Ke Deng

  • Postdoc; PhD

 

 

Ke Completed his PhD evealuating key mechanisms that help prostate cancer cells survive under stress conditions. When cancer cells grow rapidly, they experience internal stress from making too many proteins. Ke discovered two genes (MTHFD2 and MOCOS) that cancer cells rely on to manage this stress, and when he blocked these genes in prostate cancer cells, tumour growth slowed significantly. Through extensive analysis, we found that MTHFD2 was involved in and regulated many other pathways to maintain cancer cell survival, while MOCOS helps regulate cellular building blocks and antioxidant responses. Blocking MOCOS disrupted DNA replication and weakened cancer cells' defences against damage. These findings are particularly significant as they suggest new treatment strategies, especially the possibility of combining MOCOS inhibition with other compounds, such as PARP inhibitors.

Ke is now working on understanding how to enhance Radiotherapy for cancer patients inhibiting key players in DNA damage repair.

 

Publications 2021

Pällmann N, Deng K, Livgård M, Tesikova M, Jin Y, Frengen NS, Kahraman N, Mokhlis HM, Ozpolat B, Kildal W, Danielsen HE, Fazli L, Rennie PS, Banerjee PP, Üren A, Jin Y, Kuzu OF, Saatcioglu F (2021)
Stress-Mediated Reprogramming of Prostate Cancer One-Carbon Cycle Drives Disease Progression
Cancer Res, 81 (15), 4066-4078
DOI 10.1158/0008-5472.CAN-20-3956, PubMed 34183356

Publications 2020

Yin YP, Shi WH, Deng K, Liu XL, Li H, Lv XT, Lui VWY, Ding C, Hong B, Lin WC (2020)
Combinations of proteasome inhibitors with obatoclax are effective for small cell lung cancer
Acta Pharmacol Sin, 42 (8), 1298-1310
DOI 10.1038/s41401-020-00544-w, PubMed 33139838

Publications 2019

Li H, Wang H, Deng K, Han W, Hong B, Lin W (2019)
The ratio of Bcl-2/Bim as a predictor of cisplatin response provides a rational combination of ABT-263 with cisplatin or radiation in small cell lung cancer
Cancer Biomark, 24 (1), 51-59
DOI 10.3233/CBM-181692, PubMed 30614795

Publications 2018

Deng K, Shen J, Wang W, Li M, Li H, Chen C, Zhao H, Zhang M, Xue T, Liu Q, Lui VWY, Hong B, Lin W (2018)
Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer
Cancer Biol Ther, 20 (1), 52-64
DOI 10.1080/15384047.2018.1504723, PubMed 30183476

Publications 2017

Hong B, Wang H, Deng K, Wang W, Dai H, Yan Lui VW, Lin W (2017)
Combination treatment of RAD001 and BEZ235 exhibits synergistic antitumor activity via down-regulation of p-4E-BP1/Mcl-1 in small cell lung cancer
Oncotarget, 8 (63), 106486-106498
DOI 10.18632/oncotarget.18984, PubMed 29290965

Wang H, Hong B, Li X, Deng K, Li H, Yan Lui VW, Lin W (2017)
JQ1 synergizes with the Bcl-2 inhibitor ABT-263 against MYCN-amplified small cell lung cancer
Oncotarget, 8 (49), 86312-86324
DOI 10.18632/oncotarget.21146, PubMed 29156797

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