Publications 2024

Amrutkar M, Guttorm SJT, Finstadsveen AV, Labori KJ, Eide L, Rootwelt H, Elgstøen KBP, Gladhaug IP, Verbeke CS (2024)
Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer
Mol Oncol (in press)
DOI 10.1002/1878-0261.13759, PubMed 39545923

Yaqub S, Røsok B, Gladhaug IP, Labori KJ (2024)
Pancreatic duct occlusion with polychloroprene-based glue for the management of postoperative pancreatic fistula after pancreatoduodenectomy-an outdated approach?
Front Surg, 11, 1386708
DOI 10.3389/fsurg.2024.1386708, PubMed 38645504

Publications 2023

Amrutkar M, Berg K, Balto A, Skilbrei MG, Finstadsveen AV, Aasrum M, Gladhaug IP, Verbeke CS (2023)
Pancreatic stellate cell-induced gemcitabine resistance in pancreatic cancer is associated with LDHA- and MCT4-mediated enhanced glycolysis
Cancer Cell Int, 23 (1), 9
DOI 10.1186/s12935-023-02852-7, PubMed 36658582

Li Y, Amrutkar M, Finstadsveen AV, Dalen KT, Verbeke CS, Gladhaug IP (2023)
Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells
Cancer Cell Int, 23 (1), 276
DOI 10.1186/s12935-023-03138-8, PubMed 37978383

Publications 2022

Amrutkar M, Verbeke CS, Finstadsveen AV, Dorg L, Labori KJ, Gladhaug IP (2022)
Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma
Mol Oncol, 17 (1), 59-81
DOI 10.1002/1878-0261.13344, PubMed 36400567

Publications 2021

Amrutkar M, Gladhaug IP (2021)
Stellate Cells Aid Growth-Permissive Metabolic Reprogramming and Promote Gemcitabine Chemoresistance in Pancreatic Cancer
Cancers (Basel), 13 (4)
DOI 10.3390/cancers13040601, PubMed 33546284

Sántha P, Lenggenhager D, Finstadsveen A, Dorg L, Tøndel K, Amrutkar M, Gladhaug IP, Verbeke C (2021)
Morphological Heterogeneity in Pancreatic Cancer Reflects Structural and Functional Divergence
Cancers (Basel), 13 (4)
DOI 10.3390/cancers13040895, PubMed 33672734

Publications 2020

Amrutkar M, Larsen EK, Aasrum M, Finstadsveen AV, Andresen PA, Verbeke CS, Gladhaug IP (2020)
Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor
Cells, 9 (1)
DOI 10.3390/cells9010227, PubMed 31963309

Amrutkar M, Vethe NT, Verbeke CS, Aasrum M, Finstadsveen AV, Sántha P, Gladhaug IP (2020)
Differential Gemcitabine Sensitivity in Primary Human Pancreatic Cancer Cells and Paired Stellate Cells Is Driven by Heterogenous Drug Uptake and Processing
Cancers (Basel), 12 (12)
DOI 10.3390/cancers12123628, PubMed 33287390

Berg JP, Gladhaug IP (2020)
[The thesis defence is part of the doctoral degree examination]
Tidsskr Nor Laegeforen, 140 (9)
DOI 10.4045/tidsskr.20.0328, PubMed 32549008

Berg JP, Gladhaug IP (2020)
The Thesis is part of the doctoral degree
Tidsskr. Nor. Laegeforen., 140 (9), 866-867

Engebretsen E, Gladhaug IP (2020)
Is there room for a nursing science community in a medical faculty?
Tidsskr Nor Laegeforen, 140 (9)
DOI 10.4045/tidsskr.20.0311, PubMed 32549028

Engebretsen E, Gladhaug IP (2020)
Is there room for a nursing science professional environment at a medical faculty?
Tidsskr. Nor. Laegeforen., 140 (9), 862-863

Publications 2019

Amrutkar M, Aasrum M, Verbeke CS, Gladhaug IP (2019)
Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells
BMC Cancer, 19 (1), 596
DOI 10.1186/s12885-019-5803-1, PubMed 31208372

Berg JP, Gladhaug IP (2019)
[It is essential to fulfil the purpose of the trial lecture]
Tidsskr Nor Laegeforen, 139 (16)
DOI 10.4045/tidsskr.19.0646, PubMed 31686487

Berg JP, Gladhaug IP (2019)
It is important that the purpose of the trial lecture is fulfilled
Tidsskr. Nor. Laegeforen., 139 (16), 1534

Bowitz Lothe IM, Kleive D, Pomianowska E, Cvancarova M, Kure E, Dueland S, Gladhaug IP, Labori KJ (2019)
Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy
Pancreatology, 19 (2), 316-324
DOI 10.1016/j.pan.2019.01.019, PubMed 30713128

