OUH - Group members

Md Mahdi Hasan-Olive

PhD candidate; MSc

Mahdi investigated how DNA damage impacts the morphology and function of the cellular powerhouse, mitochondrion during the period of 2013-2016 while working with Profs. Jon Storm-Mathisen and Linda H. Bergersen at the University of Oslo, Norway. In the Prof. Eide PK laboratory, he is interested in understanding the molecular mechanisms of cellular clearance in human aging and age-related neurodegeneration like Alzheimer’s disease and idiopathic normal pressure hydrocephalus (iNPH). More specifically, he is expert in multiple laboratory models, including iPSC-derived neurons, astrocytes, and microglial cells as well as novel transgenic mouse models, to unveil the molecular mechanisms of defective mitochondrial homeostasis in Alzheimer’s disease and iNPH.

Publications 2020

Eide PK, Hasan-Olive MM, Hansson HA, Enger R (2020)
Increased occurrence of pathological mitochondria in astrocytic perivascular endfoot processes and neurons of idiopathic intracranial hypertension
J Neurosci Res, 99 (2), 467-480
DOI 10.1002/jnr.24743, PubMed 33105056

Publications 2019

Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA (2019)
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease
Nat Neurosci, 22 (3), 401-412
DOI 10.1038/s41593-018-0332-9, PubMed 30742114

Hasan-Olive MM, Enger R, Hansson HA, Nagelhus EA, Eide PK (2019)
Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients
Fluids Barriers CNS, 16 (1), 39
DOI 10.1186/s12987-019-0160-7, PubMed 31849332

Hasan-Olive MM, Hansson HA, Enger R, Nagelhus EA, Eide PK (2019)
Blood-Brain Barrier Dysfunction in Idiopathic Intracranial Hypertension
J Neuropathol Exp Neurol, 78 (9), 808-818
DOI 10.1093/jnen/nlz063, PubMed 31393574

Publications 2018

Fakouri NB, Durhuus JA, Regnell CE, Angleys M, Desler C, Hasan-Olive MM, Martín-Pardillos A, Tsaalbi-Shtylik A, Thomsen K, Lauritzen M, Bohr VA, de Wind N, Bergersen LH, Rasmussen LJ (2018)
Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD⁺-SIRT1-PGC1α axis
Sci Rep, 8 (1), 4245
DOI 10.1038/s41598-018-20586-9, PubMed 29511198

Hasan-Olive MM, Enger R, Hansson HA, Nagelhus EA, Eide PK (2018)
Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus
Glia, 67 (1), 91-100
DOI 10.1002/glia.23528, PubMed 30306658

Hasan-Olive MM, Lauritzen KH, Ali M, Rasmussen LJ, Storm-Mathisen J, Bergersen LH (2018)
A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis
Neurochem Res, 44 (1), 22-37
DOI 10.1007/s11064-018-2588-6, PubMed 30027365

Johannessen TC, Hasan-Olive MM, Zhu H, Denisova O, Grudic A, Latif MA, Saed H, Varughese JK, Røsland GV, Yang N, Sundstrøm T, Nordal A, Tronstad KJ, Wang J, Lund-Johansen M, Simonsen A, Janji B, Westermarck J, Bjerkvig R, Prestegarden L (2018)
Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide
Int J Cancer, 144 (7), 1735-1745
DOI 10.1002/ijc.31912, PubMed 30289977

Publications 2017

Fakouri NB, Durhuus JA, Regnell CE, Angleys M, Desler C, Hasan-Olive MM, Martín-Pardillos A, Tsaalbi-Shtylik A, Thomsen K, Lauritzen M, Bohr VA, de Wind N, Bergersen LH, Rasmussen LJ (2017)
Rev1 contributes to proper mitochondrial function via the PARP-NAD⁺-SIRT1-PGC1α axis
Sci Rep, 7 (1), 12480
DOI 10.1038/s41598-017-12662-3, PubMed 28970491

Thomsen K, Yokota T, Hasan-Olive MM, Sherazi N, Fakouri NB, Desler C, Regnell CE, Larsen S, Rasmussen LJ, Dela F, Bergersen LH, Lauritzen M (2017)
Initial brain aging: heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus
Neurobiol Aging, 61, 215-224
DOI 10.1016/j.neurobiolaging.2017.08.004, PubMed 29031832

Publications 2016

Abu Sayed M, Alam MA, Islam MS, Ali MT, Ullah ME, Shibly A, Ali MA, Hasan-Olive MM (2016)
Leonurus sibiricus L. (honeyweed): A review of its phytochemistry and pharmacology
Asian Pac. Trop. Biomed., 6 (12), 1076-1080
DOI 10.1016/j.apjtb.2016.10.003

Kolko M, Vosborg F, Henriksen UL, Hasan-Olive MM, Diget EH, Vohra R, Gurubaran IR, Gjedde A, Mariga ST, Skytt DM, Utheim TP, Storm-Mathisen J, Bergersen LH (2016)
Erratum to: Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease
Neurochem Res, 41 (6), 1237
DOI 10.1007/s11064-016-1916-y, PubMed 27113043

Lauritzen KH, Hasan-Olive MM, Regnell CE, Kleppa L, Scheibye-Knudsen M, Gjedde A, Klungland A, Bohr VA, Storm-Mathisen J, Bergersen LH (2016)
A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain
Neurobiol Aging, 48, 34-47
DOI 10.1016/j.neurobiolaging.2016.08.005, PubMed 27639119

Publications 2015

Kolko M, Vosborg F, Henriksen UL, Hasan-Olive MM, Diget EH, Vohra R, Gurubaran IR, Gjedde A, Mariga ST, Skytt DM, Utheim TP, Storm-Mathisen J, Bergersen LH (2015)
Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease
Neurochem Res, 41 (6), 1229-36
DOI 10.1007/s11064-015-1792-x, PubMed 26677077

Publications 2014

Scheibye-Knudsen M, Mitchell SJ, Fang EF, Iyama T, Ward T, Wang J, Dunn CA, Singh N, Veith S, Hasan-Olive MM, Mangerich A, Wilson MA, Mattson MP, Bergersen LH, Cogger VC, Warren A, Le Couteur DG, Moaddel R, Wilson DM, Croteau DL, de Cabo R, Bohr VA (2014)
A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome
Cell Metab, 20 (5), 840-855
DOI 10.1016/j.cmet.2014.10.005, PubMed 25440059