Projects
- High throughput DNA sequencing of T-cell and B-cell receptors on single cell and bulk cell levels
- Transcriptome analysis of disease relevant effector immune cells (B cells and T cells)
- Development of novel diagnostic tools; detection of disease specific effector cells in peripheral blood and development of serological assays for immunoglobulin detection
- Characterization of models for breakage of B-cell tolerance by use of immunoglobulin knock-in mouse model • Characterization of the autoimmune B-cell response and biology of the autoantigen transglutaminase 2