Light Meets Precision:
EIC Pathfinder Project SCALPEL Pioneering a Revolutionary Photoimmunotherapy for Cancer
Theo Theodossiou, Project coordinator
In a groundbreaking effort to revolutionise modern oncology, the SCALPEL project launches a Europe wide initiative aimed at redefining cancer treatment by using light to precisely ‘click’ tags to cancer cells, enabling the immune system to recognise and destroy them with unparalleled accuracy. Project coordinator is Theo Theodossiou, head of the Protonics project group at the Department of Radiation Biology at OUH.
The multidisciplinary initiative funded by the European Innovation Council Pathfinder programme under Horizon Europe with a total budget of more than EUR 4 million aims to revolutionise modern oncology offering new hope for millions worldwide.
From major journals, first or last author from the Institute for Cancer Research
Skotland T, Ekroos K, Llorente A, Sandvig K(2025) Quantitative Lipid Analysis of Extracellular Vesicle Preparations: A Perspective J Extracell Vesicles, 14(3), e70049 DOI 10.1002/jev2.70049, PubMed 40091364
Yin Y, Xu H, He L, Brown JR, Mato AR, Aittokallio T, Skånland SS(2025) Protein profiles predict treatment responses to the PI3K inhibitor umbralisib in patients with chronic lymphocytic leukemia Clin Cancer Res(in press) DOI 10.1158/1078-0432.CCR-24-2911, PubMed 40085050
Taskén K, Mahon P(2025) Accelerating precision oncology by converging pragmatic trials and real-world evidence Nat Rev Drug Discov(in press) DOI 10.1038/d41573-025-00047-5, PubMed 40082591
Yin Y, Xu H, He L, Brown JR, Mato AR, Aittokallio T, Skånland SS(2025) Protein profiles predict treatment responses to the PI3K inhibitor umbralisib in patients with chronic lymphocytic leukemia Clin Cancer Res(in press) DOI 10.1158/1078-0432.CCR-24-2911, PubMed 40085050
Taskén K, Mahon P(2025) Accelerating precision oncology by converging pragmatic trials and real-world evidence Nat Rev Drug Discov(in press) DOI 10.1038/d41573-025-00047-5, PubMed 40082591
Lindemann K, Siegenthaler F, Lande KT, Casas-Arozamena C, Nebdal D, Rau TT, Hoivik EA, Mueller MD, Gold RM, Imboden S, Davidson B, Krakstad C, Sørlie T(2025) Prognostic value of assessing ctDNA in patients with endometrial carcinoma - an international multicenter study Gynecol Oncol, 195, 98-105(in press) DOI 10.1016/j.ygyno.2025.03.002, PubMed 40081113