Publications 2024

Frank AK, Chung BK, De Novales MLL, Engesæter LK, Hoyle HW, Øgaard J, Heslop J, Karlsen TH, Tysoe O, Brevini T, Tchorz JS, Vallier L, Mohorianu I, Sampaziotis F, Melum E (2024)
Single-Cell Transcriptomic Profiling of Cholangiocyte Organoids Derived from Bile Ducts of Primary Sclerosing Cholangitis Patients
Dig Dis Sci, 69 (10), 3810-3823
DOI 10.1007/s10620-024-08570-y, PubMed 39160386

Gregersen I, Kong XY, Kooijman S, Foyn H, Grannes H, Olsen MB, Lone AM, Yang K, Quiles-Jiménez A, Tran M, Øgaard J, Segers FM, Rashidi A, Sagen EL, Lauritzen KH, Pronk ACM, de Boer JF, Holven KB, Melum E, Aukrust P, Taskén K, Holm S, Rensen PCN, Dahl TB, Halvorsen B (2024)
T cells with increased responsiveness cause obesity in mice without diet intervention
iScience, 27 (4), 109471
DOI 10.1016/j.isci.2024.109471, PubMed 38551005

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS (2024)
Author Correction: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Nature, 626 (8001), E19
DOI 10.1038/s41586-024-07164-y, PubMed 38336833

Nikitina D, Lukosevicius R, Tilinde D, Muskieta T, Hov JR, Melum E, Klovins J, Org E, Kiudelis G, Kupcinskas J, Skieceviciene J (2024)
Cell-Free Microbial DNA Analysis: Effects of Blood Plasma and Serum Quantity, Biobanking Protocols, and Isolation Kits
Biopreserv Biobank, 22 (4), 363-372
DOI 10.1089/bio.2023.0048, PubMed 38416864

Oldereid TS, Jiang X, Øgaard J, Schrumpf E, Bjørnholt JV, Rasmussen H, Melum E (2024)
Microbial exposure during early life regulates development of bile duct inflammation
Scand J Gastroenterol, 59 (2), 192-201
DOI 10.1080/00365521.2023.2278423, PubMed 37997753

Publications 2023

Andersen IM, Reims HM, Grzyb K, Fevang B, Melum E, Aukrust P, Wiencke K, Nordøy I, Line PD, Jørgensen SF (2023)
Long-term survival after liver transplantation in patients with common variable immunodeficiency
Liver Transpl, 29 (8), 894-899
DOI 10.1097/LVT.0000000000000130, PubMed 36932715

Bergsmark T, Engesæter LK, Rasmussen A, Bennet W, Nordin A, Pall V, Line PD, Ericzon BG, Melum E (2023)
Long-term survival after liver transplantation for alcohol-related liver disease in the Nordic countries
Scand J Gastroenterol, 58 (8), 923-930
DOI 10.1080/00365521.2023.2184193, PubMed 36872559

Braadland PR, Bergquist A, Kummen M, Bossen L, Engesæter LK, Reims HM, Björk I, Grzyb K, Abildgaard A, Småstuen MC, Folseraas T, Trøseid M, Ulvik A, Ueland PM, Melum E, Line PD, Høivik ML, Grønbæk H, Karlsen TH, Vesterhus M, Hov JR (2023)
Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation
J Hepatol, 79 (4), 955-966
DOI 10.1016/j.jhep.2023.05.038, PubMed 37328069

Busek M, Aizenshtadt A, Koch T, Frank A, Delon L, Martinez MA, Golovin A, Dumas C, Stokowiec J, Gruenzner S, Melum E, Krauss S (2023)
Pump-less, recirculating organ-on-a-chip (rOoC) platform
Lab Chip, 23 (4), 591-608
DOI 10.1039/d2lc00919f, PubMed 36655405

Harrison SP, Siller R, Tanaka Y, Chollet ME, de la Morena-Barrio ME, Xiang Y, Patterson B, Andersen E, Bravo-Pérez C, Kempf H, Åsrud KS, Lunov O, Dejneka A, Mowinckel MC, Stavik B, Sandset PM, Melum E, Baumgarten S, Bonanini F, Kurek D, Mathapati S, Almaas R, Sharma K, Wilson SR, Skottvoll FS et al. (2023)
Scalable production of tissue-like vascularized liver organoids from human PSCs
Exp Mol Med, 55 (9), 2005-2024
DOI 10.1038/s12276-023-01074-1, PubMed 37653039

Jiang X, Otterdal K, Chung BK, Maucourant C, Rønneberg JD, Zimmer CL, Øgaard J, Boichuk Y, Holm S, Geanon D, Schneditz G, Bergquist A, Björkström NK, Melum E (2023)
Cholangiocytes Modulate CD100 Expression in the Liver and Facilitate Pathogenic T-Helper 17 Cell Differentiation
Gastroenterology, 166 (4), 667-679
DOI 10.1053/j.gastro.2023.11.283, PubMed 37995866

