Thomas Helle-Valle

  • Consultant Cardiologist, MD, PhD
  • +47 230 73272
Medical doctor and researcher Thomas M. Helle-Valle is a board certified specialist in Internal Medicine and Cardiology from University of Oslo. He was a post-doctoral research fellow at Johns Hopkins Univeristy Hospital, Baltimore in 2008, and received his Ph.D in 2013.
 
In his Ph.D-thesis “New non-invaisve methods for quantification of myocardial function in the left ventricle”, Helle-Valle introduced and validated new non-invasive methods for detailed assessment of myocardial function. His research demonstrated that new automated pattern recognition algorithms could be applied to echocardiography- or CT recordings to precisely quantify regional and global deformation of the left ventricle. Helle-Valle and colleagues used different models (mathematical simulation, animal experiments and clinical studies) to validate the new analytical methods and demonstrated that the percentage change in myocardial wall deformation (strain) and displacement (rotation) could be used to detect the extent of myocardial ischemia and understand the functional consequences.
 
Helle-Valle has extensive clinical experience in the use of various echocardiographic modalities and analyses, such as stress-, transesophageal- and intracardiac echocardiography, 4D-imaging and strain analysis. He is involved in several research projects, particularly regarding atrial function and dyssynchrony, and has a particular responsibility regarding echocardiography during cardiac surgery and percutaneous procedures like MitralClip, TAVI, PTSMA and PFO/ASD/LAA-closure.
 

Publications 2021

Chivulescu M, Krohg-Sorensen K, Scheirlynck E, Lindberg BR, Dejgaard LA, Lie OH, Helle-Valle T, Skjolsvik ET, Estensen ME, Edvardsen T, Lingaas PS, Haugaa KH (2021)
Mitral annulus disjunction is associated with adverse outcome in Marfan and Loeys-Dietz syndromes
Eur. Heart J.-Cardiovasc. Imaging, 22 (9), 1035-1044
DOI 10.1093/ehjci/jeaa324

Publications 2019

Dahle G, Helle-Valle T, Beitnes JO, Espinoza A, Halvorsen PS, Rein KA (2019)
Single-centre first experience with transapical transcatheter mitral valve replacement with an apical tether: factors influencing screening outcomes
Interact Cardiovasc. Thorac. Surg., 28 (5), 695-703
DOI 10.1093/icvts/ivy343

Publications 2018

Traaen GM, Aakeroy L, Hunt TE, Overland B, Lyseggen E, Aukrust P, Ueland T, Helle-Valle T, Steinshamn S, Edvardsen T, Khiabani Zare H, Aakhus S, Akre H, Anfinsen OG, Loennechen JP, Gullestad L (2018)
Treatment of sleep apnea in patients with paroxysmal atrial fibrillation: design and rationale of a randomized controlled trial
Scand. Cardiovasc. J., 52 (6), 372-377
DOI 10.1080/14017431.2019.1567933

Publications 2015

Dumont KA, Karlsen JS, Helle-Valle T, Fiane AE, Lundblad R, Urheim S (2015)
Mitral valve analysis adding a virtual semi-transparent annulus plane for detection of prolapsing segments
Cardiovasc. Ultrasound, 13, 25
DOI 10.1186/s12947-015-0019-2

Opdahl A, Helle-Valle T, Skulstad H, Smiseth OA (2015)
Strain, Strain Rate, Torsion, and Twist: Echocardiographic Evaluation
Curr. Cardiol. Rep., 17 (3), 15
DOI 10.1007/s11886-015-0568-x

Publications 2012

Opdahl A, Remme EW, Helle-Valle T, Edvardsen T, Smiseth OA (2012)
Myocardial Relaxation, Restoring Forces, and Early-Diastolic Load Are Independent Determinants of Left Ventricular Untwisting Rate
Circulation, 126 (12), 1441-1451
DOI 10.1161/CIRCULATIONAHA.111.080861

Vartdal T, Pettersen E, Helle-Valle T, Lyseggen E, Andersen K, Smith HJ, Aaberge L, Smiseth OA, Edvardsen T (2012)
Identification of Viable Myocardium in Acute Anterior Infarction Using Duration of Systolic Lengthening by Tissue Doppler Strain: A Preliminary Study
J. Am. Soc. Echocardiogr., 25 (7), 718-725
DOI 10.1016/j.echo.2012.04.016

Publications 2009

Helle-Valle T, Remme EW, Lyseggen E, Pettersen E, Vartdal T, Opdahl A, Smith HJ, Osman NF, Ihlen H, Edvardsen T, Smiseth OA (2009)
Clinical assessment of left ventricular rotation and strain: a novel approach for quantification of function in infarcted myocardium and its border zones
Am. J. Physiol.-Heart Circul. Physiol., 297 (1), H257-H267
DOI 10.1152/ajpheart.01116.2008

Lyseggen E, Vartdal T, Remme EW, Helle-Valle T, Pettersen E, Opdahl A, Edvardsen T, Smiseth OA (2009)
A novel echocardiographic marker of end systole in the ischemic left ventricle: "tug of war" sign
Am. J. Physiol.-Heart Circul. Physiol., 296 (3), H645-H654
DOI 10.1152/ajpheart.00313.2008

