Light Meets Precision:
EIC Pathfinder Project SCALPEL Pioneering a Revolutionary Photoimmunotherapy for Cancer
Theo Theodossiou, Project coordinator
In a groundbreaking effort to revolutionise modern oncology, the SCALPEL project launches a Europe wide initiative aimed at redefining cancer treatment by using light to precisely ‘click’ tags to cancer cells, enabling the immune system to recognise and destroy them with unparalleled accuracy. Project coordinator is Theo Theodossiou, head of the Protonics project group at the Department of Radiation Biology at OUH.
The multidisciplinary initiative funded by the European Innovation Council Pathfinder programme under Horizon Europe with a total budget of more than EUR 4 million aims to revolutionise modern oncology offering new hope for millions worldwide.
From major journals, first or last author from the Institute for Cancer Research
Andresen S, Al Outa A, Formica M, Enserink J, Knævelsrud H(2025) Improved detection of lipidated Atg8a by immunoblotting in drosophila melanogaster cells and tissues enables precise investigation of Atg8a flux and its termination Autophagy(in press) DOI 10.1080/15548627.2025.2508551, PubMed 40426043
Høyvik AJK, Kvassheim M, Ma LW, Wiig E, Hillestad T, Revheim ME, Liukaityte R, Bruland Ø, Juzeniene A(2025) Therapeutic evaluation of [212Pb]Pb-AB001 and [177Lu]Lu-PSMA-617 in a mouse model of disseminated prostate cancer Eur J Nucl Med Mol Imaging(in press) DOI 10.1007/s00259-025-07330-y, PubMed 40397137
Sohlberg E, Malmberg KJ(2025) The innate power of natural killer cells in cancer therapy Nat Med(in press) DOI 10.1038/s41591-025-03712-9, PubMed 40355615
Asvall J, Haugaa H, Larsen SG, Skarholt TFR, Botnen BM, Flatmark K, Tønnessen TI, Thorgersen EB(2025) Early detection of deep pelvic surgical site infection by microdialysis after abdominoperineal resection for locally advanced rectal cancer Tech Coloproctol, 29(1), 126 DOI 10.1007/s10151-025-03156-w, PubMed 40439832
Osterlund E, Hammarström K, Nunes L, Mathot L, Mezheyeuski A, Sjöblom T, Glimelius B(2025) Primary tumour location, molecular alterations, treatments, and outcome in a population-based metastatic colorectal cancer cohort BJC Rep, 3(1), 38 DOI 10.1038/s44276-025-00156-z, PubMed 40437037
Andresen S, Al Outa A, Formica M, Enserink J, Knævelsrud H(2025) Improved detection of lipidated Atg8a by immunoblotting in drosophila melanogaster cells and tissues enables precise investigation of Atg8a flux and its termination Autophagy(in press) DOI 10.1080/15548627.2025.2508551, PubMed 40426043