Oldereid TS, Jiang X, Nordhus KS, Ponzetta A, Bjørnholt JV, Björkström NK, Melum E, Rasmussen H (2023)
Role of bacteria and microbial metabolites in immune modulation during early life
Scand J Immunol, 99 (2), e13336
DOI 10.1111/sji.13336, PubMed 38441196

Tran TT, Vaage EB, Mehta A, Chopra A, Tietze L, Kolderup A, Anthi A, König M, Nygaard G, Lind A, Müller F, Nissen-Meyer LS, Magnus P, Trogstad L, Mjaaland S, Søraas A, Midtvedt K, Åsberg A, Barratt-Due A, Medhus AW, Høivik ML, Lundin K, Karlsen RF, Dahle R, Danielsson K et al. (2023)
Author Correction: Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
NPJ Vaccines, 8 (1), 4
DOI 10.1038/s41541-023-00600-6, PubMed 36697432

Publications 2022

Brevini T, Maes M, Webb GJ, John BV, Fuchs CD, Buescher G, Wang L, Griffiths C, Brown ML, Scott WE, Pereyra-Gerber P, Gelson WTH, Brown S, Dillon S, Muraro D, Sharp J, Neary M, Box H, Tatham L, Stewart J, Curley P, Pertinez H, Forrest S, Mlcochova P, Varankar SS et al. (2022)
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
Nature, 615 (7950), 134-142
DOI 10.1038/s41586-022-05594-0, PubMed 36470304

Chung BK, Øgaard J, Reims HM, Karlsen TH, Melum E (2022)
Spatial transcriptomics identifies enriched gene expression and cell types in human liver fibrosis
Hepatol Commun, 6 (9), 2538-2550
DOI 10.1002/hep4.2001, PubMed 35726350

Tran TT, Vaage EB, Mehta A, Chopra A, Tietze L, Kolderup A, Anthi A, König M, Nygaard G, Lind A, Müller F, Nissen-Meyer LS, Magnus P, Trogstad L, Mjaaland S, Søraas A, Midtvedt K, Åsberg A, Barratt-Due A, Medhus AW, Høivik ML, Lundin K, Karlsen RF, Dahle R, Danielsson K et al. (2022)
Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
NPJ Vaccines, 7 (1), 174
DOI 10.1038/s41541-022-00586-7, PubMed 36585405

Tønnessen TC, Melleby AO, Hauge-Iversen IM, Espe EKS, Ahmed MS, Ueland T, Haavardsholm EA, Atkinson SM, Melum E, Attramadal H, Sjaastad I, Vinge LE (2022)
Impact of delayed type hypersensitivity arthritis on development of heart failure by aortic constriction in mice
PLoS One, 17 (1), e0262821
DOI 10.1371/journal.pone.0262821, PubMed 35077491

Valestrand L, Zheng F, Hansen SH, Øgaard J, Hov JR, Björkström NK, Karlsen TH, Jiang X, Melum E (2022)
Bile from Patients with Primary Sclerosing Cholangitis Contains Mucosal-Associated Invariant T-Cell Antigens
Am J Pathol, 192 (4), 629-641
DOI 10.1016/j.ajpath.2021.12.008, PubMed 35063408

Yu J, Refsum E, Helsingen LM, Folseraas T, Ploner A, Wieszczy P, Barua I, Jodal HC, Melum E, Løberg M, Blom J, Bretthauer M, Adami HO, Kalager M, Ye W (2022)
Risk of hepato-pancreato-biliary cancer is increased by primary sclerosing cholangitis in patients with inflammatory bowel disease: A population-based cohort study
United European Gastroenterol J, 10 (2), 212-224
DOI 10.1002/ueg2.12204, PubMed 35107865

Publications 2021

Hausken J, Haugaa H, Hagness M, Line PD, Melum E, Tønnessen TI (2021)
Thoracic Epidural Analgesia for Postoperative Pain Management in Liver Transplantation: A 10-year Study on 685 Liver Transplant Recipients
Transplant Direct, 7 (2), e648
DOI 10.1097/TXD.0000000000001101, PubMed 33437863

Jiang X, Bergquist A, Löscher BS, Venkatesh G, Mold JE, Holm K, Laerdahl JK, Skånland SS, Maleki KT, Cornillet M, Taskén K, Franke A, Karlsen TH, Björkström NK, Melum E (2021)
A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
Sci Transl Med, 13 (582)
DOI 10.1126/scitranslmed.abb0036, PubMed 33627483

