Edward Leithe

  • Project Leader, Senior Scientist; PhD
  • 2278 1723

Publications 2024

Totland MZ, Knudsen LM, Rasmussen NL, Omori Y, Sørensen V, Elster VCW, Stenersen JM, Larsen M, Jensen CL, Zickfeldt Lade AA, Bruusgaard E, Basing S, Kryeziu K, Brech A, Aasen T, Lothe RA, Leithe E (2024)
The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation
Cell Mol Life Sci, 81 (1), 171
DOI 10.1007/s00018-024-05165-8, PubMed 38597989

Publications 2023

Totland MZ, Omori Y, Sørensen V, Kryeziu K, Aasen T, Brech A, Leithe E (2023)
Endocytic trafficking of connexins in cancer pathogenesis
Biochim Biophys Acta Mol Basis Dis, 1869 (7), 166812
DOI 10.1016/j.bbadis.2023.166812, PubMed 37454772

Publications 2019

Totland MZ, Rasmussen NL, Knudsen LM, Leithe E (2019)
Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications
Cell Mol Life Sci, 77 (4), 573-591
DOI 10.1007/s00018-019-03285-0, PubMed 31501970

Aasen T, Leithe E, Graham SV, Kameritsch P, Mayán MD, Mesnil M, Pogoda K, Tabernero A (2019)
Connexins in cancer: bridging the gap to the clinic
Oncogene, 38 (23), 4429-4451
DOI 10.1038/s41388-019-0741-6, PubMed 30814684

Publications 2017

Dukic AR, Haugen LH, Pidoux G, Leithe E, Bakke O, Taskén K (2017)
A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells
Cell Signal, 32, 1-11
DOI 10.1016/j.cellsig.2017.01.008, PubMed 28077322

Leithe E, Mesnil M, Aasen T (2017)
The connexin 43 C-terminus: A tail of many tales
Biochim Biophys Acta Biomembr, 1860 (1), 48-64
DOI 10.1016/j.bbamem.2017.05.008, PubMed 28526583

Mesnil M, Aasen T, Boucher J, Chépied A, Cronier L, Defamie N, Kameritsch P, Laird DW, Lampe PD, Lathia JD, Leithe E, Mehta PP, Monvoisin A, Pogoda K, Sin WC, Tabernero A, Yamasaki H, Yeh ES, Dagli MLZ, Naus CC (2017)
An update on minding the gap in cancer
Biochim Biophys Acta Biomembr, 1860 (1), 237-243
DOI 10.1016/j.bbamem.2017.06.015, PubMed 28655619

Sveen A, Johannessen B, Tengs T, Danielsen SA, Eilertsen IA, Lind GE, Berg KCG, Leithe E, Meza-Zepeda LA, Domingo E, Myklebost O, Kerr D, Tomlinson I, Nesbakken A, Skotheim RI, Lothe RA (2017)
Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1
Genome Med, 9 (1), 46
DOI 10.1186/s13073-017-0434-0, PubMed 28539123

Totland MZ, Bergsland CH, Fykerud TA, Knudsen LM, Rasmussen NL, Eide PW, Yohannes Z, Sørensen V, Brech A, Lothe RA, Leithe E (2017)
The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions
J Cell Sci, 130 (17), 2867-2882
DOI 10.1242/jcs.202408, PubMed 28733455

Publications 2016

Fykerud TA, Knudsen LM, Totland MZ, Sørensen V, Dahal-Koirala S, Lothe RA, Brech A, Leithe E (2016)
Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding
Cell Cycle, 15 (21), 2943-2957
DOI 10.1080/15384101.2016.1231280, PubMed 27625181

Leithe E (2016)
Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer
Biochim Biophys Acta, 1865 (2), 133-46
DOI 10.1016/j.bbcan.2016.02.001, PubMed 26855059

Publications 2015

Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA (2015)
Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
Clin Cancer Res, 21 (16), 3759-70
DOI 10.1158/1078-0432.CCR-14-3294, PubMed 25910952

