Ola Gjesdal

  • Consultant Cardiologist, MD, PhD
  • +47 230 73913

Doctor and researcher Ola Gjesdal defended his thesis «Myocardial Infarct of Non-Doppler Echocardiographic Deformation Indices» in December 2009.  He compared new and older methods of ultrasound examination of cardiac function after a heart attack. Today's methods of examining cardiac performance are not sufficiently sensitive to minor changes in cardiac function. Therefore, in case of minor injuries, patients may sometimes notice that cardiac function is reduced before it is possible to detect with today's established ultrasound techniques. There is a strong correlation between the size of the heart attack and morbidity and death after undergoing heart attack. Better detection of injury after a heart attack could thus help improve the follow-up of this patient group.

Ola Gjesdal and colleagues have shown that with new ultrasound technology, we can accurately measure the contraction of the various sections of the heart and that the degree of contraction is closely linked to the spread and extent of the heart attack. The new techniques were compared to already established ones, and showed a better ability to detect impaired cardiac function. Contrast MRI of the heart was used as a standard for the extent of the myocardial infarction. This is the most sensitive method of detecting a heart attack, but it is too expensive and less accessible to be used routinely. The techniques used are accessible on the majority of modern ultrasound devices, and the method can therefore be used immediately by the country's heart specialists.

 

Publications 2020

Storsten P, Aalen JM, Boe E, Remme EW, Gjesdal O, Larsen CK, Andersen OS, Eriksen M, Kongsgaard E, Duchenne J, Voigt JU, Smiseth OA, Skulstad H (2020)
Mechanical Effects on Right Ventricular Function From Left Bundle Branch Block and Cardiac Resynchronization Therapy
JACC-Cardiovasc. Imag., 13 (7), 1475-1484
DOI 10.1016/j.jcmg.2019.11.016

Publications 2019

van Mourik MJW, Zaar DVJ, Smulders MW, Heijman J, Lumens J, Dokter JE, Passos VL, Schalla S, Knackstedt C, Schummers G, Gjesdal O, Edvardsen T, Bekkers SCAM (2019)
Adding Speckle-Tracking Echocardiography to Visual Assessment of Systolic Wall Motion Abnormalities Improves the Detection of Myocardial Infarction
J. Am. Soc. Echocardiogr., 32 (1), 65-73
DOI 10.1016/j.echo.2018.09.007

Aalen J, Storsten P, Remme EW, Sirnes PA, Gjesdal O, Larsen CK, Kongsgaard E, Boe E, Skulstad H, Hisdal J, Smiseth OA (2019)
Afterload Hypersensitivity in Patients With Left Bundle Branch Block
JACC-Cardiovasc. Imag., 12 (6), 967-977
DOI 10.1016/j.jcmg.2017.11.025

Publications 2018

Erikssen G, Aboulhosn J, Lin J, Liestol K, Estensen ME, Gjesdal O, Skulstad H, Dohlen G, Lindberg HL (2018)
Survival in patients with univentricular hearts: the impact of right versus left ventricular morphology
Open Heart, 5 (2), UNSP e000902
DOI 10.1136/openhrt-2018-000902

Publications 2017

Nestaas E, Shih JY, Smedsrud MK, Gjesdal O, Hopp E, Haugaa KH, Edvardsen T (2017)
Comparison of Electrocardiography Markers and Speckle Tracking Echocardiography for Assessment of Left Ventricular Myocardial Scar Burden in Patients With Previous Myocardial Infarction
Am. J. Cardiol., 119 (9), 1307-1312
DOI 10.1016/j.amjcard.2017.01.020

Publications 2016

Gjesdal O, Yoneyama K, Mewton N, Wu C, Gomes AS, Hundley G, Prince M, Shea S, Liu K, Bluemke DA, Lima JAC (2016)
Reduced Long Axis Strain Is Associated With Heart Failure and Cardiovascular Events in the Multi-Ethnic Study of Atherosclerosis
J. Magn. Reson. Imaging, 44 (1), 178-185
DOI 10.1002/jmri.25135