Jiang X, Melum E (2021)
The Role of Natural Killer Cells in Nonalcoholic Steatohepatitis: An Ongoing Debate
Cell Mol Gastroenterol Hepatol, 13 (1), 348-349
DOI 10.1016/j.jcmgh.2021.10.006, PubMed 34740615

Lissing M, Nowak G, Adam R, Karam V, Boyd A, Gouya L, Meersseman W, Melum E, Ołdakowska-Jedynak U, Reiter FP, Colmenero J, Sanchez R, Herden U, Langendonk J, Ventura P, Isoniemi H, Boillot O, Braun F, Perrodin S, Mowlem E, Wahlin S, European Liver and Intestine Transplant Association (2021)
Liver Transplantation for Acute Intermittent Porphyria
Liver Transpl, 27 (4), 491-501
DOI 10.1002/lt.25959, PubMed 33259654

Sampaziotis F, Muraro D, Tysoe OC, Sawiak S, Beach TE, Godfrey EM, Upponi SS, Brevini T, Wesley BT, Garcia-Bernardo J, Mahbubani K, Canu G, Gieseck R, Berntsen NL, Mulcahy VL, Crick K, Fear C, Robinson S, Swift L, Gambardella L, Bargehr J, Ortmann D, Brown SE, Osnato A, Murphy MP et al. (2021)
Cholangiocyte organoids can repair bile ducts after transplantation in the human liver
Science, 371 (6531), 839-846
DOI 10.1126/science.aaz6964, PubMed 33602855

Zimmer CL, Filipovic I, Cornillet M, O'Rourke CJ, Berglin L, Jansson H, Sun D, Strauss O, Hertwig L, Johansson H, von Seth E, Sparrelid E, Dias J, Glaumann H, Melum E, Ellis EC, Sandberg JK, Andersen JB, Bergquist A, Björkström NK (2021)
Mucosal-associated invariant T-cell tumor infiltration predicts long-term survival in cholangiocarcinoma
Hepatology, 75 (5), 1154-1168
DOI 10.1002/hep.32222, PubMed 34719787

Publications 2020

Louwe MC, Olsen MB, Kaasbøll OJ, Yang K, Fosshaug LE, Alfsnes K, Øgaard JDS, Rashidi A, Skulberg VM, Yang M, de Miranda Fonseca D, Sharma A, Aronsen JM, Schrumpf E, Ahmed MS, Dahl CP, Nyman TA, Ueland T, Melum E, Halvorsen BE, Bjørås M, Attramadal H, Sjaastad I, Aukrust P, Yndestad A (2020)
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC Basic Transl Sci, 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013, PubMed 33426377

Valestrand L, Berntsen NL, Zheng F, Schrumpf E, Hansen SH, Karlsen TH, Blumberg RS, Hov JR, Jiang X, Melum E (2020)
Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells
Clin Exp Immunol, 203 (2), 304-314
DOI 10.1111/cei.13541, PubMed 33089489

Publications 2019

Maroni L, Pinto C, Giordano DM, Saccomanno S, Banales JM, Spallacci D, Albertini MC, Orlando F, Provinciali M, Milkiewicz M, Melum E, Labiano I, Milkiewicz P, Rychlicki C, Trozzi L, Scarpelli M, Benedetti A, Svegliati Baroni G, Marzioni M (2019)
Aging-Related Expression of Twinfilin-1 Regulates Cholangiocyte Biological Response to Injury
Hepatology, 70 (3), 883-898
DOI 10.1002/hep.30466, PubMed 30561764

Melum E, Jiang X, Baker KD, Macedo MF, Fritsch J, Dowds CM, Wang J, Pharo A, Kaser A, Tan C, Pereira CS, Kelly SL, Duan J, Karlsen TH, Exley MA, Schütze S, Zajonc DM, Merrill AH, Schuchman EH, Zeissig S, Blumberg RS (2019)
Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin
Nat Immunol, 20 (12), 1644-1655
DOI 10.1038/s41590-019-0504-0, PubMed 31636468

Tysoe OC, Justin AW, Brevini T, Chen SE, Mahbubani KT, Frank AK, Zedira H, Melum E, Saeb-Parsy K, Markaki AE, Vallier L, Sampaziotis F (2019)
Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue
Nat Protoc, 14 (6), 1884-1925
DOI 10.1038/s41596-019-0168-0, PubMed 31110298

Publications 2018

Berntsen NL, Fosby B, Tan C, Reims HM, Ogaard J, Jiang X, Schrumpf E, Valestrand L, Karlsen TH, Line PD, Blumberg RS, Melum E (2018)
Natural killer T cells mediate inflammation in the bile ducts
Mucosal Immunol, 11 (6), 1582-1590
DOI 10.1038/s41385-018-0066-8, PubMed 30115993

