Asbjørn Christophersen

  • Researcher; MD, PhD

Home page at K.G. Jebsen Coeliac Disease Research Centre, UiO

 

Publications 2021

Christophersen A, Zühlke S, Lund EG, Snir O, Dahal-Koirala S, Risnes LF, Jahnsen J, Lundin KEA, Sollid LM (2021)
Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T-Cell-Directed Therapies
Adv Sci (Weinh), 2102778
DOI 10.1002/advs.202102778, PubMed 34495570

Dahal-Koirala S, Risnes LF, Neumann RS, Christophersen A, Lundin KEA, Sandve GK, Qiao SW, Sollid LM (2021)
Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs
Front Immunol, 12, 639672
DOI 10.3389/fimmu.2021.639672, PubMed 33927715

Eggesbø LM, Risnes LF, Neumann RS, Lundin KEA, Christophersen A, Sollid LM (2021)
Single-cell TCR repertoire analysis reveals highly polyclonal composition of human intraepithelial CD8+ αβ T lymphocytes in untreated celiac disease
Eur J Immunol, 51 (6), 1542-1545
DOI 10.1002/eji.202048974, PubMed 33559929

Risnes LF, Eggesbø LM, Christophersen A, Sollid LM (2021)
Response to: "Some considerations about γδ and CD8+ T-cell responses in blood after gluten challenge in treated celiac disease"
Mucosal Immunol, 14 (5), 1216-1217
DOI 10.1038/s41385-021-00422-6, PubMed 34108593

Risnes LF, Eggesbø LM, Zühlke S, Dahal-Koirala S, Neumann RS, Lundin KEA, Christophersen A, Sollid LM (2021)
Circulating CD103+ γδ and CD8+ T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease
Mucosal Immunol, 14 (4), 842-851
DOI 10.1038/s41385-021-00385-8, PubMed 33654213

Publications 2020

Christophersen A (2020)
Peptide-MHC class I and class II tetramers: From flow to mass cytometry
HLA, 95 (3), 169-178
DOI 10.1111/tan.13789, PubMed 31891448

Publications 2019

Christophersen A, Lund EG, Snir O, Solà E, Kanduri C, Dahal-Koirala S, Zühlke S, Molberg Ø, Utz PJ, Rohani-Pichavant M, Simard JF, Dekker CL, Lundin KEA, Sollid LM, Davis MM (2019)
Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions
Nat Med, 25 (5), 734-737
DOI 10.1038/s41591-019-0403-9, PubMed 30911136

Christophersen A, Risnes LF, Dahal-Koirala S, Sollid LM (2019)
Therapeutic and Diagnostic Implications of T Cell Scarring in Celiac Disease and Beyond
Trends Mol Med, 25 (10), 836-852
DOI 10.1016/j.molmed.2019.05.009, PubMed 31331739

Eggesbø LM, Risnes LF, Neumann RS, Lundin KEA, Christophersen A, Sollid LM (2019)
Single-cell TCR sequencing of gut intraepithelial γδ T cells reveals a vast and diverse repertoire in celiac disease
Mucosal Immunol, 13 (2), 313-321
DOI 10.1038/s41385-019-0222-9, PubMed 31728027

Zühlke S, Risnes LF, Dahal-Koirala S, Christophersen A, Sollid LM, Lundin KE (2019)
CD38 expression on gluten-specific T cells is a robust marker of gluten re-exposure in coeliac disease
United European Gastroenterol J, 7 (10), 1337-1344
DOI 10.1177/2050640619874183, PubMed 31839959

Publications 2018

Dahal-Koirala S, Ciacchi L, Petersen J, Risnes LF, Neumann RS, Christophersen A, Lundin KEA, Reid HH, Qiao SW, Rossjohn J, Sollid LM (2018)
Discriminative T-cell receptor recognition of highly homologous HLA-DQ2-bound gluten epitopes
J Biol Chem, 294 (3), 941-952
DOI 10.1074/jbc.RA118.005736, PubMed 30455354

Risnes LF, Christophersen A, Dahal-Koirala S, Neumann RS, Sandve GK, Sarna VK, Lundin KE, Qiao SW, Sollid LM (2018)
Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease
J Clin Invest, 128 (6), 2642-2650
DOI 10.1172/JCI98819, PubMed 29757191

Tutturen AEV, Dørum S, Clancy T, Reims HM, Christophersen A, Lundin KEA, Sollid LM, de Souza GA, Stamnaes J (2018)
Characterization of the Small Intestinal Lesion in Celiac Disease by Label-Free Quantitative Mass Spectrometry
Am J Pathol, 188 (7), 1563-1579
DOI 10.1016/j.ajpath.2018.03.017, PubMed 29684362

Publications 2017

Sarna VK, Lundin KEA, Mørkrid L, Qiao SW, Sollid LM, Christophersen A (2017)
HLA-DQ-Gluten Tetramer Blood Test Accurately Identifies Patients With and Without Celiac Disease in Absence of Gluten Consumption
Gastroenterology, 154 (4), 886-896.e6
DOI 10.1053/j.gastro.2017.11.006, PubMed 29146521

Publications 2016

Christophersen A (2016)
[Not Available]
Tidsskr Nor Laegeforen, 136 (6), 555
DOI 10.4045/tidsskr.16.0106, PubMed 27052921

Christophersen A, Risnes LF, Bergseng E, Lundin KE, Sollid LM, Qiao SW (2016)
Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease
J Immunol, 196 (6), 2819-26
DOI 10.4049/jimmunol.1501152, PubMed 26895834

Publications 2015

Sollid LM, Iversen R, Steinsbø Ø, Qiao SW, Bergseng E, Dørum S, du Pré MF, Stamnaes J, Christophersen A, Cardoso I, Hnida K, Chen X, Snir O, Lundin KEA (2015)
Small bowel, celiac disease and adaptive immunity
Dig Dis, 33 (2), 115-121
DOI 10.1159/000369512, PubMed 25925911

Publications 2014

Christophersen A, Ráki M, Bergseng E, Lundin KE, Jahnsen J, Sollid LM, Qiao SW (2014)
Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge
United European Gastroenterol J, 2 (4), 268-78
DOI 10.1177/2050640614540154, PubMed 25083284

Dørum S, Bodd M, Fallang LE, Bergseng E, Christophersen A, Johannesen MK, Qiao SW, Stamnaes J, de Souza GA, Sollid LM (2014)
HLA-DQ molecules as affinity matrix for identification of gluten T cell epitopes
J Immunol, 193 (9), 4497-506
DOI 10.4049/jimmunol.1301466, PubMed 25261484

Publications 2013

Qiao SW, Christophersen A, Lundin KE, Sollid LM (2013)
Biased usage and preferred pairing of α- and β-chains of TCRs specific for an immunodominant gluten epitope in coeliac disease
Int Immunol, 26 (1), 13-9
DOI 10.1093/intimm/dxt037, PubMed 24038601

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