John M. Aalen

  • Postdoc and cardiology fellow; MD, PhD

John Aalen graduated as MD from University of Oslo in 2012. Since then he has been working at Vestfold Hospital Trust (Sentralsykehuset i Vestfold), first as a part of his internship and the last year as resident in internal medicine. He joined our research group in April 2014.

His PhD work "Contractile Reserve in Dyssynchrony (CRID): A novel principle to identify candidates for cardiac resynchronization therapy" focuses on identifying candidates for cardiac resynchronization therapy and the effect of increased afterload on the left ventricle during left bundle branch block. He successfully defended his PhD thesis in May 2021.
Aalen has published several research papers and presented numerous abstracts at international and national conferences and has also won prizes for his work, including the Young Investigator Award for Basic Science at EuroEcho-Imaging Congress in Lisboa in 2017.”

PhD thesis:
Insights into left ventricular dyssynchrony: Consequences for myocardial function and response to cardiac resynchronization therapys (duo.uio.no)

 

Publications 2024

Hammersboen LR, Stugaard M, Puvrez A, Larsen CK, Remme EW, Kongsgård E, Duchenne J, Galli E, Khan FH, Sletten OJ, Penicka M, Donal E, Voigt JU, Smiseth OA, Aalen JM (2024)
Mechanism and Impact of Left Atrial Dyssynchrony on Long-Term Clinical Outcome During Cardiac Resynchronization Therapy
JACC Cardiovasc Imaging (in press)
DOI 10.1016/j.jcmg.2024.09.008, PubMed 39570213

Olsen FJ, Skaarup KG, Lassen MCH, Johansen ND, Jensen GB, Schnohr P, Marott JL, Søgaard P, Gislason G, Svendsen JH, Møgelvang R, Aalen JM, Smiseth OA, Remme EW, Biering-Sørensen T (2024)
Association between myocardial work indices and cardiovascular events according to hypertension in the general population
Eur Heart J Cardiovasc Imaging, 25 (3), 413-424
DOI 10.1093/ehjci/jead292, PubMed 37930752

Rogstadkjernet M, Zha SZ, Klæboe LG, Larsen CK, Aalen JM, Scheirlynck E, Singstad BJ, Droogmans S, Cosyns B, Smiseth OA, Haugaa KH, Edvardsen T, Samset E, Brekke PH (2024)
A deep learning based method for left ventricular strain measurements: repeatability and accuracy compared to experienced echocardiographers
BMC Med Imaging, 24 (1), 305
DOI 10.1186/s12880-024-01470-7, PubMed 39528980

Publications 2023

Duchenne J, Larsen CK, Cvijic M, Galli E, Aalen JM, Klop B, Mirea O, Puvrez A, Bézy S, Wouters L, Minten L, Sirnes PA, Khan FH, Voros G, Willems R, Penicka M, Kongsgård E, Hopp E, Bogaert J, Smiseth OA, Donal E, Voigt JU (2023)
Mechanical Dyssynchrony Combined with Septal Scarring Reliably Identifies Responders to Cardiac Resynchronization Therapy
J Clin Med, 12 (18)
DOI 10.3390/jcm12186108, PubMed 37763048

Larsen CK, Smiseth OA, Duchenne J, Galli E, Aalen JM, Lederlin M, Bogaert J, Kongsgaard E, Linde C, Penicka M, Donal E, Voigt JU, Hopp E (2023)
Cardiac Magnetic Resonance Identifies Responders to Cardiac Resynchronization Therapy with an Assessment of Septal Scar and Left Ventricular Dyssynchrony
J Clin Med, 12 (22)
DOI 10.3390/jcm12227182, PubMed 38002795

Sletten OJ, Aalen JM, Smiseth OA, Khan FH, Fossa A, Kiserud CE, Villegas-Martinez M, Hisdal J, Remme EW, Skulstad H (2023)
Mental Stress Reduces Left Ventricular Strain: Can It Lead to Misinterpretation of Cancer Therapy-Related Cardiac Dysfunction?
J Am Soc Echocardiogr, 37 (5), 564-566
DOI 10.1016/j.echo.2023.11.010, PubMed 37981246