Holmer M, Melum E, Isoniemi H, Ericzon BG, Castedal M, Nordin A, Aagaard Schultz N, Rasmussen A, Line PD, Stål P, Bennet W, Hagström H (2018)
Nonalcoholic fatty liver disease is an increasing indication for liver transplantation in the Nordic countries
Liver Int, 38 (11), 2082-2090
DOI 10.1111/liv.13751, PubMed 29630771

Paquin-Proulx D, Greenspun BC, Pasquet L, Strunz B, Aleman S, Falconer K, Terabe M, Berzofsky JA, Sandberg JK, Melum E, Nixon DF, Björkström NK (2018)
IL13Rα2 expression identifies tissue-resident IL-22-producing PLZF⁺ innate T cells in the human liver
Eur J Immunol, 48 (8), 1329-1335
DOI 10.1002/eji.201747334, PubMed 29677387

Pihlstrøm HK, Mjøen G, Mucha S, Franke A, Jardine A, Fellström B, Dahle DO, Holdaas H, Melum E (2018)
Genetic markers associated with long-term cardiovascular outcome in kidney transplant recipients
Am J Transplant, 19 (5), 1444-1451
DOI 10.1111/ajt.15191, PubMed 30457209

Thorgersen EB, Melum E, Folseraas T, Larsen SG, Line PD (2018)
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei in a liver-transplanted patient: a case report
World J Surg Oncol, 16 (1), 180
DOI 10.1186/s12957-018-1482-7, PubMed 30185175

Publications 2017

Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F, Rombouts K, Böttcher K, Folseraas T, Weismüller TJ, Mason AL, Wang W, Alexander G, Alvaro D, Bergquist A, Björkström NK, Beuers U, Björnsson E, Boberg KM, Bowlus CL, Bragazzi MC, Carbone M, Chazouillères O, Cheung A, Dalekos G, Eaton J et al. (2017)
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis
Gut, 67 (8), 1517-1524
DOI 10.1136/gutjnl-2016-313598, PubMed 28779025

Berntsen NL, Fosby B, Valestrand L, Tan C, Reims HM, Schrumpf E, Karlsen TH, Line PD, Melum E (2017)
Establishment of a surgical bile duct injection technique giving direct access to the bile ducts for studies of the murine biliary tree
Am J Physiol Gastrointest Liver Physiol, 314 (3), G349-G359
DOI 10.1152/ajpgi.00124.2017, PubMed 29212771

Chellappa S, Hugenschmidt H, Hagness M, Subramani S, Melum E, Line PD, Labori KJ, Wiedswang G, Taskén K, Aandahl EM (2017)
CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer
J Immunol, 198 (4), 1729-1739
DOI 10.4049/jimmunol.1600061, PubMed 28053236

Henriksen EKK, Viken MK, Wittig M, Holm K, Folseraas T, Mucha S, Melum E, Hov JR, Lazaridis KN, Juran BD, Chazouillères O, Färkkilä M, Gotthardt DN, Invernizzi P, Carbone M, Hirschfield GM, Rushbrook SM, Goode E, UK-PSC Consortium, Ponsioen CY, Weersma RK, Eksteen B, Yimam KK, Gordon SC, Goldberg D et al. (2017)
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry
HLA, 90 (4), 228-233
DOI 10.1111/tan.13076, PubMed 28695657

Jiang X, Björkström NK, Melum E (2017)
Intact CD100-CD72 Interaction Necessary for TCR-Induced T Cell Proliferation
Front Immunol, 8, 765
DOI 10.3389/fimmu.2017.00765, PubMed 28713384

Landskron J, Kraggerud SM, Wik E, Dørum A, Bjørnslett M, Melum E, Helland Ø, Bjørge L, Lothe RA, Salvesen HB, Taskén K (2017)
C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease
PLoS One, 12 (7), e0182030
DOI 10.1371/journal.pone.0182030, PubMed 28759630

Meijerink H, White RA, Løvlie A, de Blasio BF, Dalgard O, Amundsen EJ, Melum E, Kløvstad H (2017)
Modelling the burden of hepatitis C infection among people who inject drugs in Norway, 1973-2030
BMC Infect Dis, 17 (1), 541
DOI 10.1186/s12879-017-2631-2, PubMed 28774261

Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W et al. (2017)
Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids
Nat Med, 23 (8), 954-963
DOI 10.1038/nm.4360, PubMed 28671689

Schrumpf E, Jiang X, Zeissig S, Pollheimer MJ, Anmarkrud JA, Tan C, Exley MA, Karlsen TH, Blumberg RS, Melum E (2017)
The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation
Physiol Rep, 5 (4)
DOI 10.14814/phy2.13117, PubMed 28219981

