Publications

Publications published since 2006 from OUS - Department of Molecular Oncology (2006-2014 Dept of Cancer Prev.)

357 publications found

Publications 2024

  1. Bogaard M, Strømme JM, Kidd SG, Johannessen B, Bakken AC, Lothe RA, Axcrona K, Skotheim RI, Axcrona U (2024)
    GRIN3A: A biomarker associated with a cribriform pattern and poor prognosis in prostate cancer
    Neoplasia, 55, 101023
    DOI 10.1016/j.neo.2024.101023, PubMed 38944914
  2. Gillessen S, Turco F, Davis ID, Efstathiou JA, Fizazi K, James ND, Shore N, Small E, Smith M, Sweeney CJ, Tombal B, Zilli T, Agarwal N, Antonarakis ES, Aparicio A, Armstrong AJ, Bastos DA, Attard G, Axcrona K, Ayadi M, Beltran H, Bjartell A, Blanchard P, Bourlon MT, Briganti A et al. (2024)
    Management of Patients with Advanced Prostate Cancer. Report from the 2024 Advanced Prostate Cancer Consensus Conference (APCCC)
    Eur Urol (in press)
    DOI 10.1016/j.eururo.2024.09.017, PubMed 39394013
  3. Grindedal EM, Zucknick M, Stormorken A, Rønne E, Tandstad NM, Isaacs WB, Axcrona K, Mæhle L (2024)
    Outcomes of 10 years of PSA screening for prostate cancer in Norwegian men with Lynch syndrome
    Prostate, 84 (10), 945-953
    DOI 10.1002/pros.24711, PubMed 38629217
  4. Hugosson J, Godtman RA, Wallstrom J, Axcrona U, Bergh A, Egevad L, Geterud K, Khatami A, Socratous A, Spyratou V, Svensson L, Stranne J, Månsson M, Hellstrom M (2024)
    Results after Four Years of Screening for Prostate Cancer with PSA and MRI
    N Engl J Med, 391 (12), 1083-1095
    DOI 10.1056/NEJMoa2406050, PubMed 39321360
  5. Langerud J, Eilertsen IA, Moosavi SH, Klokkerud SMK, Reims HM, Backe IF, Hektoen M, Sjo OH, Jeanmougin M, Tejpar S, Nesbakken A, Lothe RA, Sveen A (2024)
    Multiregional transcriptomics identifies congruent consensus subtypes with prognostic value beyond tumor heterogeneity of colorectal cancer
    Nat Commun, 15 (1), 4342
    DOI 10.1038/s41467-024-48706-2, PubMed 38773143
  6. Majid U, Bergsland CH, Sveen A, Bruun J, Eilertsen IA, Bækkevold ES, Nesbakken A, Yaqub S, Jahnsen FL, Lothe RA (2024)
    The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
    Cell Oncol (Dordr), 47 (4), 1267-1276
    DOI 10.1007/s13402-024-00926-w, PubMed 38407700
  7. Nunes L, Li F, Wu M, Luo T, Hammarström K, Torell E, Ljuslinder I, Mezheyeuski A, Edqvist PH, Löfgren-Burström A, Zingmark C, Edin S, Larsson C, Mathot L, Osterman E, Osterlund E, Ljungström V, Neves I, Yacoub N, Guðnadóttir U, Birgisson H, Enblad M, Ponten F, Palmqvist R, Xu X et al. (2024)
    Prognostic genome and transcriptome signatures in colorectal cancers
    Nature, 633 (8028), 137-146
    DOI 10.1038/s41586-024-07769-3, PubMed 39112715
  8. Nunes L, Stenersen JM, Kryeziu K, Sjöblom T, Glimelius B, Lothe RA, Sveen A (2024)
    Co-occurring mutations identify prognostic subgroups of microsatellite stable colorectal cancer
    Mol Cancer, 23 (1), 264
    DOI 10.1186/s12943-024-02173-x, PubMed 39587554
  9. Skotheim RI, Bogaard M, Carm KT, Axcrona U, Axcrona K (2024)
    Prostate cancer: Molecular aspects, consequences, and opportunities of the multifocal nature
    Biochim Biophys Acta Rev Cancer, 1879 (2), 189080
    DOI 10.1016/j.bbcan.2024.189080, PubMed 38272101
  10. Sveen A, Johannessen B, Klokkerud SM, Kraggerud SM, Meza-Zepeda LA, Bjørnslett M, Bischof K, Myklebost O, Taskén K, Skotheim RI, Dørum A, Davidson B, Lothe RA (2024)
    Evolutionary mode and timing of dissemination of high-grade serous carcinomas
    JCI Insight, 9 (3)
    DOI 10.1172/jci.insight.170423, PubMed 38175731
  11. Totland MZ, Knudsen LM, Rasmussen NL, Omori Y, Sørensen V, Elster VCW, Stenersen JM, Larsen M, Jensen CL, Zickfeldt Lade AA, Bruusgaard E, Basing S, Kryeziu K, Brech A, Aasen T, Lothe RA, Leithe E (2024)
    The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation
    Cell Mol Life Sci, 81 (1), 171
    DOI 10.1007/s00018-024-05165-8, PubMed 38597989
  12. Vedeld HM, Pharo H, Sørbø AK, Brandt-Winge S, Five MB, Jeanmougin M, Guldberg P, Wahlqvist R, Lind GE (2024)
    Distinct longitudinal patterns of urine tumor DNA in patients undergoing surveillance for bladder cancer
    Mol Oncol, 18 (11), 2684-2695
    DOI 10.1002/1878-0261.13639, PubMed 38720532

Publications 2023

  1. Bogaard M, Skotheim RI, Maltau AV, Kidd SG, Lothe RA, Axcrona K, Axcrona U (2023)
    'High proliferative cribriform prostate cancer' defines a patient subgroup with an inferior prognosis
    Histopathology, 83 (6), 853-869
    DOI 10.1111/his.15012, PubMed 37501635
  2. Høland M, Berg KCG, Eilertsen IA, Bjerkehagen B, Kolberg M, Boye K, Lingjærde OC, Guren TK, Mandahl N, van den Berg E, Palmerini E, Smeland S, Picci P, Mertens F, Sveen A, Lothe RA (2023)
    Transcriptomic subtyping of malignant peripheral nerve sheath tumours highlights immune signatures, genomic profiles, patient survival and therapeutic targets
    EBioMedicine, 97, 104829
    DOI 10.1016/j.ebiom.2023.104829, PubMed 37837931
  3. Jeanmougin M, Brodal HP, Dietrichson Pharo H, Vedeld HM, Lind GE (2023)
    PoDCall: positive droplet calling and normalization of droplet digital PCR DNA methylation data
    Bioinformatics, 39 (1)
    DOI 10.1093/bioinformatics/btac766, PubMed 36448696
  4. Kresse SH, Brandt-Winge S, Pharo H, Flatin BTB, Jeanmougin M, Vedeld HM, Lind GE (2023)
    Evaluation of commercial kits for isolation and bisulfite conversion of circulating cell-free tumor DNA from blood
    Clin Epigenetics, 15 (1), 151
    DOI 10.1186/s13148-023-01563-0, PubMed 37710283
  5. Meier Strømme J, Johannessen B, Skotheim RI (2023)
    Deviating Alternative Splicing as a Molecular Subtype of Microsatellite Stable Colorectal Cancer
    JCO Clin Cancer Inform, 7, e2200159
    DOI 10.1200/CCI.22.00159, PubMed 36821799
  6. Totland MZ, Omori Y, Sørensen V, Kryeziu K, Aasen T, Brech A, Leithe E (2023)
    Endocytic trafficking of connexins in cancer pathogenesis
    Biochim Biophys Acta Mol Basis Dis, 1869 (7), 166812
    DOI 10.1016/j.bbadis.2023.166812, PubMed 37454772

Publications 2022

  1. Axcrona K, Aas K, Axcrona U, Skotheim RI (2022)
    Re: Spatially Resolved Clonal Copy Number Alterations in Benign and Malignant Tissue
    Eur Urol, 83 (2), 183
    DOI 10.1016/j.eururo.2022.11.013, PubMed 36464529
  2. Bergsland CH, Jeanmougin M, Moosavi SH, Svindland A, Bruun J, Nesbakken A, Sveen A, Lothe RA (2022)
    Spatial analysis and CD25-expression identify regulatory T cells as predictors of a poor prognosis in colorectal cancer
    Mod Pathol, 35 (9), 1236-1246
    DOI 10.1038/s41379-022-01086-8, PubMed 35484226
  3. Carm KT, Johannessen B, Bogaard M, Bakken AC, Maltau AV, Hoff AM, Axcrona U, Axcrona K, Lothe RA, Skotheim RI (2022)
    Somatic mutations reveal complex metastatic seeding from multifocal primary prostate cancer
    Int J Cancer, 152 (5), 945-951
    DOI 10.1002/ijc.34226, PubMed 35880692
  4. Fontugne J, Cai PY, Alnajar H, Bhinder B, Park K, Ye H, Beg S, Sailer V, Siddiqui J, Blattner-Johnson M, Croyle JA, Noorzad Z, Calagua C, MacDonald TY, Axcrona U, Bogaard M, Axcrona K, Scherr DS, Sanda MG, Johannessen B, Chinnaiyan AM, Elemento O, Skotheim RI, Rubin MA, Barbieri CE et al. (2022)
    Collision tumors revealed by prospectively assessing subtype-defining molecular alterations in 904 individual prostate cancer foci
    JCI Insight, 7 (4)
    DOI 10.1172/jci.insight.155309, PubMed 35050902
  5. Grasso C, Popovic M, Isaevska E, Lazzarato F, Fiano V, Zugna D, Pluta J, Weathers B, D'Andrea K, Almstrup K, Anson-Cartwright L, Bishop DT, Chanock SJ, Chen C, Cortessis VK, Dalgaard MD, Daneshmand S, Ferlin A, Foresta C, Frone MN, Gamulin M, Gietema JA, Greene MH, Grotmol T, Hamilton RJ et al. (2022)
    Association Study between Polymorphisms in DNA Methylation-Related Genes and Testicular Germ Cell Tumor Risk
    Cancer Epidemiol Biomarkers Prev, 31 (9), 1769-1779
    DOI 10.1158/1055-9965.EPI-22-0123, PubMed 35700037
  6. Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
    Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
    J Transl Med, 20 (1), 225
    DOI 10.1186/s12967-022-03432-5, PubMed 35568909
  7. Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
    Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
    J Transl Med, 20 (1), 317
    DOI 10.1186/s12967-022-03518-0, PubMed 35841045
  8. Hugosson J, Månsson M, Wallström J, Axcrona U, Carlsson SV, Egevad L, Geterud K, Khatami A, Kohestani K, Pihl CG, Socratous A, Stranne J, Godtman RA, Hellström M, GÖTEBORG-2 Trial Investigators (2022)
    Prostate Cancer Screening with PSA and MRI Followed by Targeted Biopsy Only
    N Engl J Med, 387 (23), 2126-2137
    DOI 10.1056/NEJMoa2209454, PubMed 36477032
  9. Kidd SG, Bogaard M, Carm KT, Bakken AC, Maltau AMV, Løvf M, Lothe RA, Axcrona K, Axcrona U, Skotheim RI (2022)
    In situ expression of ERG protein in the context of tumor heterogeneity identifies prostate cancer patients with inferior prognosis
    Mol Oncol, 16 (15), 2810-2822
    DOI 10.1002/1878-0261.13225, PubMed 35574900
  10. Kryeziu K, Bergsland CH, Guren TK, Sveen A, Lothe RA (2022)
    Multiplex immunohistochemistry of metastatic colorectal cancer and ex vivo tumor avatars
    Biochim Biophys Acta Rev Cancer, 1877 (1), 188682
    DOI 10.1016/j.bbcan.2022.188682, PubMed 35065193
  11. Namløs HM, Skårn M, Ahmed D, Grad I, Andresen K, Kresse SH, Munthe E, Serra M, Scotlandi K, Llombart-Bosch A, Myklebost O, Lind GE, Meza-Zepeda LA (2022)
    miR-486-5p expression is regulated by DNA methylation in osteosarcoma
    BMC Genomics, 23 (1), 142
    DOI 10.1186/s12864-022-08346-6, PubMed 35172717
  12. Pharo HD, Jeanmougin M, Ager-Wick E, Vedeld HM, Sørbø AK, Dahl C, Larsen LK, Honne H, Brandt-Winge S, Five MB, Monteiro-Reis S, Henrique R, Jeronimo C, Steven K, Wahlqvist R, Guldberg P, Lind GE (2022)
    BladMetrix: a novel urine DNA methylation test with high accuracy for detection of bladder cancer in hematuria patients
    Clin Epigenetics, 14 (1), 115
    DOI 10.1186/s13148-022-01335-2, PubMed 36115961
  13. Pinto R, Hauge T, Jeanmougin M, Pharo HD, Kresse SH, Honne H, Winge SB, Five MB, Kumar T, Mala T, Hauge T, Johnson E, Lind GE (2022)
    Targeted genetic and epigenetic profiling of esophageal adenocarcinomas and non-dysplastic Barrett's esophagus
    Clin Epigenetics, 14 (1), 77
    DOI 10.1186/s13148-022-01287-7, PubMed 35701814
  14. Skotheim RI, Axcrona U, Axcrona K (2022)
    Re: Fibroblast Growth Factor Receptor 1 Drives the Metastatic Progression of Prostate Cancer
    Eur Urol, 81 (4), 431
    DOI 10.1016/j.eururo.2021.12.031, PubMed 35031159
  15. Strømme JM, Johannessen B, Kidd SG, Bogaard M, Carm KT, Zhang X, Sveen A, Mathelier A, Lothe RA, Axcrona U, Axcrona K, Skotheim RI (2022)
    Expressed prognostic biomarkers for primary prostate cancer independent of multifocality and transcriptome heterogeneity
    Cancer Gene Ther, 29 (8-9), 1276-1284
    DOI 10.1038/s41417-022-00444-7, PubMed 35194199
  16. Wolowczyk C, Neckmann U, Aure MR, Hall M, Johannessen B, Zhao S, Skotheim RI, Andersen SB, Zwiggelaar R, Steigedal TS, Lingjærde OC, Sahlberg KK, Almaas E, Bjørkøy G (2022)
    NRF2 drives an oxidative stress response predictive of breast cancer
    Free Radic Biol Med, 184, 170-184
    DOI 10.1016/j.freeradbiomed.2022.03.029, PubMed 35381325