Kleive D, Labori KJ, Line PD, Gladhaug IP, Verbeke CS (2019)
Pancreatoduodenectomy with venous resection for ductal adenocarcinoma rarely achieves complete (R0) resection
HPB (Oxford), 22 (1), 50-57
DOI 10.1016/j.hpb.2019.05.005, PubMed 31186199

Lenggenhager D, Amrutkar M, Sántha P, Aasrum M, Löhr JM, Gladhaug IP, Verbeke CS (2019)
Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells
Cells, 8 (1)
DOI 10.3390/cells8010023, PubMed 30621293

Publications 2018

Kleive D, Sahakyan M, Søreide K, Brudvik KW, Line PD, Gladhaug IP, Labori KJ (2018)
Risk for hemorrhage after pancreatoduodenectomy with venous resection
Langenbecks Arch Surg, 403 (8), 949-957
DOI 10.1007/s00423-018-1721-y, PubMed 30397778

Publications 2017

Amrutkar M, Gladhaug IP (2017)
Pancreatic Cancer Chemoresistance to Gemcitabine
Cancers (Basel), 9 (11)
DOI 10.3390/cancers9110157, PubMed 29144412

Gladhaug IP, Skomedal T, Mørland J, Christoffersen T, Osnes JB (2017)
[Not Available]
Tidsskr Nor Laegeforen, 137 (14-15)
DOI 10.4045/tidsskr.17.0518, PubMed 28828823

Haugvik SP, Basim Ibrahim I, Hedenström P, Valente R, Hayes AJ, Siuka D, Gladhaug IP, Capurso G (2017)
Smoking, alcohol and family history of cancer as risk factors for small intestinal neuroendocrine tumors: a systematic review and meta-analysis
Scand J Gastroenterol, 52 (8), 797-802
DOI 10.1080/00365521.2017.1310290, PubMed 28394712

Kleive D, Berstad AE, Sahakyan MA, Verbeke CS, Naper C, Haugvik SP, Gladhaug IP, Line PD, Labori KJ (2017)
Portal vein reconstruction using primary anastomosis or venous interposition allograft in pancreatic surgery
J Vasc Surg Venous Lymphat Disord, 6 (1), 66-74
DOI 10.1016/j.jvsv.2017.09.003, PubMed 29128301

Kleive D, Sahakyan MA, Berstad AE, Verbeke CS, Gladhaug IP, Edwin B, Fosby B, Line PD, Labori KJ (2017)
Trends in indications, complications and outcomes for venous resection during pancreatoduodenectomy
Br J Surg, 104 (11), 1558-1567
DOI 10.1002/bjs.10603, PubMed 28815556

Tjomsland V, Aasrum M, Christoffersen T, Gladhaug IP (2017)
Functional heterogeneity in tumor-derived human pancreatic stellate cells: Differential expression of HGF and implications for mitogenic signaling and migration in pancreatic cancer cells
Oncotarget, 8 (42), 71672-71684
DOI 10.18632/oncotarget.17800, PubMed 29069737

Publications 2016

Haugvik SP, Kaemmerer D, Gaujoux S, Labori KJ, Verbeke CS, Gladhaug IP (2016)
Pathology and Surgical Treatment of High-Grade Pancreatic Neuroendocrine Carcinoma: an Evolving Landscape
Curr Oncol Rep, 18 (5), 28
DOI 10.1007/s11912-016-0518-9, PubMed 26984415

Haugvik SP, Vodák D, Haugom L, Hovig E, Gladhaug IP, Heim S, Micci F (2016)
Transcriptomic Profiling of Tumor Aggressiveness in Sporadic Nonfunctioning Pancreatic Neuroendocrine Neoplasms
Pancreas, 45 (8), 1196-203
DOI 10.1097/MPA.0000000000000610, PubMed 26918873

Johannessen LE, Panagopoulos I, Haugvik SP, Gladhaug IP, Heim S, Micci F (2016)
Upregulation of INS-IGF2 read-through expression and identification of a novel INS-IGF2 splice variant in insulinomas
Oncol Rep, 36 (5), 2653-2662
DOI 10.3892/or.2016.5132, PubMed 27667266

Kleive D, Berstad AE, Verbeke CS, Haugvik SP, Gladhaug IP, Line PD, Labori KJ (2016)
Cold-stored cadaveric venous allograft for superior mesenteric/portal vein reconstruction during pancreatic surgery
HPB (Oxford), 18 (7), 615-22
DOI 10.1016/j.hpb.2016.05.010, PubMed 27346143