Ohyama Y, Ambale-Venkatesh B, Noda C, Chugh AR, Teixido-Tura G, Kim JY, Donekal S, Yoneyama K, Gjesdal O, Redheuil A, Liu CY, Nakamura T, Wu CO, Hundley WG, Bluemke DA, Lima JAC (2016)
Association of Aortic Stiffness With Left Ventricular Remodeling and Reduced Left Ventricular Function Measured by Magnetic Resonance Imaging The Multi-Ethnic Study of Atherosclerosis
Circ.-Cardiovasc. Imaging, 9 (7), e004426
DOI 10.1161/CIRCIMAGING.115.004426

Remme EW, Niederer S, Gjesdal O, Russell K, Hyde ER, Smith N, Smiseth OA (2016)
Factors determining the magnitude of the pre-ejection leftward septal motion in left bundle branch block
Europace, 18 (12), 1905-1913
DOI 10.1093/europace/euv381

Publications 2014

Boe E, Russell K, Remme EW, Gjesdal O, Smiseth OA, Skulstad H (2014)
Cardiac responses to left ventricular pacing in hearts with normal electrical conduction: beneficial effect of improved filling is counteracted by dyssynchrony
Am. J. Physiol.-Heart Circul. Physiol., 307 (3), H370-H378
DOI 10.1152/ajpheart.00089.2014

Gjesdal O, Almeida ALC, Hopp E, Beitnes JO, Lunde K, Smith HJR, Lima JAC, Edvardsen T (2014)
Long Axis Strain by MRI and Echocardiography in a Postmyocardial Infarct Population
J. Magn. Reson. Imaging, 40 (5), 1247-1251
DOI 10.1002/jmri.24485

Habibi M, Chahal H, Opdahl A, Gjesdal O, Helle-Valle TM, Heckbert SR, McClelland R, Wu CL, Shea S, Hundley G, Bluemke DA, Lima JAC (2014)
Association of CMR-Measured LA Function With Heart Failure Development Results From the MESA Study Results From the MESA Study
JACC-Cardiovasc. Imag., 7 (6), 570-579
DOI 10.1016/j.jcmg.2014.01.016

Schwartz T, Sanner H, Gjesdal O, Flato B, Sjaastad I (2014)
In juvenile dermatomyositis, cardiac systolic dysfunction is present after long-term follow-up and is predicted by sustained early skin activity
Ann. Rheum. Dis., 73 (10), 1805-1810
DOI 10.1136/annrheumdis-2013-203279

Publications 2013

Hetland A, Haugaa KH, Olseng M, Gjesdal O, Ross S, Saberniak J, Jacobsen MB, Edvardsen T (2013)
Three-Month Treatment with Adaptive Servoventilation Improves Cardiac Function and Physical Activity in Patients with Chronic Heart Failure and Cheyne-Stokes Respiration: A Prospective Randomized Controlled Trial
Cardiology, 126 (2), 81-90
DOI 10.1159/000350826

Russell K, Eriksen M, Aaberge L, Wilhelmsen N, Skulstad H, Gjesdal O, Edvardsen T, Smiseth OA (2013)
Assessment of wasted myocardial work: a novel method to quantify energy loss due to uncoordinated left ventricular contractions
Am. J. Physiol.-Heart Circul. Physiol., 305 (7), H996-H1003
DOI 10.1152/ajpheart.00191.2013

Publications 2012

Russell K, Eriksen M, Aaberge L, Wilhelmsen N, Skulstad H, Remme EW, Haugaa KH, Opdahl A, Fjeld JG, Gjesdal O, Edvardsen T, Smiseth OA (2012)
A novel clinical method for quantification of regional left ventricular pressurestrain loop area: a non-invasive index of myocardial work
Eur. Heart J., 33 (6), 724-733
DOI 10.1093/eurheartj/ehs016