Publications 2021

  1. Aranguren-Abadía L, Yadetie F, Donald CE, Sørhus E, Myklatun LE, Zhang X, Lie KK, Perrichon P, Nakken CL, Durif C, Shema S, Browman HI, Skiftesvik AB, Goksøyr A, Meier S, Karlsen OA (2021)
    Photo-enhanced toxicity of crude oil on early developmental stages of Atlantic cod (Gadus morhua)
    Sci Total Environ, 807 (Pt 1), 150697
    DOI 10.1016/j.scitotenv.2021.150697, PubMed 34610396
  2. Berg KCG, Brunsell TH, Sveen A, Alagaratnam S, Bjørnslett M, Hektoen M, Brudvik KW, Røsok BI, Bjørnbeth BA, Nesbakken A, Lothe RA (2021)
    Genomic and prognostic heterogeneity among RAS/BRAFV600E /TP53 co-mutated resectable colorectal liver metastases
    Mol Oncol, 15 (4), 830-845
    DOI 10.1002/1878-0261.12885, PubMed 33325154
  3. Bruun J, Eide PW, Bergsland CH, Bruck O, Svindland A, Arjama M, Välimäki K, Bjørnslett M, Guren MG, Kallioniemi O, Nesbakken A, Lothe RA, Pellinen T (2021)
    E-cadherin is a robust prognostic biomarker in colorectal cancer and low expression is associated with sensitivity to inhibitors of topoisomerase, aurora, and HSP90 in preclinical models
    Mol Oncol, 16 (12), 2312-2329
    DOI 10.1002/1878-0261.13159, PubMed 34890102
  4. Dale K, Yadetie F, Horvli T, Zhang X, Frøysa HG, Karlsen OA, Goksøyr A (2021)
    Single PFAS and PFAS mixtures affect nuclear receptor- and oxidative stress-related pathways in precision-cut liver slices of Atlantic cod (Gadus morhua)
    Sci Total Environ, 814, 152732
    DOI 10.1016/j.scitotenv.2021.152732, PubMed 34974025
  5. Davydova E, Shimazu T, Schuhmacher MK, Jakobsson ME, Willemen HLDM, Liu T, Moen A, Ho AYY, Małecki J, Schroer L, Pinto R, Suzuki T, Grønsberg IA, Sohtome Y, Akakabe M, Weirich S, Kikuchi M, Olsen JV, Dohmae N, Umehara T, Sodeoka M, Siino V, McDonough MA, Eijkelkamp N, Schofield CJ et al. (2021)
    The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes
    Nat Commun, 12 (1), 891
    DOI 10.1038/s41467-020-20670-7, PubMed 33563959
  6. Eide M, Zhang X, Karlsen OA, Goldstone JV, Stegeman J, Jonassen I, Goksøyr A (2021)
    The chemical defensome of five model teleost fish
    Sci Rep, 11 (1), 10546
    DOI 10.1038/s41598-021-89948-0, PubMed 34006915
  7. Eide PW, Moosavi SH, Eilertsen IA, Brunsell TH, Langerud J, Berg KCG, Røsok BI, Bjørnbeth BA, Nesbakken A, Lothe RA, Sveen A (2021)
    Metastatic heterogeneity of the consensus molecular subtypes of colorectal cancer
    NPJ Genom Med, 6 (1), 59
    DOI 10.1038/s41525-021-00223-7, PubMed 34262039
  8. Gansmo LB, Sofiyeva N, Bjørnslett M, Romundstad P, Hveem K, Vatten L, Dørum A, Lønning PE, Knappskog S (2021)
    Impact of the APOBEC3A/B deletion polymorphism on risk of ovarian cancer
    Sci Rep, 11 (1), 23463
    DOI 10.1038/s41598-021-02820-z, PubMed 34873230
  9. Helwa R, Gansmo LB, Bjørnslett M, Halle MK, Werner HMJ, Romundstad P, Hveem K, Vatten L, Dørum A, Lønning PE, Knappskog S (2021)
    Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer
    Biomarkers, 26 (4), 302-308
    DOI 10.1080/1354750X.2021.1891291, PubMed 33645339
  10. Kidd SG, Carm KT, Bogaard M, Olsen LG, Bakken AC, Løvf M, Lothe RA, Axcrona K, Axcrona U, Skotheim RI (2021)
    High expression of SCHLAP1 in primary prostate cancer is an independent predictor of biochemical recurrence, despite substantial heterogeneity
    Neoplasia, 23 (6), 634-641
    DOI 10.1016/j.neo.2021.05.012, PubMed 34107378
  11. Kryeziu K, Moosavi SH, Bergsland CH, Guren MG, Eide PW, Totland MZ, Lassen K, Abildgaard A, Nesbakken A, Sveen A, Lothe RA (2021)
    Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases
    J Transl Med, 19 (1), 384
    DOI 10.1186/s12967-021-03062-3, PubMed 34496878
  12. Moosavi SH, Eide PW, Eilertsen IA, Brunsell TH, Berg KCG, Røsok BI, Brudvik KW, Bjørnbeth BA, Guren MG, Nesbakken A, Lothe RA, Sveen A (2021)
    De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity
    Genome Med, 13 (1), 143
    DOI 10.1186/s13073-021-00956-1, PubMed 34470666
  13. Pluta J, Pyle LC, Nead KT, Wilf R, Li M, Mitra N, Weathers B, D'Andrea K, Almstrup K, Anson-Cartwright L, Benitez J, Brown CD, Chanock S, Chen C, Cortessis VK, Ferlin A, Foresta C, Gamulin M, Gietema JA, Grasso C, Greene MH, Grotmol T, Hamilton RJ, Haugen TB, Hauser R et al. (2021)
    Identification of 22 susceptibility loci associated with testicular germ cell tumors
    Nat Commun, 12 (1), 4487
    DOI 10.1038/s41467-021-24334-y, PubMed 34301922
  14. Slørdahl KS, Klotz D, Olsen JÅ, Skovlund E, Undseth C, Abildgaard HL, Brændengen M, Nesbakken A, Larsen SG, Hanekamp BA, Holmboe L, Tvedt R, Sveen A, Lothe RA, Malinen E, Kaasa S, Guren MG (2021)
    Treatment outcomes and prognostic factors after chemoradiotherapy for anal cancer
    Acta Oncol, 60 (7), 921-930
    DOI 10.1080/0284186X.2021.1918763, PubMed 33966592
  15. Sveen A, Johannessen B, Eilertsen IA, Røsok BI, Gulla M, Eide PW, Bruun J, Kryeziu K, Meza-Zepeda LA, Myklebost O, Bjørnbeth BA, Skotheim RI, Nesbakken A, Lothe RA (2021)
    The expressed mutational landscape of microsatellite stable colorectal cancers
    Genome Med, 13 (1), 142
    DOI 10.1186/s13073-021-00955-2, PubMed 34470667
  16. Tryggestad AMA, Axcrona K, Axcrona U, Bigalke I, Brennhovd B, Inderberg EM, Hønnåshagen TK, Skoge LJ, Solum G, Saebøe-Larssen S, Josefsen D, Olaussen RW, Aamdal S, Skotheim RI, Myklebust TÅ, Schendel DJ, Lilleby W, Dueland S, Kvalheim G (2021)
    Long-term first-in-man Phase I/II study of an adjuvant dendritic cell vaccine in patients with high-risk prostate cancer after radical prostatectomy
    Prostate, 82 (2), 245-253
    DOI 10.1002/pros.24267, PubMed 34762317
  17. Vedeld HM, Grimsrud MM, Andresen K, Pharo HD, von Seth E, Karlsen TH, Honne H, Paulsen V, Färkkilä MA, Bergquist A, Jeanmougin M, Aabakken L, Boberg KM, Folseraas T, Lind GE (2021)
    Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile
    Hepatology, 75 (1), 59-73
    DOI 10.1002/hep.32125, PubMed 34435693
  18. Aasebø K, Bruun J, Bergsland CH, Nunes L, Eide GE, Pfeiffer P, Dahl O, Glimelius B, Lothe RA, Sorbye H (2021)
    Prognostic role of tumour-infiltrating lymphocytes and macrophages in relation to MSI, CDX2 and BRAF status: a population-based study of metastatic colorectal cancer patients
    Br J Cancer, 126 (1), 48-56
    DOI 10.1038/s41416-021-01586-5, PubMed 34671130

Publications 2020

  1. Bergsland CH, Bruun J, Guren MG, Svindland A, Bjørnslett M, Smeby J, Hektoen M, Kolberg M, Domingo E, Pellinen T, Tomlinson I, Kerr D, Church DN, Nesbakken A, Sveen A, Lothe RA (2020)
    Prediction of relapse-free survival according to adjuvant chemotherapy and regulator of chromosome condensation 2 (RCC2) expression in colorectal cancer
    ESMO Open, 5 (6), e001040
    DOI 10.1136/esmoopen-2020-001040, PubMed 33219056
  2. Bruun J, Kryeziu K, Eide PW, Moosavi SH, Eilertsen IA, Langerud J, Røsok B, Totland MZ, Brunsell TH, Pellinen T, Saarela J, Bergsland CH, Palmer HG, Brudvik KW, Guren T, Dienstmann R, Guren MG, Nesbakken A, Bjørnbeth BA, Sveen A, Lothe RA (2020)
    Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity
    Clin Cancer Res, 26 (15), 4107-4119
    DOI 10.1158/1078-0432.CCR-19-3637, PubMed 32299813
  3. Flatin BTB, Vedeld HM, Pinto R, Langerud J, Lind GE, Lothe RA, Sveen A, Jeanmougin M (2020)
    Multiregional assessment of CIMP in primary colorectal cancers: Phenotype concordance but marker variability
    Int J Cancer, 148 (7), 1652-1657
    DOI 10.1002/ijc.33425, PubMed 33284993
  4. Guldvik IJ, Zuber V, Braadland PR, Grytli HH, Ramberg H, Lilleby W, Thiede B, Zucknick M, Saatcioglu F, Gislefoss R, Kvåle R, George A, Grönberg H, Wiklund F, Neal DE, Gnanapragasam VJ, Taskén KA, Mills IG (2020)
    Identification and Validation of Leucine-rich α-2-glycoprotein 1 as a Noninvasive Biomarker for Improved Precision in Prostate Cancer Risk Stratification
    Eur Urol Open Sci, 21, 51-60
    DOI 10.1016/j.euros.2020.08.007, PubMed 34337468
  5. Hoff AM, Kraggerud SM, Alagaratnam S, Berg KCG, Johannessen B, Høland M, Nilsen G, Lingjærde OC, Andrews PW, Lothe RA, Skotheim RI (2020)
    Frequent copy number gains of SLC2A3 and ETV1 in testicular embryonal carcinomas
    Endocr Relat Cancer, 27 (9), 457-468
    DOI 10.1530/ERC-20-0064, PubMed 32580154
  6. Jeanmougin M, Håvik AB, Cekaite L, Brandal P, Sveen A, Meling TR, Ågesen TH, Scheie D, Heim S, Lothe RA, Lind GE (2020)
    Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment
    Mol Oncol, 14 (5), 1016-1027
    DOI 10.1002/1878-0261.12668, PubMed 32171051
  7. Lopes N, Bergsland C, Bruun J, Bjørnslett M, Vieira AF, Mesquita P, Pinto R, Gomes R, Cavadas B, Bennett E, Pereira L, Lothe RA, Almeida R, David L (2020)
    A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis
    Gastric Cancer, 23 (5), 811-823
    DOI 10.1007/s10120-020-01064-6, PubMed 32215766
  8. Smeby J, Kryeziu K, Berg KCG, Eilertsen IA, Eide PW, Johannessen B, Guren MG, Nesbakken A, Bruun J, Lothe RA, Sveen A (2020)
    Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity
    EBioMedicine, 59, 102923
    DOI 10.1016/j.ebiom.2020.102923, PubMed 32799124
  9. Vedeld HM, Folseraas T, Lind GE (2020)
    Detecting cholangiocarcinoma in patients with primary sclerosing cholangitis - The promise of DNA methylation and molecular biomarkers
    JHEP Rep, 2 (5), 100143
    DOI 10.1016/j.jhepr.2020.100143, PubMed 32939446
  10. Wise JF, Nakken S, Steen CB, Vodák D, Trøen G, Johannessen B, Lingjærde OC, Hilden V, Blaker YN, Bai B, Aasheim LB, Pasanen A, Lorenz S, Sveen A, Lothe RA, Myklebost O, Leppä S, Meza-Zepeda LA, Beiske K, Lawrence MS, Hovig E, Myklebust JH, Smeland EB, Holte H (2020)
    Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
    Blood Adv, 4 (9), 1859-1866
    DOI 10.1182/bloodadvances.2019001325, PubMed 32374878
  11. Zhao S, Hoff AM, Skotheim RI (2020)
    ScaR-a tool for sensitive detection of known fusion transcripts: establishing prevalence of fusions in testicular germ cell tumors
    NAR Genom Bioinform, 2 (1), lqz025
    DOI 10.1093/nargab/lqz025, PubMed 33575572

Publications 2019

  1. Berg KCG, Sveen A, Høland M, Alagaratnam S, Berg M, Danielsen SA, Nesbakken A, Søreide K, Lothe RA (2019)
    Gene expression profiles of CMS2-epithelial/canonical colorectal cancers are largely driven by DNA copy number gains
    Oncogene, 38 (33), 6109-6122
    DOI 10.1038/s41388-019-0868-5, PubMed 31308487
  2. Brunsell TH, Cengija V, Sveen A, Bjørnbeth BA, Røsok BI, Brudvik KW, Guren MG, Lothe RA, Abildgaard A, Nesbakken A (2019)
    Heterogeneous radiological response to neoadjuvant therapy is associated with poor prognosis after resection of colorectal liver metastases
    Eur J Surg Oncol, 45 (12), 2340-2346
    DOI 10.1016/j.ejso.2019.07.017, PubMed 31350075
  3. Brunsell TH, Sveen A, Bjørnbeth BA, Røsok BI, Danielsen SA, Brudvik KW, Berg KCG, Johannessen B, Cengija V, Abildgaard A, Guren MG, Nesbakken A, Lothe RA (2019)
    High Concordance and Negative Prognostic Impact of RAS/BRAF/PIK3CA Mutations in Multiple Resected Colorectal Liver Metastases
    Clin Colorectal Cancer, 19 (1), e26-e47
    DOI 10.1016/j.clcc.2019.09.003, PubMed 31982351
  4. Burocziova M, Burdova K, Martinikova AS, Kasparek P, Kleiblova P, Danielsen SA, Borecka M, Jenikova G, Janečková L, Pavel J, Zemankova P, Schneiderova M, Schwarzova L, Ticha I, Sun XF, Jiraskova K, Liska V, Vodickova L, Vodicka P, Sedlacek R, Kleibl Z, Lothe RA, Korinek V, Macurek L (2019)
    Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon
    Cell Death Dis, 10 (11), 818
    DOI 10.1038/s41419-019-2057-4, PubMed 31659152
  5. Carm KT, Hoff AM, Bakken AC, Axcrona U, Axcrona K, Lothe RA, Skotheim RI, Løvf M (2019)
    Interfocal heterogeneity challenges the clinical usefulness of molecular classification of primary prostate cancer
    Sci Rep, 9 (1), 13579
    DOI 10.1038/s41598-019-49964-7, PubMed 31537872
  6. Dienstmann R, Villacampa G, Sveen A, Mason MJ, Niedzwiecki D, Nesbakken A, Moreno V, Warren RS, Lothe RA, Guinney J (2019)
    Relative contribution of clinicopathological variables, genomic markers, transcriptomic subtyping and microenvironment features for outcome prediction in stage II/III colorectal cancer
    Ann Oncol, 30 (10), 1622-1629
    DOI 10.1093/annonc/mdz287, PubMed 31504112
  7. Eide PW, Eilertsen IA, Sveen A, Lothe RA (2019)
    Long noncoding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell-intrinsic properties
    Int J Cancer, 144 (11), 2843-2853
    DOI 10.1002/ijc.31998, PubMed 30447009
  8. Eilertsen IA, Moosavi SH, Strømme JM, Nesbakken A, Johannessen B, Lothe RA, Sveen A (2019)
    Technical differences between sequencing and microarray platforms impact transcriptomic subtyping of colorectal cancer
    Cancer Lett, 469, 246-255
    DOI 10.1016/j.canlet.2019.10.040, PubMed 31678167
  9. Glaire MA, Domingo E, Sveen A, Bruun J, Nesbakken A, Nicholson G, Novelli M, Lawson K, Oukrif D, Kildal W, Danielsen HE, Kerr R, Kerr D, Tomlinson I, Lothe RA, Church DN (2019)
    Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
    Br J Cancer, 121 (6), 474-482
    DOI 10.1038/s41416-019-0540-4, PubMed 31388185
  10. Glaire MA, Domingo E, Sveen A, Bruun J, Nesbakken A, Nicholson G, Novelli M, Lawson K, Oukrif D, Kildal W, Danielsen HE, Kerr R, Kerr D, Tomlinson I, Lothe RA, Church DN (2019)
    Correction: Tumour-infiltrating CD8+ lymphocytes and colorectal cancer recurrence by tumour and nodal stage
    Br J Cancer, 121 (9), 807
    DOI 10.1038/s41416-019-0590-7, PubMed 31548598
  11. Joranger P, Nesbakken A, Sorbye H, Hoff G, Oshaug A, Aas E (2019)
    Survival and costs of colorectal cancer treatment and effects of changing treatment strategies: a model approach
    Eur J Health Econ, 21 (3), 321-334
    DOI 10.1007/s10198-019-01130-6, PubMed 31707584
  12. Kryeziu K, Bruun J, Guren TK, Sveen A, Lothe RA (2019)
    Combination therapies with HSP90 inhibitors against colorectal cancer
    Biochim Biophys Acta Rev Cancer, 1871 (2), 240-247
    DOI 10.1016/j.bbcan.2019.01.002, PubMed 30708039
  13. Larsen LK, Lind GE, Guldberg P, Dahl C (2019)
    DNA-Methylation-Based Detection of Urological Cancer in Urine: Overview of Biomarkers and Considerations on Biomarker Design, Source of DNA, and Detection Technologies
    Int J Mol Sci, 20 (11)
    DOI 10.3390/ijms20112657, PubMed 31151158
  14. Lopes N, Bergsland CH, Bjørnslett M, Pellinen T, Svindland A, Nesbakken A, Almeida R, Lothe RA, David L, Bruun J (2019)
    Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2
    Lab Invest, 100 (1), 120-134
    DOI 10.1038/s41374-019-0336-4, PubMed 31641225
  15. Marcuello M, Vymetalkova V, Neves RPL, Duran-Sanchon S, Vedeld HM, Tham E, van Dalum G, Flügen G, Garcia-Barberan V, Fijneman RJ, Castells A, Vodicka P, Lind GE, Stoecklein NH, Heitzer E, Gironella M (2019)
    Circulating biomarkers for early detection and clinical management of colorectal cancer
    Mol Aspects Med, 69, 107-122
    DOI 10.1016/j.mam.2019.06.002, PubMed 31189073
  16. Miranda A, Hamilton PT, Zhang AW, Pattnaik S, Becht E, Mezheyeuski A, Bruun J, Micke P, de Reynies A, Nelson BH (2019)
    Cancer stemness, intratumoral heterogeneity, and immune response across cancers
    Proc Natl Acad Sci U S A, 116 (18), 9020-9029
    DOI 10.1073/pnas.1818210116, PubMed 30996127
  17. Neckmann U, Wolowczyk C, Hall M, Almaas E, Ren J, Zhao S, Johannessen B, Skotheim RI, Bjørkøy G, Ten Dijke P, Holien T (2019)
    GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients
    Cell Commun Signal, 17 (1), 140
    DOI 10.1186/s12964-019-0467-7, PubMed 31694641
  18. Røsok BI, Høst-Brunsell T, Brudvik KW, Carling U, Dorenberg E, Björnsson B, Lothe RA, Bjørnbeth BA, Sandström P (2019)
    Characterization of early recurrences following liver resection by ALPPS and two stage hepatectomy in patients with colorectal liver-metastases and small future liver remnants; a translational substudy of the LIGRO-RCT
    HPB (Oxford), 21 (8), 1017-1023
    DOI 10.1016/j.hpb.2018.12.003, PubMed 30765198
  19. Smeby J, Sveen A, Bergsland CH, Eilertsen IA, Danielsen SA, Eide PW, Hektoen M, Guren MG, Nesbakken A, Bruun J, Lothe RA (2019)
    Exploratory analyses of consensus molecular subtype-dependent associations of TP53 mutations with immunomodulation and prognosis in colorectal cancer
    ESMO Open, 4 (3), e000523
    DOI 10.1136/esmoopen-2019-000523, PubMed 31321083
  20. Smeby J, Sveen A, Eilertsen IA, Danielsen SA, Hoff AM, Eide PW, Johannessen B, Hektoen M, Skotheim RI, Guren MG, Nesbakken A, Lothe RA (2019)
    Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer
    Oncogenesis, 8 (6), 35
    DOI 10.1038/s41389-019-0141-3, PubMed 31092812
  21. Sveen A, Cremolini C, Dienstmann R (2019)
    Predictive modeling in colorectal cancer: time to move beyond consensus molecular subtypes
    Ann Oncol, 30 (11), 1682-1685
    DOI 10.1093/annonc/mdz412, PubMed 31868904
  22. Sveen A, Kopetz S, Lothe RA (2019)
    Biomarker-guided therapy for colorectal cancer: strength in complexity
    Nat Rev Clin Oncol, 17 (1), 11-32
    DOI 10.1038/s41571-019-0241-1, PubMed 31289352
  23. Totland MZ, Rasmussen NL, Knudsen LM, Leithe E (2019)
    Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications
    Cell Mol Life Sci, 77 (4), 573-591
    DOI 10.1007/s00018-019-03285-0, PubMed 31501970
  24. Aasen T, Leithe E, Graham SV, Kameritsch P, Mayán MD, Mesnil M, Pogoda K, Tabernero A (2019)
    Connexins in cancer: bridging the gap to the clinic
    Oncogene, 38 (23), 4429-4451
    DOI 10.1038/s41388-019-0741-6, PubMed 30814684

