Xavier Tekpli

  • Project group leader, Researcher; PhD

 

Publications 2023

Heimli M, Flåm ST, Hjorthaug HS, Trinh D, Frisk M, Dumont KA, Ribarska T, Tekpli X, Saare M, Lie BA (2023)
Multimodal human thymic profiling reveals trajectories and cellular milieu for T agonist selection
Front Immunol, 13, 1092028
DOI 10.3389/fimmu.2022.1092028, PubMed 36741401

Levy-Jurgenson A, Tekpli X, Kristensen VN, Yakhini Z (2023)
Analysis of Spatial Molecular Data
Methods Mol Biol, 2614, 349-356
DOI 10.1007/978-1-0716-2914-7_20, PubMed 36587134

Publications 2022

Ankill J, Aure MR, Bjørklund S, Langberg S, Oslo Breast Cancer Consortium (OSBREAC) , Kristensen VN, Vitelli V, Tekpli X, Fleischer T (2022)
Epigenetic alterations at distal enhancers are linked to proliferation in human breast cancer
NAR Cancer, 4 (1), zcac008
DOI 10.1093/narcan/zcac008, PubMed 35350772

Bjørklund SS, Aure MR, Häkkinen J, Vallon-Christersson J, Kumar S, Evensen KB, Fleischer T, Tost J, OSBREAC, Sahlberg KK, Mathelier A, Bhanot G, Ganesan S, Tekpli X, Kristensen VN (2022)
Subtype and cell type specific expression of lncRNAs provide insight into breast cancer
Commun Biol, 5 (1), 834
DOI 10.1038/s42003-022-03559-7, PubMed 35982125

Lirussi L, Ayyildiz D, Liu Y, Montaldo NP, Carracedo S, Aure MR, Jobert L, Tekpli X, Touma J, Sauer T, Dalla E, Kristensen VN, Geisler J, Piazza S, Tell G, Nilsen H (2022)
A regulatory network comprising let-7 miRNA and SMUG1 is associated with good prognosis in ER+ breast tumours
Nucleic Acids Res, 50 (18), 10449-10468
DOI 10.1093/nar/gkac807, PubMed 36156150

Tellez-Gabriel M, Tekpli X, Reine TM, Hegge B, Nielsen SR, Chen M, Moi L, Normann LS, Busund LR, Calin GA, Mælandsmo GM, Perander M, Theocharis AD, Kolset SO, Knutsen E (2022)
Serglycin Is Involved in TGF-β Induced Epithelial-Mesenchymal Transition and Is Highly Expressed by Immune Cells in Breast Cancer Tissue
Front Oncol, 12, 868868
DOI 10.3389/fonc.2022.868868, PubMed 35494005

Publications 2021

Aure MR, Fleischer T, Bjørklund S, Ankill J, Castro-Mondragon JA, OSBREAC, Børresen-Dale AL, Tost J, Sahlberg KK, Mathelier A, Tekpli X, Kristensen VN (2021)
Crosstalk between microRNA expression and DNA methylation drives the hormone-dependent phenotype of breast cancer
Genome Med, 13 (1), 72
DOI 10.1186/s13073-021-00880-4, PubMed 33926515

Galili B, Tekpli X, Kristensen VN, Yakhini Z (2021)
Efficient gene expression signature for a breast cancer immuno-subtype
PLoS One, 16 (1), e0245215
DOI 10.1371/journal.pone.0245215, PubMed 33434192

Levy-Jurgenson A, Tekpli X, Yakhini Z (2021)
Assessing heterogeneity in spatial data using the HTA index with applications to spatial transcriptomics and imaging
Bioinformatics, 37 (21), 3796-3804
DOI 10.1093/bioinformatics/btab569, PubMed 34358288

Publications 2020

Levy-Jurgenson A, Tekpli X, Kristensen VN, Yakhini Z (2020)
Spatial transcriptomics inferred from pathology whole-slide images links tumor heterogeneity to survival in breast and lung cancer
Sci Rep, 10 (1), 18802
DOI 10.1038/s41598-020-75708-z, PubMed 33139755

Tahiri A, Tekpli X, Satheesh SV, DeWijn R, Lüders T, Bukholm IR, Hurtado A, Geisler J, Kristensen VN (2020)
Loss of progesterone receptor is associated with distinct tyrosine kinase profiles in breast cancer
Breast Cancer Res Treat, 183 (3), 585-598
DOI 10.1007/s10549-020-05763-7, PubMed 32710281

Tinholt M, Stavik B, Tekpli X, Garred Ø, Borgen E, Kristensen V, Sahlberg KK, Sandset PM, Iversen N (2020)
Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer
Oncoimmunology, 9 (1), 1824644
DOI 10.1080/2162402X.2020.1824644, PubMed 33457104

von der Lippe Gythfeldt H, Lien T, Tekpli X, Silwal-Pandit L, Borgen E, Garred Ø, Skjerven H, Schlichting E, Lundgren S, Wist E, Naume B, Kristensen V, Børresen-Dale AL, Lingjaerde OC, Engebraaten O (2020)
Immune phenotype of tumor microenvironment predicts response to bevacizumab in neoadjuvant treatment of ER-positive breast cancer
Int J Cancer, 147 (9), 2515-2525
DOI 10.1002/ijc.33108, PubMed 32488909

