Research area 3: Profiling of T-cell receptors as a tool to identify T-cell reactivities

The T-cell repertoire serves as a “fingerprint” of the immune response, and can reveal information about the nature of the antigens eliciting a T-cell response. In collaboration with clinical collaborators we have used the profiles of T-cell repertoires of patients with multiple sclerosis and with autoimmune liver disease to elucidate characteristics of targets of T cells in these diseases.

Selected references:

High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires.
Liaskou E, Klemsdal Henriksen EK, Holm K, Kaveh F, Hamm D, Fear J, Viken MK, Hov JR, Melum E, Robins H, Olweus J, Karlsen TH, Hirschfield GM.
Hepatology. 2016 May;63(5):1608-19. doi: 10.1002/hep.28116. Epub 2015 Sep 30.

Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease.
Henriksen EK, Jørgensen KK, Kaveh F, Holm K, Hamm D, Olweus J, Melum E, Chung BK, Eide TJ, Lundin KE, Boberg KM, Karlsen TH, Hirschfield GM, Liaskou E.
J Hepatol. 2017 Jan;66(1):116-122. doi: 10.1016/j.jhep.2016.09.002. Epub 2016 Sep 17.

High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8+ T cells.
Lossius A, Johansen JN, Vartdal F, Robins H, Jūratė Šaltytė B, Holmøy T, Olweus J.
Eur J Immunol. 2014 Nov;44(11):3439-52. doi: 10.1002/eji.201444662. Epub 2014 Sep 16.