Publications 2022

Duchenne J, Larsen CK, Cvijic M, Galli E, Aalen JM, Klop B, Puvrez A, Mirea O, Bézy S, Minten L, Sirnes PA, Khan FH, Voros G, Willems R, Penicka M, Kongsgård E, Hopp E, Bogaert J, Smiseth OA, Donal E, Voigt JU (2022)
Visual Presence of Mechanical Dyssynchrony Combined With Septal Scarring Identifies Responders to Cardiac Resynchronization Therapy
JACC Cardiovasc Imaging, 15 (12), 2151-2153
DOI 10.1016/j.jcmg.2022.06.020, PubMed 36481085

Galli E, Oger E, Aalen JM, Duchenne J, Larsen CK, Sade E, Hubert A, Gallard A, Penicka M, Linde C, Le Rolle V, Hernandez A, Leclercq C, Voigt JU, Smiseth OA, Donal E (2022)
Left atrial strain is a predictor of left ventricular systolic and diastolic reverse remodelling in CRT candidates
Eur Heart J Cardiovasc Imaging, 23 (10), 1373-1382
DOI 10.1093/ehjci/jeab163, PubMed 34432006

Larsen CK, Galli E, Duchenne J, Aalen JM, Stokke C, Fjeld JG, Degtiarova G, Claus P, Gheysens O, Saberniak J, Sirnes PA, Lyseggen E, Bogaert J, Kongsgaard E, Penicka M, Voigt JU, Donal E, Hopp E, Smiseth OA (2022)
Scar imaging in the dyssynchronous left ventricle: Accuracy of myocardial metabolism by positron emission tomography and function by echocardiographic strain
Int J Cardiol, 372, 122-129
DOI 10.1016/j.ijcard.2022.11.042, PubMed 36460211

Olsen FJ, Lassen MCH, Skaarup KG, Christensen J, Davidovski FS, Alhakak AS, Sengeløv M, Nielsen AB, Johansen ND, Graff C, Bundgaard H, Hassager C, Jabbari R, Carlsen J, Kirk O, Lindholm MG, Wiese L, Kristiansen OP, Nielsen OW, Lindegaard B, Tønder N, Ulrik CS, Lamberts M, Sivapalan P, Gislason G et al. (2022)
Myocardial Work in Patients Hospitalized With COVID-19: Relation to Biomarkers, COVID-19 Severity, and All-Cause Mortality
J Am Heart Assoc, 11 (19), e026571
DOI 10.1161/JAHA.122.026571, PubMed 36129046

Olsen FJ, Skaarup KG, Lassen MCH, Johansen ND, Sengeløv M, Jensen GB, Schnohr P, Marott JL, Søgaard P, Gislason G, Svendsen JH, Møgelvang R, Aalen JM, Remme EW, Smiseth OA, Biering-Sørensen T (2022)
Normal Values for Myocardial Work Indices Derived From Pressure-Strain Loop Analyses: From the CCHS
Circ Cardiovasc Imaging, 15 (5), e013712
DOI 10.1161/CIRCIMAGING.121.013712, PubMed 35535593

Publications 2021

Degtiarova G, Claus P, Duchenne J, Bogaert J, Nuyts J, Vöros G, Willems R, Larsen CK, Aalen JM, Fjeld JG, Stokke C, Hopp E, Smiseth OA, Voigt JU, Gheysens O (2021)
Left ventricular regional glucose metabolism in combination with septal scar extent identifies CRT responders
Eur J Nucl Med Mol Imaging, 48 (8), 2437-2446
DOI 10.1007/s00259-020-05161-7, PubMed 33416956

