Selected publications

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse
Taavitsainen S, Engedal N, […] Urbanucci A
Nature Communications volume 12, Article number: 5307 (2021)

Drivers of AR indifferent anti-androgen resistance in prostate cancer cells.
Handle F, Prekovic S, Helsen C, Van den Broeck T, Smeets E, Moris L, Eerlings R, Kharraz SE, Urbanucci A, Mills IG, Joniau S, Attard G, Claessens F. Sci Rep. 2019 Sep 24; 9 (1): 13786. doi: 10.1038 / s41598-019-50220-1. PMID: 31551480 Free Article

Chromatin reprogramming as an adaptation mechanism in advanced prostate cancer.
Braadland PR, Urbanucci A. Endocr Relat Cancer. 2019 Apr 1; ​​26 (4): R211-R235. doi: 10.1530 / ERC-18-0579. Review. PMID: 30844748

Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories.
Gerhauser C, Favero F, Risch T, Simon R, Feuerbach L, Assenov Y, Heckmann D, Sidiropoulos N, Waszak SM, Hübschmann D, UrbanucciA, Girma EG, Kuryshev V, Klimczak LJ, Saini N, Stütz AM, Weichenhan D, Böttcher LM, Toth R, Hendriksen JD, Koop C, Lutsik P, Matzk S, Warnatz HJ, Amstislavskiy V, Feuerstein C, Raeder B, Bogatyrova O, Schmitz EM, Hube-Magg C, Kluth M, Huland H, Graefen M, Lawerenz C, Henry GH, Yamaguchi TN, Malewska A, Meiners J, Schilling D, Reisinger E, Eils R, Schlesner M, Strand DW, Bristow RG, Boutros PC, von Kalle C, Gordenin D, Sültmann H, Brors B, Sauter G, Plass C, Yaspo ML, Korbel JO, Schlomm T, Weischenfeldt J. Cancer Cell. 2018 Dec 10; 34 (6): 996-1011.e8. doi: 10.1016 / j.ccell.2018.10.016. PMID: 30537516

The expression of AURKA is androgen regulated in castration-resistant prostate cancer.
Kivinummi K, Urbanucci A, Leinonen K, Tammela TLJ, Annala M, Isaacs WB, Bova GS, Nykter M, Visakorpi T. Sci Rep. 2017 Dec 21; 7 (1): 17978. doi: 10.1038 / s41598-017-18210-3. PMID: 29269934 Free PMC Article

Bromodomain-containing proteins in prostate cancer.
Urbanucci A, Mills IG. Mol Cell Endocrinol. 2018 Feb 15; 462 (Pt A): 31-40. doi: 10.1016 / j.mce.2017.06.007. Epub 2017 Jun 15. Review. PMID: 2862451

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer.
Urbanucci A, Barfeld SJ, Kytölä V, Itkonen HM, Coleman IM, Vodák D, Sjöblom L, Sheng X, Tolonen T, Minner S, Burdelski C, Kivinummi KK, Kohvakka A, Kregel S, Takhar M, Alshalalfa M, Davicioni E , Erho N, Lloyd P, Karnes RJ, Ross AE, Schaeffer EM, Vander Griend DJ, Knapp S, Corey E, Feng FY, Nelson PS, Saatcioglu F, Knudsen KE, Tammela TLJ, Sauter G, Schlomm T, Nykter M, Visakorpi T, Mills IG. Cell Rep. 2017 Jun 6; 19 (10): 2045-2059. doi: 10.1016 / j.celrep.2017.05.049. PMID: 28591577 Free PMC Article

c-Myc Antagonizes the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks.

Barfeld SJ, Urbanucci A, Itkonen HM, Fazli L, Hicks JL, Thiede B, Rennie PS, Yegnasubramanian S, DeMarzo AM, Mills IG. EBioMedicine. 2017 Apr; 18: 83-93. doi: 10.1016 / j.ebiom.2017.04.006. Epub 2017 Apr 5. PMID: 28412251 Free PMC Article

Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer.

Zuber V, Bettella F, Witoelar A; PRACTICAL Consortium; CRUK GWAS; BCAC Consortium; TRICL Consortium, Andreassen OA, Mills IG, Urbanucci A. BMC Genomics. 2017 Mar 31; 18 (1): 270. doi: 10.1186 / s12864-017-3620-y.
PMID: 28359301 Free PMC Article