
Theodossis Athanassios Theodossiou
- Senior Researcher, Marie Curie IntraEuropean Fellow
- +47 22 78 1987
Team leader, senior researcher in project LUMIBLAST sponsored by FET open Horizon 2020
Publications 2020
Photodynamic Efficacy of Cercosporin in 3D Tumor Cell Cultures
Photochem Photobiol, 96 (3), 699-707
DOI 10.1111/php.13257, PubMed 32125700
Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research
J Clin Med, 9 (2)
DOI 10.3390/jcm9020528, PubMed 32075165
Drug-Loaded Lipid-Coated Hybrid Organic-Inorganic "Stealth" Nanoparticles for Cancer Therapy
Front Bioeng Biotechnol, 8, 1027
DOI 10.3389/fbioe.2020.01027, PubMed 33042960
Predictive biomarkers for 5-ALA-PDT can lead to personalized treatments and overcome tumor-specific resistances
Cancer Rep (Hoboken), e1278 (in press)
DOI 10.1002/cnr2.1278, PubMed 32737955
Publications 2019
Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
Nat Commun, 10 (1), 3986
DOI 10.1038/s41467-019-12042-7, PubMed 31484929
NK cells specifically TCR-dressed to kill cancer cells
EBioMedicine, 40, 106-117
DOI 10.1016/j.ebiom.2019.01.031, PubMed 30665853
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
NPJ Breast Cancer, 5, 13
DOI 10.1038/s41523-019-0108-8, PubMed 30993194
Publications 2018
Outstanding Reviewers for Photochemical and Photobiological Sciences in 2017
Photochem. Photobiol. Sci., 17 (5), 533
Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines
Photochem Photobiol, 95 (1), 387-396
DOI 10.1111/php.12997, PubMed 30107033
Functionalized Hyperbranched Polyethylenimines as Thermosensitive Drug Delivery Nanocarriers with Controlled Transition Temperatures
Biomacromolecules, 19 (2), 315-328
DOI 10.1021/acs.biomac.7b01325, PubMed 29313672
Artesunate shows potent anti-tumor activity in B-cell lymphoma
J Hematol Oncol, 11 (1), 23
DOI 10.1186/s13045-018-0561-0, PubMed 29458389
Publications 2017
Microenvironmental autophagy promotes tumour growth
Nature, 541 (7637), 417-420
DOI 10.1038/nature20815, PubMed 28077876
Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin
Photodiagnosis Photodyn Ther, 20, 35-47
DOI 10.1016/j.pdpdt.2017.08.010, PubMed 28838761
The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy
Redox Biol, 12, 191-197
DOI 10.1016/j.redox.2017.02.018, PubMed 28254657
Publications 2015
A Family of Potent Ru(II) Photosensitizers with Enhanced DNA Intercalation: Bimodal Photokillers
Photochem Photobiol, 91 (5), 1191-202
DOI 10.1111/php.12485, PubMed 26118404
Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity
ACS Chem Biol, 11 (1), 251-62
DOI 10.1021/acschembio.5b00734, PubMed 26569462
Publications 2014
A versatile δ-aminolevulinic acid (ΑLA)-cyclodextrin bimodal conjugate-prodrug for PDT applications with the help of intracellular chemistry
Beilstein J Org Chem, 10, 2414-20
DOI 10.3762/bjoc.10.251, PubMed 25383111
Carboxylated hydroxyethyl starch: a novel polysaccharide for the delivery of doxorubicin
Chem Biol Drug Des, 85 (5), 653-8
DOI 10.1111/cbdd.12447, PubMed 25303215
Publications 2013
Protoporphyrin IX-β-cyclodextrin bimodal conjugate: nanosized drug transporter and potent phototoxin
Photochem Photobiol, 89 (5), 1011-9
DOI 10.1111/php.12127, PubMed 23819797
A multifunctional bichromophoric nanoaggregate for fluorescence imaging and simultaneous photogeneration of RNOS and ROS
Chem Asian J, 8 (11), 2634-41
DOI 10.1002/asia.201300463, PubMed 23788396
S-nitroso-β-cyclodextrins as new bimodal carriers: preparation, detailed characterization, nitric-oxide release, and molecular encapsulation
Chem Asian J, 8 (11), 2768-78
DOI 10.1002/asia.201300543, PubMed 23894118
Mitochondrial delivery of doxorubicin by triphenylphosphonium-functionalized hyperbranched nanocarriers results in rapid and severe cytotoxicity
Pharm Res, 30 (11), 2832-42
DOI 10.1007/s11095-013-1111-7, PubMed 23921486
Publications 2012
Tamoxifen subcellular localization; observation of cell-specific cytotoxicity enhancement by inhibition of mitochondrial ETC complexes I and III
Photochem Photobiol, 88 (4), 1016-22
DOI 10.1111/j.1751-1097.2012.01144.x, PubMed 22428931
Publications 2011
A novel mitotropic oligolysine nanocarrier: Targeted delivery of covalently bound D-Luciferin to cell mitochondria
Mitochondrion, 11 (6), 982-6
DOI 10.1016/j.mito.2011.08.004, PubMed 21856448
Publications 2010
Synthesis and characterization of multifunctional hyperbranched polyesters as prospective contrast agents for targeted MRI
Bioorg Med Chem Lett, 20 (14), 4177-81
DOI 10.1016/j.bmcl.2010.05.055, PubMed 20621729
Publications 2009
The multifaceted photocytotoxic profile of hypericin
Mol Pharm, 6 (6), 1775-89
DOI 10.1021/mp900166q, PubMed 19739671
Hypericin hydroquinone: potential as a red-far red photosensitizer?
