Publications by Ludvig Magne Sollid
355 publications found
Publications 2024
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New Insights on Genes, Gluten, and Immunopathogenesis of Celiac Disease
Gastroenterology, 167 (1), 4-22
DOI 10.1053/j.gastro.2024.03.042, PubMed 38670280 -
Barley based gluten free beer - A blessing or an uncontrollable risk?
Food Chem Toxicol, 193, 115019
DOI 10.1016/j.fct.2024.115019, PubMed 39307344 -
Selective activation of naïve B cells with unique epitope specificity shapes autoantibody formation in celiac disease
J Autoimmun, 146, 103241
DOI 10.1016/j.jaut.2024.103241, PubMed 38754235 -
Correction to: Separate Gut Plasma Cell Populations Produce Auto-Antibodies against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis
Adv Sci (Weinh), 11 (21), e2400894
DOI 10.1002/advs.202400894, PubMed 38477397 -
Coeliac disease as a model for understanding multiple sclerosis
Nat Rev Neurol, 20 (11), 685-690
DOI 10.1038/s41582-024-01025-y, PubMed 39379493 -
Coeliac disease: the paradox of diagnosing a food hypersensitivity disorder with autoantibodies
Gut, 73 (5), 844-853
DOI 10.1136/gutjnl-2023-331595, PubMed 38378252 -
Dissecting autoimmune encephalitis through the lens of intrathecal B cells
Proc Natl Acad Sci U S A, 121 (9), e2401337121
DOI 10.1073/pnas.2401337121, PubMed 38354256 -
Biopsy Proteome Scoring to Determine Mucosal Remodeling in Celiac Disease
Gastroenterology, 167 (3), 493-504.e10
DOI 10.1053/j.gastro.2024.03.006, PubMed 38467384 -
Biopsy Proteome Score Performs Well as an Effect Measure in a Gluten Challenge Trial of Celiac Disease
Clin Gastroenterol Hepatol (in press)
DOI 10.1016/j.cgh.2024.08.005, PubMed 39209203 -
Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease
Cell Rep, 43 (4), 114045
DOI 10.1016/j.celrep.2024.114045, PubMed 38578826 -
Coeliac disease in the Trøndelag Health Study (HUNT), Norway, a population-based cohort of coeliac disease patients
BMJ Open, 14 (1), e077131
DOI 10.1136/bmjopen-2023-077131, PubMed 38195172 -
The Prevalence and Rate of Undiagnosed Celiac Disease in an Adult General Population, the Trøndelag Health Study, Norway
Clin Gastroenterol Hepatol (in press)
DOI 10.1016/j.cgh.2024.06.027, PubMed 38987013 -
Enterocyte-Derived and Catalytically Active Transglutaminase 2 in the Gut Lumen of Mice: Implications for Celiac Disease
Gastroenterology, 167 (5), 1026-1028.e4
DOI 10.1053/j.gastro.2024.05.029, PubMed 38825048 -
Gluten-Free Diet Induces Rapid Changes in Phenotype and Survival Properties of Gluten-Specific T Cells in Celiac Disease
Gastroenterology, 167 (2), 250-263
DOI 10.1053/j.gastro.2024.03.027, PubMed 38552723 -
A human autoimmune organoid model reveals IL-7 function in coeliac disease
Nature, 632 (8024), 401-410
DOI 10.1038/s41586-024-07716-2, PubMed 39048815 -
Tolerance-inducing therapies in coeliac disease - mechanisms, progress and future directions
Nat Rev Gastroenterol Hepatol, 21 (5), 335-347
DOI 10.1038/s41575-024-00895-3, PubMed 38336920
Publications 2023
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Expression of transglutaminase 2 in human gut epithelial cells: Implications for coeliac disease
PLoS One, 18 (6), e0287662
DOI 10.1371/journal.pone.0287662, PubMed 37368893 -
Identification of gluten T cell epitopes driving celiac disease
Sci Adv, 9 (4), eade5800
DOI 10.1126/sciadv.ade5800, PubMed 36696493 -
Separate Gut Plasma Cell Populations Produce Auto-Antibodies against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis
Adv Sci (Weinh), 10 (25), e2300401
DOI 10.1002/advs.202300401, PubMed 37424036 -
Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes
Cell Host Microbe, 31 (2), 213-227.e9
DOI 10.1016/j.chom.2022.12.009, PubMed 36603588 -
Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3
Nat Commun, 14 (1), 6216
DOI 10.1038/s41467-023-42004-z, PubMed 37798283 -
Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease
Nat Commun, 14 (1), 8502
DOI 10.1038/s41467-023-44083-4, PubMed 38135691 -
Single-cell transcriptomics combined with proteomics of intrathecal IgG reveal transcriptional heterogeneity of oligoclonal IgG-secreting cells in multiple sclerosis
Front Cell Neurosci, 17, 1189709
DOI 10.3389/fncel.2023.1189709, PubMed 37362001
Publications 2022
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Transglutaminase 2 affinity and enzyme-substrate intermediate stability as determining factors for T-cell responses to gluten peptides in celiac disease
Eur J Immunol, 52 (9), 1474-1481
DOI 10.1002/eji.202249862, PubMed 35715890 -
Phenotype-Based Isolation of Antigen-Specific CD4+ T Cells in Autoimmunity: A Study of Celiac Disease
Adv Sci (Weinh), 9 (10), e2104766
DOI 10.1002/advs.202104766, PubMed 35119226 -
Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T-Cell-Directed Therapies
Adv Sci (Weinh), 9 (34), e2205912
DOI 10.1002/advs.202205912, PubMed 36482157 -
Structural basis of T cell receptor specificity and cross-reactivity of two HLA-DQ2.5-restricted gluten epitopes in celiac disease
J Biol Chem, 298 (3), 101619
DOI 10.1016/j.jbc.2022.101619, PubMed 35065967 -
TCRpower: quantifying the detection power of T-cell receptor sequencing with a novel computational pipeline calibrated by spike-in sequences
Brief Bioinform, 23 (2)
DOI 10.1093/bib/bbab566, PubMed 35062022 -
Affinity maturation of TCR-like antibodies using phage display guided by structural modeling
Protein Eng Des Sel, 35
DOI 10.1093/protein/gzac005, PubMed 35871543 -
The Immunobiology and Pathogenesis of Celiac Disease
Annu Rev Pathol, 18, 47-70
DOI 10.1146/annurev-pathmechdis-031521-032634, PubMed 36067801 -
The development and validation of a high-capacity serological assay for celiac disease
Clin Biochem, 107, 13-18
DOI 10.1016/j.clinbiochem.2022.05.010, PubMed 35660483 -
KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19
Science, 376 (6590), eabi9591
DOI 10.1126/science.abi9591, PubMed 35258337 -
Stereotyped B-cell responses are linked to IgG constant region polymorphisms in multiple sclerosis
Eur J Immunol, 52 (4), 550-565
DOI 10.1002/eji.202149576, PubMed 35094395 -
Injection of prototypic celiac anti-transglutaminase 2 antibodies in mice does not cause enteropathy
PLoS One, 17 (4), e0266543
DOI 10.1371/journal.pone.0266543, PubMed 35385534 -
Phenotypic Analysis of Disease-Relevant T Cells in Dermatitis Herpetiformis
J Invest Dermatol, 143 (1), 163-166.e2
DOI 10.1016/j.jid.2022.07.007, PubMed 35961617 -
Epstein-Barr virus as a driver of multiple sclerosis
Sci Immunol, 7 (70), eabo7799
DOI 10.1126/sciimmunol.abo7799, PubMed 35363541 -
Tango of B cells with T cells in the making of secretory antibodies to gut bacteria
Nat Rev Gastroenterol Hepatol, 20 (2), 120-128
DOI 10.1038/s41575-022-00674-y, PubMed 36056203 -
Focused B cell response to recurring gluten motif with implications for epitope spreading in celiac disease
Cell Rep, 41 (4), 111541
DOI 10.1016/j.celrep.2022.111541, PubMed 36288703
Publications 2021
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Potential impact of celiac disease genetic risk factors on T cell receptor signaling in gluten-specific CD4+ T cells
Sci Rep, 11 (1), 9252
DOI 10.1038/s41598-021-86612-5, PubMed 33927210 -
Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T-Cell-Directed Therapies
Adv Sci (Weinh), 8 (21), e2102778
DOI 10.1002/advs.202102778, PubMed 34495570 -
Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs
Front Immunol, 12, 639672
DOI 10.3389/fimmu.2021.639672, PubMed 33927715 -
Generation of an HLA-DQ2.5 Knock-In Mouse
Immunohorizons, 5 (1), 25-32
DOI 10.4049/immunohorizons.2000107, PubMed 33461981 -