Tjomsland V, Pomianowska E, Aasrum M, Sandnes D, Verbeke CS, Gladhaug IP (2016)
Profile of MMP and TIMP Expression in Human Pancreatic Stellate Cells: Regulation by IL-1α and TGFβ and Implications for Migration of Pancreatic Cancer Cells
Neoplasia, 18 (7), 447-56
DOI 10.1016/j.neo.2016.06.003, PubMed 27435927

Tjomsland V, Sandnes D, Pomianowska E, Cizmovic ST, Aasrum M, Brusevold IJ, Christoffersen T, Gladhaug IP (2016)
The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration
J Exp Clin Cancer Res, 35 (1), 122
DOI 10.1186/s13046-016-0400-5, PubMed 27473228

Verbeke CS, Gladhaug IP (2016)
Dissection of Pancreatic Resection Specimens
Surg Pathol Clin, 9 (4), 523-538
DOI 10.1016/j.path.2016.05.001, PubMed 27926357

Publications 2015

Haugvik SP, Hedenström P, Korsæth E, Valente R, Hayes A, Siuka D, Maisonneuve P, Gladhaug IP, Lindkvist B, Capurso G (2015)
Diabetes, smoking, alcohol use, and family history of cancer as risk factors for pancreatic neuroendocrine tumors: a systematic review and meta-analysis
Neuroendocrinology, 101 (2), 133-42
DOI 10.1159/000375164, PubMed 25613442

Haugvik SP, Janson ET, Österlund P, Langer SW, Falk RS, Labori KJ, Vestermark LW, Grønbæk H, Gladhaug IP, Sorbye H (2015)
Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study
Ann Surg Oncol, 23 (5), 1721-8
DOI 10.1245/s10434-015-5013-2, PubMed 26678407

Labori KJ, Katz MH, Tzeng CW, Bjørnbeth BA, Cvancarova M, Edwin B, Kure EH, Eide TJ, Dueland S, Buanes T, Gladhaug IP (2015)
Impact of early disease progression and surgical complications on adjuvant chemotherapy completion rates and survival in patients undergoing the surgery first approach for resectable pancreatic ductal adenocarcinoma - A population-based cohort study
Acta Oncol, 55 (3), 265-77
DOI 10.3109/0284186X.2015.1068445, PubMed 26213211

Labori KJ, Verbeke CS, Gladhaug IP (2015)
Information needs among patients and a surveillance strategy after surgery for pancreatic and periampullary cancer
HPB (Oxford), 17 (7), 659
DOI 10.1111/hpb.12411, PubMed 25776256

Otterdal K, Haukeland JW, Yndestad A, Dahl TB, Holm S, Segers FM, Gladhaug IP, Konopski Z, Damås JK, Halvorsen B, Aukrust P (2015)
Increased Serum Levels of LIGHT/TNFSF14 in Nonalcoholic Fatty Liver Disease: Possible Role in Hepatic Inflammation
Clin Transl Gastroenterol, 6 (7), e95
DOI 10.1038/ctg.2015.23, PubMed 26133108

Publications 2014

Haugvik SP, Gaujoux S, Røsok B, Gladhaug IP, Dousset B, Edwin B (2014)
Laparoscopic versus open pancreas resection for neuroendocrine tumours: need for evaluation of oncological outcomes
HPB (Oxford), 16 (9), 871
DOI 10.1111/hpb.12254, PubMed 25099232

Haugvik SP, Gorunova L, Haugom L, Eibak AM, Gladhaug IP, Heim S, Micci F (2014)
Loss of 11p11 is a frequent and early event in sporadic nonfunctioning pancreatic neuroendocrine neoplasms
Oncol Rep, 32 (3), 906-12
DOI 10.3892/or.2014.3328, PubMed 25018013

Pomianowska E, Sandnes D, Grzyb K, Schjølberg AR, Aasrum M, Tveteraas IH, Tjomsland V, Christoffersen T, Gladhaug IP (2014)
Inhibitory effects of prostaglandin E2 on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma
BMC Cancer, 14, 413
DOI 10.1186/1471-2407-14-413, PubMed 24912820

Pomianowska E, Schjølberg AR, Clausen OP, Gladhaug IP (2014)
COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis
BMC Cancer, 14, 458
DOI 10.1186/1471-2407-14-458, PubMed 24950702

Vedeld HM, Andresen K, Eilertsen IA, Nesbakken A, Seruca R, Gladhaug IP, Thiis-Evensen E, Rognum TO, Boberg KM, Lind GE (2014)
The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers
Int J Cancer, 136 (4), 844-53
DOI 10.1002/ijc.29039, PubMed 24948044