Sarvari SI, Gjesdal O, Gude E, Arora S, Andreassen AK, Gullestad L, Geiran O, Edvardsen T (2012)
Early Postoperative Left Ventricular Function by Echocardiographic Strain is a Predictor of 1-Year Mortality in Heart Transplant Recipients
J. Am. Soc. Echocardiogr., 25 (9), 1007-1014
DOI 10.1016/j.echo.2012.05.010

Smedsrud MK, Sarvari S, Haugaa KH, Gjesdal O, Orn S, Aaberge L, Smiseth OA, Edvardsen T (2012)
Duration of Myocardial Early Systolic Lengthening Predicts the Presence of Significant Coronary Artery Disease
J. Am. Coll. Cardiol., 60 (12), 1086-1093
DOI 10.1016/j.jacc.2012.06.022

Publications 2011

Beitnes JO, Gjesdal O, Lunde K, Solheim S, Edvardsen T, Arnesen H, Forfang K, Aakhus S (2011)
Left ventricular systolic and diastolic function improve after acute myocardial infarction treated with acute percutaneous coronary intervention, but are not influenced by intracoronary injection of autologous mononuclear bone marrow cells: a 3 year serial echocardiographic sub-study of the randomized-controlled ASTAMI study
Eur. J. Echocardiogr., 12 (2)
DOI 10.1093/ejechocard/jeq116

Gjesdal O, Remme EW, Opdahl A, Skulstad H, Russell K, Kongsgaard E, Edvardsen T, Smiseth OA (2011)
Mechanisms of Abnormal Systolic Motion of the Interventricular Septum During Left Bundle-Branch Block
Circ.-Cardiovasc. Imaging, 4 (3), 264-U109
DOI 10.1161/CIRCIMAGING.110.961417

Goebel B, Gjesdal O, Kottke D, Otto S, Jung C, Lauten A, Figulla HR, Edvardsen T, Poerner TC (2011)
Detection of irregular patterns of myocardial contraction in patients with hypertensive heart disease: a two-dimensional ultrasound speckle tracking study
J. Hypertens., 29 (11), 2255-2264
DOI 10.1097/HJH.0b013e32834bdd09

Russell K, Smiseth OA, Gjesdal O, Qvigstad E, Norseng PA, Sjaastad I, Opdahl A, Skulstad H, Edvardsen T, Remme EW (2011)
Mechanism of prolonged electromechanical delay in late activated myocardium during left bundle branch block
Am. J. Physiol.-Heart Circul. Physiol., 301 (6), H2334-H2343
DOI 10.1152/ajpheart.00644.2011

Smedsrud MK, Pettersen E, Gjesdal O, Svennevig JL, Andersen K, Ihlen H, Edvardsen T (2011)
Detection of Left Ventricular Dysfunction by Global Longitudinal Systolic Strain in Patients with Chronic Aortic Regurgitation
J. Am. Soc. Echocardiogr., 24 (11), 1253-1259
DOI 10.1016/j.echo.2011.08.003

Tsai HR, Gjesdal O, Wethal T, Haugaa KH, Fossa A, Fossa SD, Edvardsen T (2011)
Left Ventricular Function Assessed by Two-Dimensional Speckle Tracking Echocardiography in Long-Term Survivors of Hodgkin's Lymphoma Treated by Mediastinal Radiotherapy With or Without Anthracycline Therapy
Am. J. Cardiol., 107 (3), 472-477
DOI 10.1016/j.amjcard.2010.09.048

Publications 2010

Russell K, Opdahl A, Remme EW, Gjesdal O, Skulstad H, Kongsgaard E, Edvardsen T, Smiseth OA (2010)
Evaluation of Left Ventricular Dyssynchrony by Onset of Active Myocardial Force Generation A Novel Method That Differentiates Between Electrical and Mechanical Etiologies
Circ.-Cardiovasc. Imaging, 3 (4), 405-414
DOI 10.1161/CIRCIMAGING.109.905539