Publications 2018

  1. Bruun J, Sveen A, Barros R, Eide PW, Eilertsen I, Kolberg M, Pellinen T, David L, Svindland A, Kallioniemi O, Guren MG, Nesbakken A, Almeida R, Lothe RA (2018)
    Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer
    Mol Oncol, 12 (9), 1639-1655
    DOI 10.1002/1878-0261.12347, PubMed 29900672
  2. Celestino R, Nome T, Pestana A, Hoff AM, Gonçalves AP, Pereira L, Cavadas B, Eloy C, Bjøro T, Sobrinho-Simões M, Skotheim RI, Soares P (2018)
    CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension
    BMC Cancer, 18 (1), 68
    DOI 10.1186/s12885-017-3948-3, PubMed 29321030
  3. Danielsen HE, Hveem TS, Domingo E, Pradhan M, Kleppe A, Syvertsen RA, Kostolomov I, Nesheim JA, Askautrud HA, Nesbakken A, Lothe RA, Svindland A, Shepherd N, Novelli M, Johnstone E, Tomlinson I, Kerr R, Kerr DJ (2018)
    Prognostic markers for colorectal cancer: estimating ploidy and stroma
    Ann Oncol, 29 (3), 616-623
    DOI 10.1093/annonc/mdx794, PubMed 29293881
  4. Eilertsen IA, Sveen A, Strømme JM, Skotheim RI, Nesbakken A, Lothe RA (2018)
    Alternative splicing expands the prognostic impact of KRAS in microsatellite stable primary colorectal cancer
    Int J Cancer, 144 (4), 841-847
    DOI 10.1002/ijc.31809, PubMed 30121958
  5. Gleditsch D, Wexels WA, Nesbakken A (2018)
    Surgical options and trends in treating rectal prolapse: long-term results in a 19-year follow-up study
    Langenbecks Arch Surg, 403 (8), 991-998
    DOI 10.1007/s00423-018-1728-4, PubMed 30415286
  6. Høland M, Kolberg M, Danielsen SA, Bjerkehagen B, Eilertsen IA, Hektoen M, Mandahl N, van den Berg E, Smeland S, Mertens F, Sundby Hall K, Picci P, Sveen A, Lothe RA (2018)
    Inferior survival for patients with malignant peripheral nerve sheath tumors defined by aberrant TP53
    Mod Pathol, 31 (11), 1694-1707
    DOI 10.1038/s41379-018-0074-y, PubMed 29946184
  7. Kleppe A, Albregtsen F, Vlatkovic L, Pradhan M, Nielsen B, Hveem TS, Askautrud HA, Kristensen GB, Nesbakken A, Trovik J, Wæhre H, Tomlinson I, Shepherd NA, Novelli M, Kerr DJ, Danielsen HE (2018)
    Chromatin organisation and cancer prognosis: a pan-cancer study
    Lancet Oncol, 19 (3), 356-369
    DOI 10.1016/S1470-2045(17)30899-9, PubMed 29402700
  8. Lønning PE, Berge EO, Bjørnslett M, Minsaas L, Chrisanthar R, Høberg-Vetti H, Dulary C, Busato F, Bjørneklett S, Eriksen C, Kopperud R, Axcrona U, Davidson B, Bjørge L, Evans G, Howell A, Salvesen HB, Janszky I, Hveem K, Romundstad PR, Vatten LJ, Tost J, Dørum A, Knappskog S (2018)
    White Blood Cell BRCA1 Promoter Methylation Status and Ovarian Cancer Risk
    Ann Intern Med, 168 (5), 326-334
    DOI 10.7326/M17-0101, PubMed 29335712
  9. Løvf M, Zhao S, Axcrona U, Johannessen B, Bakken AC, Carm KT, Hoff AM, Myklebost O, Meza-Zepeda LA, Lie AK, Axcrona K, Lothe RA, Skotheim RI (2018)
    Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity
    Eur Urol, 75 (3), 498-505
    DOI 10.1016/j.eururo.2018.08.009, PubMed 30181068
  10. Mezheyeuski A, Bergsland CH, Backman M, Djureinovic D, Sjöblom T, Bruun J, Micke P (2018)
    Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients
    J Pathol, 244 (4), 421-431
    DOI 10.1002/path.5026, PubMed 29282718
  11. Oltedal S, Kørner H, Aasprong OG, Hussain I, Tjensvoll K, Smaaland R, Søreide JA, Søreide K, Lothe RA, Heikkilä R, Gilje B, Nordgård O (2018)
    The Prognostic Relevance of Sentinel Lymph Node Metastases Assessed by PHGR1 mRNA Quantification in Stage I to III Colon Cancer
    Transl Oncol, 11 (2), 436-443
    DOI 10.1016/j.tranon.2018.01.015, PubMed 29475140
  12. Ommundsen N, Nesbakken A, Wyller TB, Skovlund E, Bakka AO, Jordhøy MS, Rostoft S (2018)
    Post-discharge complications in frail older patients after surgery for colorectal cancer
    Eur J Surg Oncol, 44 (10), 1542-1547
    DOI 10.1016/j.ejso.2018.06.024, PubMed 30037638
  13. Ommundsen N, Wyller TB, Nesbakken A, Bakka AO, Jordhøy MS, Skovlund E, Rostoft S (2018)
    Preoperative geriatric assessment and tailored interventions in frail older patients with colorectal cancer: a randomized controlled trial
    Colorectal Dis, 20 (1), 16-25
    DOI 10.1111/codi.13785, PubMed 28649755
  14. Ommundsen N, Wyller TB, Nesbakken A, Bakka AO, Jordhøy MS, Skovlund E, Rostoft S (2018)
    Reply to Lawday et al
    Colorectal Dis, 20 (4), 350-351
    DOI 10.1111/codi.14059, PubMed 29502337
  15. Pharo HD, Andresen K, Berg KCG, Lothe RA, Jeanmougin M, Lind GE (2018)
    A robust internal control for high-precision DNA methylation analyses by droplet digital PCR
    Clin Epigenetics, 10, 24
    DOI 10.1186/s13148-018-0456-5, PubMed 29484034
  16. Pinto D, Pinto C, Guerra J, Pinheiro M, Santos R, Vedeld HM, Yohannes Z, Peixoto A, Santos C, Pinto P, Lopes P, Lothe R, Lind GE, Henrique R, Teixeira MR (2018)
    Contribution of MLH1 constitutional methylation for Lynch syndrome diagnosis in patients with tumor MLH1 downregulation
    Cancer Med, 7 (2), 433-444
    DOI 10.1002/cam4.1285, PubMed 29341452
  17. Rajpert-De Meyts E, Skotheim RI (2018)
    Complex Polygenic Nature of Testicular Germ Cell Cancer Suggests Multifactorial Aetiology
    Eur Urol, 73 (6), 832-833
    DOI 10.1016/j.eururo.2018.02.023, PubMed 29530636
  18. Smeby J, Sveen A, Merok MA, Danielsen SA, Eilertsen IA, Guren MG, Dienstmann R, Nesbakken A, Lothe RA (2018)
    CMS-dependent prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer
    Ann Oncol, 29 (5), 1227-1234
    DOI 10.1093/annonc/mdy085, PubMed 29518181
  19. Vedeld HM, Nesbakken A, Lothe RA, Lind GE (2018)
    Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer
    Clin Epigenetics, 10, 70
    DOI 10.1186/s13148-018-0503-2, PubMed 29854011
  20. Viswanathan SR, Ha G, Hoff AM, Wala JA, Carrot-Zhang J, Whelan CW, Haradhvala NJ, Freeman SS, Reed SC, Rhoades J, Polak P, Cipicchio M, Wankowicz SA, Wong A, Kamath T, Zhang Z, Gydush GJ, Rotem D, PCF/SU2C International Prostate Cancer Dream Team, Love JC, Getz G, Gabriel S, Zhang CZ, Dehm SM, Nelson PS et al. (2018)
    Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing
    Cell, 174 (2), 433-447.e19
    DOI 10.1016/j.cell.2018.05.036, PubMed 29909985

