Marie Fleur du Pré

  • Postdoc; PhD
 

Publications 2024

du Pre MF, Iversen R, Sollid LM (2024)
Coeliac disease: the paradox of diagnosing a food hypersensitivity disorder with autoantibodies
Gut, 73 (5), 844-853
DOI 10.1136/gutjnl-2023-331595, PubMed 38378252

Meling MT, Kleppa L, Besser HA, Khosla C, du Pré MF, Sollid LM (2024)
Enterocyte-derived and catalytically active transglutaminase 2 in the gut lumen of mice: Implications for celiac disease
Gastroenterology (in press)
DOI 10.1053/j.gastro.2024.05.029, PubMed 38825048

Publications 2022

Amundsen SF, Stamnaes J, du Pré MF, Sollid LM (2022)
Transglutaminase 2 affinity and enzyme-substrate intermediate stability as determining factors for T-cell responses to gluten peptides in celiac disease
Eur J Immunol, 52 (9), 1474-1481
DOI 10.1002/eji.202249862, PubMed 35715890

Lindstad CB, du Pré MF, Stamnaes J, Sollid LM (2022)
Injection of prototypic celiac anti-transglutaminase 2 antibodies in mice does not cause enteropathy
PLoS One, 17 (4), e0266543
DOI 10.1371/journal.pone.0266543, PubMed 35385534

Publications 2021

Dewan AE, Koentgen F, Johannesen MK, du Pre MF, Sollid LM (2021)
Generation of an HLA-DQ2.5 Knock-In Mouse
Immunohorizons, 5 (1), 25-32
DOI 10.4049/immunohorizons.2000107, PubMed 33461981

Frick R, Høydahl LS, Petersen J, du Pré MF, Kumari S, Berntsen G, Dewan AE, Jeliazkov JR, Gunnarsen KS, Frigstad T, Vik ES, Llerena C, Lundin KEA, Yaqub S, Jahnsen J, Gray JJ, Rossjohn J, Sollid LM, Sandlie I, Løset GÅ (2021)
A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation
Sci Immunol, 6 (62)
DOI 10.1126/sciimmunol.abg4925, PubMed 34417258

Lindstad CB, Dewan AE, Stamnaes J, Sollid LM, du Pré MF (2021)
TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease
PLoS One, 16 (11), e0259082
DOI 10.1371/journal.pone.0259082, PubMed 34731200

Publications 2020

du Pré MF, Blazevski J, Dewan AE, Stamnaes J, Kanduri C, Sandve GK, Johannesen MK, Lindstad CB, Hnida K, Fugger L, Melino G, Qiao SW, Sollid LM (2020)
B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2
J Exp Med, 217 (2)
DOI 10.1084/jem.20190860, PubMed 31727780

Iversen R, Amundsen SF, Kleppa L, du Pré MF, Stamnaes J, Sollid LM (2020)
Evidence That Pathogenic Transglutaminase 2 in Celiac Disease Derives From Enterocytes
Gastroenterology, 159 (2), 788-790
DOI 10.1053/j.gastro.2020.04.018, PubMed 32302613

Lindstad CB, Qiao SW, Johannesen MK, Fugger L, Sollid LM, du Pré MF (2020)
Characterization of T-cell receptor transgenic mice recognizing immunodominant HLA-DQ2.5-restricted gluten epitopes
Eur J Immunol, 51 (4), 1002-1005
DOI 10.1002/eji.202048859, PubMed 33368209

Publications 2017

Gunnarsen KS, Høydahl LS, Risnes LF, Dahal-Koirala S, Neumann RS, Bergseng E, Frigstad T, Frick R, du Pré MF, Dalhus B, Lundin KE, Qiao SW, Sollid LM, Sandlie I, Løset GÅ (2017)
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17)
DOI 10.1172/jci.insight.95193, PubMed 28878121

Snir O, Chen X, Gidoni M, du Pré MF, Zhao Y, Steinsbø Ø, Lundin KE, Yaari G, Sollid LM (2017)
Stereotyped antibody responses target posttranslationally modified gluten in celiac disease
JCI Insight, 2 (17)
DOI 10.1172/jci.insight.93961, PubMed 28878138

Veenbergen S, van Berkel LA, du Pré MF, Kozijn AE, Samsom JN (2017)
Monitoring and Modulation of Inducible Foxp3+ Regulatory T-Cell Differentiation in the Lymph Nodes Draining the Small Intestine and Colon
Methods Mol Biol, 1559, 241-254
DOI 10.1007/978-1-4939-6786-5_16, PubMed 28063048

