Publications by Xavier Tekpli

54 publications found

Publications 2024

  1. Ankill J, Zhao Z, Tekpli X, Kure EH, Kristensen VN, Mathelier A, Fleischer T (2024)
    Integrative pan-cancer analysis reveals a common architecture of dysregulated transcriptional networks characterized by loss of enhancer methylation
    PLoS Comput Biol, 20 (11), e1012565
    DOI 10.1371/journal.pcbi.1012565, PubMed 39556603
  2. Fjermeros K, Ghannoum S, Geisler SB, Bhargava S, Tahiri A, Klajic J, Lüders T, Fongård M, Nawaz MS, Bosnjak-Olsen T, Buvarp UE, Rosenskiold AKJ, Nguyen NT, Sletbak TT, Seyedzadeh M, Selsås K, Porojnicu AC, Skjerven HK, Hovda T, Sahlberg KK, Torland LA, Lyngra M, Hammarström CL, Hönigsperger EB, Noone JC et al. (2024)
    The NEOLETRIB trial: neoadjuvant treatment with Letrozole and Ribociclib in ER-positive, HER2-negative breast cancer
    Future Oncol, 20 (32), 2457-2466
    DOI 10.1080/14796694.2024.2377531, PubMed 39073142
  3. Kildal W, Cyll K, Kalsnes J, Islam R, Julbø FM, Pradhan M, Ersvær E, Shepherd N, Vlatkovic L, OSBREAC, Tekpli X, Garred Ø, Kristensen GB, Askautrud HA, Hveem TS, Danielsen HE, OSBREAC - Oslo Breast Cancer Consortium (2024)
    Deep learning for automated scoring of immunohistochemically stained tumour tissue sections - Validation across tumour types based on patient outcomes
    Heliyon, 10 (13), e32529
    DOI 10.1016/j.heliyon.2024.e32529, PubMed 39040241
  4. Lind SM, Sletten M, Hellenes M, Mathelier A, Tekpli X, Tinholt M, Iversen N (2024)
    Coagulation factor V in breast cancer: a p53-regulated tumor suppressor and predictive marker for treatment response to chemotherapy
    J Thromb Haemost, 22 (6), 1569-1582
    DOI 10.1016/j.jtha.2024.02.008, PubMed 38382738
  5. Schmiester L, Brasó-Maristany F, González-Farré B, Pascual T, Gavilá J, Tekpli X, Geisler J, Kristensen VN, Frigessi A, Prat A, Köhn-Luque A (2024)
    Computational Model Predicts Patient Outcomes in Luminal B Breast Cancer Treated with Endocrine Therapy and CDK4/6 Inhibition
    Clin Cancer Res, 30 (17), 3779-3787
    DOI 10.1158/1078-0432.CCR-24-0244, PubMed 38922642
  6. Shahrouzi P, Azimzade Y, Brankiewicz-Kopcinska W, Bhatia S, Kunke D, Richard D, Tekpli X, Kristensen VN, Duijf PHG (2024)
    Loss of chromosome cytoband 13q14.2 orchestrates breast cancer pathogenesis and drug response
    Breast Cancer Res, 26 (1), 170
    DOI 10.1186/s13058-024-01924-4, PubMed 39605038
  7. Tinholt M, Tekpli X, Torland LA, Tahiri A, Geisler J, Kristensen V, Sandset PM, Iversen N (2024)
    The breast cancer coagulome in the tumor microenvironment and its role in prognosis and treatment response to chemotherapy
    J Thromb Haemost, 22 (5), 1319-1335
    DOI 10.1016/j.jtha.2024.01.003, PubMed 38237862
  8. Torland LA, Lai X, Kumar S, Riis MH, Geisler J, Lüders T, Tekpli X, Kristensen V, Sahlberg K, Tahiri A (2024)
    Benign breast tumors may arise on different immunological backgrounds
    Mol Oncol, 18 (10), 2495-2509
    DOI 10.1002/1878-0261.13655, PubMed 38757377

Publications 2023

  1. Heimli M, Flåm ST, Hjorthaug HS, Trinh D, Frisk M, Dumont KA, Ribarska T, Tekpli X, Saare M, Lie BA (2023)
    Multimodal human thymic profiling reveals trajectories and cellular milieu for T agonist selection
    Front Immunol, 13, 1092028
    DOI 10.3389/fimmu.2022.1092028, PubMed 36741401
  2. Heimli M, Tennebø Flåm S, Sagsveen Hjorthaug H, Bjørnstad PM, Chernigovskaya M, Le QK, Tekpli X, Greiff V, Lie BA (2023)
    Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq
    Sci Rep, 13 (1), 17714
    DOI 10.1038/s41598-023-44693-4, PubMed 37853083
  3. Levy-Jurgenson A, Tekpli X, Kristensen VN, Yakhini Z (2023)
    Analysis of Spatial Molecular Data
    Methods Mol Biol, 2614, 349-356
    DOI 10.1007/978-1-0716-2914-7_20, PubMed 36587134