Publications 2013

Hagness M, Foss A, Line PD, Scholz T, Jørgensen PF, Fosby B, Boberg KM, Mathisen O, Gladhaug IP, Egge TS, Solberg S, Hausken J, Dueland S (2013)
Liver transplantation for nonresectable liver metastases from colorectal cancer
Ann Surg, 257 (5), 800-6
DOI 10.1097/SLA.0b013e3182823957, PubMed 23360920

Haugvik SP, Labori KJ, Waage A, Line PD, Mathisen Ø, Gladhaug IP (2013)
Pancreatic surgery with vascular reconstruction in patients with locally advanced pancreatic neuroendocrine tumors
J Gastrointest Surg, 17 (7), 1224-32
DOI 10.1007/s11605-013-2221-6, PubMed 23670519

Haugvik SP, Marangos IP, Røsok BI, Pomianowska E, Gladhaug IP, Mathisen O, Edwin B (2013)
Long-term outcome of laparoscopic surgery for pancreatic neuroendocrine tumors
World J Surg, 37 (3), 582-90
DOI 10.1007/s00268-012-1893-5, PubMed 23263686

Verbeke CS, Gladhaug IP (2013)
Authors' reply: Resection margin involvement and tumour origin in pancreatic head cancer (Br J Surg 2012; 99: 1036-1049)
Br J Surg, 100 (2), 299
DOI 10.1002/bjs.9016, PubMed 23239483

Publications 2012

Haugvik SP, Labori KJ, Edwin B, Mathisen Ø, Gladhaug IP (2012)
Surgical treatment of sporadic pancreatic neuroendocrine tumors: a state of the art review
ScientificWorldJournal, 2012, 357475
DOI 10.1100/2012/357475, PubMed 23304085

Haugvik SP, Røsok BI, Edwin B, Gladhaug IP, Mathisen Ø (2012)
Concomitant Nonfunctional Pancreatic Neuroendocrine Tumor and Gastric GIST in a Patient Without Neurofibromatosis Type 1
J Gastrointest Cancer, 43 Suppl 1, S171-4
DOI 10.1007/s12029-011-9344-3, PubMed 22083533

Marangos IP, Buanes T, Røsok BI, Kazaryan AM, Rosseland AR, Grzyb K, Villanger O, Mathisen Ø, Gladhaug IP, Edwin B (2012)
Laparoscopic resection of exocrine carcinoma in central and distal pancreas results in a high rate of radical resections and long postoperative survival
Surgery, 151 (5), 717-23
DOI 10.1016/j.surg.2011.12.016, PubMed 22284762

Pomianowska E, Grzyb K, Westgaard A, Clausen OP, Gladhaug IP (2012)
Reclassification of tumour origin in resected periampullary adenocarcinomas reveals underestimation of distal bile duct cancer
Eur J Surg Oncol, 38 (11), 1043-50
DOI 10.1016/j.ejso.2012.07.113, PubMed 22883964

Pomianowska E, Westgaard A, Mathisen Ø, Clausen OP, Gladhaug IP (2012)
Prognostic relevance of number and ratio of metastatic lymph nodes in resected pancreatic, ampullary, and distal bile duct carcinomas
Ann Surg Oncol, 20 (1), 233-41
DOI 10.1245/s10434-012-2592-z, PubMed 22893118

Verbeke CS, Gladhaug IP (2012)
Resection margin involvement and tumour origin in pancreatic head cancer
Br J Surg, 99 (8), 1036-49
DOI 10.1002/bjs.8734, PubMed 22517199

Westgaard A, Pomianowska E, Clausen OP, Gladhaug IP (2012)
Intestinal-type and pancreatobiliary-type adenocarcinomas: how does ampullary carcinoma differ from other periampullary malignancies?
Ann Surg Oncol, 20 (2), 430-9
DOI 10.1245/s10434-012-2603-0, PubMed 22956064

Publications 2011

Haukeland JW, Dahl TB, Yndestad A, Gladhaug IP, Løberg EM, Haaland T, Konopski Z, Wium C, Aasheim ET, Johansen OE, Aukrust P, Halvorsen B, Birkeland KI (2011)
Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies
Eur J Endocrinol, 166 (3), 503-10
DOI 10.1530/EJE-11-0864, PubMed 22170794

Verbeke CS, Knapp J, Gladhaug IP (2011)
Tumour growth is more dispersed in pancreatic head cancers than in rectal cancer: implications for resection margin assessment
Histopathology, 59 (6), 1111-21
DOI 10.1111/j.1365-2559.2011.04056.x, PubMed 22175891

