Thomas Helle-Valle

  • Consultant Cardiologist, MD, PhD
  • +47 230 73272
Medical doctor and researcher Thomas M. Helle-Valle is a board certified specialist in Internal Medicine and Cardiology from University of Oslo. He was a post-doctoral research fellow at Johns Hopkins Univeristy Hospital, Baltimore in 2008, and received his Ph.D in 2013.
In his Ph.D-thesis “New non-invaisve methods for quantification of myocardial function in the left ventricle”, Helle-Valle introduced and validated new non-invasive methods for detailed assessment of myocardial function. His research demonstrated that new automated pattern recognition algorithms could be applied to echocardiography- or CT recordings to precisely quantify regional and global deformation of the left ventricle. Helle-Valle and colleagues used different models (mathematical simulation, animal experiments and clinical studies) to validate the new analytical methods and demonstrated that the percentage change in myocardial wall deformation (strain) and displacement (rotation) could be used to detect the extent of myocardial ischemia and understand the functional consequences.
Helle-Valle has extensive clinical experience in the use of various echocardiographic modalities and analyses, such as stress-, transesophageal- and intracardiac echocardiography, 4D-imaging and strainanalysis. He is involved in several research projects, particularly regarding atrial function and dyssynchrony, and has a particular responsibility regarding echocardiography during cardiac surgery and percutaneous procedures like MitralClip, TAVI, PTSMA and PFO/ASD/LAA-closure.

Publications 2021

Chivulescu M, Krohg-Sørensen K, Scheirlynck E, Lindberg BR, Dejgaard LA, Lie ØH, Helle-Valle T, Skjølsvik ET, Estensen ME, Edvardsen T, Lingaas PS, Haugaa KH (2021)
Mitral annulus disjunction is associated with adverse outcome in Marfan and Loeys-Dietz syndromes
Eur Heart J Cardiovasc Imaging, 22 (9), 1035-1044
DOI 10.1093/ehjci/jeaa324, PubMed 33280029

Publications 2019

Dahle G, Helle-Valle T, Beitnes JO, Espinoza A, Halvorsen PS, Rein KA (2019)
Single-centre first experience with transapical transcatheter mitral valve replacement with an apical tether: factors influencing screening outcomes
Interact Cardiovasc Thorac Surg, 28 (5), 695-703
DOI 10.1093/icvts/ivy343, PubMed 30602024

Publications 2018

Traaen GM, Aakerøy L, Hunt TE, Øverland B, Lyseggen E, Aukrust P, Ueland T, Helle-Valle T, Steinshamn S, Edvardsen T, Khiabani Zaré H, Aakhus S, Akre H, Anfinsen OG, Loennechen JP, Gullestad L (2018)
Treatment of sleep apnea in patients with paroxysmal atrial fibrillation: design and rationale of a randomized controlled trial
Scand Cardiovasc J, 52 (6), 372-377
DOI 10.1080/14017431.2019.1567933, PubMed 30638392

Publications 2015

Dumont KA, Karlsen JS, Helle-Valle T, Fiane AE, Lundblad R, Urheim S (2015)
Mitral valve analysis adding a virtual semi-transparent annulus plane for detection of prolapsing segments
Cardiovasc Ultrasound, 13, 25
DOI 10.1186/s12947-015-0019-2, PubMed 25986226

Opdahl A, Helle-Valle T, Skulstad H, Smiseth OA (2015)
Strain, strain rate, torsion, and twist: echocardiographic evaluation
Curr Cardiol Rep, 17 (3), 568
DOI 10.1007/s11886-015-0568-x, PubMed 25676830

Publications 2012

Opdahl A, Remme EW, Helle-Valle T, Edvardsen T, Smiseth OA (2012)
Myocardial relaxation, restoring forces, and early-diastolic load are independent determinants of left ventricular untwisting rate
Circulation, 126 (12), 1441-51
DOI 10.1161/CIRCULATIONAHA.111.080861, PubMed 22865889

Vartdal T, Pettersen E, Helle-Valle T, Lyseggen E, Andersen K, Smith HJ, Aaberge L, Smiseth OA, Edvardsen T (2012)
Identification of viable myocardium in acute anterior infarction using duration of systolic lengthening by tissue Doppler strain: a preliminary study
J Am Soc Echocardiogr, 25 (7), 718-25
DOI 10.1016/j.echo.2012.04.016, PubMed 22622107

Publications 2009

Helle-Valle T, Remme EW, Lyseggen E, Pettersen E, Vartdal T, Opdahl A, Smith HJ, Osman NF, Ihlen H, Edvardsen T, Smiseth OA (2009)
Clinical assessment of left ventricular rotation and strain: a novel approach for quantification of function in infarcted myocardium and its border zones
Am J Physiol Heart Circ Physiol, 297 (1), H257-67
DOI 10.1152/ajpheart.01116.2008, PubMed 19395547

Lyseggen E, Vartdal T, Remme EW, Helle-Valle T, Pettersen E, Opdahl A, Edvardsen T, Smiseth OA (2009)
A novel echocardiographic marker of end systole in the ischemic left ventricle: "tug of war" sign
Am J Physiol Heart Circ Physiol, 296 (3), H645-54
DOI 10.1152/ajpheart.00313.2008, PubMed 19122168

Opdahl A, Remme EW, Helle-Valle T, Lyseggen E, Vartdal T, Pettersen E, Edvardsen T, Smiseth OA (2009)
Determinants of left ventricular early-diastolic lengthening velocity: independent contributions from left ventricular relaxation, restoring forces, and lengthening load
Circulation, 119 (19), 2578-86
DOI 10.1161/CIRCULATIONAHA.108.791681, PubMed 19414640