Vesterhus M, Holm A, Hov JR, Nygård S, Schrumpf E, Melum E, Thorbjørnsen LW, Paulsen V, Lundin K, Dale I, Gilja OH, Zweers SJLB, Vatn M, Schaap FG, Jansen PLM, Ueland T, Røsjø H, Moum B, Ponsioen CY, Boberg KM, Färkkilä M, Karlsen TH, Lund-Johansen F (2017)
Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis
J Hepatol, 66 (6), 1214-1222
DOI 10.1016/j.jhep.2017.01.019, PubMed 28161472

Publications 2016

Henriksen EK, Jørgensen KK, Kaveh F, Holm K, Hamm D, Olweus J, Melum E, Chung BK, Eide TJ, Lundin KE, Boberg KM, Karlsen TH, Hirschfield GM, Liaskou E (2016)
Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease
J Hepatol, 66 (1), 116-122
DOI 10.1016/j.jhep.2016.09.002, PubMed 27647428

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS (2016)
Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Nature, 536 (7616), 359
DOI 10.1038/nature17421, PubMed 26982724

Ji SG, Juran BD, Mucha S, Folseraas T, Jostins L, Melum E, Kumasaka N, Atkinson EJ, Schlicht EM, Liu JZ, Shah T, Gutierrez-Achury J, Boberg KM, Bergquist A, Vermeire S, Eksteen B, Durie PR, Farkkila M, Müller T, Schramm C, Sterneck M, Weismüller TJ, Gotthardt DN, Ellinghaus D, Braun F et al. (2016)
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
Nat Genet, 49 (2), 269-273
DOI 10.1038/ng.3745, PubMed 27992413

Maroni L, Agostinelli L, Saccomanno S, Pinto C, Giordano DM, Rychlicki C, De Minicis S, Trozzi L, Banales JM, Melum E, Karlsen TH, Benedetti A, Baroni GS, Marzioni M (2016)
Nlrp3 Activation Induces Il-18 Synthesis and Affects the Epithelial Barrier Function in Reactive Cholangiocytes
Am J Pathol, 187 (2), 366-376
DOI 10.1016/j.ajpath.2016.10.010, PubMed 27912077

Pihlstrøm HK, Mjøen G, Mucha S, Haraldsen G, Franke A, Jardine A, Fellström B, Holdaas H, Melum E (2016)
Single Nucleotide Polymorphisms and Long-Term Clinical Outcome in Renal Transplant Patients: A Validation Study
Am J Transplant, 17 (2), 528-533
DOI 10.1111/ajt.13995, PubMed 27483393

Schrumpf E, Kummen M, Valestrand L, Greiner TU, Holm K, Arulampalam V, Reims HM, Baines J, Bäckhed F, Karlsen TH, Blumberg RS, Hov JR, Melum E (2016)
The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation
J Hepatol, 66 (2), 382-389
DOI 10.1016/j.jhep.2016.09.020, PubMed 27720803

Vesterhus M, Melum E (2016)
Prognostic biomarkers and surrogate end points in PSC
Liver Int, 36 (12), 1748-1751
DOI 10.1111/liv.13216, PubMed 27864874

Publications 2015

Andersen IM, Fosby B, Boberg KM, Clausen OP, Jebsen P, Melum E, Line PD, Foss A, Schrumpf E, Karlsen TH (2015)
Indications and Outcomes in Liver Transplantation in Patients With Primary Sclerosing Cholangitis in Norway
Transplant Direct, 1 (9), e39
DOI 10.1097/TXD.0000000000000548, PubMed 27500239

Fosby B, Melum E, Bjøro K, Bennet W, Rasmussen A, Andersen IM, Castedal M, Olausson M, Wibeck C, Gotlieb M, Gjertsen H, Toivonen L, Foss S, Makisalo H, Nordin A, Sanengen T, Bergquist A, Larsson ME, Soderdahl G, Nowak G, Boberg KM, Isoniemi H, Keiding S, Foss A, Line PD et al. (2015)
Liver transplantation in the Nordic countries - An intention to treat and post-transplant analysis from The Nordic Liver Transplant Registry 1982-2013
Scand J Gastroenterol, 50 (6), 797-808
DOI 10.3109/00365521.2015.1036359, PubMed 25959101

Liaskou E, Klemsdal Henriksen EK, Holm K, Kaveh F, Hamm D, Fear J, Viken MK, Hov JR, Melum E, Robins H, Olweus J, Karlsen TH, Hirschfield GM (2015)
High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
Hepatology, 63 (5), 1608-19
DOI 10.1002/hep.28116, PubMed 26257205

