Publications 2019

Calamera G, Li D, Ulsund AH, Kim JJ, Neely OC, Moltzau LR, Bjornerem M, Paterson D, Kim C, Levy FO, Andressen KW (2019)
FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons
Commun. Biol., 2, 394
DOI 10.1038/s42003-019-0641-x

Cosson MV, Hiis HG, Moltzau LR, Levy FO, Krobert KA (2019)
Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the beta(1)-adrenoceptor-mediated inotropic response
J. Mol. Cell. Cardiol., 131, 132-145
DOI 10.1016/j.yjmcc.2019.04.017

Publications 2017

Ahamed M, Vermeulen K, Schnekenburger M, Moltzau LR, Levy FO, Marton J, Froeyen M, Olberg DE, Diederich M, Bormans G (2017)
Synthesis, Enzyme Assays and Molecular Docking Studies of Fluorinated Bioisosteres of Santacruzamate A as Potential HDAC Tracers
Lett. Drug Des. Discov., 14 (7), 787-797
DOI 10.2174/1570180813666161101152943

Meier S, Andressen KW, Aronsen JM, Sjaastad I, Hougen K, Skomedal T, Osnes JB, Qvigstad E, Levy FO, Moltzau LR (2017)
PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts
Eur. J. Pharmacol., 812, 174-183
DOI 10.1016/j.ejphar.2017.07.014

Publications 2016

Eikemo H, Moltzau LR, Hussain RI, Nguyen CHT, Qvigstad E, Levy FO, Skomedal T, Osnes JB (2016)
CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes
Biochem. Biophys. Res. Commun., 471 (1), 219-225
DOI 10.1016/j.bbrc.2016.01.132

Eikemo H, Moltzau LR, Nguyen CHT, Levy FO, Skomedal T, Osnes JB (2016)
CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes
Biochem. Biophys. Res. Commun., 477 (1), 14-19
DOI 10.1016/j.bbrc.2016.05.138

Publications 2014

Brudeli B, Navaratnarajah M, Andressen KW, Manfra O, Moltzau LR, Nilsen NO, Levy FO, Klaveness J (2014)
Discovery and pharmacological profile of new hydrophilic 5-HT4 receptor antagonists
Bioorg. Med. Chem. Lett., 24 (18), 4598-4602
DOI 10.1016/j.bmcl.2014.06.083

Moltzau LR, Aronsen JM, Meier S, Skogestad J, Orstavik O, Lothe GB, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2014)
Different Compartmentation of Responses to Brain Natriuretic Peptide and C-Type Natriuretic Peptide in Failing Rat Ventricle
J. Pharmacol. Exp. Ther., 350 (3), 681-690
DOI 10.1124/jpet.114.214882

Moltzau LR, Meier S, Aronsen JM, Afzal F, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2014)
Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium
Naunyn-Schmiedebergs Arch. Pharmacol., 387 (5), 407-417
DOI 10.1007/s00210-013-0953-1

Publications 2013

Brudeli B, Andressen KW, Moltzau LR, Nilsen NO, Levy FO, Klaveness J (2013)
Acidic biphenyl derivatives: Synthesis and biological activity of a new series of potent 5-HT4 receptor antagonists
Bioorg. Med. Chem., 21 (22), 7134-7145
DOI 10.1016/j.bmc.2013.09.004

Brudeli B, Moltzau LR, Nguyen CHT, Andressen KW, Nilsen NO, Levy FO, Klaveness J (2013)
Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist
Eur. J. Med. Chem., 64, 629-637
DOI 10.1016/j.ejmech.2013.03.060

Moltzau LR, Aronsen JM, Meier S, Nguyen CHT, Hougen K, Orstavik O, Sjaastad I, Christensen G, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2013)
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium
Br. J. Pharmacol., 170 (2), 366-379
DOI 10.1111/bph.12282

Publications 2012

Brattelid T, Qvigstad E, Moltzau LR, Bekkevold SVS, Sandnes DL, Birkeland JAK, Skomedal T, Osnes JB, Sjaastad I, Levy FO (2012)
The Cardiac Ventricular 5-HT4 Receptor Is Functional in Late Foetal Development and Is Reactivated in Heart Failure
PLoS One, 7 (9), e45489
DOI 10.1371/journal.pone.0045489

Publications 2011

Afzal F, Aronsen JM, Moltzau LR, Sjaastad I, Levy FO, Skomedal T, Osnes JB, Qvigstad E (2011)
Differential regulation of beta(2)-adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle
Br. J. Pharmacol., 162 (1), 54-71
DOI 10.1111/j.1476-5381.2010.00890.x

Afzal F, Qvigstad E, Aronsen JM, Moltzau LR, Sjaastad I, Skomedal T, Osnes JB, Levy FO (2011)
Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle
Naunyn-Schmiedebergs Arch. Pharmacol., 384 (6), 543-553
DOI 10.1007/s00210-011-0670-6

Berrade L, Aisa B, Ramirez MJ, Galiano S, Guccione S, Moltzau LR, Levy FO, Nicoletti F, Battaglia G, Molinaro G, Aldana I, Monge A, Perez-Silanes S (2011)
Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action
J. Med. Chem., 54 (8), 3086-3090
DOI 10.1021/jm2000773

Publications 2010

Brudeli B, Moltzau LR, Andressen KW, Krobert KA, Klaveness J, Levy FO (2010)
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists
Bioorg. Med. Chem., 18 (24), 8600-8613
DOI 10.1016/j.bmc.2010.10.011

Qvigstad E, Moltzau LR, Aronsen JM, Nguyen CHT, Hougen K, Sjaastad I, Levy FO, Skomedal T, Osnes JB (2010)
Natriuretic peptides increase beta(1)-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition
Cardiovasc. Res., 85 (4), 763-772
DOI 10.1093/cvr/cvp364

Publications 2008

Kloster MM, Hafte TT, Moltzau LR, Naderi EH, Dahle MK, Skalhegg BS, Gaudernack G, Levy FO, Naderi S, Blomhoff HK (2008)
EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase
Cell. Signal., 20 (6), 1169-1178
DOI 10.1016/j.cellsig.2008.02.007

Publications 2005

Moltzau LR (2005)
Novel serotonin receptor ligands: pharmacological characterisation of new 5-HT₄ receptor ligands and clonig of the 5-HT₁E and the 5-HT₂A receptor in the process to test new ligands
L.R. Moltzau, Oslo, 128 s.
BIBSYS 052191435