Marie Stugaard

  • Associate professor; MD, PhD

Marie Stugaard, MD, PhD, currently holds combined positions as Associate professor at University of Oslo, and senior cardiologist at Ringerike Hospital. She graduated as MD from University of Bergen in 1985. She obtained her PhD at Rikshospitalet, University of Oslo, in 1995, under guidance of Professor Smiseth, on studies defining physical principles and physiological underpinnings using color M-mode Doppler in quantifying left ventricular diastolic function. She has long term experience with our animal model. 

Stugaard spent 2 years as postdoc fellow at Cleveland Clinic, funded by grant from American Heart Association. She mainly worked on color M mode and extracting intraventricular pressure gradients, in collaboration with Professors Thomas and Klein.

For family reasons, Stugaard has lived in Japan many years. There, she took opportunity to work at Osaka University with Professor Nakatani, past President of Japanese Society of Echocardiography. She then organized collaborative research program between Norway and Japan.

Since 2019 Stugaard has moved back to Norway to work clinically and continue her research career.
During recent years, she has been expanding her work on cardiac mechanics and flow to include vector flow imaging.
She has several publications in high-ranked cardiology journals.

 

Publications 2025

Hammersboen LR, Boe E, Duchenne J, Aalen JM, Odland HH, Villegas-Martinez M, Frostelid VC, Khan FH, Sletten OJ, Witsoe M, Skulstad H, Rega F, Gheysens O, Voigt JU, Smiseth OA, Stugaard M, Remme EW (2025)
Non-Invasive Pressure-Volume Analysis by Three-Dimensional Echocardiography: A Novel Powerful Method for Evaluating Left Ventricular Function
J Am Soc Echocardiogr (in press)
DOI 10.1016/j.echo.2025.05.008, PubMed 40412539

Publications 2024

Hammersboen LR, Stugaard M, Puvrez A, Larsen CK, Remme EW, Kongsgård E, Duchenne J, Galli E, Khan FH, Sletten OJ, Penicka M, Donal E, Voigt JU, Smiseth OA, Aalen JM (2024)
Mechanism and Impact of Left Atrial Dyssynchrony on Long-Term Clinical Outcome During Cardiac Resynchronization Therapy
JACC Cardiovasc Imaging, 18 (4), 421-432
DOI 10.1016/j.jcmg.2024.09.008, PubMed 39570213

Ibsen J, Hov MR, Tokerud GE, Fuglum J, Linnerud Krogstad M, Stugaard M, Ihle-Hansen H, Lund CG, Hall C (2024)
Prehospital computed tomography in a rural district for rapid diagnosis and treatment of stroke
Eur Stroke J, 10 (1), 84-91
DOI 10.1177/23969873241267084, PubMed 39340436

Publications 2023

Villegas-Martinez M, Odland HH, Hammersbøen LE, Sletten OJ, Stugaard M, Witsø M, Khan F, Wajdan A, Elle OJ, Remme EW (2023)
Pulse arrival time variation as a non-invasive marker of acute response to cardiac resynchronization therapy
Europace, 25 (3), 1183-1192
DOI 10.1093/europace/euad013, PubMed 36734281

Publications 2021

Inoue K, Khan FH, Remme EW, Ohte N, García-Izquierdo E, Chetrit M, Moñivas-Palomero V, Mingo-Santos S, Andersen ØS, Gude E, Andreassen AK, Wang TKM, Kikuchi S, Stugaard M, Ha JW, Klein AL, Nagueh SF, Smiseth OA (2021)
Determinants of left atrial reservoir and pump strain and use of atrial strain for evaluation of left ventricular filling pressure
Eur Heart J Cardiovasc Imaging, 23 (1), 61-70
DOI 10.1093/ehjci/jeaa415, PubMed 33496314

Inoue K, Khan FH, Remme EW, Ohte N, García-Izquierdo E, Chetrit M, Moñivas-Palomero V, Mingo-Santos S, Andersen ØS, Gude E, Andreassen AK, Wang TKM, Kikuchi S, Stugaard M, Ha JW, Klein AL, Nagueh SF, Smiseth OA (2021)
Corrigendum to: Determinants of left atrial reservoir and pump strain and use of atrial strain for evaluation of left ventricular filling pressure
Eur Heart J Cardiovasc Imaging, 23 (1), 136
DOI 10.1093/ehjci/jeab194, PubMed 34608485