Publications 2014

Danielsen SA, Eide PW, Nesbakken A, Guren T, Leithe E, Lothe RA (2014)
Portrait of the PI3K/AKT pathway in colorectal cancer
Biochim Biophys Acta, 1855 (1), 104-21
DOI 10.1016/j.bbcan.2014.09.008, PubMed 25450577

Sirnes S, Lind GE, Bruun J, Fykerud TA, Mesnil M, Lothe RA, Rivedal E, Kolberg M, Leithe E (2014)
Connexins in colorectal cancer pathogenesis
Int J Cancer, 137 (1), 1-11
DOI 10.1002/ijc.28911, PubMed 24752574

Publications 2012

Eide PW, Cekaite L, Danielsen SA, Eilertsen IA, Kjenseth A, Fykerud TA, Ågesen TH, Bruun J, Rivedal E, Lothe RA, Leithe E (2012)
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway
Cell Signal, 25 (1), 12-8
DOI 10.1016/j.cellsig.2012.08.012, PubMed 22974840

Fykerud TA, Kjenseth A, Schink KO, Sirnes S, Bruun J, Omori Y, Brech A, Rivedal E, Leithe E (2012)
Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43
J Cell Sci, 125 (Pt 17), 3966-76
DOI 10.1242/jcs.093500, PubMed 22623726

Kjenseth A, Fykerud TA, Sirnes S, Bruun J, Yohannes Z, Kolberg M, Omori Y, Rivedal E, Leithe E (2012)
The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation
J Biol Chem, 287 (19), 15851-61
DOI 10.1074/jbc.M111.281832, PubMed 22411987

Publications 2011

Leithe E, Sirnes S, Fykerud T, Kjenseth A, Rivedal E (2011)
Endocytosis and post-endocytic sorting of connexins
Biochim Biophys Acta, 1818 (8), 1870-9
DOI 10.1016/j.bbamem.2011.09.029, PubMed 21996040

Malerød L, Pedersen NM, Sem Wegner CE, Lobert VH, Leithe E, Brech A, Rivedal E, Liestøl K, Stenmark H (2011)
Cargo-dependent degradation of ESCRT-I as a feedback mechanism to modulate endosomal sorting
Traffic, 12 (9), 1211-26
DOI 10.1111/j.1600-0854.2011.01220.x, PubMed 21564451

Mollerup S, Hofgaard JP, Braunstein TH, Kjenseth A, Leithe E, Rivedal E, Holstein-Rathlou NH, Nielsen MS (2011)
Norepinephrine inhibits intercellular coupling in rat cardiomyocytes by ubiquitination of connexin43 gap junctions
Cell Commun Adhes, 18 (4), 57-65
DOI 10.3109/15419061.2011.611920, PubMed 21936631

Sirnes S, Bruun J, Kolberg M, Kjenseth A, Lind GE, Svindland A, Brech A, Nesbakken A, Lothe RA, Leithe E, Rivedal E (2011)
Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome
Int J Cancer, 131 (3), 570-81
DOI 10.1002/ijc.26392, PubMed 21866551

Sirnes S, Honne H, Ahmed D, Danielsen SA, Rognum TO, Meling GI, Leithe E, Rivedal E, Lothe RA, Lind GE (2011)
DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer
Epigenetics, 6 (5), 602-9
DOI 10.4161/epi.6.5.15237, PubMed 21406965

Publications 2010

Kjenseth A, Fykerud T, Rivedal E, Leithe E (2010)
Regulation of gap junction intercellular communication by the ubiquitin system
Cell Signal, 22 (9), 1267-73
DOI 10.1016/j.cellsig.2010.03.005, PubMed 20206687

Leithe E, Kjenseth A, Bruun J, Sirnes S, Rivedal E (2010)
Inhibition of connexin 43 gap junction channels by the endocrine disruptor ioxynil
Toxicol Appl Pharmacol, 247 (1), 10-7
DOI 10.1016/j.taap.2010.05.006, PubMed 20510257

Publications 2009

Leithe E, Kjenseth A, Sirnes S, Stenmark H, Brech A, Rivedal E (2009)
Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101
J Cell Sci, 122 (Pt 21), 3883-93
DOI 10.1242/jcs.053801, PubMed 19808888