Wedén S, Klemp M, Gladhaug IP, Møller M, Eriksen JA, Gaudernack G, Buanes T (2011)
Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras
Int J Cancer, 128 (5), 1120-8
DOI 10.1002/ijc.25449, PubMed 20473937

Westgaard A, Clausen OP, Gladhaug IP (2011)
Survival estimates after pancreatoduodenectomy skewed by non-standardized histopathology reports
APMIS, 119 (10), 689-700
DOI 10.1111/j.1600-0463.2011.02783.x, PubMed 21917006

Publications 2010

Dahl TB, Haukeland JW, Yndestad A, Ranheim T, Gladhaug IP, Damås JK, Haaland T, Løberg EM, Arntsen B, Birkeland K, Bjøro K, Ulven SM, Konopski Z, Nebb HI, Aukrust P, Halvorsen B (2010)
Intracellular nicotinamide phosphoribosyltransferase protects against hepatocyte apoptosis and is down-regulated in nonalcoholic fatty liver disease
J Clin Endocrinol Metab, 95 (6), 3039-47
DOI 10.1210/jc.2009-2148, PubMed 20392873

Gladhaug IP, Westgaard A, Schjølberg AR, Burum-Auensen E, Pomianowska E, Clausen OP (2010)
Spindle proteins in resected pancreatic head adenocarcinomas: BubR1 is an independent prognostic factor in pancreatobiliary-type tumours
Histopathology, 56 (3), 345-55
DOI 10.1111/j.1365-2559.2010.03489.x, PubMed 20459534

Pomianowska E, Gladhaug IP, Grzyb K, Røsok BI, Edwin B, Bergestuen DS, Mathisen O (2010)
Survival following resection of pancreatic endocrine tumors: importance of R-status and the WHO and TNM classification systems
Scand J Gastroenterol, 45 (7-8), 971-9
DOI 10.3109/00365521003782363, PubMed 20441530

Publications 2009

Mathisen Ø, Dorenberg E, Edwin B, Gladhaug I, Hafsahl G, Røkke O (2009)
[Portal vein embolization before surgery for liver tumours]
Tidsskr Nor Laegeforen, 129 (1), 29-32
DOI 10.4045/tidsskr.2009.32875, PubMed 19119294

Westgaard A, Larønningen S, Mellem C, Eide TJ, Clausen OP, Møller B, Gladhaug IP (2009)
Are survival predictions reliable? Hospital volume versus standardisation of histopathologic reporting for accuracy of survival estimates after pancreatoduodenectomy for adenocarcinoma
Eur J Cancer, 45 (16), 2850-9
DOI 10.1016/j.ejca.2009.03.019, PubMed 19376696

Westgaard A, Schjølberg AR, Cvancarova M, Eide TJ, Clausen OP, Gladhaug IP (2009)
Differentiation markers in pancreatic head adenocarcinomas: MUC1 and MUC4 expression indicates poor prognosis in pancreatobiliary differentiated tumours
Histopathology, 54 (3), 337-47
DOI 10.1111/j.1365-2559.2009.03227.x, PubMed 19236510

Yndestad A, Haukeland JW, Dahl TB, Bjøro K, Gladhaug IP, Berge C, Damås JK, Haaland T, Løberg EM, Linnestad P, Birkeland K, Konopski Z, Halvorsen B, Berge RK, Aukrust P (2009)
A complex role of activin A in non-alcoholic fatty liver disease
Am J Gastroenterol, 104 (9), 2196-205
DOI 10.1038/ajg.2009.318, PubMed 19532130

Publications 2008

Frich L, Brabrand K, Aaløkken TM, Edwin B, Gladhaug IP (2008)
[Radiofrequency ablation of colorectal liver metastases]
Tidsskr Nor Laegeforen, 128 (1), 57-60
PubMed 18183060

Lerdal A, Gladhaug IP, Granli G, Thune I, Larsson G, Haugland T, Borgheim RG, Øhrn R (2008)
Nevroendokrin kreft: et informasjonshefte til pasienter og pårørende
Rikshospitalet, Oslo, 55 bl.
BIBSYS 091737575

Westgaard A, Tafjord S, Farstad IN, Cvancarova M, Eide TJ, Mathisen O, Clausen OP, Gladhaug IP (2008)
Resectable adenocarcinomas in the pancreatic head: the retroperitoneal resection margin is an independent prognostic factor
BMC Cancer, 8, 5
DOI 10.1186/1471-2407-8-5, PubMed 18194510

Westgaard A, Tafjord S, Farstad IN, Cvancarova M, Eide TJ, Mathisen O, Clausen OP, Gladhaug IP (2008)
Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma
BMC Cancer, 8, 170
DOI 10.1186/1471-2407-8-170, PubMed 18547417