Publications 2020

Minami S, Masuda K, Stugaard M, Kamimukai T, Asanuma T, Nakatani S (2020)
Noninvasive assessment of intraventricular pressure difference in left ventricular dyssynchrony using vector flow mapping
Heart Vessels, 36 (1), 92-98
DOI 10.1007/s00380-020-01664-3, PubMed 32632552

Publications 2015

Hodt A, Hisdal J, Stugaard M, Stranden E, Atar D, Steine K (2015)
Increased LV apical untwist during preload reduction in healthy humans: an echocardiographic speckle tracking study during lower body negative pressure
Physiol Rep, 3 (3)
DOI 10.14814/phy2.12330, PubMed 25802362

Larsen TH, Stugaard M, Rotevatn S, Nygård O, Nordrehaug JE (2015)
Clinical Significance of Late Enhancement and Regional Wall Remodeling Assessed by 3T Magnetic Resonance Imaging
Clin Med Insights Cardiol, 9, 17-24
DOI 10.4137/CMC.S20291, PubMed 25922586

Stugaard M, Koriyama H, Katsuki K, Masuda K, Asanuma T, Takeda Y, Sakata Y, Itatani K, Nakatani S (2015)
Energy loss in the left ventricle obtained by vector flow mapping as a new quantitative measure of severity of aortic regurgitation: a combined experimental and clinical study
Eur Heart J Cardiovasc Imaging, 16 (7), 723-30
DOI 10.1093/ehjci/jev035, PubMed 25762562

Publications 2012

Hodt A, Stugaard M, Hisdal J, Stranden E, Atar D, Steine K (2012)
Regional LV deformation in healthy individuals during isovolumetric contraction and ejection phases assessed by 2D speckle tracking echocardiography
Clin Physiol Funct Imaging, 32 (5), 372-9
DOI 10.1111/j.1475-097X.2012.01139.x, PubMed 22856344

Publications 2011

Hodt A, Hisdal J, Stugaard M, Stranden E, Atar D, Steine K (2011)
Reduced preload elicits increased LV twist in healthy humans: an echocardiographic speckle-tracking study during lower body negative pressure
Clin Physiol Funct Imaging, 31 (5), 382-9
DOI 10.1111/j.1475-097X.2011.01029.x, PubMed 21771258

Publications 2009

Nonaka A, Stugaard M, Ueda O, Hara H, Shimada T, Shiotani H (2009)
Fluorodeoxyglucose-positron emission tomography differentiating thrombus from tumor in the left ventricle
J Am Coll Cardiol, 53 (10), 894
DOI 10.1016/j.jacc.2008.11.038, PubMed 19264250

Publications 2008

Steine K, Rossebø AB, Stugaard M, Pedersen TR (2008)
Left ventricular systolic and diastolic function in asymptomatic patients with moderate aortic stenosis
Am J Cardiol, 102 (7), 897-901
DOI 10.1016/j.amjcard.2008.07.001, PubMed 18805118

Publications 2007

Steine K, Larsen JR, Stugaard M, Berg TJ, Brekke M, Dahl-Jørgensen K (2007)
LV systolic impairment in patients with asymptomatic coronary heart disease and type 1 diabetes is related to coronary atherosclerosis, glycaemic control and advanced glycation endproducts
Eur J Heart Fail, 9 (10), 1044-50
DOI 10.1016/j.ejheart.2007.07.013, PubMed 17719271

Publications 2005

Stugaard M (2005)
[Coronary artery aneurysms]
Tidsskr Nor Laegeforen, 125 (3), 297
PubMed 15768462

Publications 2003

Futani H, Yamagiwa T, Yasojimat H, Natsuaki M, Stugaard M, Maruo S (2003)
Distinction between well-differentiated liposarcoma and intramuscular lipoma by power Doppler ultrasonography
Anticancer Res, 23 (2C), 1713-8
PubMed 12820446