Olin P, Hausken J, Foss A, Karlsen TH, Melum E, Haugaa H (2015)
Continuous molecular adsorbent recirculating system treatment in 69 patients listed for liver transplantation
Scand J Gastroenterol, 50 (9), 1127-34
DOI 10.3109/00365521.2015.1027262, PubMed 25865318

Sampaziotis F, de Brito MC, Madrigal P, Bertero A, Saeb-Parsy K, Soares FAC, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WT, Davies S, Baker A, Kaser A, Alexander GJ, Hannan NRF, Vallier L (2015)
Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation
Nat Biotechnol, 33 (8), 845-852
DOI 10.1038/nbt.3275, PubMed 26167629

Schrumpf E, Tan C, Karlsen TH, Sponheim J, Björkström NK, Sundnes O, Alfsnes K, Kaser A, Jefferson DM, Ueno Y, Eide TJ, Haraldsen G, Zeissig S, Exley MA, Blumberg RS, Melum E (2015)
The biliary epithelium presents antigens to and activates natural killer T cells
Hepatology, 62 (4), 1249-59
DOI 10.1002/hep.27840, PubMed 25855031

Publications 2014

Eskesen AN, Bjøro K, Aandahl EM, Line PD, Melum E (2014)
Low use of surveillance and early diagnosis of hepatocellular carcinoma in Norway--a population-based cohort study
Cancer Epidemiol, 38 (6), 741-7
DOI 10.1016/j.canep.2014.10.005, PubMed 25454262

Fickert P, Pollheimer MJ, Beuers U, Lackner C, Hirschfield G, Housset C, Keitel V, Schramm C, Marschall HU, Karlsen TH, Melum E, Kaser A, Eksteen B, Strazzabosco M, Manns M, Trauner M, International PSC Study Group (IPSCSG) (2014)
Characterization of animal models for primary sclerosing cholangitis (PSC)
J Hepatol, 60 (6), 1290-303
DOI 10.1016/j.jhep.2014.02.006, PubMed 24560657

Fosby B, Næss S, Hov JR, Traherne J, Boberg KM, Trowsdale J, Foss A, Line PD, Franke A, Melum E, Scott H, Karlsen TH (2014)
HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation
World J Gastroenterol, 20 (14), 3986-4000
DOI 10.3748/wjg.v20.i14.3986, PubMed 24744588

Henriksen EK, Melum E, Karlsen TH (2014)
Update on primary sclerosing cholangitis genetics
Curr Opin Gastroenterol, 30 (3), 310-9
DOI 10.1097/MOG.0000000000000052, PubMed 24565892

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS (2014)
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
Nature, 517 (7534), 386-90
DOI 10.1038/nature13848, PubMed 25363763

Naess S, Björnsson E, Anmarkrud JA, Al Mamari S, Juran BD, Lazaridis KN, Chapman R, Bergquist A, Melum E, Marsh SG, Schrumpf E, Lie BA, Boberg KM, Karlsen TH, Hov JR (2014)
Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease
Liver Int, 34 (10), 1488-95
DOI 10.1111/liv.12492, PubMed 24517468

Næss S, Lie BA, Melum E, Olsson M, Hov JR, Croucher PJ, Hampe J, Thorsby E, Bergquist A, Traherne JA, Schrumpf E, Boberg KM, Schreiber S, Franke A, Karlsen TH (2014)
Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population
PLoS One, 9 (12), e114486
DOI 10.1371/journal.pone.0114486, PubMed 25521205

Zeissig S, Petersen BS, Tomczak M, Melum E, Huc-Claustre E, Dougan SK, Laerdahl JK, Stade B, Forster M, Schreiber S, Weir D, Leichtner AM, Franke A, Blumberg RS (2014)
Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4
Gut, 64 (12), 1889-97
DOI 10.1136/gutjnl-2014-308541, PubMed 25367873

Publications 2013

Ellinghaus D, Folseraas T, Holm K, Ellinghaus E, Melum E, Balschun T, Laerdahl JK, Shiryaev A, Gotthardt DN, Weismüller TJ, Schramm C, Wittig M, Bergquist A, Björnsson E, Marschall HU, Vatn M, Teufel A, Rust C, Gieger C, Wichmann HE, Runz H, Sterneck M, Rupp C, Braun F, Weersma RK et al. (2013)
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4
Hepatology, 58 (3), 1074-83
DOI 10.1002/hep.25977, PubMed 22821403

Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM, Doncheva NT, Andreassen OA, Weersma RK, Weismüller TJ, Eksteen B, Invernizzi P, Hirschfield GM, Gotthardt DN, Pares A, Ellinghaus D, Shah T, Juran BD, Milkiewicz P, Rust C, Schramm C, Müller T, Srivastava B, Dalekos G, Nöthen MM, Herms S et al. (2013)
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Nat Genet, 45 (6), 670-5
DOI 10.1038/ng.2616, PubMed 23603763