Publications 2022

  1. Ankill J, Aure MR, Bjørklund S, Langberg S, Oslo Breast Cancer Consortium (OSBREAC) , Kristensen VN, Vitelli V, Tekpli X, Fleischer T (2022)
    Epigenetic alterations at distal enhancers are linked to proliferation in human breast cancer
    NAR Cancer, 4 (1), zcac008
    DOI 10.1093/narcan/zcac008, PubMed 35350772
  2. Bjørklund SS, Aure MR, Häkkinen J, Vallon-Christersson J, Kumar S, Evensen KB, Fleischer T, Tost J, OSBREAC, Sahlberg KK, Mathelier A, Bhanot G, Ganesan S, Tekpli X, Kristensen VN (2022)
    Subtype and cell type specific expression of lncRNAs provide insight into breast cancer
    Commun Biol, 5 (1), 834
    DOI 10.1038/s42003-022-03559-7, PubMed 35982125
  3. Lirussi L, Ayyildiz D, Liu Y, Montaldo NP, Carracedo S, Aure MR, Jobert L, Tekpli X, Touma J, Sauer T, Dalla E, Kristensen VN, Geisler J, Piazza S, Tell G, Nilsen H (2022)
    A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours
    Nucleic Acids Res, 50 (18), 10449-10468
    DOI 10.1093/nar/gkac807, PubMed 36156150
  4. Tellez-Gabriel M, Tekpli X, Reine TM, Hegge B, Nielsen SR, Chen M, Moi L, Normann LS, Busund LR, Calin GA, Mælandsmo GM, Perander M, Theocharis AD, Kolset SO, Knutsen E (2022)
    Serglycin Is Involved in TGF-β Induced Epithelial-Mesenchymal Transition and Is Highly Expressed by Immune Cells in Breast Cancer Tissue
    Front Oncol, 12, 868868
    DOI 10.3389/fonc.2022.868868, PubMed 35494005

Publications 2021

  1. Aure MR, Fleischer T, Bjørklund S, Ankill J, Castro-Mondragon JA, OSBREAC, Børresen-Dale AL, Tost J, Sahlberg KK, Mathelier A, Tekpli X, Kristensen VN (2021)
    Crosstalk between microRNA expression and DNA methylation drives the hormone-dependent phenotype of breast cancer
    Genome Med, 13 (1), 72
    DOI 10.1186/s13073-021-00880-4, PubMed 33926515
  2. Galili B, Tekpli X, Kristensen VN, Yakhini Z (2021)
    Efficient gene expression signature for a breast cancer immuno-subtype
    PLoS One, 16 (1), e0245215
    DOI 10.1371/journal.pone.0245215, PubMed 33434192
  3. Levy-Jurgenson A, Tekpli X, Yakhini Z (2021)
    Assessing heterogeneity in spatial data using the HTA index with applications to spatial transcriptomics and imaging
    Bioinformatics, 37 (21), 3796-3804
    DOI 10.1093/bioinformatics/btab569, PubMed 34358288
  4. Levy-Jurgenson A, Tekpli X, Yakhini Z (2021)
    Erratum to: Assessing heterogeneity in spatial data using the HTA index with applications to spatial transcriptomics and imaging
    Bioinformatics, 37 (22), 4296
    DOI 10.1093/bioinformatics/btab692, PubMed 34718412

