Welcome to the home page of the Norwegian PSC Research Center 



Norwegian PSC Research Center (NoPSC) was established 19th of May 2008 at the Medical Department, Rikshospitalet upon signing of a contract between the University of Oslo and Rikshospitalet on the handling of funds from Canica A/S. The funds are exclusively dedicated to research related to basic and clinical aspects of the chronic liver disease PSC.

NoPSC is now a separate center within the Clinic of Surgery, Inflammatory Medicine and Transplantation at Oslo University Hospital (OUH) Rikshospitalet, and is also affiliated with the Research Institute for Internal Medicine, OUH Rikshospitalet and the Institute of Clinical Medicine at the University of Oslo.

NoPSC has a broad range of both local and international collaborators (see annual reports for more information). NoPSC has also established the International PSC Study Group (www.ipscsg.org).   

Scientific and technical personnel at Norwegian PSC Research Center. Not present: Bjarte Fosby, Sigrid Næss, Natalie Lie Berntsen (photo: Hege Dahlen Sollid, OUS).

NoPSC publishes prevalence study of PSC in IBD in Gastroenterology

The true prevalence of primary sclerosing cholangitis (PSC) in inflammatory bowel disease (IBD) has so far not been properly investigated. In a collaboration between the Department of Radiology at Akershus University Hospital, the IBSEN study group and Norwegian PSC Research center, MRI cholangiography screening was performed in IBD patients with longstanding disease as part of the 20-year follow-up of the Inflammatory Bowel disease in South-Eastern Norway (IBSEN) study. The results have now been published in the prestigious journal Gastroenterology (2016 impact factor 18.19) with Aida Lunder from AHUS as first author.

The surprising finding of the study was a prevalence of PSC-like disease in about 8%, almost 4 times the number of patients with clinically acknowledged PSC in this patient cohort. These important results provide a new understanding of the disease process of sclerosing cholangitis in IBD and open new possibilities in the studies of pathogenetic and clinical aspects of the PSC-IBD relationship. 

A new way of thinking about disease
Can knowledge about a disease help us find a treatment for another illness? Definitely.... the message from four consortia that have mapped the genetic basis of five chronic inflammatory diseases. 
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