Single-cell TCR repertoire analysis reveals highly polyclonal composition of human intraepithelial CD8+ αβ T lymphocytes in untreated celiac disease
Eur J Immunol, 51 (6), 1542-1545
DOI 10.1002/eji.202048974, PubMed 33559929 -
A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation
Sci Immunol, 6 (62)
DOI 10.1126/sciimmunol.abg4925, PubMed 34417258 -
Human KIR + CD8 + T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19
bioRxiv
DOI 10.1101/2021.12.23.473930, PubMed 34981055 -
Single-cell approaches to dissect adaptive immune responses involved in autoimmunity: the case of celiac disease
Mucosal Immunol, 15 (1), 51-63
DOI 10.1038/s41385-021-00452-0, PubMed 34531547 -
Longevity, clonal relationship, and transcriptional program of celiac disease-specific plasma cells
J Exp Med, 218 (2)
DOI 10.1084/jem.20200852, PubMed 33095260 -
TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease
PLoS One, 16 (11), e0259082
DOI 10.1371/journal.pone.0259082, PubMed 34731200 -
Immunoglobulin germline gene variation and its impact on human disease
Genes Immun, 22 (4), 205-217
DOI 10.1038/s41435-021-00145-5, PubMed 34175903 -
Germline polymorphisms and alternative splicing of human immunoglobulin light chain genes
iScience, 24 (10), 103192
DOI 10.1016/j.isci.2021.103192, PubMed 34693229 -
The immuneML ecosystem for machine learning analysis of adaptive immune receptor repertoires
Nat Mach Intell, 3 (11), 936-944
DOI 10.1038/s42256-021-00413-z, PubMed 37396030 -
Frequency of Gluten-Reactive T Cells in Active Celiac Lesions Estimated by Direct Cell Cloning
Front Immunol, 12, 646163
DOI 10.3389/fimmu.2021.646163, PubMed 33796112 -
Response to: "Some considerations about γδ and CD8+ T-cell responses in blood after gluten challenge in treated celiac disease"
Mucosal Immunol, 14 (5), 1216-1217
DOI 10.1038/s41385-021-00422-6, PubMed 34108593 -
Circulating CD103+ γδ and CD8+ T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease
Mucosal Immunol, 14 (4), 842-851
DOI 10.1038/s41385-021-00385-8, PubMed 33654213 -
Machine Learning Analysis of Naïve B-Cell Receptor Repertoires Stratifies Celiac Disease Patients and Controls
Front Immunol, 12, 627813
DOI 10.3389/fimmu.2021.627813, PubMed 33790900 -
Individualized VDJ recombination predisposes the available Ig sequence space
Genome Res, 31 (12), 2209-2224
DOI 10.1101/gr.275373.121, PubMed 34815307 -
Gut tissue-resident memory T cells in coeliac disease
Scand J Immunol, 95 (1), e13120
DOI 10.1111/sji.13120, PubMed 34796982 -
Erik Thorsby (1938-2021)
Immunogenetics, 73 (3), 203-205
DOI 10.1007/s00251-021-01218-5, PubMed 33956175 -
In memoriam: Erik Thorsby (1938-2021)
Scand. J. Immunol., 94 (1), e13055
DOI 10.1111/sji.13055 -
In Well-Treated Celiac Patients Low-Level Mucosal Inflammation Predicts Response to 14-day Gluten Challenge
Adv Sci (Weinh), 8 (4), 2003526
DOI 10.1002/advs.202003526, PubMed 33643806 -
Systematic Prioritization of Candidate Genes in Disease Loci Identifies TRAFD1 as a Master Regulator of IFNγ Signaling in Celiac Disease
Front Genet, 11, 562434
DOI 10.3389/fgene.2020.562434, PubMed 33569077 -
C-type lectin-like CD161 is not a co-signalling receptor in gluten-reactive CD4 + T cells
Scand J Immunol, 93 (6), e13016
DOI 10.1111/sji.13016, PubMed 33368526
Publications 2020
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B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2
J Exp Med, 217 (2)
DOI 10.1084/jem.20190860, PubMed 31727780 -
Evidence That Pathogenic Transglutaminase 2 in Celiac Disease Derives From Enterocytes
Gastroenterology, 159 (2), 788-790
DOI 10.1053/j.gastro.2020.04.018, PubMed 32302613 -
Autoimmunity provoked by foreign antigens
Science, 368 (6487), 132-133
DOI 10.1126/science.aay3037, PubMed 32273455 -
Characterization of T-cell receptor transgenic mice recognizing immunodominant HLA-DQ2.5-restricted gluten epitopes
Eur J Immunol, 51 (4), 1002-1005
DOI 10.1002/eji.202048859, PubMed 33368209 -
Polymorphisms in human immunoglobulin heavy chain variable genes and their upstream regions
Nucleic Acids Res, 48 (10), 5499-5510
DOI 10.1093/nar/gkaa310, PubMed 32365177 -
Lack of relationship of AT1001 to zonulin and prehaptoglobin-2: clinical implications
Gut, 70 (11), 2211-2212
DOI 10.1136/gutjnl-2020-323829, PubMed 33443022 -
A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease
Proc Natl Acad Sci U S A, 117 (6), 3063-3073
DOI 10.1073/pnas.1914308117, PubMed 31974305
Publications 2019
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Resident memory CD8 T cells persist for years in human small intestine
J Exp Med, 216 (10), 2412-2426
DOI 10.1084/jem.20190414, PubMed 31337737 -
Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions
Nat Med, 25 (5), 734-737
DOI 10.1038/s41591-019-0403-9, PubMed 30911136 -
Therapeutic and Diagnostic Implications of T Cell Scarring in Celiac Disease and Beyond
Trends Mol Med, 25 (10), 836-852
DOI 10.1016/j.molmed.2019.05.009, PubMed 31331739 -
On the immune response to barley in celiac disease: Biased and public T-cell receptor usage to a barley unique and immunodominant gluten epitope
Eur J Immunol, 50 (2), 256-269
DOI 10.1002/eji.201948253, PubMed 31628754 -
Single-cell TCR sequencing of gut intraepithelial γδ T cells reveals a vast and diverse repertoire in celiac disease
Mucosal Immunol, 13 (2), 313-321
DOI 10.1038/s41385-019-0222-9, PubMed 31728027 -
A TRAV26-1-encoded recognition motif focuses the biased T cell response in celiac disease
Eur J Immunol, 50 (1), 142-145
DOI 10.1002/eji.201948235, PubMed 31580480 -
Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping
Nat Commun, 10 (1), 628
DOI 10.1038/s41467-019-08489-3, PubMed 30733445 -
Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease
Sci Adv, 5 (8), eaaw7756
DOI 10.1126/sciadv.aaw7756, PubMed 31457091 -
Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense
J Immunol, 202 (9), 2558-2569
DOI 10.4049/jimmunol.1801454, PubMed 30926644 -
Efficient T cell-B cell collaboration guides autoantibody epitope bias and onset of celiac disease
Proc Natl Acad Sci U S A, 116 (30), 15134-15139
DOI 10.1073/pnas.1901561116, PubMed 31285344 -
Two novel HLA-DQ2.5-restricted gluten T cell epitopes in the DQ2.5-glia-γ4 epitope family
Immunogenetics, 71 (10), 665-667
DOI 10.1007/s00251-019-01138-5, PubMed 31673720 -
Transcriptional profiling of human intestinal plasma cells reveals effector functions beyond antibody production
United European Gastroenterol J, 7 (10), 1399-1407
DOI 10.1177/2050640619862461, PubMed 31839965 -
Update 2020: nomenclature and listing of celiac disease-relevant gluten epitopes recognized by CD4+ T cells
Immunogenetics, 72 (1-2), 85-88
DOI 10.1007/s00251-019-01141-w, PubMed 31735991 -
Cytokine release after gluten ingestion differentiates coeliac disease from self-reported gluten sensitivity
United European Gastroenterol J, 8 (1), 108-118
DOI 10.1177/2050640619874173, PubMed 32213060 -
CD38 expression on gluten-specific T cells is a robust marker of gluten re-exposure in coeliac disease
United European Gastroenterol J, 7 (10), 1337-1344
DOI 10.1177/2050640619874183, PubMed 31839959
Publications 2018
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Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes
J Biol Chem, 294 (3), 941-952
DOI 10.1074/jbc.RA118.005736, PubMed 30455354 -
Soluble T-cell receptor design influences functional yield in an E. coli chaperone-assisted expression system
PLoS One, 13 (4), e0195868
DOI 10.1371/journal.pone.0195868, PubMed 29649333 -
Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease
Gastroenterology, 156 (5), 1428-1439.e10