Publications 2020

  1. Levy-Jurgenson A, Tekpli X, Kristensen VN, Yakhini Z (2020)
    Spatial transcriptomics inferred from pathology whole-slide images links tumor heterogeneity to survival in breast and lung cancer
    Sci Rep, 10 (1), 18802
    DOI 10.1038/s41598-020-75708-z, PubMed 33139755
  2. Tahiri A, Tekpli X, Satheesh SV, DeWijn R, Lüders T, Bukholm IR, Hurtado A, Geisler J, Kristensen VN (2020)
    Loss of progesterone receptor is associated with distinct tyrosine kinase profiles in breast cancer
    Breast Cancer Res Treat, 183 (3), 585-598
    DOI 10.1007/s10549-020-05763-7, PubMed 32710281
  3. Tinholt M, Stavik B, Tekpli X, Garred Ø, Borgen E, Kristensen V, Sahlberg KK, Sandset PM, Iversen N (2020)
    Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer
    Oncoimmunology, 9 (1), 1824644
    DOI 10.1080/2162402X.2020.1824644, PubMed 33457104
  4. von der Lippe Gythfeldt H, Lien T, Tekpli X, Silwal-Pandit L, Borgen E, Garred Ø, Skjerven H, Schlichting E, Lundgren S, Wist E, Naume B, Kristensen V, Børresen-Dale AL, Lingjaerde OC, Engebraaten O (2020)
    Immune phenotype of tumor microenvironment predicts response to bevacizumab in neoadjuvant treatment of ER-positive breast cancer
    Int J Cancer, 147 (9), 2515-2525
    DOI 10.1002/ijc.33108, PubMed 32488909
  5. Zhu Q, Tekpli X, Troyanskaya OG, Kristensen VN (2020)
    Subtype-specific transcriptional regulators in breast tumors subjected to genetic and epigenetic alterations
    Bioinformatics, 36 (4), 994-999
    DOI 10.1093/bioinformatics/btz709, PubMed 31529022

Publications 2019

  1. Nome ME, Euceda LR, Jabeen S, Debik J, Bathen TF, Giskeødegård GF, Taskén KA, Maelandsmo GM, Halvorsen B, Yndestad A, Borgen E, Garred Ø, Aukrust P, Ueland T, Engebraaten O, Kristensen VN, Tekpli X (2019)
    Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers
    Int J Cancer, 146 (1), 223-235
    DOI 10.1002/ijc.32638, PubMed 31444972
  2. Tekpli X, Lien T, Røssevold AH, Nebdal D, Borgen E, Ohnstad HO, Kyte JA, Vallon-Christersson J, Fongaard M, Due EU, Svartdal LG, Sveli MAT, Garred Ø, OSBREAC, Frigessi A, Sahlberg KK, Sørlie T, Russnes HG, Naume B, Kristensen VN (2019)
    An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
    Nat Commun, 10 (1), 5499
    DOI 10.1038/s41467-019-13329-5, PubMed 31796750

Publications 2018

  1. Jabeen S, Espinoza JA, Torland LA, Zucknick M, Kumar S, Haakensen VD, Lüders T, Engebraaten O, Børresen-Dale AL, Kyte JA, Gromov P, Naume B, Kristensen V, Gromova I, Tekpli X (2018)
    Noninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics
    Oncoimmunology, 8 (2), e1537691
    DOI 10.1080/2162402X.2018.1537691, PubMed 30713794
  2. Jabeen S, Zucknick M, Nome M, Dannenfelser R, Fleischer T, Kumar S, Lüders T, von der Lippe Gythfeldt H, Troyanskaya O, Kyte JA, Børresen-Dale AL, Naume B, Tekpli X, Engebraaten O, Kristensen V (2018)
    Serum cytokine levels in breast cancer patients during neoadjuvant treatment with bevacizumab
    Oncoimmunology, 7 (11), e1457598
    DOI 10.1080/2162402X.2018.1457598, PubMed 30377556

Publications 2017

  1. Fleischer T, Tekpli X, Mathelier A, Wang S, Nebdal D, Dhakal HP, Sahlberg KK, Schlichting E, Oslo Breast Cancer Research Consortium (OSBREAC), Børresen-Dale AL, Borgen E, Naume B, Eskeland R, Frigessi A, Tost J, Hurtado A, Kristensen VN (2017)
    DNA methylation at enhancers identifies distinct breast cancer lineages
    Nat Commun, 8 (1), 1379
    DOI 10.1038/s41467-017-00510-x, PubMed 29123100

Publications 2016

  1. Tekpli X, Skaug V, Bæra R, Phillips DH, Haugen A, Mollerup S (2016)
    Estrogen receptor expression and gene promoter methylation in non-small cell lung cancer - a short report
    Cell Oncol (Dordr), 39 (6), 583-589
    DOI 10.1007/s13402-016-0295-3, PubMed 27572263
  2. Tekpli X, Urbanucci A, Hashim A, Vågbø CB, Lyle R, Kringen MK, Staff AC, Dybedal I, Mills IG, Klungland A, Staerk J (2016)
    Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells
    Epigenetics Chromatin, 9, 21
    DOI 10.1186/s13072-016-0070-8, PubMed 27252783

