Light Meets Precision:
EIC Pathfinder Project SCALPEL Pioneering a Revolutionary Photoimmunotherapy for Cancer
Theo Theodossiou, Project coordinator
In a groundbreaking effort to revolutionise modern oncology, the SCALPEL project launches a Europe wide initiative aimed at redefining cancer treatment by using light to precisely ‘click’ tags to cancer cells, enabling the immune system to recognise and destroy them with unparalleled accuracy. Project coordinator is Theo Theodossiou, head of the Protonics project group at the Department of Radiation Biology at OUH.
The multidisciplinary initiative funded by the European Innovation Council Pathfinder programme under Horizon Europe with a total budget of more than EUR 4 million aims to revolutionise modern oncology offering new hope for millions worldwide.
From major journals, first or last author from the Institute for Cancer Research
Trachsel-Moncho L, Mathai BJ, Veroni C, Simonsen A(2025) SNX10 at the crossroad of endocytosis and piecemeal mitophagy Autophagy, 1-3(in press) DOI 10.1080/15548627.2025.2499641, PubMed 40327657
Hektoen HH, Tsuruda KM, Brustugun OT, Neumann K, Andreassen BK(2025) Real-world comparison of pembrolizumab alone and combined with chemotherapy in metastatic lung adenocarcinoma patients with PD-L1 expression ≥50 ESMO Open, 10(5), 105073(in press) DOI 10.1016/j.esmoop.2025.105073, PubMed 40305908
Dillard C, Teles-Reis J, Jain A, Antunes MG, Ruiz-Duran P, Qi Y, Le Borgne R, Jasper H, Rusten TE(2025) NF-κB signaling driven by oncogenic Ras contributes to tumorigenesis in a Drosophila carcinoma model PLoS Biol, 23(4), e3002663 DOI 10.1371/journal.pbio.3002663, PubMed 40294135
Trachsel-Moncho L, Mathai BJ, Veroni C, Simonsen A(2025) SNX10 at the crossroad of endocytosis and piecemeal mitophagy Autophagy, 1-3(in press) DOI 10.1080/15548627.2025.2499641, PubMed 40327657
Bjørnerud B, Wesche J, Haugsten EM(2025) A rhabdomyosarcoma cell migration inhibitor screen using phase-contrast microscopy Exp Cell Res, 114582(in press) DOI 10.1016/j.yexcr.2025.114582, PubMed 40320199
Rosenberger L, Hansmann L, Anastasopoulou V, Wolf SP, Drousch K, Moewes C, Feng X, Cao G, Huang J, Yew PY, Strønen E, Kato T, Saligrama N, Olweus J, Nakamura Y, Willimsky G, Blankenstein T, Schreiber H, Leisegang M(2025) Selection of therapeutically effective T-cell receptors from the diverse tumor-bearing repertoire J Immunother Cancer, 13(5) DOI 10.1136/jitc-2024-011351, PubMed 40316304