DOI 10.1053/j.gastro.2018.12.013, PubMed 30593798 -
BraCeR: B-cell-receptor reconstruction and clonality inference from single-cell RNA-seq
Nat Methods, 15 (8), 563-565
DOI 10.1038/s41592-018-0082-3, PubMed 30065371 -
Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease
J Clin Invest, 128 (6), 2642-2650
DOI 10.1172/JCI98819, PubMed 29757191 -
The SysteMHC Atlas project
Nucleic Acids Res, 46 (D1), D1237-D1247
DOI 10.1093/nar/gkx664, PubMed 28985418 -
Characterization of the Small Intestinal Lesion in Celiac Disease by Label-Free Quantitative Mass Spectrometry
Am J Pathol, 188 (7), 1563-1579
DOI 10.1016/j.ajpath.2018.03.017, PubMed 29684362
Publications 2017
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Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies
Lancet Gastroenterol Hepatol, 2 (7), 479-493
DOI 10.1016/S2468-1253(17)30110-3, PubMed 28506538 -
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17)
DOI 10.1172/jci.insight.95193, PubMed 28878121 -
Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins
Cell Rep, 20 (10), 2357-2367
DOI 10.1016/j.celrep.2017.08.036, PubMed 28877470 -
T Cells in Celiac Disease
J Immunol, 198 (8), 3005-3014
DOI 10.4049/jimmunol.1601693, PubMed 28373482 -
Antibody-secreting plasma cells persist for decades in human intestine
J Exp Med, 214 (2), 309-317
DOI 10.1084/jem.20161590, PubMed 28104812 -
Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides
J Biol Chem, 292 (22), 9218-9228
DOI 10.1074/jbc.M117.785139, PubMed 28364043 -
Similar Responses of Intestinal T Cells From Untreated Children and Adults With Celiac Disease to Deamidated Gluten Epitopes
Gastroenterology, 153 (3), 787-798.e4
DOI 10.1053/j.gastro.2017.05.016, PubMed 28535873 -
High-Throughput Single-Cell Analysis of B Cell Receptor Usage among Autoantigen-Specific Plasma Cells in Celiac Disease
J Immunol, 199 (2), 782-791
DOI 10.4049/jimmunol.1700169, PubMed 28600290 -
HLA-DQ-Gluten Tetramer Blood Test Accurately Identifies Patients With and Without Celiac Disease in Absence of Gluten Consumption
Gastroenterology, 154 (4), 886-896.e6
DOI 10.1053/j.gastro.2017.11.006, PubMed 29146521 -
HLA-DQ:gluten tetramer test in blood gives better detection of coeliac patients than biopsy after 14-day gluten challenge
Gut, 67 (9), 1606-1613
DOI 10.1136/gutjnl-2017-314461, PubMed 28779027 -
Stereotyped antibody responses target posttranslationally modified gluten in celiac disease
JCI Insight, 2 (17)
DOI 10.1172/jci.insight.93961, PubMed 28878138 -
The roles of MHC class II genes and post-translational modification in celiac disease
Immunogenetics, 69 (8-9), 605-616
DOI 10.1007/s00251-017-0985-7, PubMed 28695286 -
Per Brandtzaeg: patron of mucosal immunology
Mucosal Immunol, 10 (1), 1-4
DOI 10.1038/mi.2016.111, PubMed 28138161 -
HLA class II alleles in Norwegian patients with coexisting type 1 diabetes and celiac disease
HLA, 89 (5), 278-284
DOI 10.1111/tan.12986, PubMed 28247576
Publications 2016
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Dissecting the interaction between transglutaminase 2 and fibronectin
Amino Acids, 49 (3), 489-500
DOI 10.1007/s00726-016-2296-y, PubMed 27394141 -
Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease
J Immunol, 196 (6), 2819-26
DOI 10.4049/jimmunol.1501152, PubMed 26895834 -
TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage
Mucosal Immunol, 9 (3), 587-96
DOI 10.1038/mi.2015.147, PubMed 26838051 -
Gluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes
Sci Rep, 6, 25565
DOI 10.1038/srep25565, PubMed 27146306 -
Epitope-dependent Functional Effects of Celiac Disease Autoantibodies on Transglutaminase 2
J Biol Chem, 291 (49), 25542-25552
DOI 10.1074/jbc.M116.738161, PubMed 27784785 -
Multivalent pIX phage display selects for distinct and improved antibody properties
Sci Rep, 6, 39066
DOI 10.1038/srep39066, PubMed 27966617 -
The human intestinal B-cell response
Mucosal Immunol, 9 (5), 1113-24
DOI 10.1038/mi.2016.59, PubMed 27461177 -
Transglutaminase 2 strongly binds to an extracellular matrix component other than fibronectin via its second C-terminal beta-barrel domain
FEBS J, 283 (21), 3994-4010
DOI 10.1111/febs.13907, PubMed 27685605
Publications 2015
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Transglutaminase 2 interactions with extracellular matrix proteins as probed with celiac disease autoantibodies
FEBS J, 282 (11), 2063-75
DOI 10.1111/febs.13276, PubMed 25808416 -
Structural Basis for Antigen Recognition by Transglutaminase 2-specific Autoantibodies in Celiac Disease
J Biol Chem, 290 (35), 21365-75
DOI 10.1074/jbc.M115.669895, PubMed 26160175 -
Responsive population dynamics and wide seeding into the duodenal lamina propria of transglutaminase-2-specific plasma cells in celiac disease
Mucosal Immunol, 9 (1), 254-64
DOI 10.1038/mi.2015.57, PubMed 26153762 -
T-cell and B-cell immunity in celiac disease
Best Pract Res Clin Gastroenterol, 29 (3), 413-23
DOI 10.1016/j.bpg.2015.04.001, PubMed 26060106 -
Igs as Substrates for Transglutaminase 2: Implications for Autoantibody Production in Celiac Disease
J Immunol, 195 (11), 5159-68
DOI 10.4049/jimmunol.1501363, PubMed 26503953 -
Coeliac disease - from genetic and immunological studies to clinical applications
Scand J Gastroenterol, 50 (6), 708-17
DOI 10.3109/00365521.2015.1030766, PubMed 25846940 -
Quantitative Proteomics of Gut-Derived Th1 and Th1/Th17 Clones Reveal the Presence of CD28+ NKG2D- Th1 Cytotoxic CD4+ T cells
Mol Cell Proteomics, 15 (3), 1007-16
DOI 10.1074/mcp.M115.050138, PubMed 26637539 -
Analysis of celiac disease autoreactive gut plasma cells and their corresponding memory compartment in peripheral blood using high-throughput sequencing
J Immunol, 194 (12), 5703-12
DOI 10.4049/jimmunol.1402611, PubMed 25972486 -
Small bowel, celiac disease and adaptive immunity
Dig Dis, 33 (2), 115-121
DOI 10.1159/000369512, PubMed 25925911 -
Enhanced B-Cell Receptor Recognition of the Autoantigen Transglutaminase 2 by Efficient Catalytic Self-Multimerization
PLoS One, 10 (8), e0134922
DOI 10.1371/journal.pone.0134922, PubMed 26244572 -
Celiac disease: Autoimmunity in response to food antigen
Semin Immunol, 27 (5), 343-52
DOI 10.1016/j.smim.2015.11.001, PubMed 26603490 -
Serologic assay for diagnosis of celiac disease based on a patient-derived monoclonal antigliadin antibody
Gastroenterology, 149 (6), 1530-1540.e3
DOI 10.1053/j.gastro.2015.07.008, PubMed 26208894
Publications 2014
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Coeliac disease-associated polymorphisms influence thymic gene expression
Genes Immun, 15 (6), 355-60
DOI 10.1038/gene.2014.26, PubMed 24871462 -
Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires
Immunogenetics, 67 (2), 73-84
DOI 10.1007/s00251-014-0819-9, PubMed 25502872 -
Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge
United European Gastroenterol J, 2 (4), 268-78
DOI 10.1177/2050640614540154, PubMed 25083284 -
HLA-DQ molecules as affinity matrix for identification of gluten T cell epitopes
J Immunol, 193 (9), 4497-506
DOI 10.4049/jimmunol.1301466, PubMed 25261484 -
Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange
Proc Natl Acad Sci U S A, 111 (48), 17146-51
DOI 10.1073/pnas.1407457111, PubMed 25404341 -
How T cells taste gluten in celiac disease
Nat Struct Mol Biol, 21 (5), 429-31
DOI 10.1038/nsmb.2826, PubMed 24777059 -
Advances in coeliac disease
Curr Opin Gastroenterol, 30 (2), 154-62
DOI 10.1097/MOG.0000000000000041, PubMed 24457347 -
Molecular mechanisms for contribution of MHC molecules to autoimmune diseases
Curr Opin Immunol, 31, 24-30
DOI 10.1016/j.coi.2014.08.005, PubMed 25216261 -
Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells
Nat Commun, 5, 4041
DOI 10.1038/ncomms5041, PubMed 24909383 -
Treatment of both native and deamidated gluten peptides with an endo-peptidase from Aspergillus niger prevents stimulation of gut-derived gluten-reactive T cells from either children or adults with celiac disease
Clin Immunol, 153 (2), 323-31
DOI 10.1016/j.clim.2014.05.009, PubMed 24905137
Publications 2013
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Direct cloning and tetramer staining to measure the frequency of intestinal gluten-reactive T cells in celiac disease
Eur J Immunol, 43 (10), 2605-12
DOI 10.1002/eji.201343382, PubMed 23775608 -
Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity
Am J Gastroenterol, 108 (5), 842-50
DOI 10.1038/ajg.2013.91, PubMed 23588237 -
Transglutaminase 2-specific autoantibodies in celiac disease target clustered, N-terminal epitopes not displayed on the surface of cells
J Immunol, 190 (12), 5981-91
DOI 10.4049/jimmunol.1300183, PubMed 23690478 -
Increased frequency of intestinal CD4+ T cells reactive with mycobacteria in patients with Crohn's disease
Scand J Gastroenterol, 48 (11), 1278-85
DOI 10.3109/00365521.2013.837952, PubMed 24131402 -
Pitfalls in determining the cytokine profile of human T cells
J Immunol Methods, 390 (1-2), 106-12
DOI 10.1016/j.jim.2013.01.015, PubMed 23416458 -
Biased usage and preferred pairing of α- and β-chains of TCRs specific for an immunodominant gluten epitope in coeliac disease
Int Immunol, 26 (1), 13-9
DOI 10.1093/intimm/dxt037, PubMed 24038601 -
Plasmacytoid dendritic cells are scarcely represented in the human gut mucosa and are not recruited to the celiac lesion
Mucosal Immunol, 6 (5), 985-92
DOI 10.1038/mi.2012.136, PubMed 23340820 -
Triggers and drivers of autoimmunity: lessons from coeliac disease
Nat Rev Immunol, 13 (4), 294-302
DOI 10.1038/nri3407, PubMed 23493116 -
Antigen processing
Curr Opin Immunol, 25 (1), 71-3
DOI 10.1016/j.coi.2012.12.002, PubMed 23287556
Publications 2012
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Rapid accumulation of CD14+CD11c+ dendritic cells in gut mucosa of celiac disease after in vivo gluten challenge
PLoS One, 7 (3), e33556
DOI 10.1371/journal.pone.0033556, PubMed 22438948 -
Evidence that HLA-DQ9 confers risk to celiac disease by presence of DQ9-restricted gluten-specific T cells
Hum Immunol, 73 (4), 376-81
DOI 10.1016/j.humimm.2012.01.016, PubMed 22342873 -
Activation and inhibition of transglutaminase 2 in mice
PLoS One, 7 (2), e30642
DOI 10.1371/journal.pone.0030642, PubMed 22319575 -
High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions
Nat Med, 18 (3), 441-5
DOI 10.1038/nm.2656, PubMed 22366952 -
The intestinal B-cell response in celiac disease
Front Immunol, 3, 313
DOI 10.3389/fimmu.2012.00313, PubMed 23060888 -
The adaptive immune response in celiac disease
Semin Immunopathol, 34 (4), 523-40
DOI 10.1007/s00281-012-0314-z, PubMed 22535446 -
Nomenclature and listing of celiac disease relevant gluten T-cell epitopes restricted by HLA-DQ molecules
Immunogenetics, 64 (6), 455-60
DOI 10.1007/s00251-012-0599-z, PubMed 22322673 -
Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule
J Biol Chem, 287 (17), 13611-9
DOI 10.1074/jbc.M111.320374, PubMed 22362761
Publications 2011
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Integration of genetic and immunological insights into a model of celiac disease pathogenesis
Annu Rev Immunol, 29, 493-525
DOI 10.1146/annurev-immunol-040210-092915, PubMed 21219178 -
Density of CD163+ CD11c+ dendritic cells increases and CD103+ dendritic cells decreases in the coeliac lesion
Scand J Immunol, 74 (2), 186-94
DOI 10.1111/j.1365-3083.2011.02549.x, PubMed 21392045 -
T-cell response to gluten in patients with HLA-DQ2.2 reveals requirement of peptide-MHC stability in celiac disease
Gastroenterology, 142 (3), 552-61
DOI 10.1053/j.gastro.2011.11.021, PubMed 22108197 -
Assessing possible celiac disease by an HLA-DQ2-gliadin Tetramer Test
Am J Gastroenterol, 106 (7), 1318-24
DOI 10.1038/ajg.2011.23, PubMed 21364548 -
Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells
Gastroenterology, 141 (2), 610-20, 620.e1-2
DOI 10.1053/j.gastro.2011.04.048, PubMed 21683079 -
CD62L(neg)CD38⁺ expression on circulating CD4⁺ T cells identifies mucosally differentiated cells in protein fed mice and in human celiac disease patients and controls
Am J Gastroenterol, 106 (6), 1147-59
DOI 10.1038/ajg.2011.24, PubMed 21386831 -
Interleukin-15 induces interleukin-17 production by synovial T cell lines from patients with rheumatoid arthritis
Scand J Immunol, 73 (3), 243-9
DOI 10.1111/j.1365-3083.2010.02498.x, PubMed 21204897 -
Activation of extracellular transglutaminase 2 by thioredoxin
J Biol Chem, 286 (43), 37866-73
DOI 10.1074/jbc.M111.287490, PubMed 21908620 -
Assessing high affinity binding to HLA-DQ2.5 by a novel peptide library based approach
Bioorg Med Chem, 19 (7), 2470-7
DOI 10.1016/j.bmc.2011.01.057, PubMed 21382721 -
Long-lived plasma cells from human small intestine biopsies secrete immunoglobulins for many weeks in vitro
J Immunol, 187 (6), 2867-74
DOI 10.4049/jimmunol.1003181, PubMed 21841131 -
Anti-PAD4 autoantibodies in rheumatoid arthritis: levels in serum over time and impact on PAD4 activity as measured with a small synthetic substrate
Rheumatol Int, 32 (5), 1271-6
DOI 10.1007/s00296-010-1765-y, PubMed 21267570 -
Posttranslational modification of gluten shapes TCR usage in celiac disease
J Immunol, 187 (6), 3064-71
DOI 10.4049/jimmunol.1101526, PubMed 21849672 -
Celiac disease and transglutaminase 2: a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disorders
Curr Opin Immunol, 23 (6), 732-8
DOI 10.1016/j.coi.2011.08.006, PubMed 21917438 -
Novel therapies for coeliac disease
J Intern Med, 269 (6), 604-13
DOI 10.1111/j.1365-2796.2011.02376.x, PubMed 21401739
Publications 2010
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HLA-DQ2-restricted gluten-reactive T cells produce IL-21 but not IL-17 or IL-22
Mucosal Immunol, 3 (6), 594-601
DOI 10.1038/mi.2010.36, PubMed 20571486 -
Rapid generation of rotavirus-specific human monoclonal antibodies from small-intestinal mucosa
J Immunol, 185 (9), 5377-83
DOI 10.4049/jimmunol.1001587, PubMed 20935207 -
The preferred substrates for transglutaminase 2 in a complex wheat gluten digest are Peptide fragments harboring celiac disease T-cell epitopes
PLoS One, 5 (11), e14056
DOI 10.1371/journal.pone.0014056, PubMed 21124911 -
Effective shutdown in the expression of celiac disease-related wheat gliadin T-cell epitopes by RNA interference
Proc Natl Acad Sci U S A, 107 (39), 17023-8
DOI 10.1073/pnas.1007773107, PubMed 20829492 -
Design of new high-affinity peptide ligands for human leukocyte antigen-DQ2 using a positional scanning peptide library
Hum Immunol, 71 (5), 475-81
DOI 10.1016/j.humimm.2010.01.021, PubMed 20105447 -
Gluten T cell epitope targeting by TG3 and TG6; implications for dermatitis herpetiformis and gluten ataxia
Amino Acids, 39 (5), 1183-91
DOI 10.1007/s00726-010-0554-y, PubMed 20300788 -
Redox regulation of transglutaminase 2 activity
J Biol Chem, 285 (33), 25402-9
DOI 10.1074/jbc.M109.097162, PubMed 20547769
Publications 2009
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Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort
Genes Immun, 11 (1), 79-86
DOI 10.1038/gene.2009.67, PubMed 19693089 -
Noninflammatory gluten peptide analogs as biomarkers for celiac sprue
Chem Biol, 16 (8), 868-81
DOI 10.1016/j.chembiol.2009.07.009, PubMed 19716477 -