Zeissig S, Olszak T, Melum E, Blumberg RS (2013)
Analyzing antigen recognition by Natural Killer T cells
Methods Mol Biol, 960, 557-572
DOI 10.1007/978-1-62703-218-6_41, PubMed 23329514

Publications 2012

Eskesen AN, Melum E, Moghaddam A, Bjøro K, Verbaan H, Ring-Larsen H, Dalgard O (2012)
Genetic variants at the ITPA locus protect against ribavirin-induced hemolytic anemia and dose reduction in an HCV G2/G3 cohort
Eur J Gastroenterol Hepatol, 24 (8), 890-6
DOI 10.1097/MEG.0b013e3283546efd, PubMed 22584257

Folseraas T, Melum E, Rausch P, Juran BD, Ellinghaus E, Shiryaev A, Laerdahl JK, Ellinghaus D, Schramm C, Weismüller TJ, Gotthardt DN, Hov JR, Clausen OP, Weersma RK, Janse M, Boberg KM, Björnsson E, Marschall HU, Cleynen I, Rosenstiel P, Holm K, Teufel A, Rust C, Gieger C, Wichmann HE et al. (2012)
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci
J Hepatol, 57 (2), 366-75
DOI 10.1016/j.jhep.2012.03.031, PubMed 22521342

Forster M, Forster P, Elsharawy A, Hemmrich G, Kreck B, Wittig M, Thomsen I, Stade B, Barann M, Ellinghaus D, Petersen BS, May S, Melum E, Schilhabel MB, Keller A, Schreiber S, Rosenstiel P, Franke A (2012)
From next-generation sequencing alignments to accurate comparison and validation of single-nucleotide variants: the pibase software
Nucleic Acids Res, 41 (1), e16
DOI 10.1093/nar/gks836, PubMed 22965131

Fosby B, Karlsen TH, Melum E (2012)
Recurrence and rejection in liver transplantation for primary sclerosing cholangitis
World J Gastroenterol, 18 (1), 1-15
DOI 10.3748/wjg.v18.i1.1, PubMed 22228965

Srivastava B, Mells GF, Cordell HJ, Muriithi A, Brown M, Ellinghaus E, Franke A, UK-PSC Consortium, Karlsen TH, Sandford RN, Alexander GJ, Chapman RW, Rushbrook SM, Melum E (2012)
Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis
Scand J Gastroenterol, 47 (7), 820-6
DOI 10.3109/00365521.2012.682090, PubMed 22554193

Publications 2011

Folseraas T, Melum E, Franke A, Karlsen TH (2011)
Genetics in primary sclerosing cholangitis
Best Pract Res Clin Gastroenterol, 25 (6), 713-26
DOI 10.1016/j.bpg.2011.09.010, PubMed 22117637

Janse M, Lamberts LE, Franke L, Raychaudhuri S, Ellinghaus E, Muri Boberg K, Melum E, Folseraas T, Schrumpf E, Bergquist A, Björnsson E, Fu J, Jan Westra H, Groen HJ, Fehrmann RS, Smolonska J, van den Berg LH, Ophoff RA, Porte RJ, Weismüller TJ, Wedemeyer J, Schramm C, Sterneck M, Günther R, Braun F et al. (2011)
Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9
Hepatology, 53 (6), 1977-85
DOI 10.1002/hep.24307, PubMed 21425313

Moghaddam A, Melum E, Reinton N, Ring-Larsen H, Verbaan H, Bjøro K, Dalgard O (2011)
IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection
Hepatology, 53 (3), 746-54
DOI 10.1002/hep.24154, PubMed 21374656

Publications 2010

Evang JA, Borota OC, Melum E, Holm R, Ramm-Pettersen J, Bollerslev J, Berg JP (2010)
HDAC2 expression and variable number of repeats in exon 1 of the HDAC2 gene in corticotroph adenomas
Clin Endocrinol (Oxf), 73 (2), 229-35
DOI 10.1111/j.1365-2265.2010.03805.x, PubMed 20346000

Holm K, Melum E, Franke A, Karlsen TH (2010)
SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels
BMC Bioinformatics, 11, 600
DOI 10.1186/1471-2105-11-600, PubMed 21167019

Hov JR, Keitel V, Laerdahl JK, Spomer L, Ellinghaus E, ElSharawy A, Melum E, Boberg KM, Manke T, Balschun T, Schramm C, Bergquist A, Weismüller T, Gotthardt D, Rust C, Henckaerts L, Onnie CM, Weersma RK, Sterneck M, Teufel A, Runz H, Stiehl A, Ponsioen CY, Wijmenga C, Vatn MH et al. (2010)
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
PLoS One, 5 (8), e12403
DOI 10.1371/journal.pone.0012403, PubMed 20811628