Publications 2009

Gjesdal O (2009)
Assessment of myocardial infarct by non-doppler echocardiographic deformation indices
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 841, 70, [8] s.
BIBSYS 09405505x, ISBN 978-82-8072-346-8

Gjesdal O (2009)
Assessment of myocardial infarct by non-doppler echocardiographic deformation indices
In Hjerteforum, Supplement, Norsk cardiologisk selskap, Oslo, 22(2009)3, 1 b. (flere pag.)
BIBSYS 10005675x

Gjesdal O, Gude E, Arora S, Leivestad T, Andreassen AK, Gullestad L, Aaberge L, Brunvand H, Edvardsen T, Geiran OR, Simonsen S (2009)
Intra-aortic balloon counterpulsation as a bridge to heart transplantation does not impair long-term survival
Eur. J. Heart Fail., 11 (7), 709-714
DOI 10.1093/eurjhf/hfp078

Gjesdal O, Vartdal T, Hopp E, Lunde K, Brunvand H, Smith HJ, Edvardsen T (2009)
Left Ventricle Longitudinal Deformation Assessment by Mitral Annulus Displacement or Global Longitudinal Strain in Chronic Ischemic Heart Disease: Are They Interchangeable?
J. Am. Soc. Echocardiogr., 22 (7), 823-830
DOI 10.1016/j.echo.2009.04.023

Publications 2008

Gjesdal O, Helle-Valle T, Hopp E, Lunde K, Vandal T, Aakhus S, Smith HJ, Ihlen H, Edvardsen T (2008)
Noninvasive Separation of Large, Medium, and Small Myocardial Infarcts in Survivors of Reperfused ST-Elevation Myocardial Infarction A Comprehensive Tissue Doppler and Speckle-Tracking Echocardiography Study
Circ.-Cardiovasc. Imaging, 1 (3), 189-196
DOI 10.1161/CIRCIMAGING.108.784900

Publications 2007

Gjesdal O, Hopp E, Vartdal T, Lunde K, Helle-Valle T, Aakhus S, Smith HJ, Ihlen H, Edvardsen T (2007)
Global longitudinal strain measured by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease
Clin. Sci., 113 (5-6), 287-296
DOI 10.1042/CS20070066

Publications 2003

Gudmundsson A, Gjesdal O, Brenner SL, Fjeldskaar I (2003)
Effects of linking up of discontinuities on fracture growth and groundwater transport
Hydrogeol. J., 11 (1), 84-99
DOI 10.1007/s10040-002-0238-0

Publications 1996

Bjoras M, Gjesdal O, Erickson JD, Torp R, Levy LM, Ottersen OP, Degree M, StormMathisen J, Seeberg E, Danbolt NC (1996)
Cloning and expression of a neuronal rat brain glutamate transporter
Mol. Brain Res., 36 (1), 163-168
DOI 10.1016/0169-328X(95)00279-2

Trotti D, Rossi D, Gjesdal O, Levy LM, Racagni G, Danbolt NC, Volterra A (1996)
Peroxynitrite inhibits glutamate transporter subtypes
J. Biol. Chem., 271 (11), 5976-5979
DOI 10.1074/jbc.271.11.5976

Publications 1995

TROTTI D, VOLTERRA A, LEHRE KP, ROSSI D, GJESDAL O, RACAGNI G, DANBOLT NC (1995)
ARACHIDONIC-ACID INHIBITS A PURIFIED AND RECONSTITUTED GLUTAMATE TRANSPORTER DIRECTLY FROM THE WATER PHASE AND NOT VIA THE PHOSPHOLIPID MEMBRANE
J. Biol. Chem., 270 (17), 9890-9895
DOI 10.1074/jbc.270.17.9890

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