Both genetic and epigenetic alterations can control the progression of cancer, and epigenetic alterations are frequent in cancer. However, the functional effects of epigenetic alterations still remain unclear.
The approach of the project group is to use large scale 'omics data and advanced bioinformatic and biostatistical tools to identify cancer-promoting biological functions under epigenetic dysregulation, and to use CRISPR epigenetic editing to assess the causal regulatory role of epigenetic alterations. This knowledge will be used to develop refined classification of breast cancer patients and novel treatment strategies.
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