Publications 2007

Frich L, Hagen G, Brabrand K, Edwin B, Mathisen O, Aaløkken TM, Gladhaug IP (2007)
Local tumor progression after radiofrequency ablation of colorectal liver metastases: evaluation of ablative margin and three-dimensional volumetric analysis
J Vasc Interv Radiol, 18 (9), 1134-40
DOI 10.1016/j.jvir.2007.06.007, PubMed 17804776

Frich L, Halvorsen PS, Skulstad H, Damås JK, Gladhaug IP (2007)
Microbubbles in the pulmonary artery generated during experimental hepatic radiofrequency ablation is correlated with increased pulmonary arterial pressure
J Vasc Interv Radiol, 18 (3), 437-42
DOI 10.1016/j.jvir.2006.12.010, PubMed 17377191

Publications 2006

Frich L, Bjørnland K, Pettersen S, Clausen OP, Gladhaug IP (2006)
Increased activity of matrix metalloproteinase 2 and 9 after hepatic radiofrequency ablation
J Surg Res, 135 (2), 297-304
DOI 10.1016/j.jss.2006.05.010, PubMed 16934296

Frich L, Hol PK, Roy S, Mala T, Edwin B, Clausen OP, Gladhaug IP (2006)
Experimental hepatic radiofrequency ablation using wet electrodes: electrode-to-vessel distance is a significant predictor for delayed portal vein thrombosis
Eur Radiol, 16 (9), 1990-9
DOI 10.1007/s00330-006-0177-6, PubMed 16541225

Frich L, Mala T, Gladhaug IP (2006)
Hepatic radiofrequency ablation using perfusion electrodes in a pig model: effect of the Pringle manoeuvre
Eur J Surg Oncol, 32 (5), 527-32
DOI 10.1016/j.ejso.2006.02.021, PubMed 16595167

Publications 2005

Frich L, Edwin B, Brabrand K, Rosseland AR, Mala T, Mathisen O, Gladhaug I (2005)
Gastric perforation after percutaneous radiofrequency ablation of a colorectal liver metastasis in a patient with adhesions in the peritoneal cavity
AJR Am J Roentgenol, 184 (3 Suppl), S120-2
DOI 10.2214/ajr.184.3_supplement.0184s120, PubMed 15728002

Mala T, Edwin B, Rosseland AR, Gladhaug I, Fosse E, Mathisen O (2005)
Laparoscopic liver resection: experience of 53 procedures at a single center
J Hepatobiliary Pancreat Surg, 12 (4), 298-303
DOI 10.1007/s00534-005-0974-3, PubMed 16133696

Publications 2004

Edwin B, Mala T, Mathisen Ø, Gladhaug I, Buanes T, Lunde OC, Søreide O, Bergan A, Fosse E (2004)
Laparoscopic resection of the pancreas: a feasibility study of the short-term outcome
Surg Endosc, 18 (3), 407-11
DOI 10.1007/s00464-003-9007-y, PubMed 14752628

Edwin BG, Mala T, Mathisen Ø, Gladhaug I, Buanes T, Lunde OC, Søreide O, Bergan A, Fosse E (2004)
Laparoscopicresection of the pancreas: a feasibility study of short-term outcome
In Surgical endoscopy, Springer International, Berlin, 18(2004)3, S. 407-11
BIBSYS 051908484

Frich L, Bjørnerud A, Fossheim S, Tillung T, Gladhaug I (2004)
Experimental application of thermosensitive paramagnetic liposomes for monitoring magnetic resonance imaging guided thermal ablation
Magn Reson Med, 52 (6), 1302-9
DOI 10.1002/mrm.20289, PubMed 15562487

Mala T, Edwin B, Mathisen Ø, Tillung T, Fosse E, Bergan A, SØreide O, Gladhaug I (2004)
Cryoablation of colorectal liver metastases: minimally invasive tumour control
Scand J Gastroenterol, 39 (6), 571-8
DOI 10.1080/00365520410000510, PubMed 15223683

Stensvold E, Aass N, Gladhaug I, Stenwig AE, Claussen OP, Fosså SD (2004)
Erroneous diagnosis of pancreatic cancer after radiotherapy of testicular cancer
Eur J Surg Oncol, 30 (3), 352-5
DOI 10.1016/j.ejso.2003.09.006, PubMed 15028321

Publications 2003

Mala T, Edwin B, Tillung T, Kristian Hol P, Søreide O, Gladhaug I (2003)
Percutaneous cryoablation of colorectal liver metastases: potentiated by two consecutive freeze-thaw cycles
Cryobiology, 46 (1), 99-102
DOI 10.1016/s0011-2240(02)00163-3, PubMed 12623032