Publications 2017

  1. Barfeld SJ, Urbanucci A, Itkonen HM, Fazli L, Hicks JL, Thiede B, Rennie PS, Yegnasubramanian S, DeMarzo AM, Mills IG (2017)
    c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks
    EBioMedicine, 18, 83-93
    DOI 10.1016/j.ebiom.2017.04.006, PubMed 28412251
  2. Berg KCG, Eide PW, Eilertsen IA, Johannessen B, Bruun J, Danielsen SA, Bjørnslett M, Meza-Zepeda LA, Eknæs M, Lind GE, Myklebost O, Skotheim RI, Sveen A, Lothe RA (2017)
    Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
    Mol Cancer, 16 (1), 116
    DOI 10.1186/s12943-017-0691-y, PubMed 28683746
  3. Dienstmann R, Mason MJ, Sinicrope FA, Phipps AI, Tejpar S, Nesbakken A, Danielsen SA, Sveen A, Buchanan DD, Clendenning M, Rosty C, Bot B, Alberts SR, Milburn Jessup J, Lothe RA, Delorenzi M, Newcomb PA, Sargent D, Guinney J (2017)
    Prediction of overall survival in stage II and III colon cancer beyond TNM system: a retrospective, pooled biomarker study
    Ann Oncol, 28 (5), 1023-1031
    DOI 10.1093/annonc/mdx052, PubMed 28453697
  4. Dukic AR, Haugen LH, Pidoux G, Leithe E, Bakke O, Taskén K (2017)
    A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells
    Cell Signal, 32, 1-11
    DOI 10.1016/j.cellsig.2017.01.008, PubMed 28077322
  5. Eide PW, Bruun J, Lothe RA, Sveen A (2017)
    CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models
    Sci Rep, 7 (1), 16618
    DOI 10.1038/s41598-017-16747-x, PubMed 29192179
  6. Gansmo LB, Bjørnslett M, Halle MK, Salvesen HB, Romundstad P, Hveem K, Vatten L, Dørum A, Lønning PE, Knappskog S (2017)
    MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk
    BMC Cancer, 17 (1), 97
    DOI 10.1186/s12885-017-3094-y, PubMed 28158999
  7. Itkonen HM, Brown M, Urbanucci A, Tredwell G, Ho Lau C, Barfeld S, Hart C, Guldvik IJ, Takhar M, Heemers HV, Erho N, Bloch K, Davicioni E, Derua R, Waelkens E, Mohler JL, Clarke N, Swinnen JV, Keun HC, Rekvig OP, Mills IG (2017)
    Lipid degradation promotes prostate cancer cell survival
    Oncotarget, 8 (24), 38264-38275
    DOI 10.18632/oncotarget.16123, PubMed 28415728
  8. Kivinummi K, Urbanucci A, Leinonen K, Tammela TLJ, Annala M, Isaacs WB, Bova GS, Nykter M, Visakorpi T (2017)
    The expression of AURKA is androgen regulated in castration-resistant prostate cancer
    Sci Rep, 7 (1), 17978
    DOI 10.1038/s41598-017-18210-3, PubMed 29269934
  9. Kolberg M, Bruun J, Murumägi A, Mpindi JP, Bergsland CH, Høland M, Eilertsen IA, Danielsen SA, Kallioniemi O, Lothe RA (2017)
    Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors
    Mol Oncol, 11 (9), 1156-1171
    DOI 10.1002/1878-0261.12086, PubMed 28556483
  10. Labori KJ, Guren MG, Brudvik KW, Røsok BI, Waage A, Nesbakken A, Larsen S, Dueland S, Edwin B, Bjørnbeth BA (2017)
    Resection of synchronous liver metastases between radiotherapy and definitive surgery for locally advanced rectal cancer: short-term surgical outcomes, overall survival and recurrence-free survival
    Colorectal Dis, 19 (8), 731-738
    DOI 10.1111/codi.13622, PubMed 28181384
  11. Landskron J, Kraggerud SM, Wik E, Dørum A, Bjørnslett M, Melum E, Helland Ø, Bjørge L, Lothe RA, Salvesen HB, Taskén K (2017)
    C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease
    PLoS One, 12 (7), e0182030
    DOI 10.1371/journal.pone.0182030, PubMed 28759630
  12. Leithe E, Mesnil M, Aasen T (2017)
    The connexin 43 C-terminus: A tail of many tales
    Biochim Biophys Acta Biomembr, 1860 (1), 48-64
    DOI 10.1016/j.bbamem.2017.05.008, PubMed 28526583
  13. Lind GE, Guriby M, Ahlquist T, Hussain I, Jeanmougin M, Søreide K, Kørner H, Lothe RA, Nordgård O (2017)
    Prognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients
    Clin Epigenetics, 9, 97
    DOI 10.1186/s13148-017-0397-4, PubMed 28878843
  14. Lind GE, van Engeland M (2017)
    Details matter: the role of genomic location and assay standardization in DNA methylation analyses
    Epigenomics, 9 (7), 933-935
    DOI 10.2217/epi-2017-0053, PubMed 28617096
  15. Lågstad S, Zhao S, Hoff AM, Johannessen B, Lingjærde OC, Skotheim RI (2017)
    chimeraviz: a tool for visualizing chimeric RNA
    Bioinformatics, 33 (18), 2954-2956
    DOI 10.1093/bioinformatics/btx329, PubMed 28525538
  16. Mesnil M, Aasen T, Boucher J, Chépied A, Cronier L, Defamie N, Kameritsch P, Laird DW, Lampe PD, Lathia JD, Leithe E, Mehta PP, Monvoisin A, Pogoda K, Sin WC, Tabernero A, Yamasaki H, Yeh ES, Dagli MLZ, Naus CC (2017)
    An update on minding the gap in cancer
    Biochim Biophys Acta Biomembr, 1860 (1), 237-243
    DOI 10.1016/j.bbamem.2017.06.015, PubMed 28655619
  17. Smebye ML, Agostini A, Johannessen B, Thorsen J, Davidson B, Tropé CG, Heim S, Skotheim RI, Micci F (2017)
    Involvement of DPP9 in gene fusions in serous ovarian carcinoma
    BMC Cancer, 17 (1), 642
    DOI 10.1186/s12885-017-3625-6, PubMed 28893231
  18. Solheim O, Førsund M, Tropé CG, Kraggerud SM, Nesland JM, Davidson B (2017)
    Epithelial-mesenchymal transition markers in malignant ovarian germ cell tumors
    APMIS, 125 (9), 781-786
    DOI 10.1111/apm.12715, PubMed 28585395
  19. Sveen A, Bruun J, Eide PW, Eilertsen IA, Ramirez L, Murumägi A, Arjama M, Danielsen SA, Kryeziu K, Elez E, Tabernero J, Guinney J, Palmer HG, Nesbakken A, Kallioniemi O, Dienstmann R, Lothe RA (2017)
    Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies
    Clin Cancer Res, 24 (4), 794-806
    DOI 10.1158/1078-0432.CCR-17-1234, PubMed 29242316
  20. Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA (2017)
    Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1
    Genome Med, 9 (1), 46
    DOI 10.1186/s13073-017-0434-0, PubMed 28539123
  21. Totland MZ, Bergsland CH, Fykerud TA, Knudsen LM, Rasmussen NL, Eide PW, Yohannes Z, Sørensen V, Brech A, Lothe RA, Leithe E (2017)
    The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions
    J Cell Sci, 130 (17), 2867-2882
    DOI 10.1242/jcs.202408, PubMed 28733455
  22. Urbanucci A, Barfeld SJ, Kytölä V, Itkonen HM, Coleman IM, Vodák D, Sjöblom L, Sheng X, Tolonen T, Minner S, Burdelski C, Kivinummi KK, Kohvakka A, Kregel S, Takhar M, Alshalalfa M, Davicioni E, Erho N, Lloyd P, Karnes RJ, Ross AE, Schaeffer EM, Vander Griend DJ, Knapp S, Corey E et al. (2017)
    Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer
    Cell Rep, 19 (10), 2045-2059
    DOI 10.1016/j.celrep.2017.05.049, PubMed 28591577
  23. Urbanucci A, Mills IG (2017)
    Bromodomain-containing proteins in prostate cancer
    Mol Cell Endocrinol, 462 (Pt A), 31-40
    DOI 10.1016/j.mce.2017.06.007, PubMed 28624514
  24. Vedeld HM, Goel A, Lind GE (2017)
    Epigenetic biomarkers in gastrointestinal cancers: The current state and clinical perspectives
    Semin Cancer Biol, 51, 36-49
    DOI 10.1016/j.semcancer.2017.12.004, PubMed 29253542
  25. Vedeld HM, Merok M, Jeanmougin M, Danielsen SA, Honne H, Presthus GK, Svindland A, Sjo OH, Hektoen M, Eknaes M, Nesbakken A, Lothe RA, Lind GE (2017)
    CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers
    Int J Cancer, 141 (5), 967-976
    DOI 10.1002/ijc.30796, PubMed 28542846
  26. Zhao S, Løvf M, Carm KT, Bakken AC, Hoff AM, Skotheim RI (2017)
    Novel transcription-induced fusion RNAs in prostate cancer
    Oncotarget, 8 (30), 49133-49143
    DOI 10.18632/oncotarget.17099, PubMed 28467780
  27. Zuber V, Bettella F, Witoelar A, PRACTICAL Consortium, CRUK GWAS, BCAC Consortium, TRICL Consortium, Andreassen OA, Mills IG, Urbanucci A (2017)
    Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer
    BMC Genomics, 18 (1), 270
    DOI 10.1186/s12864-017-3620-y, PubMed 28359301

Publications 2016

  1. Banales JM, Cardinale V, Carpino G, Marzioni M, Andersen JB, Invernizzi P, Lind GE, Folseraas T, Forbes SJ, Fouassier L, Geier A, Calvisi DF, Mertens JC, Trauner M, Benedetti A, Maroni L, Vaquero J, Macias RI, Raggi C, Perugorria MJ, Gaudio E, Boberg KM, Marin JJ, Alvaro D (2016)
    Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
    Nat Rev Gastroenterol Hepatol, 13 (5), 261-80
    DOI 10.1038/nrgastro.2016.51, PubMed 27095655
  2. Barfeld SJ, Mills IG (2016)
    Mapping Protein-DNA Interactions Using ChIP-exo and Illumina-Based Sequencing
    Methods Mol Biol, 1443, 119-37
    DOI 10.1007/978-1-4939-3724-0_8, PubMed 27246337
  3. Boye K, Jacob H, Frikstad KA, Nesland JM, Maelandsmo GM, Dahl O, Nesbakken A, Flatmark K (2016)
    Prognostic significance of S100A4 expression in stage II and III colorectal cancer: results from a population-based series and a randomized phase III study on adjuvant chemotherapy
    Cancer Med, 5 (8), 1840-9
    DOI 10.1002/cam4.766, PubMed 27273130
  4. Cekaite L, Eide PW, Lind GE, Skotheim RI, Lothe RA (2016)
    MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer
    Oncotarget, 7 (6), 6476-505
    DOI 10.18632/oncotarget.6390, PubMed 26623728
  5. Domingo E, Freeman-Mills L, Rayner E, Glaire M, Briggs S, Vermeulen L, Fessler E, Medema JP, Boot A, Morreau H, van Wezel T, Liefers GJ, Lothe RA, Danielsen SA, Sveen A, Nesbakken A, Zlobec I, Lugli A, Koelzer VH, Berger MD, Castellví-Bel S, Muñoz J, Epicolon consortium, de Bruyn M, Nijman HW et al. (2016)
    Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study
    Lancet Gastroenterol Hepatol, 1 (3), 207-216
    DOI 10.1016/S2468-1253(16)30014-0, PubMed 28404093
  6. Fiorito E, Sharma Y, Gilfillan S, Wang S, Singh SK, Satheesh SV, Katika MR, Urbanucci A, Thiede B, Mills IG, Hurtado A (2016)
    CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions
    Nucleic Acids Res, 44 (22), 10588-10602
    DOI 10.1093/nar/gkw785, PubMed 27638884
  7. Fykerud TA, Knudsen LM, Totland MZ, Sørensen V, Dahal-Koirala S, Lothe RA, Brech A, Leithe E (2016)
    Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding
    Cell Cycle, 15 (21), 2943-2957
    DOI 10.1080/15384101.2016.1231280, PubMed 27625181
  8. Gansmo LB, Bjørnslett M, Halle MK, Salvesen HB, Dørum A, Birkeland E, Hveem K, Romundstad P, Vatten L, Lønning PE, Knappskog S (2016)
    The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian-but not endometrial cancer
    Tumour Biol, 37 (8), 10697-702
    DOI 10.1007/s13277-016-4940-2, PubMed 26867771
  9. Gao J, Zhao S, Halstensen TS (2016)
    Increased interleukin-6 expression is associated with poor prognosis and acquired cisplatin resistance in head and neck squamous cell carcinoma
    Oncol Rep, 35 (6), 3265-74
    DOI 10.3892/or.2016.4765, PubMed 27108527
  10. Gerner L, Munack S, Temmerman K, Lawrence-Dörner AM, Besir H, Wilmanns M, Jensen JK, Thiede B, Mills IG, Morth JP (2016)
    Using the fluorescent properties of STO-609 as a tool to assist structure-function analyses of recombinant CaMKK2
    Biochem Biophys Res Commun, 476 (2), 102-7
    DOI 10.1016/j.bbrc.2016.05.045, PubMed 27178209
  11. Gerner L, Munack S, Temmerman K, Lawrence-Dörner AM, Besir H, Wilmanns M, Jensen JK, Thiede B, Mills IG, Morth JP (2016)
    Data for the co-expression and purification of human recombinant CaMKK2 in complex with calmodulin in Escherichia coli
    Data Brief, 8, 733-40
    DOI 10.1016/j.dib.2016.06.033, PubMed 27508226
  12. Gleditsch D, Søreide OK, Nesbakken A (2016)
    Managing Malignant Colorectal Obstruction with Self-Expanding Stents. A Closer Look at Bowel Perforations and Failed Procedures
    J Gastrointest Surg, 20 (9), 1643-9
    DOI 10.1007/s11605-016-3186-z, PubMed 27342437
  13. Itkonen HM, Gorad SS, Duveau DY, Martin SE, Barkovskaya A, Bathen TF, Moestue SA, Mills IG (2016)
    Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism
    Oncotarget, 7 (11), 12464-76
    DOI 10.18632/oncotarget.7039, PubMed 26824323
  14. Leithe E (2016)
    Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer
    Biochim Biophys Acta, 1865 (2), 133-46
    DOI 10.1016/j.bbcan.2016.02.001, PubMed 26855059
  15. Lorenz S, Barøy T, Sun J, Nome T, Vodák D, Bryne JC, Håkelien AM, Fernandez-Cuesta L, Möhlendick B, Rieder H, Szuhai K, Zaikova O, Ahlquist TC, Thomassen GO, Skotheim RI, Lothe RA, Tarpey PS, Campbell P, Flanagan A, Myklebost O, Meza-Zepeda LA (2016)
    Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations
    Oncotarget, 7 (5), 5273-88
    DOI 10.18632/oncotarget.6567, PubMed 26672768
  16. Massie CE, Mills IG, Lynch AG (2016)
    The importance of DNA methylation in prostate cancer development
    J Steroid Biochem Mol Biol, 166, 1-15
    DOI 10.1016/j.jsbmb.2016.04.009, PubMed 27117390
  17. McNair C, Urbanucci A, Comstock CE, Augello MA, Goodwin JF, Launchbury R, Zhao SG, Schiewer MJ, Ertel A, Karnes J, Davicioni E, Wang L, Wang Q, Mills IG, Feng FY, Li W, Carroll JS, Knudsen KE (2016)
    Cell cycle-coupled expansion of AR activity promotes cancer progression
    Oncogene, 36 (12), 1655-1668
    DOI 10.1038/onc.2016.334, PubMed 27669432
  18. Moen LV, Ramberg H, Zhao S, Grytli HH, Sveen A, Berge V, Skotheim RI, Taskén KA, Skålhegg BS (2016)
    Observed correlation between the expression levels of catalytic subunit, Cβ2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness
    Urol Oncol, 35 (3), 111.e1-111.e8
    DOI 10.1016/j.urolonc.2016.10.002, PubMed 27838142
  19. Munkley J, Mills IG, Elliott DJ (2016)
    The role of glycans in the development and progression of prostate cancer
    Nat Rev Urol, 13 (6), 324-33
    DOI 10.1038/nrurol.2016.65, PubMed 27091662
  20. Munkley J, Vodak D, Livermore KE, James K, Wilson BT, Knight B, Mccullagh P, Mcgrath J, Crundwell M, Harries LW, Leung HY, Robson CN, Mills IG, Rajan P, Elliott DJ (2016)
    Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability
    EBioMedicine, 8, 103-116
    DOI 10.1016/j.ebiom.2016.04.018, PubMed 27428423
  21. Pharo HD, Honne H, Vedeld HM, Dahl C, Andresen K, Liestøl K, Jeanmougin M, Guldberg P, Lind GE (2016)
    Experimental factors affecting the robustness of DNA methylation analysis
    Sci Rep, 6, 33936
    DOI 10.1038/srep33936, PubMed 27671843
  22. Ramalho-Carvalho J, Martins JB, Cekaite L, Sveen A, Torres-Ferreira J, Graça I, Costa-Pinheiro P, Eilertsen IA, Antunes L, Oliveira J, Lothe RA, Henrique R, Jerónimo C (2016)
    Epigenetic disruption of miR-130a promotes prostate cancer by targeting SEC23B and DEPDC1
    Cancer Lett, 385, 150-159
    DOI 10.1016/j.canlet.2016.10.028, PubMed 27984115
  23. Ramberg H, Grytli HH, Nygård S, Wang W, Ögren O, Zhao S, Løvf M, Katz B, Skotheim RI, Bjartell A, Eri LM, Berge V, Svindland A, Taskén KA (2016)
    PBX3 is a putative biomarker of aggressive prostate cancer
    Int J Cancer, 139 (8), 1810-20
    DOI 10.1002/ijc.30220, PubMed 27273830
  24. Ross-Adams H, Ball S, Lawrenson K, Halim S, Russell R, Wells C, Strand SH, Ørntoft TF, Larson M, Armasu S, Massie CE, Asim M, Mortensen MM, Borre M, Woodfine K, Warren AY, Lamb AD, Kay J, Whitaker H, Ramos-Montoya A, Murrell A, Sørensen KD, Fridley BL, Goode EL, Gayther SA et al. (2016)
    HNF1B variants associate with promoter methylation and regulate gene networks activated in prostate and ovarian cancer
    Oncotarget, 7 (46), 74734-74746
    DOI 10.18632/oncotarget.12543, PubMed 27732966
  25. Rønning B, Wyller TB, Nesbakken A, Skovlund E, Jordhøy MS, Bakka A, Rostoft S (2016)
    Quality of life in older and frail patients after surgery for colorectal cancer-A follow-up study
    J Geriatr Oncol, 7 (3), 195-200
    DOI 10.1016/j.jgo.2016.03.002, PubMed 27067579
  26. Smebye ML, Haugom L, Davidson B, Trope CG, Heim S, Skotheim RI, Micci F (2016)
    Bilateral ovarian carcinomas differ in the expression of metastasis-related genes
    Oncol Lett, 13 (1), 184-190
    DOI 10.3892/ol.2016.5384, PubMed 28123539
  27. Stornes T, Wibe A, Nesbakken A, Myklebust TÅ, Endreseth BH (2016)
    National Early Rectal Cancer Treatment Revisited
    Dis Colon Rectum, 59 (7), 623-9
    DOI 10.1097/DCR.0000000000000591, PubMed 27270514
  28. Sveen A, Løes IM, Alagaratnam S, Nilsen G, Høland M, Lingjærde OC, Sorbye H, Berg KC, Horn A, Angelsen JH, Knappskog S, Lønning PE, Lothe RA (2016)
    Intra-patient Inter-metastatic Genetic Heterogeneity in Colorectal Cancer as a Key Determinant of Survival after Curative Liver Resection
    PLoS Genet, 12 (7), e1006225
    DOI 10.1371/journal.pgen.1006225, PubMed 27472274
  29. Tekpli X, Urbanucci A, Hashim A, Vågbø CB, Lyle R, Kringen MK, Staff AC, Dybedal I, Mills IG, Klungland A, Staerk J (2016)
    Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells
    Epigenetics Chromatin, 9, 21
    DOI 10.1186/s13072-016-0070-8, PubMed 27252783
  30. Whitington T, Gao P, Song W, Ross-Adams H, Lamb AD, Yang Y, Svezia I, Klevebring D, Mills IG, Karlsson R, Halim S, Dunning MJ, Egevad L, Warren AY, Neal DE, Grönberg H, Lindberg J, Wei GH, Wiklund F (2016)
    Gene regulatory mechanisms underpinning prostate cancer susceptibility
    Nat Genet, 48 (4), 387-97
    DOI 10.1038/ng.3523, PubMed 26950096

