The research group studies cyclic nucleotide signalling causing different functional effects in the heart and the regulation of this signalling and function by different proteins such as phosphodiesterases and interacting proteins. The group has a special focus on the mechanisms and effects of natriuretic peptides and cGMP-mediated signalling with the aim of providing the scientific basis for novel approaches to pharmacological treatment of cardiovascular diseases. In this process, the group is also screening for and developing ligands targeting proteins in the signalling pathway with the ambition to treat cardiovascular diseases.
Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts
Int J Mol Sci, 23 (4)
CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors
Cardiovasc Res, 118 (6), 1506-1519
FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons
Commun Biol, 2, 394