Christian Kranjec

  • Researcher; PhD
 

Publications 2025

Kranjec C, Oftedal TF, Ovchinnikov KV, da Silva Duarte V, Hermansen S, Kaus-Drobek M, Sabała I, Porcellato D, Carlsen H, Kjos M (2025)
An antibiotic-free antimicrobial combination of bacteriocins and a peptidoglycan hydrolase: in vitro and in vivo assessment of its efficacy
Appl Environ Microbiol, 91 (7), e0243324
DOI 10.1128/aem.02433-24, PubMed 40552825

Publications 2024

Kranjec C, Mathew JP, Ovchinnikov K, Fadayomi I, Yang Y, Kjos M, Li WW (2024)
A bacteriocin-based coating strategy to prevent vancomycin-resistant Enterococcus faecium biofilm formation on materials of interest for indwelling medical devices
Biofilm, 8, 100211
DOI 10.1016/j.bioflm.2024.100211, PubMed 39071174

Publications 2022

Ovchinnikov KV, Kranjec C, Thorstensen T, Carlsen H, Diep DB (2022)
Bacteriocins Revitalize Non-Effective Penicillin G to Overcome Methicillin-Resistant Staphylococcus pseudintermedius
Antibiotics (Basel), 11 (12)
DOI 10.3390/antibiotics11121691, PubMed 36551348

Publications 2021

Kranjec C, Kristensen SS, Bartkiewicz KT, Brønner M, Cavanagh JP, Srikantam A, Mathiesen G, Diep DB (2021)
A bacteriocin-based treatment option for Staphylococcus haemolyticus biofilms
Sci Rep, 11 (1), 13909
DOI 10.1038/s41598-021-93158-z, PubMed 34230527

Kranjec C, Morales Angeles D, Torrissen Mårli M, Fernández L, García P, Kjos M, Diep DB (2021)
Staphylococcal Biofilms: Challenges and Novel Therapeutic Perspectives
Antibiotics (Basel), 10 (2)
DOI 10.3390/antibiotics10020131, PubMed 33573022

Ovchinnikov KV, Kranjec C, Telke A, Kjos M, Thorstensen T, Scherer S, Carlsen H, Diep DB (2021)
A Strong Synergy Between the Thiopeptide Bacteriocin Micrococcin P1 and Rifampicin Against MRSA in a Murine Skin Infection Model
Front Immunol, 12, 676534
DOI 10.3389/fimmu.2021.676534, PubMed 34276663

Publications 2020

Kranjec C, Ovchinnikov KV, Grønseth T, Ebineshan K, Srikantam A, Diep DB (2020)
A bacteriocin-based antimicrobial formulation to effectively disrupt the cell viability of methicillin-resistant Staphylococcus aureus (MRSA) biofilms
NPJ Biofilms Microbiomes, 6 (1), 58
DOI 10.1038/s41522-020-00166-4, PubMed 33268776

Ovchinnikov KV, Kranjec C, Thorstensen T, Carlsen H, Diep DB (2020)
Successful Development of Bacteriocins into Therapeutic Formulation for Treatment of MRSA Skin Infection in a Murine Model
Antimicrob Agents Chemother, 64 (12)
DOI 10.1128/AAC.00829-20, PubMed 32958719

Publications 2019

Murakami I, Egawa N, Griffin H, Yin W, Kranjec C, Nakahara T, Kiyono T, Doorbar J (2019)
Roles for E1-independent replication and E6-mediated p53 degradation during low-risk and high-risk human papillomavirus genome maintenance
PLoS Pathog, 15 (5), e1007755
DOI 10.1371/journal.ppat.1007755, PubMed 31083694

Publications 2017

Kranjec C, Holleywood C, Libert D, Griffin H, Mahmood R, Isaacson E, Doorbar J (2017)
Modulation of basal cell fate during productive and transforming HPV-16 infection is mediated by progressive E6-driven depletion of Notch
J Pathol, 242 (4), 448-462
DOI 10.1002/path.4917, PubMed 28497579

Periyasamy M, Singh AK, Gemma C, Kranjec C, Farzan R, Leach DA, Navaratnam N, Pálinkás HL, Vértessy BG, Fenton TR, Doorbar J, Fuller-Pace F, Meek DW, Coombes RC, Buluwela L, Ali S (2017)
p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells
Nucleic Acids Res, 45 (19), 11056-11069
DOI 10.1093/nar/gkx721, PubMed 28977491

