Bergan A (1988)
    [The polyposis project]
    Tidsskr Nor Laegeforen, 108 (29), 2465-8
    PubMed 2905084

Publications 1987

  1. Lothe RA, Gedde-Dahl T, Lier ME, Aamdahl S, Bergan A, Stenwig AE, Broegger A (1987)
    Loss of one chromosome #13 during development of a polyposis tumor
    Cancer Genet Cytogenet, 28 (2), 335-42
    DOI 10.1016/0165-4608(87)90220-2, PubMed 2887278

Publications 1985

  1. Lothe RA, Frøholm LO, Westre G, Kjennerud U (1985)
    Stainer and Scholte's pertussis medium with an alternative buffer
    J Biol Stand, 13 (2), 129-34
    DOI 10.1016/s0092-1157(85)80018-4, PubMed 2860114
 
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