Rivedal E, Witz G, Leithe E (2009)
Gap junction intercellular communication and benzene toxicity
Chem Biol Interact, 184 (1-2), 229-32
DOI 10.1016/j.cbi.2009.11.013, PubMed 19932693

Sirnes S, Kjenseth A, Leithe E, Rivedal E (2009)
Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication
Biochem Biophys Res Commun, 382 (1), 41-5
DOI 10.1016/j.bbrc.2009.02.141, PubMed 19258009

Publications 2008

Rivedal E, Leithe E (2008)
The benzene metabolite trans,trans-muconaldehyde blocks gap junction intercellular communication by cross-linking connexin43
Toxicol Appl Pharmacol, 232 (3), 463-8
DOI 10.1016/j.taap.2008.07.022, PubMed 18723040

Sirnes S, Leithe E, Rivedal E (2008)
The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis
Biochem Biophys Res Commun, 373 (4), 597-601
DOI 10.1016/j.bbrc.2008.06.095, PubMed 18601906

Publications 2007

Leithe E, Rivedal E (2007)
Ubiquitination of gap junction proteins
J Membr Biol, 217 (1-3), 43-51
DOI 10.1007/s00232-007-9050-z, PubMed 17657522

Publications 2006

Leithe E (2006)
Regulation of the gap junction protein connexin43 by phosphorylation and ubiquitination
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 414, 1 b. (flere pag.)
BIBSYS 061007544, ISBN 82-8072-227-0

Leithe E, Brech A, Rivedal E (2006)
Endocytic processing of connexin43 gap junctions: a morphological study
Biochem J, 393 (Pt 1), 59-67
DOI 10.1042/BJ20050674, PubMed 16162097

Leithe E, Sirnes S, Omori Y, Rivedal E (2006)
Downregulation of gap junctions in cancer cells
Crit Rev Oncog, 12 (3-4), 225-56
DOI 10.1615/critrevoncog.v12.i3-4.30, PubMed 17425504

Publications 2005

Rivedal E, Leithe E (2005)
Connexin43 synthesis, phosphorylation, and degradation in regulation of transient inhibition of gap junction intercellular communication by the phorbol ester TPA in rat liver epithelial cells
Exp Cell Res, 302 (2), 143-52
DOI 10.1016/j.yexcr.2004.09.004, PubMed 15561096

Publications 2004

Leithe E, Rivedal E (2004)
Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43
J Cell Sci, 117 (Pt 7), 1211-20
DOI 10.1242/jcs.00951, PubMed 14970263

Leithe E, Rivedal E (2004)
Ubiquitination and down-regulation of gap junction protein connexin-43 in response to 12-O-tetradecanoylphorbol 13-acetate treatment
J Biol Chem, 279 (48), 50089-96
DOI 10.1074/jbc.M402006200, PubMed 15371442

Publications 2003

Cruciani V, Leithe E, Mikalsen SO (2003)
Ilimaquinone inhibits gap-junctional communication prior to Golgi fragmentation and block in protein transport
Exp Cell Res, 287 (1), 130-42
DOI 10.1016/s0014-4827(03)00124-1, PubMed 12799189

Leithe E, Cruciani V, Sanner T, Mikalsen SO, Rivedal E (2003)
Recovery of gap junctional intercellular communication after phorbol ester treatment requires proteasomal degradation of protein kinase C
Carcinogenesis, 24 (7), 1239-45
DOI 10.1093/carcin/bgg066, PubMed 12807762

Publications 2002

Mallardo M, Leithe E, Schleich S, Roos N, Doglio L, Krijnse Locker J (2002)
Relationship between vaccinia virus intracellular cores, early mRNAs, and DNA replication sites
J Virol, 76 (10), 5167-83
DOI 10.1128/jvi.76.10.5167-5183.2002, PubMed 11967332

Publications 2001

Leithe E (2001)
The vaccinia virus replication complexes associate with the endoplasmic reticulum
E. Leithe, Oslo, 1 b. (flere pag.)
BIBSYS 010317562

Page visits: 3332