Selected publications Olweus group

Ali M, Giannakopoulou E, Li Y, Lehander M, Virding Culleton S, Yang W, Knetter C, Odabasi MC, Bollineni RC, Yang X, Foldvari Z, Böschen ML, Taraldsrud E, Strønen E, Toebes M, Hillen A, Mazzi S, de Ru AH, Janssen GMC, Kolstad A, Tjønnfjord GE, Lie BA, Griffioen M, Lehmann S, Osnes LT et al. (2021)
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
Nat Biotechnol
DOI 10.1038/s41587-021-01089-x, PubMed 34873326


Bartok O, Pataskar A, Nagel R, Laos M, Goldfarb E, Hayoun D, Levy R, Körner PR, Kreuger IZM, Champagne J, Zaal EA, Bleijerveld OB, Huang X, Kenski J, Wargo J, Brandis A, Levin Y, Mizrahi O, Alon M, Lebon S, Yang W, Nielsen MM, Stern-Ginossar N, Altelaar M, Berkers CR et al. (2020)
Anti-tumour immunity induces aberrant peptide presentation in melanoma
Nature, 590 (7845), 332-337
DOI 10.1038/s41586-020-03054-1, PubMed 33328638


Ali M, Foldvari Z, Giannakopoulou E, Böschen ML, Strønen E, Yang W, Toebes M, Schubert B, Kohlbacher O, Schumacher TN, Olweus J (2019)
Induction of neoantigen-reactive T cells from healthy donors
Nat Protoc, 14 (6), 1926-1943
DOI 10.1038/s41596-019-0170-6, PubMed 31101906 

Here we provide a protocol for high-throughput discovery of neo-antigen reactive T cells and their targets for adoptive T cell therapy and vaccine design.


Olweus J(2017)
Manufacture of CAR-T cells in the body
Nat Biotechnol, 35 (6), 520-521
PubMed 28591119


Taraldsrud EFevang BJørgensen SF, Moltu K, Hilden VTaskén KAukrust PMyklebust JHOlweus J(2017)
Defective IL-4 signaling in T cells defines severe common variable immunodeficiency
J Autoimmun, 81, 110-119
PubMed 28476239 


Strønen E, Toebes M, Kelderman S, van Buuren MM, Yang W, van Rooij N, Donia M, Böschen MLLund-Johansen FOlweus J, Schumacher TN (2016)
Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
Science, 352 (6291), 1337-41
PubMed 27198675

We show that healthy donor T cells can recognize 5-fold more mutations than tumor-infiltrating T cells from the patient, and that donor T-cell receptors can mediate efficient and specific killing of patient tumor cells harboring the relevant mutations.
Commentaries: Science. 2016;352(6291):1275-1276, and N Engl J Med. 2017;376(5):491-493, and in Mol Ther 2016 Aug;24(7):1170-3


Liaskou E, Klemsdal Henriksen EK, Holm KKaveh F, Hamm D, Fear J, Viken MKHov JRMelum E, Robins H, Olweus JKarlsen TH, Hirschfield GM (2015)
High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
Hepatology, 63 (5), 1608-19
PubMed 26257205

We identify liver-infiltrating, disease-associated T cell clonotypes in two autoimmune liver diseases and in alcoholic liver disease, and evidence for antigen-driven clonal expansions.


Kolstad A, Kumari S, Walczak M, Madsbu U, Hagtvedt T, Bogsrud TV, Kvalheim G, Holte H, Aurlien E, Delabie J, Tierens A, Olweus J (2014)
Sequential intranodal immunotherapy induces antitumor immunity and correlated regression of disseminated follicular lymphoma
Blood, 125 (1), 82-9
PubMed 25293773

We demonstrate that the magnitude of anti-tumor CD8 T cell responses correlate with clinical responses to a novel immunotherapy.
Commentary in Blood 2015; 125(5) 5-7


Kumari SWälchli SFallang LE, Yang W, Lund-Johansen F, Schumacher TN, Olweus J (2013)
Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes
Proc Natl Acad Sci U S A, 111 (1), 403-8
PubMed 24344295


Abrahamsen IWStronen EWälchli S, Johansen JN, Kjellevoll S, Kumari S, Komada M, Gaudernack GTjonnfjord G, Toebes M, Schumacher TN, Lund-Johansen FOlweus J (2010)
Targeting B cell leukemia with highly specific allogeneic T cells with a public recognition motif
Leukemia, 24 (11), 1901-9
PubMed 20844564


Kvale EOFløisand YLund-Johansen FRollag HFarkas L, Ghanekar S, Brandtzaeg PJahnsen FLOlweus J (2006)
Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells
Blood, 109 (8), 3369-76
PubMed 17158235


Kvale EØDalgaard JLund-Johansen FRollag HFarkas LMidtvedt KJahnsen FLBrinchmann JEOlweus J (2005)
CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell-stimulatory capability upon infection
Blood, 107 (5), 2022-9
PubMed 16269620 

 
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