Mala T, Frich L, Aurdal L, Clausen OP, Edwin B, Soreide O, Gladhaug I (2003)
Intraoperative contrast-enhanced MR-imaging as predictor of tissue damage during cryoablation of porcine liver
Magn Reson Imaging, 21 (7), 733-40
DOI 10.1016/s0730-725x(03)00176-0, PubMed 14559337

Mala T, Frich L, Aurdal L, Clausen OP, Edwin B, Søreide O, Gladhaug IP (2003)
Hepatic vascular inflow occlusion enhances tissue destruction during cryoablation of porcine liver
J Surg Res, 115 (2), 265-71
DOI 10.1016/j.jss.2003.07.009, PubMed 14697293

Publications 2002

Mala T, Edwin B, Gladhaug I, Fosse E, Søreide O, Bergan A, Mathisen O (2002)
A comparative study of the short-term outcome following open and laparoscopic liver resection of colorectal metastases
Surg Endosc, 16 (7), 1059-63
DOI 10.1007/s00464-001-9176-5, PubMed 12165823

Mala T, Edwin B, Gladhaug I, Søreide O, Fosse E, Mathisen Ø, Bergan A (2002)
[Laparoscopic resection of the liver]
Tidsskr Nor Laegeforen, 122 (29), 2768-71
PubMed 12523141

Publications 2001

Edwin B, Mala T, Gladhaug I, Fosse E, Mathisen Y, Bergan A, Søreide O (2001)
Liver tumors and minimally invasive surgery: a feasibility study
J Laparoendosc Adv Surg Tech A, 11 (3), 133-9
DOI 10.1089/10926420152389260, PubMed 11441989

Gjertsen MK, Buanes T, Rosseland AR, Bakka A, Gladhaug I, Søreide O, Eriksen JA, Møller M, Baksaas I, Lothe RA, Saeterdal I, Gaudernack G (2001)
Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma
Int J Cancer, 92 (3), 441-50
DOI 10.1002/ijc.1205, PubMed 11291084

Mala T, Bergan A, Edwin B, Gladhaug I, Mathisen Ø (2001)
[Liver resection--indications and results]
Tidsskr Nor Laegeforen, 121 (21), 2476-80
PubMed 11875922

Mala T, Edwin B, Samset E, Gladhaug I, Hol PK, Fosse E, Mathisen O, Bergan A, Søreide O (2001)
Magnetic-resonance-guided percutaneous cryoablation of hepatic tumours
Eur J Surg, 167 (8), 610-7
DOI 10.1080/110241501753171227, PubMed 11716448

Mala T, Frich L, Edwin B, Samset E, Hol PK, Fosse E, Mathisen Ø, Bergan A, Søreide O, Gladhaug I (2001)
[Cryoablation--a treatment option for inoperable liver tumors?]
Tidsskr Nor Laegeforen, 121 (21), 2510-5
PubMed 11875929

Mala T, Samset E, Aurdal L, Gladhaug I, Edwin B, Søreide O (2001)
Magnetic resonance imaging-estimated three-dimensional temperature distribution in liver cryolesions: a study of cryolesion characteristics assumed necessary for tumor ablation
Cryobiology, 43 (3), 268-75
DOI 10.1006/cryo.2001.2351, PubMed 11888220

Samset E, Mala T, Edwin B, Gladhaug I, Søreide O, Fosse E (2001)
Validation of estimated 3D temperature maps during hepatic cryo surgery
Magn Reson Imaging, 19 (5), 715-21
DOI 10.1016/s0730-725x(01)00389-7, PubMed 11672630

Publications 2000

Bergan A, Gladhaug IP, Schjolberg A, Bergan AB, Clausen OP (2000)
p53 accumulation confers prognostic information in resectable adenocarcinomas with ductal but not with intestinal differentiation in the pancreatic head
Int J Oncol, 17 (5), 921-6
DOI 10.3892/ijo.17.5.921, PubMed 11029493

Publications 1998

Fiane AE, Videm V, Mellbye OJ, Foerster A, Geiran OR, Gladhaug IP, Svennevig JL, Mollnes TE (1998)
Immunoglobulin prolongs survival of pig kidneys perfused ex vivo with human blood
Scand J Immunol, 47 (6), 568-74
DOI 10.1046/j.1365-3083.1998.00341.x, PubMed 9652825

Publications 1992

Gladhaug IP, Refsnes M, Christoffersen T (1992)
Regulation of surface expression of high-affinity receptors for epidermal growth factor (EGF) in hepatocytes by hormones, differentiating agents, and phorbol ester
Dig Dis Sci, 37 (2), 233-9
DOI 10.1007/BF01308177, PubMed 1735341

