
Nicholas Paul Casey
- Postdoc; PhD, Msc
- +47 22 78 23 16
HELSE SØR ØST
Education:
2005-2010: Ph.D., Disciplines of Medicine and Pathology, University of Tasmania
1995-2000: Master of Science (Research), Department of Zoology, La Trobe University, Australia
1991-1994: Bachelor of Science (Honours)Honours B.Sc., Biology, Department of Anatomy, University of Queensland
Research interests/projects:
- Development of CAR
Work experience:
2019/present: Postdoctoral Fellow, Department of Cellular Therapy, OUS Radiumhospitalet, Oslo, Norway
2017/2019: Postdoctoral Fellow, Section Department of Cellular Therapy, OUS Radiumhospitalet, Oslo, Norway
2016/2017: Specialist Editor, Cactus Communications
2012/2016: Postdoctoral Fellow, Ehime University Graduate School of Medicine, Toon, Japan
2009/2011: Postdoctoral Fellow, Department of Hematology, University of Washington, USA
2008/2009: Research Assistant, University of Tasmania Clinical School, Australia
2004/2005: Visiting Scholar, National Medical Centre, Hungary
2002: Visiting Scholar, Semmelweis University of Medicine, Hungary
Grant and awards:
-July 2012 – JSPS Postdoctoral Fellowship for Foreign Researchers
-May 2011 – David Collins Leukaemia Foundation Grant
-Mar. 2009 – Overseas Postdoctoral Fellowship from the Children’s Hospital, Westmead, Sydney, Australia
-Oct. 2008 – Menzies Research Institute Student Travel Grant
-Sept. 2007 – David Collins Leukaemia Foundation Professional Development Grant
-August 2003 – University of Tasmania Strategic Postgraduate Scholarship
Publications 2023
Development of a TGFβ-IL-2/15 Switch Receptor for Use in Adoptive Cell Therapy
Biomedicines, 11 (2)
DOI 10.3390/biomedicines11020459, PubMed 36830995
Efficient chimeric antigen receptor targeting of a central epitope of CD22
J Biol Chem, 299 (7), 104883
DOI 10.1016/j.jbc.2023.104883, PubMed 37269947
ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
Nat Commun, 14 (1), 3375
DOI 10.1038/s41467-023-39097-x, PubMed 37291203
Publications 2022
How CAR T Cells Breathe
Cells, 11 (9)
DOI 10.3390/cells11091454, PubMed 35563759
Publications 2021
Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors
Oncoimmunology, 10 (1), 1936757
DOI 10.1080/2162402X.2021.1936757, PubMed 34235003
Publications 2020
SJI 2020 special issue: A catalogue of Ovarian Cancer targets for CAR therapy
Scand J Immunol, 92 (4), e12917
DOI 10.1111/sji.12917, PubMed 32557659
Use of RNA Interference with TCR Transfer to Enhance Safety and Efficiency
Methods Mol Biol, 2115, 327-349
DOI 10.1007/978-1-0716-0290-4_18, PubMed 32006409
Publications 2018
An unusual, CD4 and CD8 dual-positive, CD25 negative, tumor cell phenotype in a patient with adult T-cell leukemia/lymphoma
Leuk Lymphoma, 59 (11), 2740-2742
DOI 10.1080/10428194.2018.1439168, PubMed 29465309
Publications 2016
Novel immunotherapy for adult T-cell leukemia/lymphoma: Targeting aurora kinase A
Oncoimmunology, 5 (11), e1239006
DOI 10.1080/2162402X.2016.1239006, PubMed 27999761
A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy
PLoS One, 11 (6), e0156896
DOI 10.1371/journal.pone.0156896, PubMed 27271876
Development of Engineered T Cells Expressing a Chimeric CD16-CD3ζ Receptor to Improve the Clinical Efficacy of Mogamulizumab Therapy Against Adult T-Cell Leukemia
Clin Cancer Res, 22 (17), 4405-16
DOI 10.1158/1078-0432.CCR-15-2714, PubMed 27091408
Publications 2012
Anti-PML-RARα shRNA sensitises promyelocytic leukaemia cells to all-trans retinoic acid
J RNAi Gene Silencing, 8, 464-9
PubMed 23300507
Publications 2006
Reduction of Bcr-Abl function leads to erythroid differentiation of K562 cells via downregulation of ERK
Ann N Y Acad Sci, 1090, 344-54
DOI 10.1196/annals.1378.038, PubMed 17384279
Publications 2003
Removal of the shell coat affects maintenance of epithelia in blastocysts of the Brushtail Possum in vitro
Cells Tissues Organs, 173 (1), 21-45
DOI 10.1159/000068215, PubMed 12566625
Publications 2002
Outer egg coats of the marsupial conceptus: secretion and protein composition
Mol Reprod Dev, 62 (2), 181-94
DOI 10.1002/mrd.10073, PubMed 11984828