Publications 2015

  1. Andreassen OA, Desikan RS, Wang Y, Thompson WK, Schork AJ, Zuber V, Doncheva NT, Ellinghaus E, Albrecht M, Mattingsdal M, Franke A, Lie BA, Mills IG, Aukrust P, McEvoy LK, Djurovic S, Karlsen TH, Dale AM (2015)
    Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms
    PLoS One, 10 (4), e0123057
    DOI 10.1371/journal.pone.0123057, PubMed 25853426
  2. Andresen K, Boberg KM, Vedeld HM, Honne H, Jebsen P, Hektoen M, Wadsworth CA, Clausen OP, Lundin KE, Paulsen V, Foss A, Mathisen Ø, Aabakken L, Schrumpf E, Lothe RA, Lind GE (2015)
    Four DNA methylation biomarkers in biliary brush samples accurately identify the presence of cholangiocarcinoma
    Hepatology, 61 (5), 1651-9
    DOI 10.1002/hep.27707, PubMed 25644509
  3. Asim M, Massie CE, Orafidiya F, Pértega-Gomes N, Warren AY, Esmaeili M, Selth LA, Zecchini HI, Luko K, Qureshi A, Baridi A, Menon S, Madhu B, Escriu C, Lyons S, Vowler SL, Zecchini VR, Shaw G, Hessenkemper W, Russell R, Mohammed H, Stefanos N, Lynch AG, Grigorenko E, D'Santos C et al. (2015)
    Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target
    J Natl Cancer Inst, 108 (5)
    DOI 10.1093/jnci/djv371, PubMed 26657335
  4. Barfeld SJ, Fazli L, Persson M, Marjavaara L, Urbanucci A, Kaukoniemi KM, Rennie PS, Ceder Y, Chabes A, Visakorpi T, Mills IG (2015)
    Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer
    Oncotarget, 6 (14), 12587-602
    DOI 10.18632/oncotarget.3494, PubMed 25869206
  5. Bjørnslett M, Dahl AA, Sørebø Ø, Dørum A (2015)
    Psychological distress related to BRCA testing in ovarian cancer patients
    Fam Cancer, 14 (4), 495-504
    DOI 10.1007/s10689-015-9811-2, PubMed 25980896
  6. Bollineni RC, Guldvik IJ, Grönberg H, Wiklund F, Mills IG, Thiede B (2015)
    A differential protein solubility approach for the depletion of highly abundant proteins in plasma using ammonium sulfate
    Analyst, 140 (24), 8109-17
    DOI 10.1039/c5an01560j, PubMed 26541119
  7. Brabrand S, Johannessen B, Axcrona U, Kraggerud SM, Berg KG, Bakken AC, Bruun J, Fosså SD, Lothe RA, Lehne G, Skotheim RI (2015)
    Exome sequencing of bilateral testicular germ cell tumors suggests independent development lineages
    Neoplasia, 17 (2), 167-74
    DOI 10.1016/j.neo.2014.12.005, PubMed 25748235
  8. Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA (2015)
    Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
    Clin Cancer Res, 21 (16), 3759-70
    DOI 10.1158/1078-0432.CCR-14-3294, PubMed 25910952
  9. Du H, Liang Z, Zhao S, Nan MG, Tran LS, Lu K, Huang YB, Li JN (2015)
    The Evolutionary History of R2R3-MYB Proteins Across 50 Eukaryotes: New Insights Into Subfamily Classification and Expansion
    Sci Rep, 5, 11037
    DOI 10.1038/srep11037, PubMed 26047035
  10. Guren MG, Kørner H, Pfeffer F, Myklebust TÅ, Eriksen MT, Edna TH, Larsen SG, Knudsen KO, Nesbakken A, Wasmuth HH, Vonen B, Hofsli E, Færden AE, Brændengen M, Dahl O, Steigen SE, Johansen MJ, Lindsetmo RO, Drolsum A, Tollåli G, Dørum LM, Møller B, Wibe A (2015)
    Nationwide improvement of rectal cancer treatment outcomes in Norway, 1993-2010
    Acta Oncol, 54 (10), 1714-22
    DOI 10.3109/0284186X.2015.1034876, PubMed 25924970
  11. Hoff AM, Alagaratnam S, Zhao S, Bruun J, Andrews PW, Lothe RA, Skotheim RI (2015)
    Identification of Novel Fusion Genes in Testicular Germ Cell Tumors
    Cancer Res, 76 (1), 108-16
    DOI 10.1158/0008-5472.CAN-15-1790, PubMed 26659575
  12. Hoff AM, Johannessen B, Alagaratnam S, Zhao S, Nome T, Løvf M, Bakken AC, Hektoen M, Sveen A, Lothe RA, Skotheim RI (2015)
    Novel RNA variants in colorectal cancers
    Oncotarget, 6 (34), 36587-602
    DOI 10.18632/oncotarget.5500, PubMed 26474385
  13. Johannessen B, Sveen A, Skotheim RI (2015)
    TIN: An R Package for Transcriptome Instability Analysis
    Cancer Inform, 14, 109-12
    DOI 10.4137/CIN.S31363, PubMed 26448683
  14. Khanna A, Rane JK, Kivinummi KK, Urbanucci A, Helenius MA, Tolonen TT, Saramäki OR, Latonen L, Manni V, Pimanda JE, Maitland NJ, Westermarck J, Visakorpi T (2015)
    CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations
    Oncotarget, 6 (23), 19661-70
    DOI 10.18632/oncotarget.3875, PubMed 25965834
  15. Kolberg M, Høland M, Lind GE, Ågesen TH, Skotheim RI, Hall KS, Mandahl N, Smeland S, Mertens F, Davidson B, Lothe RA (2015)
    Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection
    Mol Oncol, 9 (6), 1129-39
    DOI 10.1016/j.molonc.2015.02.005, PubMed 25769404
  16. Kumar S, Krabberød AK, Neumann RS, Michalickova K, Zhao S, Zhang X, Shalchian-Tabrizi K (2015)
    BIR Pipeline for Preparation of Phylogenomic Data
    Evol Bioinform Online, 11, 79-83
    DOI 10.4137/EBO.S10189, PubMed 25987827
  17. Lund K, Dembinski JL, Solberg N, Urbanucci A, Mills IG, Krauss S (2015)
    Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment
    PLoS One, 10 (4), e0123684
    DOI 10.1371/journal.pone.0123684, PubMed 25860483
  18. Mesquita D, Barros-Silva JD, Santos J, Skotheim RI, Lothe RA, Paulo P, Teixeira MR (2015)
    Specific and redundant activities of ETV1 and ETV4 in prostate cancer aggressiveness revealed by co-overexpression cellular contexts
    Oncotarget, 6 (7), 5217-36
    DOI 10.18632/oncotarget.2847, PubMed 25595908
  19. Mills IG (2015)
    Molecular subtyping of prostate cancer: a partnership model
    Eur Urol, 68 (4), 568-9
    DOI 10.1016/j.eururo.2015.05.012, PubMed 26001612
  20. Munkley J, Oltean S, Vodák D, Wilson BT, Livermore KE, Zhou Y, Star E, Floros VI, Johannessen B, Knight B, McCullagh P, McGrath J, Crundwell M, Skotheim RI, Robson CN, Leung HY, Harries LW, Rajan P, Mills IG, Elliott DJ (2015)
    The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer
    Oncotarget, 6 (33), 34358-74
    DOI 10.18632/oncotarget.6024, PubMed 26452038
  21. Pickard A, Mills IG (2015)
    Maintaining a Healthy Balance: Targeting TERT to Stem Benign Prostatic Hyperplasia
    Eur Urol, 69 (4), 555-556
    DOI 10.1016/j.eururo.2015.10.028, PubMed 26520704
  22. Ross-Adams H, Lamb AD, Dunning MJ, Halim S, Lindberg J, Massie CM, Egevad LA, Russell R, Ramos-Montoya A, Vowler SL, Sharma NL, Kay J, Whitaker H, Clark J, Hurst R, Gnanapragasam VJ, Shah NC, Warren AY, Cooper CS, Lynch AG, Stark R, Mills IG, Grönberg H, Neal DE, CamCaP Study Group (2015)
    Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study
    EBioMedicine, 2 (9), 1133-44
    DOI 10.1016/j.ebiom.2015.07.017, PubMed 26501111
  23. Rounge TB, Furu K, Skotheim RI, Haugen TB, Grotmol T, Enerly E (2015)
    Profiling of the small RNA populations in human testicular germ cell tumors shows global loss of piRNAs
    Mol Cancer, 14, 153
    DOI 10.1186/s12943-015-0411-4, PubMed 26265322
  24. Seglen PO, Luhr M, Mills IG, Sætre F, Szalai P, Engedal N (2015)
    Macroautophagic cargo sequestration assays
    Methods, 75, 25-36
    DOI 10.1016/j.ymeth.2014.12.021, PubMed 25576638
  25. Sevilla LM, Latorre V, Carceller E, Boix J, Vodák D, Mills IG, Pérez P (2015)
    Glucocorticoid receptor and Klf4 co-regulate anti-inflammatory genes in keratinocytes
    Mol Cell Endocrinol, 412, 281-9
    DOI 10.1016/j.mce.2015.05.015, PubMed 26001834
  26. Shaw GL, Whitaker H, Corcoran M, Dunning MJ, Luxton H, Kay J, Massie CE, Miller JL, Lamb AD, Ross-Adams H, Russell R, Nelson AW, Eldridge MD, Lynch AG, Ramos-Montoya A, Mills IG, Taylor AE, Arlt W, Shah N, Warren AY, Neal DE (2015)
    The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer
    Eur Urol, 70 (2), 214-8
    DOI 10.1016/j.eururo.2015.10.042, PubMed 26572708
  27. Sheng X, Arnoldussen YJ, Storm M, Tesikova M, Nenseth HZ, Zhao S, Fazli L, Rennie P, Risberg B, Wæhre H, Danielsen H, Mills IG, Jin Y, Hotamisligil G, Saatcioglu F (2015)
    Divergent androgen regulation of unfolded protein response pathways drives prostate cancer
    EMBO Mol Med, 7 (6), 788-801
    DOI 10.15252/emmm.201404509, PubMed 25864123
  28. Sveen A, Kilpinen S, Ruusulehto A, Lothe RA, Skotheim RI (2015)
    Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
    Oncogene, 35 (19), 2413-27
    DOI 10.1038/onc.2015.318, PubMed 26300000
  29. Szalai P, Hagen LK, Sætre F, Luhr M, Sponheim M, Øverbye A, Mills IG, Seglen PO, Engedal N (2015)
    Autophagic bulk sequestration of cytosolic cargo is independent of LC3, but requires GABARAPs
    Exp Cell Res, 333 (1), 21-38
    DOI 10.1016/j.yexcr.2015.02.003, PubMed 25684710

Publications 2014

  1. Almeida M, Costa VL, Costa NR, Ramalho-Carvalho J, Baptista T, Ribeiro FR, Paulo P, Teixeira MR, Oliveira J, Lothe RA, Lind GE, Henrique R, Jerónimo C (2014)
    Epigenetic regulation of EFEMP1 in prostate cancer: biological relevance and clinical potential
    J Cell Mol Med, 18 (11), 2287-97
    DOI 10.1111/jcmm.12394, PubMed 25211630
  2. Andreassen OA, Zuber V, Thompson WK, Schork AJ, Bettella F, PRACTICAL Consortium, CRUK GWAS, Djurovic S, Desikan RS, Mills IG, Dale AM (2014)
    Shared common variants in prostate cancer and blood lipids
    Int J Epidemiol, 43 (4), 1205-14
    DOI 10.1093/ije/dyu090, PubMed 24786909
  3. Barfeld SJ, East P, Zuber V, Mills IG (2014)
    Meta-analysis of prostate cancer gene expression data identifies a novel discriminatory signature enriched for glycosylating enzymes
    BMC Med Genomics, 7, 513
    DOI 10.1186/s12920-014-0074-9, PubMed 25551447
  4. Barfeld SJ, Itkonen HM, Urbanucci A, Mills IG (2014)
    Androgen-regulated metabolism and biosynthesis in prostate cancer
    Endocr Relat Cancer, 21 (4), T57-66
    DOI 10.1530/ERC-13-0515, PubMed 24497572
  5. Bethge N, Honne H, Andresen K, Hilden V, Trøen G, Liestøl K, Holte H, Delabie J, Lind GE, Smeland EB (2014)
    A gene panel, including LRP12, is frequently hypermethylated in major types of B-cell lymphoma
    PLoS One, 9 (9), e104249
    DOI 10.1371/journal.pone.0104249, PubMed 25226156
  6. Bon H, Wadhwa K, Schreiner A, Osborne M, Carroll T, Ramos-Montoya A, Ross-Adams H, Visser M, Hoffmann R, Ahmed AA, Neal DE, Mills IG (2014)
    Salt-inducible kinase 2 regulates mitotic progression and transcription in prostate cancer
    Mol Cancer Res, 13 (4), 620-635
    DOI 10.1158/1541-7786.MCR-13-0182-T, PubMed 25548099
  7. Bruun J, Kolberg M, Nesland JM, Svindland A, Nesbakken A, Lothe RA (2014)
    Prognostic Significance of β-Catenin, E-Cadherin, and SOX9 in Colorectal Cancer: Results from a Large Population-Representative Series
    Front Oncol, 4, 118
    DOI 10.3389/fonc.2014.00118, PubMed 24904831
  8. Danielsen SA, Eide PW, Nesbakken A, Guren T, Leithe E, Lothe RA (2014)
    Portrait of the PI3K/AKT pathway in colorectal cancer
    Biochim Biophys Acta, 1855 (1), 104-21
    DOI 10.1016/j.bbcan.2014.09.008, PubMed 25450577
  9. Danielsen SA, Lind GE, Kolberg M, Høland M, Bjerkehagen B, Sundby Hall K, van den Berg E, Mertens F, Smeland S, Picci P, Lothe RA (2014)
    Methylated RASSF1A in malignant peripheral nerve sheath tumors identifies neurofibromatosis type 1 patients with inferior prognosis
    Neuro Oncol, 17 (1), 63-9
    DOI 10.1093/neuonc/nou140, PubMed 25038505
  10. Engedal N, Mills IG (2014)
    Endosomal signaling and oncogenesis
    Methods Enzymol, 535, 179-200
    DOI 10.1016/B978-0-12-397925-4.00012-2, PubMed 24377925
  11. Hveem TS, Merok MA, Pretorius ME, Novelli M, Bævre MS, Sjo OH, Clinch N, Liestøl K, Svindland A, Lothe RA, Nesbakken A, Danielsen HE (2014)
    Prognostic impact of genomic instability in colorectal cancer
    Br J Cancer, 110 (8), 2159-64
    DOI 10.1038/bjc.2014.133, PubMed 24642618
  12. Itkonen HM, Engedal N, Babaie E, Luhr M, Guldvik IJ, Minner S, Hohloch J, Tsourlakis MC, Schlomm T, Mills IG (2014)
    UAP1 is overexpressed in prostate cancer and is protective against inhibitors of N-linked glycosylation
    Oncogene, 34 (28), 3744-50
    DOI 10.1038/onc.2014.307, PubMed 25241896
  13. Joranger P, Nesbakken A, Hoff G, Sorbye H, Oshaug A, Aas E (2014)
    Modeling and validating the cost and clinical pathway of colorectal cancer
    Med Decis Making, 35 (2), 255-65
    DOI 10.1177/0272989X14544749, PubMed 25073464
  14. Løvf M, Nome T, Bruun J, Eknaes M, Bakken AC, Mpindi JP, Kilpinen S, Rognum TO, Nesbakken A, Kallioniemi O, Lothe RA, Skotheim RI (2014)
    A novel transcript, VNN1-AB, as a biomarker for colorectal cancer
    Int J Cancer, 135 (9), 2077-84
    DOI 10.1002/ijc.28855, PubMed 24687856
  15. Mills IG (2014)
    HOXB13, RFX6 and prostate cancer risk
    Nat Genet, 46 (2), 94-5
    DOI 10.1038/ng.2881, PubMed 24473320
  16. Mills IG (2014)
    Maintaining and reprogramming genomic androgen receptor activity in prostate cancer
    Nat Rev Cancer, 14 (3), 187-98
    DOI 10.1038/nrc3678, PubMed 24561445
  17. Nome T, Hoff AM, Bakken AC, Rognum TO, Nesbakken A, Skotheim RI (2014)
    High frequency of fusion transcripts involving TCF7L2 in colorectal cancer: novel fusion partner and splice variants
    PLoS One, 9 (3), e91264
    DOI 10.1371/journal.pone.0091264, PubMed 24608966
  18. Oppelt A, Haugsten EM, Zech T, Danielsen HE, Sveen A, Lobert VH, Skotheim RI, Wesche J (2014)
    PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1
    Biochem J, 461 (3), 383-90
    DOI 10.1042/BJ20140132, PubMed 24840251
  19. Ramos-Montoya A, Lamb AD, Russell R, Carroll T, Jurmeister S, Galeano-Dalmau N, Massie CE, Boren J, Bon H, Theodorou V, Vias M, Shaw GL, Sharma NL, Ross-Adams H, Scott HE, Vowler SL, Howat WJ, Warren AY, Wooster RF, Mills IG, Neal DE (2014)
    HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network
    EMBO Mol Med, 6 (5), 651-61
    DOI 10.1002/emmm.201303581, PubMed 24737870
  20. Sharma NL, Massie CE, Butter F, Mann M, Bon H, Ramos-Montoya A, Menon S, Stark R, Lamb AD, Scott HE, Warren AY, Neal DE, Mills IG (2014)
    The ETS family member GABPα modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancer
    Nucleic Acids Res, 42 (10), 6256-69
    DOI 10.1093/nar/gku281, PubMed 24753418
  21. Sirnes S, Lind GE, Bruun J, Fykerud TA, Mesnil M, Lothe RA, Rivedal E, Kolberg M, Leithe E (2014)
    Connexins in colorectal cancer pathogenesis
    Int J Cancer, 137 (1), 1-11
    DOI 10.1002/ijc.28911, PubMed 24752574
  22. Smebye ML, Sveen A, Haugom L, Davidson B, Tropé CG, Lothe RA, Heim S, Skotheim RI, Micci F (2014)
    Chromosome 19 rearrangements in ovarian carcinomas: zinc finger genes are particularly targeted
    Genes Chromosomes Cancer, 53 (7), 558-67
    DOI 10.1002/gcc.22166, PubMed 24634323
  23. Sveen A, Johannessen B, Teixeira MR, Lothe RA, Skotheim RI (2014)
    Transcriptome instability as a molecular pan-cancer characteristic of carcinomas
    BMC Genomics, 15 (1), 672
    DOI 10.1186/1471-2164-15-672, PubMed 25109687
  24. Søndenaa K, Quirke P, Hohenberger W, Sugihara K, Kobayashi H, Kessler H, Brown G, Tudyka V, D'Hoore A, Kennedy RH, West NP, Kim SH, Heald R, Storli KE, Nesbakken A, Moran B (2014)
    The rationale behind complete mesocolic excision (CME) and a central vascular ligation for colon cancer in open and laparoscopic surgery : proceedings of a consensus conference
    Int J Colorectal Dis, 29 (4), 419-28
    DOI 10.1007/s00384-013-1818-2, PubMed 24477788
  25. Sørlie T, Johnsen H, Vu P, Lind GE, Lothe R, Børresen-Dale AL (2014)
    Mutation screening of the TP53 gene by temporal temperature gel electrophoresis (TTGE)
    Methods Mol Biol, 1105, 315-24
    DOI 10.1007/978-1-62703-739-6_25, PubMed 24623239
  26. Vedeld HM, Andresen K, Eilertsen IA, Nesbakken A, Seruca R, Gladhaug IP, Thiis-Evensen E, Rognum TO, Boberg KM, Lind GE (2014)
    The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers
    Int J Cancer, 136 (4), 844-53
    DOI 10.1002/ijc.29039, PubMed 24948044
  27. Vedeld HM, Skotheim RI, Lothe RA, Lind GE (2014)
    The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer
    Epigenetics, 9 (3), 346-50
    DOI 10.4161/epi.27582, PubMed 24384857
  28. Zecchini V, Madhu B, Russell R, Pértega-Gomes N, Warren A, Gaude E, Borlido J, Stark R, Ireland-Zecchini H, Rao R, Scott H, Boren J, Massie C, Asim M, Brindle K, Griffiths J, Frezza C, Neal DE, Mills IG (2014)
    Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer
    EMBO J, 33 (12), 1365-82
    DOI 10.15252/embj.201386874, PubMed 24837709