Nakatani S, Stugaard M, Hanatani A, Katsuki K, Kanzaki H, Yamagishi M, Kitakaze M, Miyatake K (2003)
Quantitative assessment of short axis wall motion using myocardial strain rate imaging
Echocardiography, 20 (2), 145-9
DOI 10.1046/j.1540-8175.2003.03015.x, PubMed 12848679

Yasuda H, Nakatani S, Stugaard M, Tsujita-Kuroda Y, Bando K, Kobayashi J, Yamagishi M, Kitakaze M, Kitamura S, Miyatake K (2003)
Failure to prevent progressive dilation of ascending aorta by aortic valve replacement in patients with bicuspid aortic valve: comparison with tricuspid aortic valve
Circulation, 108 Suppl 1, II291-4
DOI 10.1161/01.cir.0000087449.03964.fb, PubMed 12970248

Publications 2002

Skulstad H, Edvardsen T, Urheim S, Rabben SI, Stugaard M, Lyseggen E, Ihlen H, Smiseth OA (2002)
Postsystolic shortening in ischemic myocardium: active contraction or passive recoil?
Circulation, 106 (6), 718-24
DOI 10.1161/01.cir.0000024102.55150.b6, PubMed 12163433

Steine K, Stugaard M, Smiseth O (2002)
Mechanisms of diastolic intraventricular regional pressure differences and flow in the inflow and outflow tracts
J Am Coll Cardiol, 40 (5), 983-90
DOI 10.1016/s0735-1097(02)02046-6, PubMed 12225727

Publications 2001

Rajagopalan N, Garcia MJ, Rodriguez L, Murray RD, Apperson-Hansen C, Stugaard M, Thomas JD, Klein AL (2001)
Comparison of new Doppler echocardiographic methods to differentiate constrictive pericardial heart disease and restrictive cardiomyopathy
Am J Cardiol, 87 (1), 86-94
DOI 10.1016/s0002-9149(00)01278-9, PubMed 11137840

Publications 1999

Steine K, Stugaard M, Smiseth OA (1999)
Mechanisms of retarded apical filling in acute ischemic left ventricular failure
Circulation, 99 (15), 2048-54
DOI 10.1161/01.cir.99.15.2048, PubMed 10209011

Publications 1998

Paulus WJ, Brutsaert DL, Gillebert TC, Rademakers FE, Stanislas U, Leite-Moreira AF, Hess OM, Jiang ZH, Kaufmann P, Mandinov L, Matter C, Marino P, Gibson DG, Henein MY, Manolas J, Smiseth OA, Stugaard M, Hatle LK, Spirito P, Betocchi S, Villari B, Goetzsche O, Shah AM, European Study Grp Diastolic Heart Failure (1998)
How to diagnose diastolic heart failure
Eur. Heart J., 19 (7), 990-1003

Smiseth OA, Steine K, Sandbaek G, Stugaard M, Gjolberg T (1998)
Mechanics of intraventricular filling: study of LV early diastolic pressure gradients and flow velocities
Am J Physiol, 275 (3), H1062-9
DOI 10.1152/ajpheart.1998.275.3.H1062, PubMed 9724314

Steine K, Fløgstad T, Stugaard M, Smiseth OA (1998)
Early diastolic intraventricular filling pattern in acute myocardial infarction by color M-mode Doppler echocardiography
J Am Soc Echocardiogr, 11 (2), 119-25
DOI 10.1016/s0894-7317(98)70069-0, PubMed 9517550

Publications 1996

Lund MB, Ihlen H, Voss BM, Abrahamsen AF, Nome O, Kongerud J, Stugaard M, Forfang K (1996)
Increased risk of heart valve regurgitation after mediastinal radiation for Hodgkin's disease: an echocardiographic study
Heart, 75 (6), 591-5
DOI 10.1136/hrt.75.6.591, PubMed 8697163

Retterstøl K, Stugaard M, Gørbitz C, Ose L (1996)
Results of intensive long-term treatment of familial hypercholesterolemia
Am J Cardiol, 78 (12), 1369-74
DOI 10.1016/s0002-9149(96)00649-2, PubMed 8970408