Publications 1990

Gladhaug IP (1990)
Epidermal growth factor receptors in hepatocytes
Department of Pharmacology, Faculty of Medicine, University of Oslo, Oslo, 1 b. (flere pag.)
BIBSYS 900839783, ISBN 82-91012-00-8

Gladhaug IP, Christoffersen T (1990)
Amiloride inhibits constitutive internalization and increases the surface number of epidermal growth factor receptors in intact rat hepatocytes
J Cell Physiol, 143 (1), 188-95
DOI 10.1002/jcp.1041430126, PubMed 2318906

Thoresen GH, Sand TE, Refsnes M, Dajani OF, Guren TK, Gladhaug IP, Killi A, Christoffersen T (1990)
Dual effects of glucagon and cyclic AMP on DNA synthesis in cultured rat hepatocytes: stimulatory regulation in early G1 and inhibition shortly before the S phase entry
J Cell Physiol, 144 (3), 523-30
DOI 10.1002/jcp.1041440321, PubMed 2167904

Publications 1989

Gladhaug IP, Christoffersen T (1989)
n-butyrate and dexamethasone synergistically modulate the surface expression of epidermal growth factor receptors in cultured rat hepatocytes
FEBS Lett, 243 (1), 21-4
DOI 10.1016/0014-5793(89)81209-8, PubMed 2646145

Gladhaug IP, Refsnes M, Christoffersen T (1989)
Regulation of hepatocyte epidermal growth factor receptors by n-butyrate and dimethyl sulfoxide: sensitivity to modulation by the tumor promoter TPA
Anticancer Res, 9 (6), 1587-92
PubMed 2627113

Sand TE, Gladhaug IP, Refsnes M, Christoffersen T (1989)
DNA synthesis in cultured adult rat hepatocytes: effect of serum and calcium
Liver, 9 (1), 20-6
DOI 10.1111/j.1600-0676.1989.tb00373.x, PubMed 2646505

Thoresen GH, Gjone IH, Gladhaug IP, Refsnes M, Ostby E, Christoffersen T (1989)
Studies of glucocorticoid enhancement of the capacity of hepatocytes to accumulate cyclic AMP
Pharmacol Toxicol, 65 (3), 175-80
DOI 10.1111/j.1600-0773.1989.tb01151.x, PubMed 2478993

Publications 1988

Gladhaug IP, Christoffersen T (1988)
Rapid constitutive internalization and externalization of epidermal growth factor receptors in isolated rat hepatocytes. Monensin inhibits receptor externalization and reduces the capacity for continued endocytosis of epidermal growth factor
J Biol Chem, 263 (25), 12199-203
PubMed 3261725

Gladhaug IP, Refsnes M, Sand TE, Christoffersen T (1988)
Effects of butyrate on epidermal growth factor receptor binding, morphology, and DNA synthesis in cultured rat hepatocytes
Cancer Res, 48 (22), 6560-4
PubMed 3263190

Melien O, Winsnes R, Refsnes M, Gladhaug IP, Christoffersen T (1988)
Pertussis toxin abolishes the inhibitory effects of prostaglandins E1, E2, I2 and F2 alpha on hormone-induced cAMP accumulation in cultured hepatocytes
Eur J Biochem, 172 (2), 293-7
DOI 10.1111/j.1432-1033.1988.tb13886.x, PubMed 2832160

Publications 1987

Brønstad GO, Gladhaug IP, Haffner F, Rugstad HE, Christoffersen T (1987)
The regulation of cyclic AMP levels in cultured MH1C1 rat hepatoma cells and in solid tumours derived from MH1C1 cell inoculates
Anticancer Res, 7 (2), 155-60
PubMed 3035996

Gladhaug IP, Christoffersen T (1987)
Kinetics of epidermal growth factor binding and processing in isolated intact rat hepatocytes. Dynamic externalization of receptors during ligand internalization
Eur J Biochem, 164 (2), 267-75
DOI 10.1111/j.1432-1033.1987.tb11054.x, PubMed 3494603

Publications 1986

Sandnes D, Sand TE, Sager G, Brønstad GO, Refsnes MR, Gladhaug IP, Jacobsen S, Christoffersen T (1986)
Elevated level of beta-adrenergic receptors in hepatocytes from regenerating rat liver. Time study of [125I]iodocyanopindolol binding following partial hepatectomy and its relationship to catecholamine-sensitive adenylate cyclase
Exp Cell Res, 165 (1), 117-26
DOI 10.1016/0014-4827(86)90537-9, PubMed 3011477