Galli E, Le Rolle V, Smiseth OA, Duchenne J, Aalen JM, Larsen CK, Sade EA, Hubert A, Anilkumar S, Penicka M, Linde C, Leclercq C, Hernandez A, Voigt JU, Donal E (2021)
Importance of Systematic Right Ventricular Assessment in Cardiac Resynchronization Therapy Candidates: A Machine Learning Approach
J Am Soc Echocardiogr, 34 (5), 494-502
DOI 10.1016/j.echo.2020.12.025, PubMed 33422667

Galli E, Smiseth OA, Aalen JM, Larsen CK, Sade E, Hubert A, Anilkumar S, Penicka M, Linde C, Le Rolle V, Hernandez A, Leclercq C, Duchenne J, Voigt JU, Donal E (2021)
Prognostic utility of the assessment of diastolic function in patients undergoing cardiac resynchronization therapy
Int J Cardiol, 331, 144-151
DOI 10.1016/j.ijcard.2021.01.046, PubMed 33535079

Sletten OJ, Aalen JM, Izci H, Duchenne J, Remme EW, Larsen CK, Hopp E, Galli E, Sirnes PA, Kongsgard E, Donal E, Voigt JU, Smiseth OA, Skulstad H (2021)
Lateral Wall Dysfunction Signals Onset of Progressive Heart Failure in Left Bundle Branch Block
JACC Cardiovasc Imaging, 14 (11), 2059-2069
DOI 10.1016/j.jcmg.2021.04.017, PubMed 34147454

Smiseth OA, Aalen JM (2021)
Right ventricular work: a step forward for non-invasive assessment of right ventricular function
Eur Heart J Cardiovasc Imaging, 22 (2), 153-154
DOI 10.1093/ehjci/jeaa296, PubMed 33279985

Smiseth OA, Aalen JM, Skulstad H (2021)
Heart failure and systolic function: time to leave diagnostics based on ejection fraction?
Eur Heart J, 42 (7), 786-788
DOI 10.1093/eurheartj/ehaa979, PubMed 33454774

Aalen JM, Smiseth OA (2021)
Strain identifies pseudo-normalized right ventricular function in tricuspid regurgitation
Eur Heart J Cardiovasc Imaging, 22 (8), 876-877
DOI 10.1093/ehjci/jeab089, PubMed 34148090

Publications 2020

Andersen ØS, Krogh MR, Boe E, Storsten P, Aalen JM, Larsen CK, Skulstad H, Odland HH, Smiseth OA, Remme EW (2020)
Left bundle branch block increases left ventricular diastolic pressure during tachycardia due to incomplete relaxation
J Appl Physiol (1985), 128 (4), 729-738
DOI 10.1152/japplphysiol.01002.2018, PubMed 31999529

Duchenne J, Aalen JM, Cvijic M, Larsen CK, Galli E, Bézy S, Beela AS, Ünlü S, Pagourelias ED, Winter S, Hopp E, Kongsgård E, Donal E, Fehske W, Smiseth OA, Voigt JU (2020)
Acute redistribution of regional left ventricular work by cardiac resynchronization therapy determines long-term remodelling
Eur Heart J Cardiovasc Imaging, 21 (6), 619-628
DOI 10.1093/ehjci/jeaa003, PubMed 32031587

Larsen CK, Aalen JM, Stokke C, Fjeld JG, Kongsgaard E, Duchenne J, Degtiarova G, Gheysens O, Voigt JU, Smiseth OA, Hopp E (2020)
Regional myocardial work by cardiac magnetic resonance and non-invasive left ventricular pressure: a feasibility study in left bundle branch block
Eur Heart J Cardiovasc Imaging, 21 (2), 143-153
DOI 10.1093/ehjci/jez231, PubMed 31599327

Storsten P, Aalen JM, Boe E, Remme EW, Gjesdal O, Larsen CK, Andersen ØS, Eriksen M, Kongsgaard E, Duchenne J, Voigt JU, Smiseth OA, Skulstad H (2020)
Mechanical Effects on Right Ventricular Function From Left Bundle Branch Block and Cardiac Resynchronization Therapy
JACC Cardiovasc Imaging, 13 (7), 1475-1484
DOI 10.1016/j.jcmg.2019.11.016, PubMed 31954643

