In order to stimulate excellent research and draw attention to the hospital's research activity, Oslo University Hospital rewards outstanding publications every half-year.
Six research groups were awarded for their excellent papers published the first half-year of 2023 during a ceremony on December 8th. Each group received NOK 50.000 earmarked for further research, and the prize winners gave short presentations of their main findings.
The awards for outstanding research articles are distributed twice a year based on more than 2,400 scientific articles published annually by OUH. It is the research committees in the hospital divisions that nominate the articles. An external committee evaluates the nominated articles, and finally selects the six worthy winners. The winning articles must have achieved international impact or excelled in other ways. It is also required that the articles maintain a particularly high quality and communicate important findings.
Among the awardwinning articles we find new knowledge about the development of the heart, the connection between cannabis use and mental disorders, regulation of cell division during wound healing with implications for cancer cells, new methods for single-cell studies of modified mRNA, new treatment methods for eye disease with tailored antibodies, genetic cause of Aagenæs syndrome and mapping a treatable neurometabolic disease that can be detected with newborn screening.
The winning articles show that OUS makes important contributions to the understanding of processes in disease development and improved diagnosis and treatment, says research director Erlend Smeland, who led the ceremony.
News article, including popular science summaries of the findings and the committee's statements:
Fremragende forskningsartikler fra OUS første halvår 2023 (www.oslo-universitetssykehus.no)
Award-winning articles, firste half-year 2023
New insights into basic biological phenomena in the heart's development and function
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes
Harmonie Perdreau-Dahl, David B. Lipsett, Michael Frisk, Fatemeh Kermani, Cathrine R. Carlson, Andreas Brech, Xin Shen, Anna Bergan-Dahl, Yufeng Hou, Tomi Tuomainen, Pasi Tavi, Peter P. Jones, Marianne Lunde, J. Andrew Wasserstrom, Jocelyn Laporte, Nina D. Ullrich, Geir Christensen, J. Preben Morth, William E. Louch
Circulation Research https://doi.org/10.1161/CIRCRESAHA.122.321732
Relationship between cannabis use and psychotic disorders
The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study
Weiqiu Cheng*, Nadine Parker*, Naz Karadag, Elise Koch, Guy Hindley, Romain Icick, Alexey Shadrin, Kevin S. O’Connell, Thomas Bjella, Shahram Bahrami, Zillur Rahman, Markos Tesfaye, Piotr Jaholkowski, Linn Rødevand, Børge Holen, Trine Vik Lagerberg, Nils Eiel Steen, Srdjan Djurovic, Anders M. Dale, Oleksandr Frei, Olav B. Smeland, Ole A. Andreassen
The Lancet Psychiatry https://doi.org/10.1016/S2215-0366(23)00143-8
A new method for single-cell mapping of m6A modification of mRNA
Single-cell m6A mapping in vivo using picoMeRIP-seq
Yanjiao Li, Yunhao Wang, Maria Vera-Rodriguez, Leif Christopher Lindeman, Linda Ellevog Skuggen, Erik M. K. Rasmussen, Ingunn Jermstad, Shaista Khan, Madeleine Fosslie, Trine Skuland, Marie Indahl, Sherif Khodeer, Eva Kristine Klemsdal, Kang-Xuan Jin, Knut Tomas Dalen, Peter Fedorcsak, Gareth D. Greggains, Mads Lerdrup, Arne Klungland, Kin Fai Au, John Arne Dahl
Nature Biotechnology https://doi.org/10.1038/s41587-023-01831-7
Tailored antibody to block the protein Jagged1 may slow widespread eye disease
Antibody blockade of Jagged1 attenuates choroidal neovascularization
Torleif Tollefsrud Gjølberg, Jonas Aakre Wik, Hanna Johannessen, Stig Krüger, Nicola Bassi, Panagiotis F. Christopoulos, Malin Bern, Stian Foss, Goran Petrovski, Morten C. Moe, Guttorm Haraldsen, Johanna Hol Fosse, Bjørn Steen Skålhegg, Jan Terje Andersen, Eirik Sundlisæter
Nature Communications https://doi.org/10.1038/s41467-023-38563-w
Genetic cause of Aagenæs syndrome localized to a region of the gene UNC45A on chromosome 15
Aagenaes syndrome/lymphedema cholestasis syndrome 1 is caused by a founder variant in the 5’-untranslated region of UNC45A
Runar Almaas, Monica Atneosen-Åsegg, Mari Eknes Ytre-Arne, Maria Melheim, Hanne Sørmo Sorte, Dana Cízková, Henrik Mikael Reims, Aleš Bezrouk, Sean Philip Harrison, Janne Strand, Johanne Uthus Hermansen, Sofie Strøm Andersen, Kristin Louise Eiklid, Jaroslav Mokrý, Gareth John Sullivan, Asbjørg Stray-Pedersen
Journal of Hepatology https://doi.org/10.1016/j.jhep.2023.05.037
BCKDK defect – a treatable neurometabolic disease detectable by newborn screening
BCKDK deficiency: a treatable neurodevelopmental disease amenable to newborn screening
Trine Tangeraas, Juliana R Constante, Paul Hoff Backe, Alfonso Oyarzábal, Julia Neugebauer, Natalie Weinhold, Francois Boemer, François G Debray, Burcu Ozturk-Hism, Gumus Evren, Eminoglu F. Tuba, Oncul Ummuhan, Emma Footitt, James Davison, Caroline Martinez, Clarissa Bueno, Irene Machado, Pilar Rodríguez-Pombo, Nouriya Al-Sannaa, Mariela De Los Santos, Jordi Muchart López, Hatice Ozturkmen-Akay, Meryem Karaca, Mustafa Tekin, Sonia Pajares, Aida Ormazabal, Stephanie D. Stoway, Rafael Artuch, Marjorie Dixon, Lars Mørkrid, Angeles García-Cazorla