Zhi Zhao

  • Researcher; PhD
Research interests: 
Interested in developing statistical methodologies for precision medicine, particularly personalized cancer therapies, to better understand the mechanisms of cancer progression and treatment response. Experienced with Bayesian hierarchical models and penalized likelihood approaches for identifying multi-omics biomarkers predictive of treatment response in cancer. Background in statistics, biostatistics, and statistical machine learning. 
 
 

Publications 2026

Willoch-Allen K, Zhao Z, Ayuda-Durán P, Mikaeloff F, Struyf N, Österroos A, Lehmann S, Kallioniemi O, Saarela J, Tyner JW, Erkers T, Enserink JM, Aittokallio T (2026)
A multi-center study on the consistency of drug sensitivity testing in patients with acute myeloid leukemia
NPJ Precis Oncol (in press)
DOI 10.1038/s41698-026-01480-4, PubMed 42135420

Publications 2025

Romero-Becerra R, Zhao Z, Nebdal D, Müller E, Bergholtz H, Norum JH, Aittokallio T (2025)
Improved analysis of in vivo drug combination experiments with a comprehensive statistical framework and web-tool
Nat Commun, 16 (1), 10151
DOI 10.1038/s41467-025-65218-9, PubMed 41258298

Publications 2024

Ankill J, Zhao Z, Tekpli X, Kure EH, Kristensen VN, Mathelier A, Fleischer T (2024)
Integrative pan-cancer analysis reveals a common architecture of dysregulated transcriptional networks characterized by loss of enhancer methylation
PLoS Comput Biol, 20 (11), e1012565
DOI 10.1371/journal.pcbi.1012565, PubMed 39556603

Farooqi SJ, Zhao Z, Öjlert ÅK, Thunold S, Juul HV, Bjaanæs MM, Horndalsveen H, Nymoen HMG, Helland Å, Haakensen VD (2024)
Serum cytokines as a biomarker for immune checkpoint inhibitor toxicity in patients with pleural mesothelioma
Front Immunol, 15, 1480183
DOI 10.3389/fimmu.2024.1480183, PubMed 39687621

Sommen SL, Zhao Z, Segtnan S, Stiansen-Sonerud T, Selvakumar J, Beier Havdal L, Gjerstad J, Wyller VBB, Lund Berven L (2024)
Bulk RNA sequencing for analysis of post COVID-19 condition in adolescents and young adults
J Transl Med, 22 (1), 312
DOI 10.1186/s12967-024-05117-7, PubMed 38532465

Zhao Z, Zobolas J, Zucknick M, Aittokallio T (2024)
Tutorial on survival modeling with applications to omics data
Bioinformatics, 40 (3)
DOI 10.1093/bioinformatics/btae132, PubMed 38445722

Publications 2023

Wu Y, Wang Z, Zhao Z, Song X, Miao M, Zhang X (2023)
Bile acid metabolites in early pregnancy and risk of gestational diabetes mellitus: Results from a prospective cohort study
Diabetes Obes Metab, 25 (8), 2255-2267
DOI 10.1111/dom.15104, PubMed 37161712

Publications 2022

Zhao Z, Wang S, Zucknick M, Aittokallio T (2022)
Tissue-specific identification of multi-omics features for pan-cancer drug response prediction
iScience, 25 (8), 104767
DOI 10.1016/j.isci.2022.104767, PubMed 35992090

Zhao Z, Zucknick M, Aittokallio T (2022)
EnrichIntersect: an R package for custom set enrichment analysis and interactive visualization of intersecting sets
Bioinform Adv, 2 (1), vbac073
DOI 10.1093/bioadv/vbac073, PubMed 36699400

Publications 2021

Zhao Z, Banterle M, Bottolo L, Richardson S, Lewin A, Zucknick M (2021)
BayesSUR: An R Package for High-Dimensional Multivariate Bayesian Variable and Covariance Selection in Linear Regression
J. Stat. Softw., 100 (11), 1-32
DOI 10.18637/jss.v100.i11

Publications 2020

Gao Y, Zhao Z, Chen Y, Mahara G, Huang J, Lin Z, Zhang J (2020)
Automatic epileptic seizure classification in multichannel EEG time series with linear discriminant analysis
Technol Health Care, 28 (1), 23-33
DOI 10.3233/THC-181548, PubMed 31282443

Mai TT, Rønneberg L, Zhao Z, Zucknick M, Corander J (2020)
Learning Cancer Drug Sensitivities in Large-Scale Screens from Multi-omics Data with Local Low-Rank Structure
Lecture Notes in Computer Science (LNCS), 12313, 67-79
DOI 10.1007/978-3-030-63061-4_7, PublikaID 380

Zhao Z, Zucknick M (2020)
Structured penalized regression for drug sensitivity prediction
J. R. Stat. Soc. Ser. C-Appl. Stat., 69 (3), 525-545
DOI 10.1111/rssc.12400

Publications 2017

Pan H, Shi X, Xiao D, He J, Zhang Y, Liang W, Zhao Z, Guo Z, Zou X, Zhang J, He J (2017)
Nomogram prediction for the survival of the patients with small cell lung cancer
J. Thorac. Dis., 9, 507
DOI 10.21037/jtd.2017.03.121, PublikaID 382

Zhang J, Zhao Z, Xue Y, Chen Z, Ma X, Zhou Q (2017)
Time series analysis
In Handbook of Medical Statistics (Fang J, ed.), World Scientific Publishing, 269-299
DOI 10.1142/9789813148963_0009, PublikaID 381, ISBN 978-9813148956

Publications 2016

Lin Y, Lin H, Lin Q, Zhang J, Zhu P, Lu Y, Zhao Z, Lv J, Lee MK, Xu Y (2016)
A novel three-dimensional smile analysis based on dynamic evaluation of facial curve contour
Sci. Rep., 6, 22103
DOI 10.1038/srep22103, PublikaID 383