Remme EW, Lyseggen E, Helle-Valle T, Pettersen E, Ragnarsson A, Ihlen H, Edvardsen T, Smiseth OA, Opdahl A, Vartdal T, Ljosland M (2009)
Response to Letter Regarding Article, "Mechanisms of Preejection and Postejection Velocity Spikes in Left Ventricular Myocardium: Interaction Between Wall Deformation and Valve Events"
Circulation, 119 (6), E205
DOI 10.1161/CIRCULATIONAHA.108.823716

Rosen BD, Fernandes VR, Nasir K, Helle-Valle T, Jerosch-Herold M, Bluemke DA, Lima JA (2009)
Age, increased left ventricular mass, and lower regional myocardial perfusion are related to greater extent of myocardial dyssynchrony in asymptomatic individuals: the multi-ethnic study of atherosclerosis
Circulation, 120 (10), 859-66
DOI 10.1161/CIRCULATIONAHA.108.787408, PubMed 19704101

Publications 2008

Crosby J, Amundsen BH, Helle-Valle T, Steen PA, Torp H (2008)
A new tissue Doppler method for examination of left ventricular rotation
Ultrasound Med Biol, 34 (11), 1741-51
DOI 10.1016/j.ultrasmedbio.2008.03.022, PubMed 18547711

Gjesdal O, Helle-Valle T, Hopp E, Lunde K, Vartdal T, Aakhus S, Smith HJ, Ihlen H, Edvardsen T (2008)
Noninvasive separation of large, medium, and small myocardial infarcts in survivors of reperfused ST-elevation myocardial infarction: a comprehensive tissue Doppler and speckle-tracking echocardiography study
Circ Cardiovasc Imaging, 1 (3), 189-96, 2 p following 196
DOI 10.1161/CIRCIMAGING.108.784900, PubMed 19808542

Opdahl A, Helle-Valle T, Remme EW, Vartdal T, Pettersen E, Lunde K, Edvardsen T, Smiseth OA (2008)
Apical rotation by speckle tracking echocardiography: a simplified bedside index of left ventricular twist
J Am Soc Echocardiogr, 21 (10), 1121-8
DOI 10.1016/j.echo.2008.06.012, PubMed 18760568

Remme EW, Lyseggen E, Helle-Valle T, Opdahl A, Pettersen E, Vartdal T, Ragnarsson A, Ljosland M, Ihlen H, Edvardsen T, Smiseth OA (2008)
Mechanisms of preejection and postejection velocity spikes in left ventricular myocardium: interaction between wall deformation and valve events
Circulation, 118 (4), 373-80
DOI 10.1161/CIRCULATIONAHA.107.748491, PubMed 18606917

Publications 2007

Gjesdal O, Hopp E, Vartdal T, Lunde K, Helle-Valle T, Aakhus S, Smith HJ, Ihlen H, Edvardsen T (2007)
Global longitudinal strain measured by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease
Clin Sci (Lond), 113 (6), 287-96
DOI 10.1042/CS20070066, PubMed 17501720

Pettersen E, Helle-Valle T, Edvardsen T, Lindberg H, Smith HJ, Smevik B, Smiseth OA, Andersen K (2007)
Contraction pattern of the systemic right ventricle shift from longitudinal to circumferential shortening and absent global ventricular torsion
J Am Coll Cardiol, 49 (25), 2450-6
DOI 10.1016/j.jacc.2007.02.062, PubMed 17599609

Vartdal T, Brunvand H, Pettersen E, Smith HJ, Lyseggen E, Helle-Valle T, Skulstad H, Ihlen H, Edvardsen T (2007)
Early prediction of infarct size by strain Doppler echocardiography after coronary reperfusion
J Am Coll Cardiol, 49 (16), 1715-21
DOI 10.1016/j.jacc.2006.12.047, PubMed 17448374

Publications 2006

Amundsen BH, Helle-Valle T, Edvardsen T, Torp H, Crosby J, Lyseggen E, Støylen A, Ihlen H, Lima JA, Smiseth OA, Slørdahl SA (2006)
Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging
J Am Coll Cardiol, 47 (4), 789-93
DOI 10.1016/j.jacc.2005.10.040, PubMed 16487846

Edvardsen T, Helle-Valle T, Smiseth OA (2006)
Systolic dysfunction in heart failure with normal ejection fraction: speckle-tracking echocardiography
Prog Cardiovasc Dis, 49 (3), 207-14
DOI 10.1016/j.pcad.2006.08.008, PubMed 17084180

Publications 2005

Crosby J, Helle-Valle T, Amundsen BH, Torp H (2005)
Tracking of regional left ventricular rotation by tissue Doppler imaging.
ULTRASON, 2050-2053

Helle-Valle T, Crosby J, Edvardsen T, Lyseggen E, Amundsen BH, Smith HJ, Rosen BD, Lima JA, Torp H, Ihlen H, Smiseth OA (2005)
New noninvasive method for assessment of left ventricular rotation: speckle tracking echocardiography
Circulation, 112 (20), 3149-56
DOI 10.1161/CIRCULATIONAHA.104.531558, PubMed 16286606

Lyseggen E, Skulstad H, Helle-Valle T, Vartdal T, Urheim S, Rabben SI, Opdahl A, Ihlen H, Smiseth OA (2005)
Myocardial strain analysis in acute coronary occlusion: a tool to assess myocardial viability and reperfusion
Circulation, 112 (25), 3901-10
DOI 10.1161/CIRCULATIONAHA.105.533372, PubMed 16365210

Publications 1995

Helle-Valle T (1995)
[Health services in Nepal--much ado, little health]
Tidsskr Nor Laegeforen, 115 (6), 736-8
PubMed 7900140

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