Zhu Q, Tekpli X, Troyanskaya OG, Kristensen VN (2020)
Subtype-specific transcriptional regulators in breast tumors subjected to genetic and epigenetic alterations
Bioinformatics, 36 (4), 994-999
DOI 10.1093/bioinformatics/btz709, PubMed 31529022

Publications 2019

Nome ME, Euceda LR, Jabeen S, Debik J, Bathen TF, Giskeødegård GF, Taskén KA, Maelandsmo GM, Halvorsen B, Yndestad A, Borgen E, Garred Ø, Aukrust P, Ueland T, Engebraaten O, Kristensen VN, Tekpli X (2019)
Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers
Int J Cancer, 146 (1), 223-235
DOI 10.1002/ijc.32638, PubMed 31444972

Tekpli X, Lien T, Røssevold AH, Nebdal D, Borgen E, Ohnstad HO, Kyte JA, Vallon-Christersson J, Fongaard M, Due EU, Svartdal LG, Sveli MAT, Garred Ø, OSBREAC, Frigessi A, Sahlberg KK, Sørlie T, Russnes HG, Naume B, Kristensen VN (2019)
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
Nat Commun, 10 (1), 5499
DOI 10.1038/s41467-019-13329-5, PubMed 31796750

Publications 2018

Jabeen S, Espinoza JA, Torland LA, Zucknick M, Kumar S, Haakensen VD, Lüders T, Engebraaten O, Børresen-Dale AL, Kyte JA, Gromov P, Naume B, Kristensen V, Gromova I, Tekpli X (2018)
Noninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics
Oncoimmunology, 8 (2), e1537691
DOI 10.1080/2162402X.2018.1537691, PubMed 30713794

Jabeen S, Zucknick M, Nome M, Dannenfelser R, Fleischer T, Kumar S, Lüders T, von der Lippe Gythfeldt H, Troyanskaya O, Kyte JA, Børresen-Dale AL, Naume B, Tekpli X, Engebraaten O, Kristensen V (2018)
Serum cytokine levels in breast cancer patients during neoadjuvant treatment with bevacizumab
Oncoimmunology, 7 (11), e1457598
DOI 10.1080/2162402X.2018.1457598, PubMed 30377556

Publications 2017

Fleischer T, Tekpli X, Mathelier A, Wang S, Nebdal D, Dhakal HP, Sahlberg KK, Schlichting E, Oslo Breast Cancer Research Consortium (OSBREAC), Børresen-Dale AL, Borgen E, Naume B, Eskeland R, Frigessi A, Tost J, Hurtado A, Kristensen VN (2017)
DNA methylation at enhancers identifies distinct breast cancer lineages
Nat Commun, 8 (1), 1379
DOI 10.1038/s41467-017-00510-x, PubMed 29123100

Publications 2016

Tekpli X, Skaug V, Bæra R, Phillips DH, Haugen A, Mollerup S (2016)
Estrogen receptor expression and gene promoter methylation in non-small cell lung cancer - a short report
Cell Oncol (Dordr), 39 (6), 583-589
DOI 10.1007/s13402-016-0295-3, PubMed 27572263

Tekpli X, Urbanucci A, Hashim A, Vågbø CB, Lyle R, Kringen MK, Staff AC, Dybedal I, Mills IG, Klungland A, Staerk J (2016)
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells
Epigenetics Chromatin, 9, 21
DOI 10.1186/s13072-016-0070-8, PubMed 27252783

Publications 2015

Hardonnière K, Huc L, Podechard N, Fernier M, Tekpli X, Gallais I, Sergent O, Lagadic-Gossmann D (2015)
Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential
Toxicol In Vitro, 29 (7), 1597-608
DOI 10.1016/j.tiv.2015.06.010, PubMed 26086121

Publications 2013

Dendelé B, Tekpli X, Hardonnière K, Holme JA, Debure L, Catheline D, Arlt VM, Nagy E, Phillips DH, Ovrebø S, Mollerup S, Poët M, Chevanne M, Rioux V, Dimanche-Boitrel MT, Sergent O, Lagadic-Gossmann D (2013)
Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway
Chem Biol Interact, 207, 41-51
DOI 10.1016/j.cbi.2013.11.002, PubMed 24246761

Tekpli X, Holme TA, Sergent O, Lagadic-Gossmann D (2013)
Role for membrane remodeling in cell death: Implication for health and disease
Toxicology, 304, 141-157
DOI 10.1016/j.tox.2012.12.014