Opdahl A, Remme EW, Helle-Valle T, Lyseggen E, Vartdal T, Pettersen E, Edvardsen T, Smiseth OA (2009)
Determinants of Left Ventricular Early-Diastolic Lengthening Velocity Independent Contributions From Left Ventricular Relaxation, Restoring Forces, and Lengthening Load
Circulation, 119 (19), 2578-2586
DOI 10.1161/CIRCULATIONAHA.108.791681

Remme EW, Lyseggen E, Helle-Valle T, Pettersen E, Ragnarsson A, Ihlen H, Edvardsen T, Smiseth OA, Opdahl A, Vartdal T, Ljosland M (2009)
Response to Letter Regarding Article, "Mechanisms of Preejection and Postejection Velocity Spikes in Left Ventricular Myocardium: Interaction Between Wall Deformation and Valve Events"
Circulation, 119 (6), E205
DOI 10.1161/CIRCULATIONAHA.108.823716

Publications 2008

Crosby J, Amundsen BH, Helle-Valle T, Steen PA, Torp H (2008)
A NEW TISSUE DOPPLER METHOD FOR EXAMINATION OF LEFT VENTRICULAR ROTATION
Ultrasound Med. Biol., 34 (11), 1741-1751
DOI 10.1016/j.ultrasmedbio.2008.03.022

Gjesdal O, Helle-Valle T, Hopp E, Lunde K, Vandal T, Aakhus S, Smith HJ, Ihlen H, Edvardsen T (2008)
Noninvasive Separation of Large, Medium, and Small Myocardial Infarcts in Survivors of Reperfused ST-Elevation Myocardial Infarction A Comprehensive Tissue Doppler and Speckle-Tracking Echocardiography Study
Circ.-Cardiovasc. Imaging, 1 (3), 189-196
DOI 10.1161/CIRCIMAGING.108.784900

Opdahl A, Helle-Valle T, Remme EW, Vartdal T, Pettersen E, Lunde K, Edvardsen T, Smiseth OA (2008)
Apical rotation by speckle tracking echocardiography: A simplified bedside index of left ventricular twist
J. Am. Soc. Echocardiogr., 21 (10), 1121-1128
DOI 10.1016/j.echo.2008.06.012

Remme EW, Lyseggen E, Helle-Valle T, Opdahl A, Pettersen E, Vartdal T, Ragnarsson A, Ljosland M, Ihlen H, Edvardsen T, Smiseth OA (2008)
Mechanisms of preejection and postejection velocity spikes in left ventricular myocardium - Interaction between wall deformation and valve events
Circulation, 118 (4), 373-380
DOI 10.1161/CIRCULATIONAHA.107.748491

Publications 2007

Gjesdal O, Hopp E, Vartdal T, Lunde K, Helle-Valle T, Aakhus S, Smith HJ, Ihlen H, Edvardsen T (2007)
Global longitudinal strain measured by two-dimensional speckle tracking echocardiography is closely related to myocardial infarct size in chronic ischaemic heart disease
Clin. Sci., 113 (5-6), 287-296
DOI 10.1042/CS20070066

Pettersen E, Helle-Valle T, Edvardsen T, Lindberg H, Smith HJ, Smevik B, Smiseth OA, Andersen K (2007)
Contraction pattern of the systemic right ventricle - Shift from longitudinal to circumferential shortening and absent global ventricular torsion
J. Am. Coll. Cardiol., 49 (25), 2450-2456
DOI 10.1016/j.jacc.2007.02.062

Vartdal T, Brunvand H, Pettersen E, Smith HJ, Lyseggen E, Helle-Valle T, Skulstad H, Ihlen H, Edvardsen T (2007)
Early prediction of infarct size by strain Doppler echocardiography after coronary reperfusion
J. Am. Coll. Cardiol., 49 (16), 1715-1721
DOI 10.1016/j.jacc.2006.12.047

Publications 2006

Amundsen BH, Helle-Valle T, Edvardsen T, Torp H, Crosby J, Lyseggen E, Stoylen A, Ihlen H, Lima JAC, Smiseth OA, Slordahl SA (2006)
Noninvasive myocardial strain measurement by speckle tracking echocardiography - Validation against sonomicrometry and tagged magnetic resonance imaging
J. Am. Coll. Cardiol., 47 (4), 789-793
DOI 10.1016/j.jacc.2005.10.040

Edvardsen T, Helle-Valle T, Smiseth OA (2006)
Systolic dysfunction in heart failure with normal ejection fraction: Speckle-tracking echocardiography
Prog. Cardiovasc. Dis., 49 (3), 207-214
DOI 10.1016/j.pcad.2006.08.008

Publications 2005

Crosby J, Helle-Valle T, Amundsen BH, Torp H (2005)
Tracking of regional left ventricular rotation by tissue Doppler imaging.
ULTRASON, 2050-2053

Helle-Valle T, Crosby J, Edvardsen T, Lyseggen E, Amundsen BH, Smith HJ, Rosen BD, Lima JAC, Torp H, Ihlen H, Smiseth OA (2005)
New noninvasive method for assessment of left ventricular rotation - Speckle tracking echocardiography
Circulation, 112 (20), 3149-3156
DOI 10.1161/CIRCULATIONAHA.104.531558

Lyseggen E, Skulstad H, Helle-Valle T, Vartdal T, Urheim S, Rabben SI, Opdahl A, Ihlen H, Smiseth OA (2005)
Myocardial strain analysis in acute coronary occlusion - A tool to assess myocardial viability and reperfusion
Circulation, 112 (25), 3901-3910
DOI 10.1161/CIRCULATIONAHA.105.533372

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