A quantitative analysis of transglutaminase 2-mediated deamidation of gluten peptides: implications for the T-cell response in celiac disease
J Proteome Res, 8 (4), 1748-55
DOI 10.1021/pr800960n, PubMed 19239248 -
Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation
Nat Immunol, 10 (10), 1096-101
DOI 10.1038/ni.1780, PubMed 19718029 -
Tissue-mediated control of immunopathology in coeliac disease
Nat Rev Immunol, 9 (12), 858-70
DOI 10.1038/nri2670, PubMed 19935805 -
Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients
PLoS One, 4 (5), e5641
DOI 10.1371/journal.pone.0005641, PubMed 19479064 -
Antigen presentation in celiac disease
Curr Opin Immunol, 21 (1), 111-7
DOI 10.1016/j.coi.2009.03.004, PubMed 19342211 -
Enzymatic detoxification of gluten by germinating wheat proteases: implications for new treatment of celiac disease
Ann Med, 41 (5), 390-400
DOI 10.1080/07853890902878138, PubMed 19353359 -
Primary sequence, together with other factors, influence peptide deimination by peptidylarginine deiminase-4
Biol Chem, 390 (2), 99-107
DOI 10.1515/BC.2009.019, PubMed 19040354
Publications 2008
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Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families
Genes Immun, 9 (4), 364-7
DOI 10.1038/gene.2008.27, PubMed 18418394 -
Analysis of the binding of gluten T-cell epitopes to various human leukocyte antigen class II molecules
Hum Immunol, 69 (2), 94-100
DOI 10.1016/j.humimm.2008.01.002, PubMed 18361933 -
Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM
J Immunol, 181 (8), 5451-5461
DOI 10.4049/jimmunol.181.8.5451, PubMed 18832702 -
The role of HLA-DQ8 beta57 polymorphism in the anti-gluten T-cell response in coeliac disease
Nature, 456 (7221), 534-8
DOI 10.1038/nature07524, PubMed 19037317 -
Soluble HLA-DQ2 expressed in S2 cells copurifies with a high affinity insect cell derived protein
Immunogenetics, 61 (2), 81-9
DOI 10.1007/s00251-008-0338-7, PubMed 18987854 -
Dependence of antibody-mediated presentation of antigen on FcRn
Proc Natl Acad Sci U S A, 105 (27), 9337-42
DOI 10.1073/pnas.0801717105, PubMed 18599440 -
Hunting for celiac disease genes
Gastroenterology, 134 (3), 869-71
DOI 10.1053/j.gastro.2008.01.020, PubMed 18325395 -
Animal models of inflammatory bowel disease at the dawn of the new genetics era
PLoS Med, 5 (9), e198
DOI 10.1371/journal.pmed.0050198, PubMed 18828669 -
Diagnosis and treatment of celiac disease
Mucosal Immunol, 2 (1), 3-7
DOI 10.1038/mi.2008.74, PubMed 19079329 -
The monoclonal antibody 6B9 recognizes CD44 and not cell surface transglutaminase 2
Scand J Immunol, 68 (5), 534-42
DOI 10.1111/j.1365-3083.2008.02173.x, PubMed 18803608 -
The propensity for deamidation and transamidation of peptides by transglutaminase 2 is dependent on substrate affinity and reaction conditions
Biochim Biophys Acta, 1784 (11), 1804-11
DOI 10.1016/j.bbapap.2008.08.011, PubMed 18793760 -
Recombinant antibodies for delivery of antigen: a single loop between beta-strands in the constant region can accommodate long, complex and tandem T cell epitopes
Int Immunol, 20 (3), 295-306
DOI 10.1093/intimm/dxm141, PubMed 18252695
Publications 2007
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Fine mapping study in Scandinavian families suggests association between coeliac disease and haplotypes in chromosome region 5q32
Tissue Antigens, 71 (1), 27-34
DOI 10.1111/j.1399-0039.2007.00955.x, PubMed 17971050 -
A comprehensive screen for SNP associations on chromosome region 5q31-33 in Swedish/Norwegian celiac disease families
Eur J Hum Genet, 15 (9), 980-7
DOI 10.1038/sj.ejhg.5201870, PubMed 17551518 -
Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients
Proc Natl Acad Sci U S A, 104 (8), 2831-6
DOI 10.1073/pnas.0608610104, PubMed 17307878 -
Surface expression of transglutaminase 2 by dendritic cells and its potential role for uptake and presentation of gluten peptides to T cells
Scand J Immunol, 65 (3), 213-20
DOI 10.1111/j.1365-3083.2006.01881.x, PubMed 17309775 -
Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease
Bioorg Med Chem, 15 (20), 6565-73
DOI 10.1016/j.bmc.2007.07.001, PubMed 17681795
Publications 2006
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Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort
Hum Immunol, 67 (4-5), 341-5
DOI 10.1016/j.humimm.2006.03.020, PubMed 16720215 -
Association analysis of MYO9B gene polymorphisms and inflammatory bowel disease in a Norwegian cohort
Tissue Antigens, 68 (3), 249-52
DOI 10.1111/j.1399-0039.2006.00665.x, PubMed 16948647 -
Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease
Chem Biol, 13 (6), 637-47
DOI 10.1016/j.chembiol.2006.04.008, PubMed 16793521 -
FOXP3 polymorphisms in type 1 diabetes and coeliac disease
J Autoimmun, 27 (2), 140-4
DOI 10.1016/j.jaut.2006.06.007, PubMed 16996248 -
Specific modification of peptide-bound citrulline residues
Anal Biochem, 352 (1), 68-76
DOI 10.1016/j.ab.2006.02.007, PubMed 16540076 -
Mechanisms of disease: immunopathogenesis of celiac disease
Nat Clin Pract Gastroenterol Hepatol, 3 (9), 516-25
DOI 10.1038/ncpgasthep0582, PubMed 16951668 -
A gut feeling for joint inflammation - using coeliac disease to understand rheumatoid arthritis
Trends Immunol, 27 (4), 188-94
DOI 10.1016/j.it.2006.02.006, PubMed 16530013 -
A unique dendritic cell subset accumulates in the celiac lesion and efficiently activates gluten-reactive T cells
Gastroenterology, 131 (2), 428-38
DOI 10.1053/j.gastro.2006.06.002, PubMed 16890596 -
Cross-dressing T cells go wild
Nat Med, 12 (6), 611-2
DOI 10.1038/nm0606-611, PubMed 16761002 -
Mapping genes and pathways in autoimmune disease
Trends Immunol, 27 (7), 336-42
DOI 10.1016/j.it.2006.05.008, PubMed 16753344 -
HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease
J Clin Invest, 116 (8), 2226-36
DOI 10.1172/JCI27620, PubMed 16878175 -
Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin
J Am Chem Soc, 128 (6), 1859-67
DOI 10.1021/ja056423o, PubMed 16464085
Publications 2005
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Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule
J Biol Chem, 280 (23), 21791-6
DOI 10.1074/jbc.M501558200, PubMed 15826953 -
Molecular characterization of covalent transglutaminase (TG2)-gliadin peptide complexes involved in coeliac disease
Peptides 2004, Proceedings: BRIDGES BETWEEN DISCIPLINES, 73-74 -
Putative efficacy and dosage of prolyl endopeptidase for digesting and detoxifying gliadin peptides
Gastroenterology, 129 (4), 1362-3; author reply 1363
DOI 10.1053/j.gastro.2005.08.044, PubMed 16230098 -
Pathomechanisms in celiac disease
Best Pract Res Clin Gastroenterol, 19 (3), 373-87
DOI 10.1016/j.bpg.2005.02.003, PubMed 15925843 -
Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease
Gastroenterology, 128 (2), 393-401
DOI 10.1053/j.gastro.2004.11.003, PubMed 15685550 -
Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation
J Immunol, 175 (1), 254-61
DOI 10.4049/jimmunol.175.1.254, PubMed 15972656 -
Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease
J Immunol, 174 (3), 1657-63
DOI 10.4049/jimmunol.174.3.1657, PubMed 15661929 -
The effects of atorvastatin on gluten-induced intestinal T cell responses in coeliac disease
Clin Exp Immunol, 142 (2), 333-40
DOI 10.1111/j.1365-2249.2005.02915.x, PubMed 16232221 -
Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue
J Proteome Res, 4 (5), 1732-41
DOI 10.1021/pr050173t, PubMed 16212427 -
Celiac disease as a model of gastrointestinal inflammation
J Pediatr Gastroenterol Nutr, 40 Suppl 1, S41-2
DOI 10.1097/00005176-200504001-00025, PubMed 15805849 -
Is celiac disease an autoimmune disorder?
