Publications 2020

Alhazzani W, Belley-Cote E, Møller MH, Angus DC, Papazian L, Arabi YM, Citerio G, Connolly B, Denehy L, Fox-Robichaud A, Hough CL, Laake JH, Machado FR, Ostermann M, Piraino T, Sharif S, Szczeklik W, Young PJ, Gouskos A, Kiedrowski K, Burns KEA (2020)
Neuromuscular blockade in patients with ARDS: a rapid practice guideline
Intensive Care Med (in press)
DOI 10.1007/s00134-020-06227-8, PubMed 33104824

Aslam TN, Klitgaard TL, Møller MH, Perner A, Hofsø K, Skrubbeltrang C, Flaatten HI, Rasmussen BS, Laake JH (2020)
Spontaneous versus controlled mechanical ventilation in patients with acute respiratory distress syndrome - Protocol for a scoping review
Acta Anaesthesiol Scand, 64 (6), 857-860
DOI 10.1111/aas.13570, PubMed 32157683

Becker F, Laake JH, Hofso K (2020)
Rehabilitation after Covid-19
Tidsskr. Nor. Laegeforen., 140 (9), 880-883

Becker F, Laake JH, Hofsø K (2020)
Rehabilitering etter covid-19
Tidsskr Nor Laegeforen, 140 (9)
DOI 10.4045/tidsskr.20.0352, PubMed 32549011

Lamontagne F, Agoritsas T, Macdonald H, Leo YS, Diaz J, Agarwal A, Appiah JA, Arabi Y, Blumberg L, Calfee CS, Cao B, Cecconi M, Cooke G, Dunning J, Geduld H, Gee P, Manai H, Hui DS, Kanda S, Kawano-Dourado L, Kim YJ, Kissoon N, Kwizera A, Laake JH, Machado FR et al. (2020)
A living WHO guideline on drugs for covid-19
BMJ, 370, m3379
DOI 10.1136/bmj.m3379, PubMed 32887691

Laake JH (2020)
COVID-19: Evidence, eminence, or experience-based
Tidsskr. Nor. Laegeforen., 140 (12), 1214

Laake JH, Aasmundstad TA, Kåsine T, Pischke SE, Barratt-Due A (2020)
Covid-19: Evidens-, eminens-, eller erfaringsbasert behandling?
Tidsskr Nor Laegeforen, 140 (12)
DOI 10.4045/tidsskr.20.0649, PubMed 32900165

Schjørring OL, Klitgaard TL, Perner A, Wetterslev J, Lange T, Keus F, Laake JH, Morgan M, Bäcklund M, Siegemund M, Thormar KM, Rasmussen BS (2020)
The handling oxygenation targets in the intensive care unit (HOT-ICU) trial: Detailed statistical analysis plan
Acta Anaesthesiol Scand, 64 (6), 847-856
DOI 10.1111/aas.13569, PubMed 32068884

Publications 2019

Anthon CT, Granholm A, Perner A, Laake JH, Møller MH (2019)
Overall bias and sample sizes were unchanged in ICU trials over time: a meta-epidemiological study
J Clin Epidemiol, 113, 189-199
DOI 10.1016/j.jclinepi.2019.05.021, PubMed 31150836

Granholm A, Anthon CT, Perner A, Laake JH, Møller MH (2019)
Transparent and systematic reporting of meta-epidemiological studies
J Clin Epidemiol, 112, 93-95
DOI 10.1016/j.jclinepi.2019.04.014, PubMed 31048022

Kjaer MN, Meyhoff TS, Madsen MB, Hjortrup PB, Møller MH, Egerod I, Wetterslev J, Lange T, Cronhjort M, Laake JH, Jakob SM, Nalos M, Pettilä V, van der Horst ICC, Ostermann M, Mouncey P, Cecconi M, Ferrer R, Malbrain MLNG, Ahlstedt C, Hoffmann S, Bestle MH, Gyldensted L, Nebrich L, Russell L et al. (2019)
Long-term patient-important outcomes after septic shock: A protocol for 1-year follow-up of the CLASSIC trial
Acta Anaesthesiol Scand, 64 (3), 410-416
DOI 10.1111/aas.13519, PubMed 31828753

Marker S, Krag M, Perner A, Wetterslev J, Lange T, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Schefold JC, Rasmussen BS, Elkmann T, Bestle M, Arenkiel B, Laake JH, Kamper MK, Lång M, Pawlowicz-Dworzanska MB, Karlsson S, Liisanantti J, Dey N, Knudsen H, Granholm A, Møller MH et al. (2019)
Pantoprazole in ICU patients at risk for gastrointestinal bleeding-1-year mortality in the SUP-ICU trial
Acta Anaesthesiol Scand, 63 (9), 1184-1190
DOI 10.1111/aas.13436, PubMed 31282567