Publications 1995

Stugaard M, Smiseth OA, Risøe C, Ihlen H (1995)
Intraventricular early diastolic velocity profile during acute myocardial ischemia: a color M-mode Doppler echocardiographic study
J Am Soc Echocardiogr, 8 (3), 270-9
DOI 10.1016/s0894-7317(05)80037-9, PubMed 7640020

Publications 1994

Stugaard M, Brodahl U, Torp H, Ihlen H (1994)
Abnormalities of left ventricular filling in patients with coronary artery disease: assessment by colour M-mode Doppler technique
Eur Heart J, 15 (3), 318-27
DOI 10.1093/oxfordjournals.eurheartj.a060497, PubMed 8013503

Stugaard M, Risöe C, Ihlen H, Smiseth OA (1994)
Intracavitary filling pattern in the failing left ventricle assessed by color M-mode Doppler echocardiography
J Am Coll Cardiol, 24 (3), 663-70
DOI 10.1016/0735-1097(94)90012-4, PubMed 8077536

Stugaard M, Steen T, Lundervold A, Smiseth OA, Ihlen H (1994)
Visual assessment of intra ventricular flow from colour M-mode Doppler images
Int J Card Imaging, 10 (4), 279-87
DOI 10.1007/BF01137719, PubMed 7722349

Publications 1993

Stugaard M, Smiseth OA, Risöe C, Ihlen H (1993)
Intraventricular early diastolic filling during acute myocardial ischemia, assessment by multigated color m-mode Doppler echocardiography
Circulation, 88 (6), 2705-13
DOI 10.1161/01.cir.88.6.2705, PubMed 8252682

Publications 1992

Stugaard M, Wiig I, Lund H, Ose L, Norseth J (1992)
[Familial hypercholesterolemia--intensive diet therapy combined with drug therapy]
Tidsskr Nor Laegeforen, 112 (20), 2642-6
PubMed 1412289

Publications 1991

Knutsen KM, Michelsen S, Otterstad JE, Frøland G, Wasenius A, Stugaard M (1991)
Correlations between left ventricular mass and systolic blood pressure at rest and during maximal exercise in moderately hypertensive men
J Hum Hypertens, 5 (3), 149-54
PubMed 1920338

Otterstad JE, Froeland G, Wasenius AK, Knutsen KM, Michelsen S, Stugaard M (1991)
Validity of the ECG diagnosis of left ventricular hypertrophy in normotensive and moderately hypertensive men when using the echocardiographic assessment of left ventricular mass index as reference
J Hum Hypertens, 5 (2), 101-6
PubMed 1830106

Publications 1990

Michelsen S, Knutsen KM, Stugaard M, Otterstad JE (1990)
Is left ventricular mass in apparently healthy, normotensive men correlated to maximal blood pressure during exercise?
Eur Heart J, 11 (3), 241-8
DOI 10.1093/oxfordjournals.eurheartj.a059690, PubMed 2138544

Wasenius A, Stugaard M, Otterstad JE, Frøyshov D (1990)
Diurnal and monthly intra-individual variability of the concentration of lipids, lipoproteins and apoproteins
Scand J Clin Lab Invest, 50 (6), 635-42
DOI 10.3109/00365519009089181, PubMed 2247768

Publications 1989

Knutsen KM, Stugaard M, Michelsen S, Otterstad JE (1989)
M-mode echocardiographic findings in apparently healthy, non-athletic Norwegians aged 20-70 years. Influence of age, sex and body surface area
J Intern Med, 225 (2), 111-5
DOI 10.1111/j.1365-2796.1989.tb00049.x, PubMed 2921591

Michelsen S, Hurlen M, Stugaard M, Otterstad JE (1989)
Influence of age on physical performance, heart rate and systolic blood pressure response during exercise in apparently healthy women
Scand J Clin Lab Invest, 49 (1), 97-102
DOI 10.3109/00365518909089083, PubMed 2727622

Stugaard M, Wasenius A, Michelsen S, Otterstad JE, Rynning S (1989)
[Serum cholesterol in a selected group of healthy individuals aged 20-70 years. Influence of age and sex]
Tidsskr Nor Laegeforen, 109 (6), 709-11
PubMed 2784236

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