Karlsen TH, Melum E, Franke A (2010)
The utility of genome-wide association studies in hepatology
Hepatology, 51 (5), 1833-42
DOI 10.1002/hep.23564, PubMed 20232293

Lorentzen AR, Melum E, Ellinghaus E, Smestad C, Mero IL, Aarseth JH, Myhr KM, Celius EG, Lie BA, Karlsen TH, Franke A, Harbo HF (2010)
Association to the Glypican-5 gene in multiple sclerosis
J Neuroimmunol, 226 (1-2), 194-7
DOI 10.1016/j.jneuroim.2010.07.003, PubMed 20692050

Melum E (2010)
From single markers to genome-wide association: a study of primary sclerosing cholangitis genetics
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 946, 1 b. (flere pag.)
BIBSYS 10118672x, ISBN 978-82-8072-614-8

Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Björnsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M et al. (2010)
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci
Nat Genet, 43 (1), 17-9
DOI 10.1038/ng.728, PubMed 21151127

Melum E, May S, Schilhabel MB, Thomsen I, Karlsen TH, Rosenstiel P, Schreiber S, Franke A (2010)
SNP discovery performance of two second-generation sequencing platforms in the NOD2 gene region
Hum Mutat, 31 (7), 875-85
DOI 10.1002/humu.21276, PubMed 20506538

Publications 2009

Karlsen TH, Franke A, Melum E, Kaser A, Hov JR, Balschun T, Lie BA, Bergquist A, Schramm C, Weismüller TJ, Gotthardt D, Rust C, Philipp EE, Fritz T, Henckaerts L, Weersma RK, Stokkers P, Ponsioen CY, Wijmenga C, Sterneck M, Nothnagel M, Hampe J, Teufel A, Runz H, Rosenstiel P et al. (2009)
Genome-wide association analysis in primary sclerosing cholangitis
Gastroenterology, 138 (3), 1102-11
DOI 10.1053/j.gastro.2009.11.046, PubMed 19944697

Melum E, Franke A, Karlsen TH (2009)
Genome-wide association studies--a summary for the clinical gastroenterologist
World J Gastroenterol, 15 (43), 5377-96
DOI 10.3748/wjg.15.5377, PubMed 19916168

Publications 2008

Melum E, Buch S, Schafmayer C, Kalthoff H, Tepel J, Schreiber S, Karlsen TH, Hampe J (2008)
Investigation of cholangiocarcinoma associated NKG2D polymorphisms in colorectal carcinoma
Int J Cancer, 123 (1), 241-2
DOI 10.1002/ijc.23517, PubMed 18398827

Melum E, Karlsen TH, Bergquist A, Schrumpf E, Boberg KM (2008)
An interleukin-6 (IL-6) receptor polymorphism affecting serum levels of IL-6 does not increase the risk of cholangiocarcinoma in primary sclerosing cholangitis
Am J Gastroenterol, 103 (4), 1045; author reply 1045-6
DOI 10.1111/j.1572-0241.2007.01772_5.x, PubMed 18397431

Melum E, Karlsen TH, Schrumpf E, Bergquist A, Thorsby E, Boberg KM, Lie BA (2008)
Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms
Hepatology, 47 (1), 90-6
DOI 10.1002/hep.21964, PubMed 18023027

Publications 2007

Lindner E, Nordang GB, Melum E, Flatø B, Selvaag AM, Thorsby E, Kvien TK, Førre OT, Lie BA (2007)
Lack of association between the chemokine receptor 5 polymorphism CCR5delta32 in rheumatoid arthritis and juvenile idiopathic arthritis
BMC Med Genet, 8, 33
DOI 10.1186/1471-2350-8-33, PubMed 17565662

Melum E, Friman S, Bjøro K, Rasmussen A, Isoniemi H, Gjertsen H, Bäckman L, Oksanen A, Olausson M, Duraj FF, Ericzon BG (2007)
Hepatitis C impairs survival following liver transplantation irrespective of concomitant hepatocellular carcinoma
J Hepatol, 47 (6), 777-83
DOI 10.1016/j.jhep.2007.06.013, PubMed 17714825

Publications 2006

Melum E, Karlsen TH, Broomé U, Thorsby E, Schrumpf E, Boberg KM, Lie BA (2006)
The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Delta32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients
Tissue Antigens, 68 (1), 78-81
DOI 10.1111/j.1399-0039.2006.00604.x, PubMed 16774544

Melum E, Schrumpf E, Bjøro K (2006)
Liver TX for hepatitis C cirrhosis in a low prevalence population: risk factors and status at evaluation
Scand J Gastroenterol, 41 (5), 592-6
DOI 10.1080/00365520500347113, PubMed 16638703