Publications 2015

  1. Hardonnière K, Huc L, Podechard N, Fernier M, Tekpli X, Gallais I, Sergent O, Lagadic-Gossmann D (2015)
    Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential
    Toxicol In Vitro, 29 (7), 1597-608
    DOI 10.1016/j.tiv.2015.06.010, PubMed 26086121

Publications 2013

  1. Dendelé B, Tekpli X, Hardonnière K, Holme JA, Debure L, Catheline D, Arlt VM, Nagy E, Phillips DH, Ovrebø S, Mollerup S, Poët M, Chevanne M, Rioux V, Dimanche-Boitrel MT, Sergent O, Lagadic-Gossmann D (2013)
    Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway
    Chem Biol Interact, 207, 41-51
    DOI 10.1016/j.cbi.2013.11.002, PubMed 24246761

Publications 2012

  1. Tekpli X, Holme JA, Sergent O, Lagadic-Gossmann D (2012)
    Role for membrane remodeling in cell death: implication for health and disease
    Toxicology, 304, 141-57
    DOI 10.1016/j.tox.2012.12.014, PubMed 23287390
  2. Tekpli X, Huc L, Sergent O, Dendelé B, Dimanche-Boitrel MT, Holme JA, Lagadic-Gossmann D (2012)
    NHE-1 relocation outside cholesterol-rich membrane microdomains is associated with its benzo[a]pyrene-related apoptotic function
    Cell Physiol Biochem, 29 (5-6), 657-66
    DOI 10.1159/000171027, PubMed 22613966
  3. Tekpli X, Landvik NE, Anmarkud KH, Skaug V, Haugen A, Zienolddiny S (2012)
    DNA methylation at promoter regions of interleukin 1B, interleukin 6, and interleukin 8 in non-small cell lung cancer
    Cancer Immunol Immunother, 62 (2), 337-45
    DOI 10.1007/s00262-012-1340-3, PubMed 22923190
  4. Tekpli X, Landvik NE, Skaug V, Gulsvik A, Haugen A, Zienolddiny S (2012)
    Functional effect of polymorphisms in 15q25 locus on CHRNA5 mRNA, bulky DNA adducts and TP53 mutations
    Int J Cancer, 132 (8), 1811-20
    DOI 10.1002/ijc.27870, PubMed 23011884
  5. Tekpli X, Zienolddiny S, Skaug V, Stangeland L, Haugen A, Mollerup S (2012)
    DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung
    Int J Cancer, 131 (7), 1509-16
    DOI 10.1002/ijc.27421, PubMed 22213191

Publications 2011

  1. Dendelé B, Tekpli X, Sergent O, Dimanche-Boitrel MT, Holme JA, Huc L, Lagadic-Gossmann D (2011)
    Identification of the couple GSK3α/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis
    Toxicol In Vitro, 26 (1), 94-101
    DOI 10.1016/j.tiv.2011.11.001, PubMed 22100782
  2. Tekpli X, Holme JA, Sergent O, Lagadic-Gossmann D (2011)
    Importance of plasma membrane dynamics in chemical-induced carcinogenesis
    Recent Pat Anticancer Drug Discov, 6 (3), 347-53
    DOI 10.2174/157489211796957784, PubMed 21756246

Publications 2010

  1. Rebillard A, Jouan-Lanhouet S, Jouan E, Legembre P, Pizon M, Sergent O, Gilot D, Tekpli X, Lagadic-Gossmann D, Dimanche-Boitrel MT (2010)
    Cisplatin-induced apoptosis involves a Fas-ROCK-ezrin-dependent actin remodelling in human colon cancer cells
    Eur J Cancer, 46 (8), 1445-55
    DOI 10.1016/j.ejca.2010.01.034, PubMed 20202822

Publications 2009

  1. Asare N, Tekpli X, Rissel M, Solhaug A, Landvik N, Lecureur V, Podechard N, Brunborg G, Låg M, Lagadic-Gossmann D, Holme JA (2009)
    Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells
    Mutagenesis, 24 (6), 481-93
    DOI 10.1093/mutage/gep032, PubMed 19703935
  2. Beauchamp E, Tekpli X, Marteil G, Lagadic-Gossmann D, Legrand P, Rioux V (2009)
    N-Myristoylation targets dihydroceramide Delta4-desaturase 1 to mitochondria: partial involvement in the apoptotic effect of myristic acid
    Biochimie, 91 (11-12), 1411-9
    DOI 10.1016/j.biochi.2009.07.014, PubMed 19647031
  3. Tekpli X, Rissel M, Huc L, Catheline D, Sergent O, Rioux V, Legrand P, Holme JA, Dimanche-Boitrel MT, Lagadic-Gossmann D (2009)
    Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis
    Toxicol Appl Pharmacol, 243 (1), 68-76
    DOI 10.1016/j.taap.2009.11.014, PubMed 19931295