Curr Opin Immunol, 17 (6), 595-600
DOI 10.1016/j.coi.2005.09.015, PubMed 16214317 -
Future therapeutic options for celiac disease
Nat Clin Pract Gastroenterol Hepatol, 2 (3), 140-7
DOI 10.1038/ncpgasthep0111, PubMed 16265155 -
Celiac disease genetics: current concepts and practical applications
Clin Gastroenterol Hepatol, 3 (9), 843-51
DOI 10.1016/s1542-3565(05)00532-x, PubMed 16234020 -
Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases
Genes Immun, 6 (3), 271-3
DOI 10.1038/sj.gene.6364178, PubMed 15759012 -
Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2
Biochemistry, 44 (11), 4442-9
DOI 10.1021/bi047747c, PubMed 15766274
Publications 2004
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Genetic analysis of the CD28/CTLA4/ICOS (CELIAC3) region in coeliac disease
Tissue Antigens, 64 (5), 593-9
DOI 10.1111/j.1399-0039.2004.00312.x, PubMed 15496203 -
The molecular basis for oat intolerance in patients with celiac disease
PLoS Med, 1 (1), e1
DOI 10.1371/journal.pmed.0010001, PubMed 15526039 -
Molecular characterization of covalent complexes between tissue transglutaminase and gliadin peptides
J Biol Chem, 279 (17), 17607-16
DOI 10.1074/jbc.M310198200, PubMed 14747475 -
Candidate gene region 2q33 in European families with coeliac disease
Tissue Antigens, 63 (3), 212-22
DOI 10.1111/j.1399-0039.2004.00189.x, PubMed 14989710 -
Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease
Proc Natl Acad Sci U S A, 101 (12), 4175-9
DOI 10.1073/pnas.0306885101, PubMed 15020763 -
HLA-DQ relative risks for coeliac disease in European populations: a study of the European Genetics Cluster on Coeliac Disease
Tissue Antigens, 63 (6), 562-7
DOI 10.1111/j.0001-2815.2004.00237.x, PubMed 15140032 -
Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization
J Pharmacol Exp Ther, 312 (1), 19-26
DOI 10.1124/jpet.104.073312, PubMed 15358813 -
Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion
J Immunol, 173 (3), 1757-62
DOI 10.4049/jimmunol.173.3.1757, PubMed 15265905 -
Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue
Biochem J, 383 (Pt 2), 311-8
DOI 10.1042/BJ20040907, PubMed 15245330 -
Intraepithelial lymphocytes in celiac disease: license to kill revealed
Immunity, 21 (3), 303-4
DOI 10.1016/j.immuni.2004.08.002, PubMed 15357941 -
A role for bacteria in celiac disease?
Am J Gastroenterol, 99 (5), 905-6
DOI 10.1111/j.1572-0241.2004.04158.x, PubMed 15128358
Publications 2003
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Meta and pooled analysis of European coeliac disease data
Eur J Hum Genet, 11 (11), 828-34
DOI 10.1038/sj.ejhg.5201051, PubMed 14571266 -
HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease
Hum Immunol, 64 (4), 469-77
DOI 10.1016/s0198-8859(03)00027-2, PubMed 12651074 -
Coeliac disease patients carry conserved HLA-DR3-DQ2 haplotypes revealed by association of TNF alleles
Immunogenetics, 55 (5), 339-43
DOI 10.1007/s00251-003-0586-5, PubMed 12845502 -
A collaborative European search for non-DQA1*05-DQB1*02 celiac disease loci on HLA-DR3 haplotypes: analysis of transmission from homozygous parents
Hum Immunol, 64 (3), 350-8
DOI 10.1016/s0198-8859(02)00822-4, PubMed 12590980 -
HLA in coeliac disease: unravelling the complex genetics of a complex disorder
Tissue Antigens, 61 (2), 105-17
DOI 10.1034/j.1399-0039.2003.00017.x, PubMed 12694579 -
[Coeliac disease--new clinical findings and diagnostic tools]
Tidsskr Nor Laegeforen, 123 (22), 3226-9
PubMed 14714016 -
Gliadin peptide specific intestinal T cells in coeliac disease
Gut, 52 (2), 162
DOI 10.1136/gut.52.2.162, PubMed 12524389 -
Intestinal T-cell responses to high-molecular-weight glutenins in celiac disease
Gastroenterology, 125 (2), 337-44
DOI 10.1016/s0016-5085(03)00890-4, PubMed 12891534 -
[Disease mechanisms in coeliac disease]
Tidsskr Nor Laegeforen, 123 (22), 3230-3
PubMed 14714017
Publications 2002
-
Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues
Gastroenterology, 123 (3), 803-9
DOI 10.1053/gast.2002.35381, PubMed 12198706 -
Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process
J Biol Chem, 277 (37), 34109-16
DOI 10.1074/jbc.M204521200, PubMed 12093810 -
HLA in coeliac disease families: a novel test of risk modification by the 'other' haplotype when at least one DQA1*05-DQB1*02 haplotype is carried
Tissue Antigens, 60 (2), 147-54
DOI 10.1034/j.1399-0039.2002.600205.x, PubMed 12392509 -
Coeliac disease candidate genes: no association with functional polymorphisms in matrix metalloproteinase 1 and 3 gene promoters
Scand J Gastroenterol, 37 (8), 931-5
DOI 10.1080/003655202760230892, PubMed 12229968 -
The IL12B gene does not confer susceptibility to coeliac disease
Tissue Antigens, 59 (1), 70-2
DOI 10.1034/j.1399-0039.2002.590117.x, PubMed 11972887 -
Troybodies and pepbodies
Biochem Soc Trans, 30 (4), 500-6
DOI 10.1042/bst0300500, PubMed 12196123 -
A mouse C kappa-specific T cell clone indicates that DC-SIGN is an efficient target for antibody-mediated delivery of T cell epitopes for MHC class II presentation
Int Immunol, 14 (12), 1423-30
DOI 10.1093/intimm/dxf110, PubMed 12456590 -
Structural basis for gluten intolerance in celiac sprue
Science, 297 (5590), 2275-9
DOI 10.1126/science.1074129, PubMed 12351792 -
Coeliac disease: dissecting a complex inflammatory disorder
Nat Rev Immunol, 2 (9), 647-55
DOI 10.1038/nri885, PubMed 12209133 -
Breast milk against coeliac disease
Gut, 51 (6), 767-8
DOI 10.1136/gut.51.6.767, PubMed 12427772
Publications 2001
-
T cell recognition of the dominant I-A(k)-restricted hen egg lysozyme epitope: critical role for asparagine deamidation
J Exp Med, 193 (11), 1239-46
DOI 10.1084/jem.193.11.1239, PubMed 11390431 -
T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase
Eur J Immunol, 31 (5), 1317-23
DOI 10.1002/1521-4141(200105)31:5<1317::AID-IMMU1317>3.0.CO;2-I, PubMed 11465088 -
Genome-wide linkage analysis of Scandinavian affected sib-pairs supports presence of susceptibility loci for celiac disease on chromosomes 5 and 11
Eur J Hum Genet, 9 (12), 938-44
DOI 10.1038/sj.ejhg.5200752, PubMed 11840196 -
Staining of celiac disease-relevant T cells by peptide-DQ2 multimers
J Immunol, 167 (9), 4861-8
DOI 10.4049/jimmunol.167.9.4861, PubMed 11673490 -
Coeliac disease. An inappropriate immune response
Lancet, 358 Suppl, S13
DOI 10.1016/s0140-6736(01)07026-x, PubMed 11784562 -
Genes and environment in celiac disease
Acta Odontol Scand, 59 (3), 183-6
DOI 10.1080/000163501750266792, PubMed 11501889
Publications 2000
-
Production of a panel of recombinant gliadins for the characterisation of T cell reactivity in coeliac disease
Gut, 46 (1), 46-51
DOI 10.1136/gut.46.1.46, PubMed 10601054 -
The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase
J Exp Med, 191 (4), 603-12
DOI 10.1084/jem.191.4.603, PubMed 10684852 -
Getting to grips with gluten
Gut, 47 (6), 743-5
DOI 10.1136/gut.47.6.743, PubMed 11076867 -
Studies of gliadin-specific T-cells in celiac disease
Methods Mol Med, 41, 105-24
DOI 10.1385/1-59259-082-9:105, PubMed 21374436 -
Role of tissue transglutaminase in celiac disease
J Pediatr Gastroenterol Nutr, 30 (3), 232-40
DOI 10.1097/00005176-200003000-00005, PubMed 10749404 -
The CTLA4/CD28 gene region on chromosome 2q33 confers susceptibility to celiac disease in a way possibly distinct from that of type 1 diabetes and other chronic inflammatory disorders
Tissue Antigens, 56 (4), 350-5
DOI 10.1034/j.1399-0039.2000.560407.x, PubMed 11098935 -
Molecular basis of celiac disease
Annu Rev Immunol, 18, 53-81
DOI 10.1146/annurev.immunol.18.1.53, PubMed 10837052
Publications 1999
-
A gene telomeric of the HLA class I region is involved in predisposition to both type 1 diabetes and coeliac disease
Tissue Antigens, 54 (2), 162-8
DOI 10.1034/j.1399-0039.1999.540207.x, PubMed 10488743 -
HLA binding and T cell recognition of a tissue transglutaminase-modified gliadin epitope