Publications 2013

  1. Ahmed D, Eide PW, Eilertsen IA, Danielsen SA, Eknæs M, Hektoen M, Lind GE, Lothe RA (2013)
    Epigenetic and genetic features of 24 colon cancer cell lines
    Oncogenesis, 2 (9), e71
    DOI 10.1038/oncsis.2013.35, PubMed 24042735
  2. Alagaratnam S, Harrison N, Bakken AC, Hoff AM, Jones M, Sveen A, Moore HD, Andrews PW, Lothe RA, Skotheim RI (2013)
    Transforming pluripotency: an exon-level study of malignancy-specific transcripts in human embryonal carcinoma and embryonic stem cells
    Stem Cells Dev, 22 (7), 1136-46
    DOI 10.1089/scd.2012.0369, PubMed 23137282
  3. Avery S, Hirst AJ, Baker D, Lim CY, Alagaratnam S, Skotheim RI, Lothe RA, Pera MF, Colman A, Robson P, Andrews PW, Knowles BB (2013)
    BCL-XL mediates the strong selective advantage of a 20q11.21 amplification commonly found in human embryonic stem cell cultures
    Stem Cell Reports, 1 (5), 379-86
    DOI 10.1016/j.stemcr.2013.10.005, PubMed 24286026
  4. Barros-Silva JD, Paulo P, Bakken AC, Cerveira N, Løvf M, Henrique R, Jerónimo C, Lothe RA, Skotheim RI, Teixeira MR (2013)
    Novel 5' fusion partners of ETV1 and ETV4 in prostate cancer
    Neoplasia, 15 (7), 720-6
    DOI 10.1593/neo.13232, PubMed 23814484
  5. Berg M, Guriby M, Nordgård O, Nedrebø BS, Ahlquist TC, Smaaland R, Oltedal S, Søreide JA, Kørner H, Lothe RA, Søreide K (2013)
    Influence of microsatellite instability and KRAS and BRAF mutations on lymph node harvest in stage I-III colon cancers
    Mol Med, 19 (1), 286-93
    DOI 10.2119/molmed.2013.00049, PubMed 23979710
  6. Bethge N, Honne H, Hilden V, Trøen G, Eknæs M, Liestøl K, Holte H, Delabie J, Smeland EB, Lind GE (2013)
    Identification of highly methylated genes across various types of B-cell non-hodgkin lymphoma
    PLoS One, 8 (11), e79602
    DOI 10.1371/journal.pone.0079602, PubMed 24260260
  7. Bethge N, Lothe RA, Honne H, Andresen K, Trøen G, Eknæs M, Liestøl K, Holte H, Delabie J, Smeland EB, Lind GE (2013)
    Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma
    Epigenetics, 9 (3), 428-36
    DOI 10.4161/epi.27554, PubMed 24362313
  8. Chung CC, Kanetsky PA, Wang Z, Hildebrandt MA, Koster R, Skotheim RI, Kratz CP, Turnbull C, Cortessis VK, Bakken AC, Bishop DT, Cook MB, Erickson RL, Fosså SD, Jacobs KB, Korde LA, Kraggerud SM, Lothe RA, Loud JT, Rahman N, Skinner EC, Thomas DC, Wu X, Yeager M, Schumacher FR et al. (2013)
    Meta-analysis identifies four new loci associated with testicular germ cell tumor
    Nat Genet, 45 (6), 680-5
    DOI 10.1038/ng.2634, PubMed 23666239
  9. Engedal N, Torgersen ML, Guldvik IJ, Barfeld SJ, Bakula D, Sætre F, Hagen LK, Patterson JB, Proikas-Cezanne T, Seglen PO, Simonsen A, Mills IG (2013)
    Modulation of intracellular calcium homeostasis blocks autophagosome formation
    Autophagy, 9 (10), 1475-90
    DOI 10.4161/auto.25900, PubMed 23970164
  10. Håvik AB, Lind GE, Honne H, Meling TR, Scheie D, Hall KS, van den Berg E, Mertens F, Picci P, Lothe RA, Heim S, Brandal P (2013)
    Sequencing IDH1/2 glioma mutation hotspots in gliomas and malignant peripheral nerve sheath tumors
    Neuro Oncol, 16 (2), 320-2
    DOI 10.1093/neuonc/not230, PubMed 24311631
  11. Itkonen HM, Mills IG (2013)
    N-linked glycosylation supports cross-talk between receptor tyrosine kinases and androgen receptor
    PLoS One, 8 (5), e65016
    DOI 10.1371/journal.pone.0065016, PubMed 23724116
  12. Itkonen HM, Minner S, Guldvik IJ, Sandmann MJ, Tsourlakis MC, Berge V, Svindland A, Schlomm T, Mills IG (2013)
    O-GlcNAc transferase integrates metabolic pathways to regulate the stability of c-MYC in human prostate cancer cells
    Cancer Res, 73 (16), 5277-87
    DOI 10.1158/0008-5472.CAN-13-0549, PubMed 23720054
  13. Kraggerud SM, Hoei-Hansen CE, Alagaratnam S, Skotheim RI, Abeler VM, Rajpert-De Meyts E, Lothe RA (2013)
    Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis
    Endocr Rev, 34 (3), 339-76
    DOI 10.1210/er.2012-1045, PubMed 23575763
  14. Løvf M, Thomassen GO, Mertens F, Cerveira N, Teixeira MR, Lothe RA, Skotheim RI (2013)
    Assessment of fusion gene status in sarcomas using a custom made fusion gene microarray
    PLoS One, 8 (8), e70649
    DOI 10.1371/journal.pone.0070649, PubMed 23967081
  15. Mesquita B, Lopes P, Rodrigues A, Pereira D, Afonso M, Leal C, Henrique R, Lind GE, Jerónimo C, Lothe RA, Teixeira MR (2013)
    Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes
    Breast Cancer Res Treat, 138 (1), 37-45
    DOI 10.1007/s10549-013-2408-2, PubMed 23329352
  16. Nome T, Thomassen GO, Bruun J, Ahlquist T, Bakken AC, Hoff AM, Rognum T, Nesbakken A, Lorenz S, Sun J, Barros-Silva JD, Lind GE, Myklebost O, Teixeira MR, Meza-Zepeda LA, Lothe RA, Skotheim RI (2013)
    Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing
    Transl Oncol, 6 (5), 546-53
    DOI 10.1593/tlo.13457, PubMed 24151535
  17. Schumacher FR, Wang Z, Skotheim RI, Koster R, Chung CC, Hildebrandt MA, Kratz CP, Bakken AC, Bishop DT, Cook MB, Erickson RL, Fosså SD, Greene MH, Jacobs KB, Kanetsky PA, Kolonel LN, Loud JT, Korde LA, Le Marchand L, Lewinger JP, Lothe RA, Pike MC, Rahman N, Rubertone MV, Schwartz SM et al. (2013)
    Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23
    Hum Mol Genet, 22 (13), 2748-53
    DOI 10.1093/hmg/ddt109, PubMed 23462292

Publications 2012

  1. Agesen TH, Sveen A, Merok MA, Lind GE, Nesbakken A, Skotheim RI, Lothe RA (2012)
    ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis
    Gut, 61 (11), 1560-7
    DOI 10.1136/gutjnl-2011-301179, PubMed 22213796
  2. Ahmed D, Danielsen SA, Aagesen TH, Bretthauer M, Thiis-Evensen E, Hoff G, Rognum TO, Nesbakken A, Lothe RA, Lind GE (2012)
    A tissue-based comparative effectiveness analysis of biomarkers for early detection of colorectal tumors
    Clin Transl Gastroenterol, 3 (12), e27
    DOI 10.1038/ctg.2012.21, PubMed 23324654
  3. Andresen K, Boberg KM, Vedeld HM, Honne H, Hektoen M, Wadsworth CA, Clausen OP, Karlsen TH, Foss A, Mathisen O, Schrumpf E, Lothe RA, Lind GE (2012)
    Novel target genes and a valid biomarker panel identified for cholangiocarcinoma
    Epigenetics, 7 (11), 1249-57
    DOI 10.4161/epi.22191, PubMed 22983262
  4. Camões MJ, Paulo P, Ribeiro FR, Barros-Silva JD, Almeida M, Costa VL, Cerveira N, Skotheim RI, Lothe RA, Henrique R, Jerónimo C, Teixeira MR (2012)
    Potential downstream target genes of aberrant ETS transcription factors are differentially affected in Ewing's sarcoma and prostate carcinoma
    PLoS One, 7 (11), e49819
    DOI 10.1371/journal.pone.0049819, PubMed 23185447
  5. Cekaite L, Rantala JK, Bruun J, Guriby M, Agesen TH, Danielsen SA, Lind GE, Nesbakken A, Kallioniemi O, Lothe RA, Skotheim RI (2012)
    MiR-9, -31, and -182 deregulation promote proliferation and tumor cell survival in colon cancer
    Neoplasia, 14 (9), 868-79
    DOI 10.1593/neo.121094, PubMed 23019418
  6. Celestino R, Sigstad E, Løvf M, Thomassen GO, Grøholt KK, Jørgensen LH, Berner A, Castro P, Lothe RA, Bjøro T, Sobrinho-Simões M, Soares P, Skotheim RI (2012)
    Survey of 548 oncogenic fusion transcripts in thyroid tumors supports the importance of the already established thyroid fusions genes
    Genes Chromosomes Cancer, 51 (12), 1154-64
    DOI 10.1002/gcc.22003, PubMed 22961909
  7. Eide PW, Cekaite L, Danielsen SA, Eilertsen IA, Kjenseth A, Fykerud TA, Ågesen TH, Bruun J, Rivedal E, Lothe RA, Leithe E (2012)
    NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway
    Cell Signal, 25 (1), 12-8
    DOI 10.1016/j.cellsig.2012.08.012, PubMed 22974840
  8. Fykerud TA, Kjenseth A, Schink KO, Sirnes S, Bruun J, Omori Y, Brech A, Rivedal E, Leithe E (2012)
    Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43
    J Cell Sci, 125 (Pt 17), 3966-76
    DOI 10.1242/jcs.093500, PubMed 22623726
  9. Grisanzio C, Werner L, Takeda D, Awoyemi BC, Pomerantz MM, Yamada H, Sooriakumaran P, Robinson BD, Leung R, Schinzel AC, Mills I, Ross-Adams H, Neal DE, Kido M, Yamamoto T, Petrozziello G, Stack EC, Lis R, Kantoff PW, Loda M, Sartor O, Egawa S, Tewari AK, Hahn WC, Freedman ML (2012)
    Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis
    Proc Natl Acad Sci U S A, 109 (28), 11252-7
    DOI 10.1073/pnas.1200853109, PubMed 22730461
  10. Hart LS, Cunningham JT, Datta T, Dey S, Tameire F, Lehman SL, Qiu B, Zhang H, Cerniglia G, Bi M, Li Y, Gao Y, Liu H, Li C, Maity A, Thomas-Tikhonenko A, Perl AE, Koong A, Fuchs SY, Diehl JA, Mills IG, Ruggero D, Koumenis C (2012)
    ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth
    J Clin Invest, 122 (12), 4621-34
    DOI 10.1172/JCI62973, PubMed 23143306
  11. Håvik AB, Brandal P, Honne H, Dahlback HS, Scheie D, Hektoen M, Meling TR, Helseth E, Heim S, Lothe RA, Lind GE (2012)
    MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR
    J Transl Med, 10, 36
    DOI 10.1186/1479-5876-10-36, PubMed 22390413
  12. Kjenseth A, Fykerud TA, Sirnes S, Bruun J, Yohannes Z, Kolberg M, Omori Y, Rivedal E, Leithe E (2012)
    The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation
    J Biol Chem, 287 (19), 15851-61
    DOI 10.1074/jbc.M111.281832, PubMed 22411987
  13. Kolberg M, Høland M, Agesen TH, Brekke HR, Liestøl K, Hall KS, Mertens F, Picci P, Smeland S, Lothe RA (2012)
    Survival meta-analyses for >1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1
    Neuro Oncol, 15 (2), 135-47
    DOI 10.1093/neuonc/nos287, PubMed 23161774
  14. Kristjansson SR, Ronning B, Hurria A, Skovlund E, Jordhoy MS, Nesbakken A, Wyller TB (2012)
    A comparison of two pre-operative frailty measures in older surgical cancer patients
    J. Geriatr. Oncol., 3 (1), 1-7
    DOI 10.1016/j.jgo.2011.09.002
  15. Lind GE, Ahmed D, Lothe RA (2012)
    Vimentin in upper gastrointestinal pathologies--letter
    Cancer Epidemiol Biomarkers Prev, 21 (10), 1889; author reply 1890
    DOI 10.1158/1055-9965.EPI-12-0894, PubMed 22929079
  16. Lindberg J, Mills IG, Klevebring D, Liu W, Neiman M, Xu J, Wikström P, Wiklund P, Wiklund F, Egevad L, Grönberg H (2012)
    The mitochondrial and autosomal mutation landscapes of prostate cancer
    Eur Urol, 63 (4), 702-8
    DOI 10.1016/j.eururo.2012.11.053, PubMed 23265383
  17. Lobert VH, Bruun J, Abrahamsen H, Lothe RA, Stenmark H, Kolberg M, Campsteijn C (2012)
    Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin
    EMBO Rep, 14 (1), 10-1
    DOI 10.1038/embor.2012.188, PubMed 23229585
  18. Matheu A, Collado M, Wise C, Manterola L, Cekaite L, Tye AJ, Canamero M, Bujanda L, Schedl A, Cheah KS, Skotheim RI, Lothe RA, López de Munain A, Briscoe J, Serrano M, Lovell-Badge R (2012)
    Oncogenicity of the developmental transcription factor Sox9
    Cancer Res, 72 (5), 1301-15
    DOI 10.1158/0008-5472.CAN-11-3660, PubMed 22246670
  19. Merok MA, Ahlquist T, Røyrvik EC, Tufteland KF, Hektoen M, Sjo OH, Mala T, Svindland A, Lothe RA, Nesbakken A (2012)
    Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series
    Ann Oncol, 24 (5), 1274-82
    DOI 10.1093/annonc/mds614, PubMed 23235802
  20. Nordgård O, Oltedal S, Aasprong OG, Søreide JA, Søreide K, Tjensvoll K, Gilje B, Heikkilä R, Guriby M, Lothe RA, Smaaland R, Kørner H (2012)
    Prognostic relevance of occult metastases detected by cytokeratin 20 and mucin 2 mRNA levels in sentinel lymph nodes from colon cancer patients
    Ann Surg Oncol, 19 (12), 3719-26
    DOI 10.1245/s10434-012-2454-8, PubMed 22752373
  21. Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012)
    Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma
    PLoS One, 7 (11), e49705
    DOI 10.1371/journal.pone.0049705, PubMed 23185413
  22. Paulo P, Ribeiro FR, Santos J, Mesquita D, Almeida M, Barros-Silva JD, Itkonen H, Henrique R, Jerónimo C, Sveen A, Mills IG, Skotheim RI, Lothe RA, Teixeira MR (2012)
    Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements
    Neoplasia, 14 (7), 600-11
    DOI 10.1593/neo.12600, PubMed 22904677
  23. Sharma NL, Massie CE, Ramos-Montoya A, Zecchini V, Scott HE, Lamb AD, MacArthur S, Stark R, Warren AY, Mills IG, Neal DE (2012)
    The androgen receptor induces a distinct transcriptional program in castration-resistant prostate cancer in man
    Cancer Cell, 23 (1), 35-47
    DOI 10.1016/j.ccr.2012.11.010, PubMed 23260764
  24. Sjo OH, Merok MA, Svindland A, Nesbakken A (2012)
    Prognostic impact of lymph node harvest and lymph node ratio in patients with colon cancer
    Dis Colon Rectum, 55 (3), 307-15
    DOI 10.1097/DCR.0b013e3182423f62, PubMed 22469798
  25. Sveen A, Bakken AC, Ågesen TH, Lind GE, Nesbakken A, Nordgård O, Brackmann S, Rognum TO, Lothe RA, Skotheim RI (2012)
    The exon-level biomarker SLC39A14 has organ-confined cancer-specificity in colorectal cancer
    Int J Cancer, 131 (6), 1479-85
    DOI 10.1002/ijc.27399, PubMed 22173985
  26. Sveen A, Ågesen TH, Nesbakken A, Meling GI, Rognum TO, Liestøl K, Skotheim RI, Lothe RA (2012)
    ColoGuidePro: a prognostic 7-gene expression signature for stage III colorectal cancer patients
    Clin Cancer Res, 18 (21), 6001-10
    DOI 10.1158/1078-0432.CCR-11-3302, PubMed 22991413

