Julie Elisabeth Heggelund

  • Postdoc

Publications 2023

Heggelund JE, Das S, Stamnaes J, Iversen R, Sollid LM (2023)
Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3
Nat Commun, 14 (1), 6216
DOI 10.1038/s41467-023-42004-z, PubMed 37798283

Publications 2019

Heggelund JE, Heim JB, Bajc G, Hodnik V, Anderluh G, Krengel U (2019)
Specificity of Escherichia coli Heat-Labile Enterotoxin Investigated by Single-Site Mutagenesis and Crystallography
Int J Mol Sci, 20 (3)
DOI 10.3390/ijms20030703, PubMed 30736336

Heim JB, Hodnik V, Heggelund JE, Anderluh G, Krengel U (2019)
Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site
Sci Rep, 9 (1), 12243
DOI 10.1038/s41598-019-48579-2, PubMed 31439922

Publications 2018

Bjerregaard-Andersen K, Johannesen H, Abdel-Rahman N, Heggelund JE, Hoås HM, Abraha F, Bousquet PA, Høydahl LS, Burschowsky D, Rojas G, Oscarson S, Løset GÅ, Krengel U (2018)
Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture
Sci Rep, 8 (1), 10836
DOI 10.1038/s41598-018-28918-5, PubMed 30022069

Publications 2017

Hatlem D, Heggelund JE, Burschowsky D, Krengel U, Kristiansen PE (2017)
1H, 13C, 15N backbone assignment of the human heat-labile enterotoxin B-pentamer and chemical shift mapping of neolactotetraose binding
Biomol NMR Assign, 11 (1), 99-104
DOI 10.1007/s12104-017-9728-9, PubMed 28243889

Heggelund JE, Mackenzie A, Martinsen T, Heim JB, Cheshev P, Bernardi A, Krengel U (2017)
Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics
Sci Rep, 7 (1), 2326
DOI 10.1038/s41598-017-02179-0, PubMed 28539625

Heggelund JE, Varrot A, Imberty A, Krengel U (2017)
Histo-blood group antigens as mediators of infections
Curr Opin Struct Biol, 44, 190-200
DOI 10.1016/j.sbi.2017.04.001, PubMed 28544984

Publications 2016

Heggelund JE, Burschowsky D, Bjørnestad VA, Hodnik V, Anderluh G, Krengel U (2016)
High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence
PLoS Pathog, 12 (4), e1005567
DOI 10.1371/journal.ppat.1005567, PubMed 27082955

Publications 2014

Vasile F, Reina JJ, Potenza D, Heggelund JE, Mackenzie A, Krengel U, Bernardi A (2014)
Comprehensive analysis of blood group antigen binding to classical and El Tor cholera toxin B-pentamers by NMR
Glycobiology, 24 (8), 766-78
DOI 10.1093/glycob/cwu040, PubMed 24829308

Publications 2012

Fladeby C, Vik ES, Laerdahl JK, Gran Neurauter C, Heggelund JE, Thorgaard E, Strøm-Andersen P, Bjørås M, Dalhus B, Alseth I (2012)
The human homolog of Escherichia coli endonuclease V is a nucleolar protein with affinity for branched DNA structures
PLoS One, 7 (11), e47466
DOI 10.1371/journal.pone.0047466, PubMed 23139746

Heggelund JE, Haugen E, Lygren B, Mackenzie A, Holmner Å, Vasile F, Reina JJ, Bernardi A, Krengel U (2012)
Both El Tor and classical cholera toxin bind blood group determinants
Biochem Biophys Res Commun, 418 (4), 731-5
DOI 10.1016/j.bbrc.2012.01.089, PubMed 22305717

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