Publications 2008

  1. Asare N, Landvik NE, Lagadic-Gossmann D, Rissel M, Tekpli X, Ask K, Låg M, Holme JA (2008)
    1-Nitropyrene (1-NP) induces apoptosis and apparently a non-apoptotic programmed cell death (paraptosis) in Hepa1c1c7 cells
    Toxicol Appl Pharmacol, 230 (2), 175-86
    DOI 10.1016/j.taap.2008.02.015, PubMed 18417179
  2. Gorria M, Tekpli X, Rissel M, Sergent O, Huc L, Landvik N, Fardel O, Dimanche-Boitrel MT, Holme JA, Lagadic-Gossmann D (2008)
    A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells
    Toxicol Appl Pharmacol, 228 (2), 212-24
    DOI 10.1016/j.taap.2007.12.021, PubMed 18255115
  3. Lacroix J, Poët M, Huc L, Morello V, Djerbi N, Ragno M, Rissel M, Tekpli X, Gounon P, Lagadic-Gossmann D, Counillon L (2008)
    Kinetic analysis of the regulation of the Na+/H+ exchanger NHE-1 by osmotic shocks
    Biochemistry, 47 (51), 13674-85
    DOI 10.1021/bi801368n, PubMed 19035652
  4. Nourissat P, Travert M, Chevanne M, Tekpli X, Rebillard A, Le Moigne-Müller G, Rissel M, Cillard J, Dimanche-Boitrel MT, Lagadic-Gossmann D, Sergent O (2008)
    Ethanol induces oxidative stress in primary rat hepatocytes through the early involvement of lipid raft clustering
    Hepatology, 47 (1), 59-70
    DOI 10.1002/hep.21958, PubMed 18038449
  5. Tekpli X, Huc L, Lacroix J, Rissel M, Poët M, Noël J, Dimanche-Boitrel MT, Counillon L, Lagadic-Gossmann D (2008)
    Regulation of Na+/H+ exchanger 1 allosteric balance by its localization in cholesterol- and caveolin-rich membrane microdomains
    J Cell Physiol, 216 (1), 207-20
    DOI 10.1002/jcp.21395, PubMed 18264982

Publications 2007

  1. Holme JA, Gorria M, Arlt VM, Ovrebø S, Solhaug A, Tekpli X, Landvik NE, Huc L, Fardel O, Lagadic-Gossmann D (2007)
    Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells
    Chem Biol Interact, 167 (1), 41-55
    DOI 10.1016/j.cbi.2007.01.008, PubMed 17289009
  2. Huc L, Tekpli X, Holme JA, Rissel M, Solhaug A, Gardyn C, Le Moigne G, Gorria M, Dimanche-Boitrel MT, Lagadic-Gossmann D (2007)
    c-Jun NH2-terminal kinase-related Na+/H+ exchanger isoform 1 activation controls hexokinase II expression in benzo(a)pyrene-induced apoptosis
    Cancer Res, 67 (4), 1696-705
    DOI 10.1158/0008-5472.CAN-06-2327, PubMed 17308111
  3. Rebillard A, Tekpli X, Meurette O, Sergent O, LeMoigne-Muller G, Vernhet L, Gorria M, Chevanne M, Christmann M, Kaina B, Counillon L, Gulbins E, Lagadic-Gossmann D, Dimanche-Boitrel MT (2007)
    Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells
    Cancer Res, 67 (16), 7865-74
    DOI 10.1158/0008-5472.CAN-07-0353, PubMed 17699793

Publications 2006

  1. Gorria M, Tekpli X, Sergent O, Huc L, Gaboriau F, Rissel M, Chevanne M, Dimanche-Boitrel MT, Lagadic-Gossmann D (2006)
    Membrane fluidity changes are associated with benzo[a]pyrene-induced apoptosis in F258 cells: protection by exogenous cholesterol
    Ann N Y Acad Sci, 1090, 108-12
    DOI 10.1196/annals.1378.011, PubMed 17384252
  2. Huc L, Rissel M, Solhaug A, Tekpli X, Gorria M, Torriglia A, Holme JA, Dimanche-Boitrel MT, Lagadic-Gossmann D (2006)
    Multiple apoptotic pathways induced by p53-dependent acidification in benzo[a]pyrene-exposed hepatic F258 cells
    J Cell Physiol, 208 (3), 527-37
    DOI 10.1002/jcp.20686, PubMed 16688778