Publications 2012

Dendele B, Tekpli X, Sergent O, Dimanche-Boitrel MT, Holme JA, Huc L, Lagadic-Gossmann D (2012)
Identification of the couple GSK3 alpha/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis
Toxicol. Vitro, 26 (1), 94-101
DOI 10.1016/j.tiv.2011.11.001

Tekpli X, Huc L, Sergent O, Dendele B, Dimanche-Boitrel MT, Holme JA, Lagadic-Gossmann D (2012)
NHE-1 Relocation Outside Cholesterol-rich Membrane Microdomains is Associated with its Benzo[a]pyrene-related Apoptotic Function
Cell. Physiol. Biochem., 29 (5-6), 657-666
DOI 10.1159/000171027

Tekpli X, Landvik NE, Anmarkud KH, Skaug V, Haugen A, Zienolddiny S (2012)
DNA methylation at promoter regions of interleukin 1B, interleukin 6, and interleukin 8 in non-small cell lung cancer
Cancer Immunol Immunother, 62 (2), 337-45
DOI 10.1007/s00262-012-1340-3, PubMed 22923190

Tekpli X, Landvik NE, Skaug V, Gulsvik A, Haugen A, Zienolddiny S (2012)
Functional effect of polymorphisms in 15q25 locus on CHRNA5 mRNA, bulky DNA adducts and TP53 mutations
Int J Cancer, 132 (8), 1811-20
DOI 10.1002/ijc.27870, PubMed 23011884

Tekpli X, Zienolddiny S, Skaug V, Stangeland L, Haugen A, Mollerup S (2012)
DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung
Int J Cancer, 131 (7), 1509-16
DOI 10.1002/ijc.27421, PubMed 22213191

Publications 2011

Tekpli X, Holme JA, Sergent O, Lagadic-Gossmann D (2011)
Importance of Plasma Membrane Dynamics in Chemical-Induced Carcinogenesis
Recent Patents Anti-Canc. Drug Discov., 6 (3), 347-353
DOI 10.2174/157489211796957784

Publications 2010

Tekpli X, Rissel M, Huc L, Catheline D, Sergent O, Rioux V, Legrand P, Holme JA, Dimanche-Boitrel MT, Lagadic-Gossmann D (2010)
Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis
Toxicol. Appl. Pharmacol., 243 (1), 68-76
DOI 10.1016/j.taap.2009.11.014

Publications 2009

Asare N, Tekpli X, Rissel M, Solhaug A, Landvik N, Lecureur V, Podechard N, Brunborg G, Låg M, Lagadic-Gossmann D, Holme JA (2009)
Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells
Mutagenesis, 24 (6), 481-93
DOI 10.1093/mutage/gep032, PubMed 19703935

Publications 2008

Asare N, Landvik NE, Lagadic-Gossmann D, Rissel M, Tekpli X, Ask K, Låg M, Holme JA (2008)
1-Nitropyrene (1-NP) induces apoptosis and apparently a non-apoptotic programmed cell death (paraptosis) in Hepa1c1c7 cells
Toxicol Appl Pharmacol, 230 (2), 175-86
DOI 10.1016/j.taap.2008.02.015, PubMed 18417179

Morgane G, Tekpli X, Rissel M, Sergent O, Huc L, Landvik N, Fardel O, Dimanche-Boitrel MT, Holme JA, Lagadic-Gossmann D (2008)
A new lactoferrin- and iron-dependent lysosomal death pathway is induced. by benzo[a]pyrene in hepatic epithelial cells
Toxicol. Appl. Pharmacol., 228 (2), 212-224
DOI 10.1016/j.taap.2007.12.021

Publications 2007

Holme JA, Gorria M, Arlt VM, Ovrebø S, Solhaug A, Tekpli X, Landvik NE, Huc L, Fardel O, Lagadic-Gossmann D (2007)
Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells
Chem Biol Interact, 167 (1), 41-55
DOI 10.1016/j.cbi.2007.01.008, PubMed 17289009

Huc L, Tekpli X, Holme JA, Rissel M, Solhaug A, Gardyn C, Le Moigne G, Gorria M, Dimanche-Boitrel MT, Lagadic-Gossmann D (2007)
c-Jun NH2-terminal kinase-related Na+/H+ exchanger isoform 1 activation controls hexokinase II expression in benzo(a)pyrene-induced apoptosis
Cancer Res, 67 (4), 1696-705
DOI 10.1158/0008-5472.CAN-06-2327, PubMed 17308111

Publications 2006

Huc L, Rissel M, Solhaug A, Tekpli X, Gorria M, Torriglia A, Holme JA, Dimanche-Boitrel MT, Lagadic-Gossmann D (2006)
Multiple apoptotic pathways induced by p53-dependent acidification in benzo[a]pyrene-exposed hepatic F258 cells
J Cell Physiol, 208 (3), 527-37
DOI 10.1002/jcp.20686, PubMed 16688778

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