Publications 2016

Hnida K, Stamnaes J, du Pré MF, Mysling S, Jørgensen TJ, Sollid LM, Iversen R (2016)
Epitope-dependent Functional Effects of Celiac Disease Autoantibodies on Transglutaminase 2
J Biol Chem, 291 (49), 25542-25552
DOI 10.1074/jbc.M116.738161, PubMed 27784785

van Leeuwen MA, Costes LMM, van Berkel LA, Simons-Oosterhuis Y, du Pré MF, Kozijn AE, Raatgeep HC, Lindenbergh-Kortleve DJ, van Rooijen N, Koning F, Samsom JN (2016)
Macrophage-mediated gliadin degradation and concomitant IL-27 production drive IL-10- and IFN-γ-secreting Tr1-like-cell differentiation in a murine model for gluten tolerance
Mucosal Immunol, 10 (3), 635-649
DOI 10.1038/mi.2016.76, PubMed 27579860

Publications 2015

du Pré MF, Sollid LM (2015)
T-cell and B-cell immunity in celiac disease
Best Pract Res Clin Gastroenterol, 29 (3), 413-23
DOI 10.1016/j.bpg.2015.04.001, PubMed 26060106

Sollid LM, Iversen R, Steinsbø Ø, Qiao SW, Bergseng E, Dørum S, du Pré MF, Stamnaes J, Christophersen A, Cardoso I, Hnida K, Chen X, Snir O, Lundin KEA (2015)
Small bowel, celiac disease and adaptive immunity
Dig Dis, 33 (2), 115-121
DOI 10.1159/000369512, PubMed 25925911

Stamnaes J, Iversen R, du Pré MF, Chen X, Sollid LM (2015)
Enhanced B-Cell Receptor Recognition of the Autoantigen Transglutaminase 2 by Efficient Catalytic Self-Multimerization
PLoS One, 10 (8), e0134922
DOI 10.1371/journal.pone.0134922, PubMed 26244572

Veenbergen S, van Berkel LA, du Pré MF, He J, Karrich JJ, Costes LM, Luk F, Simons-Oosterhuis Y, Raatgeep HC, Cerovic V, Cupedo T, Mowat AM, Kelsall BL, Samsom JN (2015)
Colonic tolerance develops in the iliac lymph nodes and can be established independent of CD103(+) dendritic cells
Mucosal Immunol, 9 (4), 894-906
DOI 10.1038/mi.2015.118, PubMed 26577569

Publications 2013

van Leeuwen MA, du Pré MF, van Wanrooij RL, de Ruiter LF, Raatgeep HR, Lindenbergh-Kortleve DJ, Mulder CJ, de Ridder L, Escher JC, Samsom JN (2013)
Changes in natural Foxp3(+)Treg but not mucosally-imprinted CD62L(neg)CD38(+)Foxp3(+)Treg in the circulation of celiac disease patients
PLoS One, 8 (7), e68432
DOI 10.1371/journal.pone.0068432, PubMed 23874626

Publications 2012

Di Niro R, Mesin L, Zheng NY, Stamnaes J, Morrissey M, Lee JH, Huang M, Iversen R, du Pré MF, Qiao SW, Lundin KE, Wilson PC, Sollid LM (2012)
High abundance of plasma cells secreting transglutaminase 2-specific IgA autoantibodies with limited somatic hypermutation in celiac disease intestinal lesions
Nat Med, 18 (3), 441-5
DOI 10.1038/nm.2656, PubMed 22366952

Publications 2011

Du Pré MF, Kozijn AE, van Berkel LA, ter Borg MN, Lindenbergh-Kortleve D, Jensen LT, Kooy-Winkelaar Y, Koning F, Boon L, Nieuwenhuis EE, Sollid LM, Fugger L, Samsom JN (2011)
Tolerance to ingested deamidated gliadin in mice is maintained by splenic, type 1 regulatory T cells
Gastroenterology, 141 (2), 610-20, 620.e1-2
DOI 10.1053/j.gastro.2011.04.048, PubMed 21683079

du Pré MF, van Berkel LA, Ráki M, van Leeuwen MA, de Ruiter LF, Broere F, Ter Borg MN, Lund FE, Escher JC, Lundin KE, Sollid LM, Kraal G, Nieuwenhuis EE, Samsom JN (2011)
CD62L(neg)CD38⁺ expression on circulating CD4⁺ T cells identifies mucosally differentiated cells in protein fed mice and in human celiac disease patients and controls
Am J Gastroenterol, 106 (6), 1147-59
DOI 10.1038/ajg.2011.24, PubMed 21386831

Publications 2010

du Pré MF, Samsom JN (2010)
Adaptive T-cell responses regulating oral tolerance to protein antigen
Allergy, 66 (4), 478-90
DOI 10.1111/j.1398-9995.2010.02519.x, PubMed 21143239

Publications 2009

Broere F, du Pré MF, van Berkel LA, Garssen J, Schmidt-Weber CB, Lambrecht BN, Hendriks RW, Nieuwenhuis EE, Kraal G, Samsom JN (2009)
Cyclooxygenase-2 in mucosal DC mediates induction of regulatory T cells in the intestine through suppression of IL-4
Mucosal Immunol, 2 (3), 254-64
DOI 10.1038/mi.2009.2, PubMed 19262503

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