Publications 2016

Ganti K, Massimi P, Manzo-Merino J, Tomaić V, Pim D, Playford MP, Lizano M, Roberts S, Kranjec C, Doorbar J, Banks L (2016)
Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways
PLoS Pathog, 12 (9), e1005854
DOI 10.1371/journal.ppat.1005854, PubMed 27649450

Kranjec C, Doorbar J (2016)
Human papillomavirus infection and induction of neoplasia: a matter of fitness
Curr Opin Virol, 20, 129-136
DOI 10.1016/j.coviro.2016.08.011, PubMed 27600900

Kranjec C, Tomaić V, Massimi P, Nicolaides L, Doorbar J, Banks L (2016)
The high-risk HPV E6 target scribble (hScrib) is required for HPV E6 expression in cervical tumour-derived cell lines
Papillomavirus Res, 2, 70-77
DOI 10.1016/j.pvr.2016.04.001, PubMed 29074188

Publications 2015

Doorbar J, Egawa N, Griffin H, Kranjec C, Murakami I (2015)
Human papillomavirus molecular biology and disease association
Rev Med Virol, 25 Suppl 1 (Suppl Suppl 1), 2-23
DOI 10.1002/rmv.1822, PubMed 25752814

Seiki T, Nagasaka K, Kranjec C, Kawana K, Maeda D, Nakamura H, Taguchi A, Matsumoto Y, Arimoto T, Wada-Hiraike O, Oda K, Nakagawa S, Yano T, Fukayama M, Banks L, Osuga Y, Fujii T (2015)
HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1γ in cervical malignancy
BMC Cancer, 15, 230
DOI 10.1186/s12885-015-1141-0, PubMed 25886518

Publications 2014

Kranjec C, Massimi P, Banks L (2014)
Restoration of MAGI-1 expression in human papillomavirus-positive tumor cells induces cell growth arrest and apoptosis
J Virol, 88 (13), 7155-69
DOI 10.1128/JVI.03247-13, PubMed 24696483

Publications 2013

Nagasaka K, Seiki T, Yamashita A, Massimi P, Subbaiah VK, Thomas M, Kranjec C, Kawana K, Nakagawa S, Yano T, Taketani Y, Fujii T, Kozuma S, Banks L (2013)
A novel interaction between hScrib and PP1γ downregulates ERK signaling and suppresses oncogene-induced cell transformation
PLoS One, 8 (1), e53752
DOI 10.1371/journal.pone.0053752, PubMed 23359326

Publications 2012

Pim D, Bergant M, Boon SS, Ganti K, Kranjec C, Massimi P, Subbaiah VK, Thomas M, Tomaić V, Banks L (2012)
Human papillomaviruses and the specificity of PDZ domain targeting
FEBS J, 279 (19), 3530-3537
DOI 10.1111/j.1742-4658.2012.08709.x, PubMed 22805590

Publications 2011

Nicolaides L, Davy C, Raj K, Kranjec C, Banks L, Doorbar J (2011)
Stabilization of HPV16 E6 protein by PDZ proteins, and potential implications for genome maintenance
Virology, 414 (2), 137-45
DOI 10.1016/j.virol.2011.03.017, PubMed 21489588

Subbaiah VK, Kranjec C, Thomas M, Banks L (2011)
PDZ domains: the building blocks regulating tumorigenesis
Biochem J, 439 (2), 195-205
DOI 10.1042/BJ20110903, PubMed 21954943

Thomas M, Kranjec C, Nagasaka K, Matlashewski G, Banks L (2011)
Analysis of the PDZ binding specificities of Influenza A virus NS1 proteins
Virol J, 8, 25
DOI 10.1186/1743-422X-8-25, PubMed 21247458

Publications 2010

Kranjec C, Banks L (2010)
A systematic analysis of human papillomavirus (HPV) E6 PDZ substrates identifies MAGI-1 as a major target of HPV type 16 (HPV-16) and HPV-18 whose loss accompanies disruption of tight junctions
J Virol, 85 (4), 1757-64
DOI 10.1128/JVI.01756-10, PubMed 21123374

Nagasaka K, Massimi P, Pim D, Subbaiah VK, Kranjec C, Nakagawa S, Yano T, Taketani Y, Banks L (2010)
The mechanism and implications of hScrib regulation of ERK
Small GTPases, 1 (2), 108-112
DOI 10.4161/sgtp.1.2.13649, PubMed 21686263