Eur J Immunol, 29 (8), 2506-14
DOI 10.1002/(SICI)1521-4141(199908)29:08<2506::AID-IMMU2506>3.0.CO;2-9, PubMed 10458765
Publications 1998
-
Major histocompatibility complex class II-dependent antigen presentation by human intestinal endothelial cells
Gastroenterology, 114 (4), 649-56
DOI 10.1016/s0016-5085(98)70578-5, PubMed 9516385 -
HLA restriction patterns of gliadin- and astrovirus-specific CD4+ T cells isolated in parallel from the small intestine of celiac disease patients
Tissue Antigens, 52 (5), 407-15
DOI 10.1111/j.1399-0039.1998.tb03066.x, PubMed 9864029 -
Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
Nat Med, 4 (6), 713-7
DOI 10.1038/nm0698-713, PubMed 9623982 -
CD4+ T cells with specific reactivity against astrovirus isolated from normal human small intestine
Gastroenterology, 114 (1), 115-22
DOI 10.1016/s0016-5085(98)70639-0, PubMed 9428225 -
Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease
Gastroenterology, 115 (3), 551-63
DOI 10.1016/s0016-5085(98)70134-9, PubMed 9721152 -
The P9 pocket of HLA-DQ2 (non-Aspbeta57) has no particular preference for negatively charged anchor residues found in other type 1 diabetes-predisposing non-Aspbeta57 MHC class II molecules
Int Immunol, 10 (8), 1229-36
DOI 10.1093/intimm/10.8.1229, PubMed 9723710 -
Identification of a gliadin T-cell epitope in coeliac disease: general importance of gliadin deamidation for intestinal T-cell recognition
Scand J Immunol, 48 (2), 111-5
DOI 10.1046/j.1365-3083.1998.00397.x, PubMed 9716100 -
Genetics of the immune response to gluten in coeliac disease
Dig Dis, 16 (6), 345-7
DOI 10.1159/000016889, PubMed 10207220 -
New tool to predict celiac disease on its way to the clinics
Gastroenterology, 115 (6), 1584-6
DOI 10.1016/s0016-5085(98)70040-x, PubMed 9834289 -
A peptide-binding assay for the disease-associated HLA-DQ8 molecule
Scand J Immunol, 47 (6), 561-7
DOI 10.1046/j.1365-3083.1998.00342.x, PubMed 9652824 -
Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin
Proc Natl Acad Sci U S A, 95 (17), 10050-4
DOI 10.1073/pnas.95.17.10050, PubMed 9707598
Publications 1997
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Heterogeneous reactivity patterns of HLA-DQ-restricted, small intestinal T-cell clones from patients with celiac disease
Gastroenterology, 112 (3), 752-9
DOI 10.1053/gast.1997.v112.pm9041236, PubMed 9041236 -
Gliadin specific, HLA DQ2-restricted T cells are commonly found in small intestinal biopsies from coeliac disease patients, but not from controls
Scand J Immunol, 46 (1), 103-8
PubMed 9246215 -
Gliadin specific, HLA DQ2-restricted T cells are commonly found in small intestinal biopsies from coeliac disease patients, but not from controls
Scand J Immunol, 46 (3), 103-9
DOI 10.1046/j.1365-3083.1997.d01-93.x, PubMed 9315123 -
Immunopathology of gluten-sensitive enteropathy
Springer Semin Immunopathol, 18 (4), 535-53
DOI 10.1007/BF00824057, PubMed 9144869 -
Autoantibodies in coeliac disease: tissue transglutaminase--guilt by association?
Gut, 41 (6), 851-2
DOI 10.1136/gut.41.6.851, PubMed 9462222 -
Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (alpha 1*0501, beta 1*02) or the HLA-DQ (alpha 1*03, beta 1*0302) heterodimers
Tissue Antigens, 49 (1), 29-34
DOI 10.1111/j.1399-0039.1997.tb02706.x, PubMed 9027962
Publications 1996
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Binding of peptides from the N-terminal region of alpha-gliadin to the celiac disease-associated HLA-DQ2 molecule assessed in biochemical and T cell assays
Clin Immunol Immunopathol, 79 (3), 288-93
DOI 10.1006/clin.1996.0081, PubMed 8635288 -
Both alpha and beta chain polymorphisms determine the specificity of the disease-associated HLA-DQ2 molecules, with beta chain residues being most influential
Immunogenetics, 45 (2), 142-50
DOI 10.1007/s002510050182, PubMed 8952964 -
Identification of a putative motif for binding of peptides to HLA-DQ2
Int Immunol, 8 (2), 177-82
DOI 10.1093/intimm/8.2.177, PubMed 8671602 -
HLA genotypes and the increased incidence of coeliac disease in Sweden
Scand J Gastroenterol, 31 (11), 1092-7
DOI 10.3109/00365529609036892, PubMed 8938902 -
The peptide binding motif of the disease associated HLA-DQ (alpha 1* 0501, beta 1* 0201) molecule
Eur J Immunol, 26 (11), 2764-72
DOI 10.1002/eji.1830261132, PubMed 8921967
Publications 1995
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Gliadin-specific T cell responses in peripheral blood of healthy individuals involve T cells restricted by the coeliac disease associated DQ2 heterodimer
Scand J Immunol, 42 (1), 166-70
DOI 10.1111/j.1365-3083.1995.tb03640.x, PubMed 7543212 -
DQCAR microsatellite polymorphisms in three selected HLA class II-associated diseases
Tissue Antigens, 46 (4), 299-304
DOI 10.1111/j.1399-0039.1995.tb02496.x, PubMed 8560448 -
Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma
Gut, 37 (6), 766-76
DOI 10.1136/gut.37.6.766, PubMed 8537046 -
HLA-DQ2-restricted T-cell recognition of gluten-derived peptides in celiac disease. Influence of amino acid substitutions in the membrane distal domain of DQ beta 1*0201
Hum Immunol, 42 (2), 145-53
DOI 10.1016/0198-8859(94)00086-6, PubMed 7744618 -
Histological changes in small bowel mucosa induced by gliadin sensitive T lymphocytes can be blocked by anti-interferon gamma antibody
Gut, 36 (6), 874-9
DOI 10.1136/gut.36.6.874, PubMed 7615276 -
Influence on antibody recognition of amino acid substitutions in the cleft of HLA-DQ2 molecules. Suggestive evidence of peptide-dependent epitopes
Hum Immunol, 44 (2), 63-9
DOI 10.1016/0198-8859(95)00047-8, PubMed 8847230 -
Characterization of an HLA-DQ2-specific monoclonal antibody. Influence of amino acid substitutions in DQ beta 1*0202
Hum Immunol, 42 (4), 319-27
DOI 10.1016/0198-8859(94)00110-c, PubMed 7558917
Publications 1994
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T cells recognize a peptide derived from alpha-gliadin presented by the celiac disease-associated HLA-DQ (alpha 1*0501, beta 1*0201) heterodimer
Hum Immunol, 39 (4), 243-52
DOI 10.1016/0198-8859(94)90267-4, PubMed 7520895 -
T cells from the peripheral blood of coeliac disease patients recognize gluten antigens when presented by HLA-DR, -DQ, or -DP molecules
Scand J Immunol, 39 (6), 567-74
DOI 10.1111/j.1365-3083.1994.tb03414.x, PubMed 8009173 -
Binding of peptides to HLA-DQ molecules: peptide binding properties of the disease-associated HLA-DQ(alpha 1*0501, beta 1*0201) molecule
Int Immunol, 6 (3), 453-61
DOI 10.1093/intimm/6.3.453, PubMed 8186196 -
Binding of ras oncogene peptides to purified HLA-DQ (alpha 1*0102, beta 1*0602) and -DR (alpha, beta 1*0101) molecules
Scand J Immunol, 40 (4), 468
DOI 10.1111/j.1365-3083.1994.tb03491.x, PubMed 7939420 -
Binding of ras oncogene peptides to purified HLA-DQ(alpha 1*0102,beta 1*0602) and -DR(alpha,beta 1*0101) molecules
Scand J Immunol, 39 (6), 607-12
DOI 10.1111/j.1365-3083.1994.tb03420.x, PubMed 8009176 -
Function of DQ2 and DQ8 as HLA susceptibility molecules in celiac disease
Hum Immunol, 41 (1), 24-7
DOI 10.1016/0198-8859(94)90079-5, PubMed 7836060 -
T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8
Hum Immunol, 41 (4), 285-91
DOI 10.1016/0198-8859(94)90047-7, PubMed 7883596
Publications 1993
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Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients
J Exp Med, 178 (1), 187-96
DOI 10.1084/jem.178.1.187, PubMed 8315377 -
On the HLA-DQ(alpha 1*0501, beta 1*0201)-associated susceptibility in celiac disease: a possible gene dosage effect of DQB1*0201
Tissue Antigens, 41 (4), 173-7
DOI 10.1111/j.1399-0039.1993.tb01998.x, PubMed 8362409 -
HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis
Gastroenterology, 105 (3), 910-22
DOI 10.1016/0016-5085(93)90912-v, PubMed 8359659
Publications 1992
