Cover article in Neoplasia by Lin Thorstensen and coworkers. February 2005.
"Genetic and epigenetic changes ofcomponents affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability".
Cover Illustration:
A close up of a primary adenocarcinoma from the colon investigated in a study by Thorstensen et. al. was chosen as the visual on the cover of the February issue of Neoplasia (Vol. 7, Number 2). Lin Thorstensen was a post doc in the Lothe lab until recently. She is now a scientist at the Norwegian Institute of Public Health.
In this article, WNT signaling, which is important in normal development as well as in cancer, is studied in a large series of Norwegian colorectal cancer patients. One or more of eight analysed genes revealed mutations or methylation modifications in more than 90% of the cases. Patients with a mutated APC (adenomatous polyposis coli) gene affecting all b-catenin binding sites in their tumor, had a poor disease outcome.
Cover Illustration:
A close up of a primary adenocarcinoma from the colon investigated in a study by Thorstensen et. al. was chosen as the visual on the cover of the February issue of Neoplasia (Vol. 7, Number 2). Lin Thorstensen was a post doc in the Lothe lab until recently. She is now a scientist at the Norwegian Institute of Public Health.
In this article, WNT signaling, which is important in normal development as well as in cancer, is studied in a large series of Norwegian colorectal cancer patients. One or more of eight analysed genes revealed mutations or methylation modifications in more than 90% of the cases. Patients with a mutated APC (adenomatous polyposis coli) gene affecting all b-catenin binding sites in their tumor, had a poor disease outcome.