Photochem Photobiol, 86 (1), 18-22
DOI 10.1111/j.1751-1097.2009.00668.x, PubMed 20003155
Publications 2008
Interactive transport, subcellular relocation and enhanced phototoxicity of hypericin encapsulated in guanidinylated liposomes via molecular recognition
Photochem Photobiol, 84 (5), 1073-83
DOI 10.1111/j.1751-1097.2008.00392.x, PubMed 18627515
A novel micellar PEGylated hyperbranched polyester as a prospective drug delivery system for paclitaxel
Macromol Biosci, 8 (9), 871-81
DOI 10.1002/mabi.200800015, PubMed 18484566
Novel amiodarone-doxorubicin cocktail liposomes enhance doxorubicin retention and cytotoxicity in DU145 human prostate carcinoma cells
J Med Chem, 51 (19), 6067-74
DOI 10.1021/jm800493j, PubMed 18783209
Guanidinylated dendritic molecular transporters: prospective drug delivery systems and application in cell transfection
ChemMedChem, 3 (11), 1635-43
DOI 10.1002/cmdc.200800190, PubMed 18985650
Molecular modeling and experimental evidence for hypericin as a substrate for mitochondrial complex III; mitochondrial photodamage as demonstrated using specific inhibitors
Free Radic Biol Med, 45 (11), 1581-90
DOI 10.1016/j.freeradbiomed.2008.09.015, PubMed 18852042
Publications 2007
Interactive transport of guanidinylated poly(propylene imine)-based dendrimers through liposomal and cellular membranes
Chembiochem, 8 (15), 1865-76
DOI 10.1002/cbic.200700289, PubMed 17854019
Interaction and transport of poly(L-lysine) dendrigrafts through liposomal and cellular membranes: the role of generation and surface functionalization
Biomacromolecules, 8 (10), 3263-70
DOI 10.1021/bm700668w, PubMed 17880235
Publications 2006
Mitochondria are a primary target of hypericin phototoxicity: synergy of intracellular calcium mobilisation in cell killing
Int J Biochem Cell Biol, 38 (11), 1946-56
DOI 10.1016/j.biocel.2006.05.009, PubMed 16814590
Second harmonic generation confocal microscopy of collagen type I from rat tendon cryosections
Biophys J, 91 (12), 4665-77
DOI 10.1529/biophysj.106.093740, PubMed 17130233
Publications 2004
Evidence for intracellular aggregation of hypericin and the impact on its photocytotoxicity in PAM 212 murine keratinocytes
Photochem Photobiol, 80 (3), 438-43
DOI 10.1562/0031-8655(2004)080<0438:EFIAOH>2.0.CO;2, PubMed 15623327
Publications 2003
A system to monitor for fibre breakage during photodynamic therapy with diffuser fibres
Lasers Med Sci, 18 (3), 162-4
DOI 10.1007/s10103-003-0270-x, PubMed 14505200
Firefly luciferin-activated rose bengal: in vitro photodynamic therapy by intracellular chemiluminescence in transgenic NIH 3T3 cells
Cancer Res, 63 (8), 1818-21
PubMed 12702568
Publications 2002
Comparison of the photodynamic effect of exogenous photoprotoporphyrin and protoporphyrin IX on PAM 212 murine keratinocytes
Photochem Photobiol, 76 (5), 530-7
DOI 10.1562/0031-8655(2002)076<0530:cotpeo>2.0.co;2, PubMed 12462649
Thermally induced irreversible conformational changes in collagen probed by optical second harmonic generation and laser-induced fluorescence
Lasers Med Sci, 17 (1), 34-41
DOI 10.1007/s10103-002-8264-7, PubMed 11845366
Publications 2001
Visual observation of infrared laser speckle patterns at half their fundamental wavelength
Lasers Med Sci, 16 (1), 34-9
DOI 10.1007/pl00011334, PubMed 11486336
Photochemical effects and hypericin photosensitized processes in collagen
J Biomed Opt, 6 (1), 52-7
DOI 10.1117/1.1331559, PubMed 11178580