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HLA-DR and -DQ genotypes of celiac disease patients serologically typed to be non-DR3 or non-DR5/7
Hum Immunol, 35 (3), 188-92
DOI 10.1016/0198-8859(92)90104-u, PubMed 1293082 -
Clustering of IgA-producing immunocytes related to HLA-DR-positive ducts in normal and inflamed salivary glands
Scand J Immunol, 35 (1), 43-51
DOI 10.1111/j.1365-3083.1992.tb02832.x, PubMed 1734495
Publications 1991
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Mucosal immunology and food antigens
Bibl Nutr Dieta (48), 30-54
DOI 10.1159/000420035, PubMed 1930122 -
Novel HLA-DR2 and -DR3 haplotypes among Norwegian Caucasians
Tissue Antigens, 37 (4), 165-7
DOI 10.1111/j.1399-0039.1991.tb01866.x, PubMed 1926125
Publications 1990
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T-cell recognition of HLA class II molecules induced by gamma-interferon on a colonic adenocarcinoma cell line (HT29)
Scand J Immunol, 31 (4), 469-75
DOI 10.1111/j.1365-3083.1990.tb02794.x, PubMed 2110380 -
T lymphocyte recognition of a celiac disease-associated cis- or trans-encoded HLA-DQ alpha/beta-heterodimer
J Immunol, 145 (1), 136-9
PubMed 1972714 -
The primary association of celiac disease to a given HLA-DQ alpha/beta heterodimer explains the divergent HLA-DR associations observed in various Caucasian populations
Tissue Antigens, 36 (3), 136-7
DOI 10.1111/j.1399-0039.1990.tb01816.x, PubMed 2278049 -
Susceptibility to develop celiac disease is primarily associated with HLA-DQ alleles
Hum Immunol, 29 (3), 157-65
DOI 10.1016/0198-8859(90)90111-2, PubMed 1980918 -
Two-colour immunofluorescence marker study of pleomorphic adenomas
Histochemistry, 93 (5), 459-68
DOI 10.1007/BF00266401, PubMed 2158957 -
Abundant dendritic cells express HLA-DR in pleomorphic adenomas
Virchows Arch B Cell Pathol Incl Mol Pathol, 59 (4), 195-203
DOI 10.1007/BF02899405, PubMed 1980169
Publications 1989
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T lymphocytes in human gut epithelium preferentially express the alpha/beta antigen receptor and are often CD45/UCHL1-positive
Scand J Immunol, 30 (1), 123-8
DOI 10.1111/j.1365-3083.1989.tb01196.x, PubMed 2526965 -
Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes
Gastroenterology, 97 (6), 1562-84
DOI 10.1016/0016-5085(89)90406-x, PubMed 2684725 -
Positive selection of Tac- (CD25) positive cells following T-cell activation. Use of immunomagnetic separation and implications for T-cell cloning
J Immunogenet, 16 (2), 185-91
DOI 10.1111/j.1744-313x.1989.tb00461.x, PubMed 2687389 -
Alloreactive T cells recognizing determinants dependent on the DQ beta chain of DQw2
Tissue Antigens, 34 (5), 312-6
DOI 10.1111/j.1399-0039.1989.tb01748.x, PubMed 2483467 -
Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer
J Exp Med, 169 (1), 345-50
DOI 10.1084/jem.169.1.345, PubMed 2909659 -
Molecular basis and functional importance of some disease-associated HLA polymorphisms
Tissue Antigens, 34 (1), 39-49
DOI 10.1111/j.1399-0039.1989.tb01716.x, PubMed 2683208 -
[Gene technology in immunologic research, diagnosis and treatment]
Tidsskr Nor Laegeforen, 109 (30), 3111-4
PubMed 2683198 -
Patients with multiple sclerosis carry DQB1 genes which encode shared polymorphic amino acid sequences
Hum Immunol, 25 (2), 103-10
DOI 10.1016/0198-8859(89)90074-8, PubMed 2737928
Publications 1988
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The poly-Ig receptor--functional aspects of secretory component expression
Adv Exp Med Biol, 237, 9-20
DOI 10.1007/978-1-4684-5535-9_2, PubMed 3151046 -
Interactions of lymphoid cells with the epithelial environment
Monogr Allergy, 24, 51-9
PubMed 3163099 -
Lymphoepithelial interactions in the mucosal immune system
Gut, 29 (8), 1116-30
DOI 10.1136/gut.29.8.1116, PubMed 3044933 -
Rapid selection of cultured cells with increased expression of a membrane marker (secretory component)
Int J Cancer, 42 (4), 638-41
DOI 10.1002/ijc.2910420428, PubMed 2459074 -
Tumor necrosis factor-alpha up-regulates expression of secretory component, the epithelial receptor for polymeric Ig
J Immunol, 140 (9), 3086-9
PubMed 3361127 -
T lymphocyte clones recognizing an HLA-DQw3.2-associated epitope involving residue 57 on the DQ beta chain
Hum Immunol, 22 (4), 235-46
DOI 10.1016/0198-8859(88)90003-1, PubMed 2459088 -
HLA-DQw3.1 and DQw3.2 associated exon polymorphisms detected by oligonucleotide probes
Tissue Antigens, 31 (4), 204-10
DOI 10.1111/j.1399-0039.1988.tb02082.x, PubMed 3406934 -
Expression of MHC class II determinants by jejunal epithelium in coeliac disease
J Pediatr Gastroenterol Nutr, 7 (1), 145-6
DOI 10.1097/00005176-198801000-00027, PubMed 3335977 -
Jejunal epithelium of patients with coeliac disease shows enhanced expression of MHC class II subregion products
Adv Exp Med Biol, 237, 689-93
DOI 10.1007/978-1-4684-5535-9_103, PubMed 3075870 -
T cell-epithelium interactions in relation to gut immunity
Monogr Allergy, 24, 60-5
PubMed 3129651 -
[Cancer and immune defense]
Tidsskr Nor Laegeforen, 108 (15), 1205-9
PubMed 3291190
Publications 1987
-
Production and secretion of immunoglobulins in the gastrointestinal tract
Ann Allergy, 59 (5 Pt 2), 21-39
PubMed 3318585 -
Immunoblotting detection of lectins in gluten and white rice flour
Biochem Biophys Res Commun, 142 (3), 717-23
DOI 10.1016/0006-291x(87)91473-2, PubMed 3827897 -
Determination of the HLA-DR profile of an HLA class II negative carcinoma cell line by restriction fragment length polymorphism (RFLP) analysis
Tissue Antigens, 29 (4), 186-94
DOI 10.1111/j.1399-0039.1987.tb01575.x, PubMed 2887045 -
Expression of major histocompatibility complex class II subregion products by jejunal epithelium in patients with coeliac disease
Scand J Immunol, 26 (5), 563-71
DOI 10.1111/j.1365-3083.1987.tb02290.x, PubMed 3500504 -
HLA class II profile of a human carcinoma cell line: detection on genomic level and after exposure to gamma-interferon
Transplant Proc, 19 (1 Pt 1), 215
PubMed 3152692 -
Induction of various HLA class II molecules in a human colonic adenocarcinoma cell line
Scand J Immunol, 25 (2), 175-80
DOI 10.1111/j.1365-3083.1987.tb01061.x, PubMed 2434988 -
Interferon-gamma enhances expression of secretory component, the epithelial receptor for polymeric immunoglobulins
J Immunol, 138 (12), 4303-6
PubMed 3108385 -
Synthesis of cytoplasmic and functional membrane SC induced by gamma-interferon
Adv Exp Med Biol, 216B, 1109-16
PubMed 3122531 -
Pleomorphic adenomas contain a keratin-negative population of HLA-DR-positive dendritic cells
Adv Exp Med Biol, 216A, 437-44
DOI 10.1007/978-1-4684-5344-7_51, PubMed 2446470
Publications 1986
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The role of the CD8-positive subset of T cells in proliferative responses to soluble antigens. II. CD8-positive cells are not responsible for DR-associated differences in responsiveness to mumps and Coxsackie B4
Scand J Immunol, 23 (4), 469-73
PubMed 3010444 -
The proliferative T-lymphocyte response to streptokinase
J Clin Lab Immunol, 20 (2), 69-74
PubMed 2942694 -
The role of the CD8-positive subset of T cells in proliferative responses to soluble antigens. I. Studies of healthy subjects, type 1 diabetics, and coeliac disease patients
Scand J Immunol, 23 (4), 461-7
DOI 10.1111/j.1365-3083.1986.tb03077.x, PubMed 3010443 -
Antibodies to wheat germ agglutinin in coeliac disease
Clin Exp Immunol, 63 (1), 95-100
PubMed 3754186 -
Serum antibodies to wheat germ agglutinin and gluten in patients with dermatitis herpetiformis
Arch Dermatol Res, 278 (6), 433-6
DOI 10.1007/BF00455158, PubMed 3789802
Publications 1985
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Lectin activity of gluten identified as wheat germ agglutinin
Biochem Biophys Res Commun, 130 (2), 867-72
DOI 10.1016/0006-291x(85)90496-6, PubMed 3839672 -
SUPPRESSOR-CELL ACTIVITY IN CELIAC-DISEASE
Lancet, 1 (8422), 229