Publications 2011

  1. Ahmed D, Lothe RA, Rivedal E, Lind GE (2011)
    Quantitative validation of GJC1 promoter hypermethylation in benign and malignant colorectal tumors
    Endocr Relat Cancer, 18 (6), C31-4
    DOI 10.1530/ERC-11-0204, PubMed 21868474
  2. Alagaratnam S, Lind GE, Kraggerud SM, Lothe RA, Skotheim RI (2011)
    The testicular germ cell tumour transcriptome
    Int J Androl, 34 (4 Pt 2), e133-50; discussion e150-1
    DOI 10.1111/j.1365-2605.2011.01169.x, PubMed 21651573
  3. Costa VL, Henrique R, Danielsen SA, Eknaes M, Patrício P, Morais A, Oliveira J, Lothe RA, Teixeira MR, Lind GE, Jerónimo C (2011)
    TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers
    Epigenetics, 6 (9), 1120-30
    DOI 10.4161/epi.6.9.16376, PubMed 21847011
  4. Danielsen SA, Cekaite L, Ågesen TH, Sveen A, Nesbakken A, Thiis-Evensen E, Skotheim RI, Lind GE, Lothe RA (2011)
    Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome
    PLoS One, 6 (9), e24419
    DOI 10.1371/journal.pone.0024419, PubMed 21909432
  5. Hølmebakk T, Solbakken A, Mala T, Nesbakken A (2011)
    Clinical prediction of survival by surgeons for patients with incurable abdominal malignancy
    Eur J Surg Oncol, 37 (7), 571-5
    DOI 10.1016/j.ejso.2011.02.009, PubMed 21444178
  6. Johansen D, Cruciani V, Sundset R, Ytrehus K, Mikalsen SO (2011)
    Ischemia induces closure of gap junctional channels and opening of hemichannels in heart-derived cells and tissue
    Cell Physiol Biochem, 28 (1), 103-14
    DOI 10.1159/000331719, PubMed 21865853
  7. Leithe E, Sirnes S, Fykerud T, Kjenseth A, Rivedal E (2011)
    Endocytosis and post-endocytic sorting of connexins
    Biochim Biophys Acta, 1818 (8), 1870-9
    DOI 10.1016/j.bbamem.2011.09.029, PubMed 21996040
  8. Lind GE, Danielsen SA, Ahlquist T, Merok MA, Andresen K, Skotheim RI, Hektoen M, Rognum TO, Meling GI, Hoff G, Bretthauer M, Thiis-Evensen E, Nesbakken A, Lothe RA (2011)
    Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas
    Mol Cancer, 10, 85
    DOI 10.1186/1476-4598-10-85, PubMed 21777459
  9. Lind GE, Raiborg C, Danielsen SA, Rognum TO, Thiis-Evensen E, Hoff G, Nesbakken A, Stenmark H, Lothe RA (2011)
    SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis
    Oncogene, 30 (37), 3967-78
    DOI 10.1038/onc.2011.109, PubMed 21499309
  10. Løvf M, Thomassen GO, Bakken AC, Celestino R, Fioretos T, Lind GE, Lothe RA, Skotheim RI (2011)
    Fusion gene microarray reveals cancer type-specificity among fusion genes
    Genes Chromosomes Cancer, 50 (5), 348-57
    DOI 10.1002/gcc.20860, PubMed 21305644
  11. Mills IG (2011)
    Nuclear translocation and functions of growth factor receptors
    Semin Cell Dev Biol, 23 (2), 165-71
    DOI 10.1016/j.semcdb.2011.09.004, PubMed 21930229
  12. Ohnstad HO, Paulsen EB, Noordhuis P, Berg M, Lothe RA, Vassilev LT, Myklebost O (2011)
    MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines
    BMC Cancer, 11, 211:1-11
    DOI 10.1186/1471-2407-11-211, PubMed 21624110
  13. Paulo P, Barros-Silva JD, Ribeiro FR, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR (2011)
    FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer
    Genes Chromosomes Cancer, 51 (3), 240-9
    DOI 10.1002/gcc.20948, PubMed 22081504
  14. Ribeiro FR, Paulo P, Costa VL, Barros-Silva JD, Ramalho-Carvalho J, Jerónimo C, Henrique R, Lind GE, Skotheim RI, Lothe RA, Teixeira MR (2011)
    Cysteine-rich secretory protein-3 (CRISP3) is strongly up-regulated in prostate carcinomas with the TMPRSS2-ERG fusion gene
    PLoS One, 6 (7), e22317
    DOI 10.1371/journal.pone.0022317, PubMed 21814574
  15. Sagona AP, Nezis IP, Bache KG, Haglund K, Bakken AC, Skotheim RI, Stenmark H (2011)
    A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis
    PLoS One, 6 (3), e17086
    DOI 10.1371/journal.pone.0017086, PubMed 21455500
  16. Sirnes S, Bruun J, Kolberg M, Kjenseth A, Lind GE, Svindland A, Brech A, Nesbakken A, Lothe RA, Leithe E, Rivedal E (2011)
    Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome
    Int J Cancer, 131 (3), 570-81
    DOI 10.1002/ijc.26392, PubMed 21866551
  17. Sirnes S, Honne H, Ahmed D, Danielsen SA, Rognum TO, Meling GI, Leithe E, Rivedal E, Lothe RA, Lind GE (2011)
    DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer
    Epigenetics, 6 (5), 602-9
    DOI 10.4161/epi.6.5.15237, PubMed 21406965
  18. Sjo OH, Berg M, Merok MA, Kolberg M, Svindland A, Lothe RA, Nesbakken A (2011)
    Peritoneal carcinomatosis of colon cancer origin: highest incidence in women and in patients with right-sided tumors
    J Surg Oncol, 104 (7), 792-7
    DOI 10.1002/jso.21959, PubMed 21547915
  19. Sveen A, Agesen TH, Nesbakken A, Rognum TO, Lothe RA, Skotheim RI (2011)
    Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival
    Genome Med, 3 (5), 32
    DOI 10.1186/gm248, PubMed 21619627
  20. Ågesen TH, Berg M, Clancy T, Thiis-Evensen E, Cekaite L, Lind GE, Nesland JM, Bakka A, Mala T, Hauss HJ, Fetveit T, Vatn MH, Hovig E, Nesbakken A, Lothe RA, Skotheim RI (2011)
    CLC and IFNAR1 are differentially expressed and a global immunity score is distinct between early- and late-onset colorectal cancer
    Genes Immun, 12 (8), 653-62
    DOI 10.1038/gene.2011.43, PubMed 21716316

Publications 2010

  1. Berg M, Agesen TH, Thiis-Evensen E, INFAC-study group, Merok MA, Teixeira MR, Vatn MH, Nesbakken A, Skotheim RI, Lothe RA (2010)
    Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
    Mol Cancer, 9, 100
    DOI 10.1186/1476-4598-9-100, PubMed 20459617
  2. Berg M, Danielsen SA, Ahlquist T, Merok MA, Ågesen TH, Vatn MH, Mala T, Sjo OH, Bakka A, Moberg I, Fetveit T, Mathisen Ø, Husby A, Sandvik O, Nesbakken A, Thiis-Evensen E, Lothe RA (2010)
    DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset
    PLoS One, 5 (11), e13978
    DOI 10.1371/journal.pone.0013978, PubMed 21103049
  3. Berge G, Costea DE, Berg M, Rasmussen H, Grotterød I, Lothe RA, Mælandsmo GM, Flatmark K (2010)
    Coexpression and nuclear colocalization of metastasis-promoting protein S100A4 and p53 without mutual regulation in colorectal carcinoma
    Amino Acids, 41 (4), 875-84
    DOI 10.1007/s00726-010-0514-6, PubMed 20191297
  4. Brekke HR, Ribeiro FR, Kolberg M, Agesen TH, Lind GE, Eknaes M, Hall KS, Bjerkehagen B, van den Berg E, Teixeira MR, Mandahl N, Smeland S, Mertens F, Skotheim RI, Lothe RA (2010)
    Genomic changes in chromosomes 10, 16, and X in malignant peripheral nerve sheath tumors identify a high-risk patient group
    J Clin Oncol, 28 (9), 1573-82
    DOI 10.1200/JCO.2009.24.8989, PubMed 20159821
  5. Burum-Auensen E, Skotheim RI, Schjølberg AR, Røislien J, Lothe RA, Clausen OP (2010)
    Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors
    J Carcinog, 9, 1
    DOI 10.4103/1477-3163.60358, PubMed 20411023
  6. Costa VL, Henrique R, Danielsen SA, Duarte-Pereira S, Eknaes M, Skotheim RI, Rodrigues A, Magalhães JS, Oliveira J, Lothe RA, Teixeira MR, Jerónimo C, Lind GE (2010)
    Three epigenetic biomarkers, GDF15, TMEFF2, and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples
    Clin Cancer Res, 16 (23), 5842-51
    DOI 10.1158/1078-0432.CCR-10-1312, PubMed 20975101
  7. Kjenseth A, Fykerud T, Rivedal E, Leithe E (2010)
    Regulation of gap junction intercellular communication by the ubiquitin system
    Cell Signal, 22 (9), 1267-73
    DOI 10.1016/j.cellsig.2010.03.005, PubMed 20206687
  8. Knævelsrud H, Ahlquist T, Merok MA, Nesbakken A, Stenmark H, Lothe RA, Simonsen A (2010)
    UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy
    Autophagy, 6 (7), 863-70
    DOI 10.4161/auto.6.7.13033, PubMed 20724836
  9. Kristjansson SR, Jordhoy MS, Nesbakken A, Skovlund E, Bakka A, Johannessen HO, Wyller TB (2010)
    Which elements of a comprehensive geriatric assessment (CGA) predict post-operative complications and early mortality after colorectal cancer surgery?
    J. Geriatr. Oncol., 1 (2), 57-65
    DOI 10.1016/j.jgo.2010.06.001
  10. Leithe E, Kjenseth A, Bruun J, Sirnes S, Rivedal E (2010)
    Inhibition of connexin 43 gap junction channels by the endocrine disruptor ioxynil
    Toxicol Appl Pharmacol, 247 (1), 10-7
    DOI 10.1016/j.taap.2010.05.006, PubMed 20510257
  11. Micci F, Haugom L, Ahlquist T, Andersen HK, Abeler VM, Davidson B, Trope CG, Lothe RA, Heim S (2010)
    Genomic aberrations in borderline ovarian tumors
    J Transl Med, 8, 21
    DOI 10.1186/1479-5876-8-21, PubMed 20184781
  12. Micci F, Skotheim RI, Haugom L, Weimer J, Eibak AM, Abeler VM, Trope CG, Arnold N, Lothe RA, Heim S (2010)
    Array-CGH analysis of microdissected chromosome 19 markers in ovarian carcinoma identifies candidate target genes
    Genes Chromosomes Cancer, 49 (11), 1046-53
    DOI 10.1002/gcc.20813, PubMed 20725991
  13. Nesbakken A (2010)
    [Pilonidal disease--an underprioritized disorder]
    Tidsskr Nor Laegeforen, 130 (9), 920
    DOI 10.4045/tidsskr.10.0376, PubMed 20453940
  14. Pinheiro M, Ahlquist T, Danielsen SA, Lind GE, Veiga I, Pinto C, Costa V, Afonso L, Sousa O, Fragoso M, Santos L, Henrique R, Lopes P, Lopes C, Lothe RA, Teixeira MR (2010)
    Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin
    BMC Cancer, 10, 587
    DOI 10.1186/1471-2407-10-587, PubMed 20979647
  15. Sagona AP, Nezis IP, Pedersen NM, Liestøl K, Poulton J, Rusten TE, Skotheim RI, Raiborg C, Stenmark H (2010)
    PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody
    Nat Cell Biol, 12 (4), 362-71
    DOI 10.1038/ncb2036, PubMed 20208530
  16. Zwierzina H, Bardelli A, Ciardiello F, Gariboldi M, Håkansson L, Lambrechts D, Lind GE, Loeffler-Ragg J, Schmoll H, Siena S, Tabernero J, Van Cutsem E (2010)
    Molecularly targeted therapies for colorectal cancer: Strategies for implementing translational research in clinical trials
    Curr Opin Mol Ther, 12 (6), 703-11
    PubMed 21154162

