
Md Mahdi Hasan-Olive
- PhD candidate; MSc
Mahdi investigated how DNA damage impacts the morphology and function of the cellular powerhouse, mitochondrion during the period of 2013-2016 while working with Profs. Jon Storm-Mathisen and Linda H. Bergersen at the University of Oslo, Norway. In the Prof. Eide PK laboratory, he is interested in understanding the molecular mechanisms of cellular clearance in human aging and age-related neurodegeneration like Alzheimer’s disease and idiopathic normal pressure hydrocephalus (iNPH). More specifically, he is expert in multiple laboratory models, including iPSC-derived neurons, astrocytes, and microglial cells as well as novel transgenic mouse models, to unveil the molecular mechanisms of defective mitochondrial homeostasis in Alzheimer’s disease and iNPH.
Publications 2020
Increased occurrence of pathological mitochondria in astrocytic perivascular endfoot processes and neurons of idiopathic intracranial hypertension
J Neurosci Res, 99 (2), 467-480
DOI 10.1002/jnr.24743, PubMed 33105056
Publications 2019
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease
Nat Neurosci, 22 (3), 401-412
DOI 10.1038/s41593-018-0332-9, PubMed 30742114
Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients
Fluids Barriers CNS, 16 (1), 39
DOI 10.1186/s12987-019-0160-7, PubMed 31849332
Blood-Brain Barrier Dysfunction in Idiopathic Intracranial Hypertension
J Neuropathol Exp Neurol, 78 (9), 808-818
DOI 10.1093/jnen/nlz063, PubMed 31393574
Publications 2018
Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis
Sci Rep, 8 (1), 4245
DOI 10.1038/s41598-018-20586-9, PubMed 29511198
Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus
Glia, 67 (1), 91-100
DOI 10.1002/glia.23528, PubMed 30306658
A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis
Neurochem Res, 44 (1), 22-37
DOI 10.1007/s11064-018-2588-6, PubMed 30027365
Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide
Int J Cancer, 144 (7), 1735-1745
DOI 10.1002/ijc.31912, PubMed 30289977
Publications 2017
Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis
Sci Rep, 7 (1), 12480
DOI 10.1038/s41598-017-12662-3, PubMed 28970491
Initial brain aging: heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus
Neurobiol Aging, 61, 215-224
DOI 10.1016/j.neurobiolaging.2017.08.004, PubMed 29031832
Publications 2016
Leonurus sibiricus L. (honeyweed): A review of its phytochemistry and pharmacology
Asian Pac. Trop. Biomed., 6 (12), 1076-1080
DOI 10.1016/j.apjtb.2016.10.003
Erratum to: Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease
Neurochem Res, 41 (6), 1237
DOI 10.1007/s11064-016-1916-y, PubMed 27113043
A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain
Neurobiol Aging, 48, 34-47
DOI 10.1016/j.neurobiolaging.2016.08.005, PubMed 27639119
Publications 2015
Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease
Neurochem Res, 41 (6), 1229-36
DOI 10.1007/s11064-015-1792-x, PubMed 26677077
Publications 2014
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome
Cell Metab, 20 (5), 840-855
DOI 10.1016/j.cmet.2014.10.005, PubMed 25440059