Identification of epigenetically regulated pathways in cancer is possible using the expression methylation quantitative trait loci (emQTL) approach published in Fleischer, Tekpli et al. 2017. Using an improved version of this method, we have now identified epigenetic dysregulation associated with increased activity of the cell cycle, showing that epigenetic dysregulation in triple negative breast cancer may provide a growth advantage in these tumors.
Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor
Mol Syst Biol, 17 (3), e9526
Epigenome-wide gene-age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients
Aging (Albany NY), 12 (11), 10642-10662
Independent Validation of Early-Stage Non-Small Cell Lung Cancer Prognostic Scores Incorporating Epigenetic and Transcriptional Biomarkers With Gene-Gene Interactions and Main Effects
Chest, 158 (2), 808-819