Publications 2009

  1. Bottillo I, Ahlquist T, Brekke H, Danielsen SA, van den Berg E, Mertens F, Lothe RA, Dallapiccola B (2009)
    Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours
    J Pathol, 217 (5), 693-701
    DOI 10.1002/path.2494, PubMed 19142971
  2. Brech A, Ahlquist T, Lothe RA, Stenmark H (2009)
    Autophagy in tumour suppression and promotion
    Mol Oncol, 3 (4), 366-75
    DOI 10.1016/j.molonc.2009.05.007, PubMed 19559660
  3. Brekke HR, Kolberg M, Skotheim RI, Hall KS, Bjerkehagen B, Risberg B, Domanski HA, Mandahl N, Liestøl K, Smeland S, Danielsen HE, Mertens F, Lothe RA (2009)
    Identification of p53 as a strong predictor of survival for patients with malignant peripheral nerve sheath tumors
    Neuro Oncol, 11 (5), 514-28
    DOI 10.1215/15228517-2008-127, PubMed 19182148
  4. Danielsen SA, Lind GE, Biornslett M, Meling GI, Rognum TO, Heim S, Lothe RA (2009)
    Novel Mutations of the Suppressor Gene PTEN in Colorectal Carcinomas Stratified by Microsatellite Instability- and TP53 Mutation- Status (vol 29, pg E252, 2008)
    Hum. Mutat., 30 (6), 1023
    DOI 10.1002/humu.21048
  5. Godmann M, Gashaw I, Eildermann K, Schweyer S, Bergmann M, Skotheim RI, Behr R (2009)
    The pluripotency transcription factor Krüppel-like factor 4 is strongly expressed in intratubular germ cell neoplasia unclassified and seminoma
    Mol Hum Reprod, 15 (8), 479-88
    DOI 10.1093/molehr/gap040, PubMed 19505997
  6. Kraggerud SM, Oldenburg J, Alnaes GI, Berg M, Kristensen VN, Fossa SD, Lothe RA (2009)
    Functional glutathione S-transferase genotypes among testicular germ cell tumor survivors: associations with primary and post-chemotherapy tumor histology
    Pharmacogenet Genomics, 19 (10), 751-9
    DOI 10.1097/FPC.0b013e3283304253, PubMed 19741569
  7. Leithe E, Kjenseth A, Sirnes S, Stenmark H, Brech A, Rivedal E (2009)
    Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101
    J Cell Sci, 122 (Pt 21), 3883-93
    DOI 10.1242/jcs.053801, PubMed 19808888
  8. Micci F, Haugom L, Ahlquist T, Abeler VM, Trope CG, Lothe RA, Heim S (2009)
    Tumor spreading to the contralateral ovary in bilateral ovarian carcinoma is a late event in clonal evolution
    J Oncol, 2010, 646340
    DOI 10.1155/2010/646340, PubMed 19759843
  9. Micci F, Weimer J, Haugom L, Skotheim RI, Grunewald R, Abeler VM, Silins I, Lothe RA, Trope CG, Arnold N, Heim S (2009)
    Reverse painting of microdissected chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map
    Genes Chromosomes Cancer, 48 (2), 184-93
    DOI 10.1002/gcc.20628, PubMed 18973136
  10. Pretorius ME, Waehre H, Abeler VM, Davidson B, Vlatkovic L, Lothe RA, Giercksky KE, Danielsen HE (2009)
    Large scale genomic instability as an additive prognostic marker in early prostate cancer
    Cell Oncol, 31 (4), 251-9
    DOI 10.3233/CLO-2009-0463, PubMed 19633362
  11. Rivedal E, Witz G, Leithe E (2009)
    Gap junction intercellular communication and benzene toxicity
    Chem Biol Interact, 184 (1-2), 229-32
    DOI 10.1016/j.cbi.2009.11.013, PubMed 19932693
  12. Sirnes S, Kjenseth A, Leithe E, Rivedal E (2009)
    Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication
    Biochem Biophys Res Commun, 382 (1), 41-5
    DOI 10.1016/j.bbrc.2009.02.141, PubMed 19258009
  13. Skotheim RI, Thomassen GO, Eken M, Lind GE, Micci F, Ribeiro FR, Cerveira N, Teixeira MR, Heim S, Rognes T, Lothe RA (2009)
    A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis
    Mol Cancer, 8, 5
    DOI 10.1186/1476-4598-8-5, PubMed 19152679
  14. Tekpli X, Rivedal E, Gorria M, Landvik NE, Rissel M, Dimanche-Boitrel MT, Baffet G, Holme JA, Lagadic-Gossmann D (2009)
    The B[a]P-increased intercellular communication via translocation of connexin-43 into gap junctions reduces apoptosis
    Toxicol Appl Pharmacol, 242 (2), 231-40
    DOI 10.1016/j.taap.2009.10.012, PubMed 19874837

Publications 2008

  1. Ahlquist T, Bottillo I, Danielsen SA, Meling GI, Rognum TO, Lind GE, Dallapiccola B, Lothe RA (2008)
    RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A
    Neoplasia, 10 (7), 680-6, 2 p following 686
    DOI 10.1593/neo.08312, PubMed 18592002
  2. Ahlquist T, Lind GE, Costa VL, Meling GI, Vatn M, Hoff GS, Rognum TO, Skotheim RI, Thiis-Evensen E, Lothe RA (2008)
    Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers
    Mol Cancer, 7, 94
    DOI 10.1186/1476-4598-7-94, PubMed 19117505
  3. Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA (2008)
    TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours
    Mol Cell Endocrinol, 306 (1-2), 75-80
    DOI 10.1016/j.mce.2008.10.043, PubMed 19041365
  4. Danielsen SA, Lind GE, Bjørnslett M, Meling GI, Rognum TO, Heim S, Lothe RA (2008)
    Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status
    Hum Mutat, 29 (11), E252-62
    DOI 10.1002/humu.20860, PubMed 18781614
  5. Faerden AE, Sjo OH, Andersen SN, Hauglann B, Nazir N, Gravdehaug B, Moberg I, Svinland A, Nesbakken A, Bakka A (2008)
    Sentinel node mapping does not improve staging of lymph node metastasis in colonic cancer
    Dis Colon Rectum, 51 (6), 891-6
    DOI 10.1007/s10350-007-9185-0, PubMed 18259817
  6. Haugen MH, Flatmark K, Mikalsen SO, Malandsmo GM (2008)
    The metastasis-associated protein S100A4 exists in several charged variants suggesting the presence of posttranslational modifications
    BMC Cancer, 8, 172
    DOI 10.1186/1471-2407-8-172, PubMed 18554396
  7. Hofstad B, Nesbakken A, Eritsland J, Brørs O, Sandset PM (2008)
    [Should platelet inhibitors be discontinued before gastrointestinal endoscopy?]
    Tidsskr Nor Laegeforen, 128 (21), 2440-2
    PubMed 19096466
  8. Kilpinen S, Autio R, Ojala K, Iljin K, Bucher E, Sara H, Pisto T, Saarela M, Skotheim RI, Björkman M, Mpindi JP, Haapa-Paananen S, Vainio P, Edgren H, Wolf M, Astola J, Nees M, Hautaniemi S, Kallioniemi O (2008)
    Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues
    Genome Biol, 9 (9), R139
    DOI 10.1186/gb-2008-9-9-r139, PubMed 18803840
  9. Lind GE, Ahlquist T, Kolberg M, Berg M, Eknaes M, Alonso MA, Kallioniemi A, Meling GI, Skotheim RI, Rognum TO, Thiis-Evensen E, Lothe RA (2008)
    Hypermethylated MAL gene - a silent marker of early colon tumorigenesis
    J Transl Med, 6, 13
    DOI 10.1186/1479-5876-6-13, PubMed 18346269
  10. Rivedal E, Leithe E (2008)
    The benzene metabolite trans,trans-muconaldehyde blocks gap junction intercellular communication by cross-linking connexin43
    Toxicol Appl Pharmacol, 232 (3), 463-8
    DOI 10.1016/j.taap.2008.07.022, PubMed 18723040
  11. Sirnes S, Leithe E, Rivedal E (2008)
    The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis
    Biochem Biophys Res Commun, 373 (4), 597-601
    DOI 10.1016/j.bbrc.2008.06.095, PubMed 18601906

Publications 2007

  1. Almstrup K, Leffers H, Lothe RA, Skakkebaek NE, Sonne SB, Nielsen JE, Rajpert-De Meyts E, Skotheim RI (2007)
    Improved gene expression signature of testicular carcinoma in situ
    Int J Androl, 30 (4), 292-302; discussion 303
    DOI 10.1111/j.1365-2605.2007.00758.x, PubMed 17488342
  2. Cruciani V, Mikalsen SO (2007)
    Evolutionary selection pressure and family relationships among connexin genes
    Biol Chem, 388 (3), 253-64
    DOI 10.1515/BC.2007.028, PubMed 17338632
  3. Hoei-Hansen CE, Kraggerud SM, Abeler VM, Kaern J, Rajpert-De Meyts E, Lothe RA (2007)
    Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markers
    Mol Cancer, 6, 12
    DOI 10.1186/1476-4598-6-12, PubMed 17274819
  4. Hofstad B, Andersen SN, Nesbakken A (2007)
    [Colorectal polyps]
    Tidsskr Nor Laegeforen, 127 (20), 2692-5
    PubMed 17952154
  5. Kleivi K, Lind GE, Diep CB, Meling GI, Brandal LT, Nesland JM, Myklebost O, Rognum TO, Giercksky KE, Skotheim RI, Lothe RA (2007)
    Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses
    Mol Cancer, 6, 2
    DOI 10.1186/1476-4598-6-2, PubMed 17201907
  6. Leithe E, Rivedal E (2007)
    Ubiquitination of gap junction proteins
    J Membr Biol, 217 (1-3), 43-51
    DOI 10.1007/s00232-007-9050-z, PubMed 17657522
  7. Lind GE, Ahlquist T, Lothe RA (2007)
    DNA hypermethylation of MAL: a promising diagnostic biomarker for colorectal tumors
    Gastroenterology, 132 (4), 1631-2; author reply 1632
    DOI 10.1053/j.gastro.2007.03.003, PubMed 17408629
  8. Lind GE, Skotheim RI, Lothe RA (2007)
    The epigenome of testicular germ cell tumors
    APMIS, 115 (10), 1147-60
    DOI 10.1111/j.1600-0463.2007.apm_660.xml.x, PubMed 18042148
  9. Oldenburg J, Kraggerud SM, Brydøy M, Cvancarova M, Lothe RA, Fossa SD (2007)
    Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study
    J Transl Med, 5, 70
    DOI 10.1186/1479-5876-5-70, PubMed 18162130
  10. Oldenburg J, Kraggerud SM, Cvancarova M, Lothe RA, Fossa SD (2007)
    Cisplatin-induced long-term hearing impairment is associated with specific glutathione s-transferase genotypes in testicular cancer survivors
    J Clin Oncol, 25 (6), 708-14
    DOI 10.1200/JCO.2006.08.9599, PubMed 17228018
  11. Røyrvik EC, Ahlquist T, Rognes T, Lothe RA (2007)
    Slip slidin' away: a duodecennial review of targeted genes in mismatch repair deficient colorectal cancer
    Crit Rev Oncog, 13 (3), 229-57
    DOI 10.1615/critrevoncog.v13.i3.20, PubMed 18298386
  12. Sjo OH, Lunde OC, Nygaard K, Sandvik L, Nesbakken A (2007)
    Tumour location is a prognostic factor for survival in colonic cancer patients
    Colorectal Dis, 10 (1), 33-40
    DOI 10.1111/j.1463-1318.2007.01302.x, PubMed 17672872
  13. Skotheim RI, Nees M (2007)
    Alternative splicing in cancer: noise, functional, or systematic?
    Int J Biochem Cell Biol, 39 (7-8), 1432-49
    DOI 10.1016/j.biocel.2007.02.016, PubMed 17416541
  14. Søvik TT, Aasheim ET, Kristinsson J, Schou CF, Nesbakken A, Mala T (2007)
    [Surgical treatment of morbid obesity at a regional center]
    Tidsskr Nor Laegeforen, 127 (1), 47-9
    PubMed 17205090
  15. Wu Q, Lind GE, Aasheim HC, Micci F, Silins I, Tropé CG, Nesland JM, Lothe RA, Suo Z (2007)
    The EPH receptor Bs (EPHBs) promoters are unmethylated in colon and ovarian cancers
    Epigenetics, 2 (4), 237-43
    DOI 10.4161/epi.2.4.5406, PubMed 18281782
  16. Wu Q, Lothe RA, Ahlquist T, Silins I, Tropé CG, Micci F, Nesland JM, Suo Z, Lind GE (2007)
    DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets
    Mol Cancer, 6, 45
    DOI 10.1186/1476-4598-6-45, PubMed 17623056

Publications 2006

  1. da Silva Ribeiro FR (2006)
    Diagnostic and prognostic value of molecular cytogenetic analyses of sextant biopsies from prostate cancer suspects
    Crit Rev Oncog, 12 (3-4), 303-4; discussion 304
    DOI 10.1615/critrevoncog.v12.i3-4.100, PubMed 17425511
  2. Diep CB, Kleivi K, Ribeiro FR, Teixeira MR, Lindgjaerde OC, Lothe RA (2006)
    The order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes
    Genes Chromosomes Cancer, 45 (1), 31-41
    DOI 10.1002/gcc.20261, PubMed 16145679
  3. Iacopetta B, Russo A, Bazan V, Dardanoni G, Gebbia N, Soussi T, Kerr D, Elsaleh H, Soong R, Kandioler D, Janschek E, Kappel S, Lung M, Leung CS, Ko JM, Yuen S, Ho J, Leung SY, Crapez E, Duffour J, Ychou M, Leahy DT, O'Donoghue DP, Agnese V, Cascio S et al. (2006)
    Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study
    Ann Oncol, 17 (5), 842-7
    DOI 10.1093/annonc/mdl035, PubMed 16524972
  4. Iljin K, Wolf M, Edgren H, Gupta S, Kilpinen S, Skotheim RI, Peltola M, Smit F, Verhaegh G, Schalken J, Nees M, Kallioniemi O (2006)
    TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming
    Cancer Res, 66 (21), 10242-6
    DOI 10.1158/0008-5472.CAN-06-1986, PubMed 17079440
  5. Leithe E, Brech A, Rivedal E (2006)
    Endocytic processing of connexin43 gap junctions: a morphological study
    Biochem J, 393 (Pt 1), 59-67
    DOI 10.1042/BJ20050674, PubMed 16162097
  6. Leithe E, Sirnes S, Omori Y, Rivedal E (2006)
    Downregulation of gap junctions in cancer cells
    Crit Rev Oncog, 12 (3-4), 225-56
    DOI 10.1615/critrevoncog.v12.i3-4.30, PubMed 17425504
  7. Lind GE, Kleivi K, Meling GI, Teixeira MR, Thiis-Evensen E, Rognum TO, Lothe RA (2006)
    ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis
    Cell Oncol, 28 (5-6), 259-72
    DOI 10.1155/2006/949506, PubMed 17167179
  8. Lind GE, Kleivi K, Meling GI, Teixeira MR, Thiis-Evensen E, Rognum TO, Lothe RA (2006)
    ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis
    Cell. Oncol., 28 (5-6), 259-272
  9. Lind GE, Skotheim RI, Fraga MF, Abeler VM, Esteller M, Lothe RA (2006)
    Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1)
    J Pathol, 210 (4), 441-9
    DOI 10.1002/path.2064, PubMed 17029216
  10. Lothe RA, Skotheim RI, Kallioniemi O, Esteller M (2006)
    To the Readers and Future Authors of Critical Reviews in Oncogenesis
    Critical Reviews in Oncogenesis, 12 (1-2), 1-2
    PublikaID 27
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