Aalen JM, Donal E, Larsen CK, Duchenne J, Lederlin M, Cvijic M, Hubert A, Voros G, Leclercq C, Bogaert J, Hopp E, Fjeld JG, Penicka M, Linde C, Aalen OO, Kongsgård E, Galli E, Voigt JU, Smiseth OA (2020)
Imaging predictors of response to cardiac resynchronization therapy: left ventricular work asymmetry by echocardiography and septal viability by cardiac magnetic resonance
Eur Heart J, 41 (39), 3813-3823
DOI 10.1093/eurheartj/ehaa603, PubMed 32918449

Publications 2019

Boe E, Smiseth OA, Storsten P, Andersen OS, Aalen J, Eriksen M, Krogh MR, Kongsgaard E, Remme EW, Skulstad H (2019)
Left ventricular end-systolic volume is a more sensitive marker of acute response to cardiac resynchronization therapy than contractility indices: insights from an experimental study
Europace, 21 (2), 347-355
DOI 10.1093/europace/euy221, PubMed 30418572

Kvale KF, Bersvendsen J, Remme EW, Salles S, Aalen JM, Brekke PH, Edvardsen T, Samset E (2019)
Detection of Regional Mechanical Activation of the Left Ventricular Myocardium Using High Frame Rate Ultrasound Imaging
IEEE Trans Med Imaging, 38 (11), 2665-2675
DOI 10.1109/TMI.2019.2909358, PubMed 30969919

Kvale KF, Salles S, Brekke PH, Remme EW, Aalen JM, Edvardsen T, Samset E (2019)
Comparison of two methods for mechanical activation detection using high frame rate ultrasound imaging
IEEE INT ULTRA SYM, 1410-1413

Stensrud MJ, Aalen JM, Aalen OO, Valberg M (2019)
Limitations of hazard ratios in clinical trials
Eur Heart J, 40 (17), 1378-1383
DOI 10.1093/eurheartj/ehy770, PubMed 30500891

Sörensen J, Harms HJ, Aalen JM, Baron T, Smiseth OA, Flachskampf FA (2019)
Myocardial Efficiency: A Fundamental Physiological Concept on the Verge of Clinical Impact
JACC Cardiovasc Imaging, 13 (7), 1564-1576
DOI 10.1016/j.jcmg.2019.08.030, PubMed 31864979

Aalen JM, Remme EW, Larsen CK, Andersen OS, Krogh M, Duchenne J, Hopp E, Ross S, Beela AS, Kongsgaard E, Bergsland J, Odland HH, Skulstad H, Opdahl A, Voigt JU, Smiseth OA (2019)
Mechanism of Abnormal Septal Motion in Left Bundle Branch Block: Role of Left Ventricular Wall Interactions and Myocardial Scar
JACC Cardiovasc Imaging, 12 (12), 2402-2413
DOI 10.1016/j.jcmg.2018.11.030, PubMed 30772230

Aalen JM, Smiseth OA (2019)
Editorial commentary: Septal flash - what is behind the flashy name?
Trends Cardiovasc Med, 30 (2), 123-124
DOI 10.1016/j.tcm.2019.04.003, PubMed 31010721

Publications 2018

Smiseth OA, Aalen JM (2018)
Mechanism of harm from left bundle branch block
Trends Cardiovasc Med, 29 (6), 335-342
DOI 10.1016/j.tcm.2018.10.012, PubMed 30401603

Aalen J, Storsten P, Remme EW, Sirnes PA, Gjesdal O, Larsen CK, Kongsgaard E, Boe E, Skulstad H, Hisdal J, Smiseth OA (2018)
Afterload Hypersensitivity in Patients With Left Bundle Branch Block
JACC Cardiovasc Imaging, 12 (6), 967-977
DOI 10.1016/j.jcmg.2017.11.025, PubMed 29361486

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