Meyhoff TS, Hjortrup PB, Møller MH, Wetterslev J, Lange T, Kjaer MN, Jonsson AB, Hjortsø CJS, Cronhjort M, Laake JH, Jakob SM, Nalos M, Pettilä V, van der Horst I, Ostermann M, Mouncey P, Rowan K, Cecconi M, Ferrer R, Malbrain MLNG, Ahlstedt C, Hoffmann S, Bestle MH, Nebrich L, Russell L et al. (2019)
Conservative vs liberal fluid therapy in septic shock (CLASSIC) trial-Protocol and statistical analysis plan
Acta Anaesthesiol Scand, 63 (9), 1262-1271
DOI 10.1111/aas.13434, PubMed 31276193

Robertsen A, Helseth E, Laake JH, Førde R (2019)
Neurocritical care physicians' doubt about whether to withdraw life-sustaining treatment the first days after devastating brain injury: an interview study
Scand J Trauma Resusc Emerg Med, 27 (1), 81
DOI 10.1186/s13049-019-0648-9, PubMed 31462245

Schjørring OL, Perner A, Wetterslev J, Lange T, Keus F, Laake JH, Okkonen M, Siegemund M, Morgan M, Thormar KM, Rasmussen BS, HOT-ICU Investigators (2019)
Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure
Acta Anaesthesiol Scand, 63 (7), 956-965
DOI 10.1111/aas.13356, PubMed 30883686

Publications 2018

Anthon CT, Granholm A, Perner A, Laake JH, Møller MH (2018)
Bias and sample size in intensive care unit trials: Protocol for a meta-epidemiological study
Acta Anaesthesiol Scand, 63 (1), 117-121
DOI 10.1111/aas.13258, PubMed 30203472

Anthon CT, Granholm A, Perner A, Laake JH, Møller MH (2018)
No firm evidence that lack of blinding affects estimates of mortality in randomized clinical trials of intensive care interventions: a systematic review and meta-analysis
J Clin Epidemiol, 100, 71-81
DOI 10.1016/j.jclinepi.2018.04.016, PubMed 29705093

Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Schefold JC, Keus F, Guttormsen AB, Bendel S, Borthwick M, Lange T, Rasmussen BS, Siegemund M, Bundgaard H, Elkmann T, Jensen JV, Nielsen RD, Liboriussen L, Bestle MH, Elkjær JM, Palmqvist DF, Bäcklund M, Laake JH, Bådstøløkken PM, Grönlund J et al. (2018)
Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU
N Engl J Med, 379 (23), 2199-2208
DOI 10.1056/NEJMoa1714919, PubMed 30354950

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A et al. (2018)
Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study
Intensive Care Med, 44 (1), 157-165
DOI 10.1007/s00134-017-4981-z, PubMed 29138899

Laake JH, Møller MH (2018)
Continued licensing of hydroxyethyl starch despite high-quality data documenting harm in vulnerable patient populations: A sad day for patient safety
Acta Anaesthesiol Scand, 63 (1), 131-132
DOI 10.1111/aas.13261, PubMed 30203537

Laake JH, Tønnessen TI, Chew MS, Lipcsey M, Hjelmqvist H, Wilkman E, Pettilä V, Hoffmann-Petersen J, Møller MH, Board of the Scandinavian Society of Anaesthesiology Intensive Care Medicine (SSAI) (2018)
The SSAI fully supports the suspension of hydroxyethyl-starch solutions commissioned by the European Medicines Agency
Acta Anaesthesiol Scand, 62 (6), 874-875
DOI 10.1111/aas.13120, PubMed 29658984

Møller MH, Granholm A, Junttila E, Haney M, Oscarsson-Tibblin A, Haavind A, Laake JH, Wilkman E, Sverrisson KÖ, Perner A (2018)
Scandinavian SSAI clinical practice guideline on choice of inotropic agent for patients with acute circulatory failure
Acta Anaesthesiol Scand, 62 (4), 420-450
DOI 10.1111/aas.13089, PubMed 29479665

Perner A, Laake JH, van der Horst ICC (2018)
Innovation and safety in critical care: should we collaborate with the industry? Con
Intensive Care Med, 44 (12), 2279-2281
DOI 10.1007/s00134-018-5295-5, PubMed 30406807

Rochwerg B, Almenawer SA, Siemieniuk RAC, Vandvik PO, Agoritsas T, Lytvyn L, Alhazzani W, Archambault P, D'Aragon F, Farhoumand PD, Guyatt G, Laake JH, Beltrán-Arroyave C, McCredie V, Price A, Chabot C, Zervakis T, Badhiwala J, St-Onge M, Szczeklik W, Møller MH, Lamontagne F (2018)
Atraumatic (pencil-point) versus conventional needles for lumbar puncture: a clinical practice guideline
BMJ, 361, k1920
DOI 10.1136/bmj.k1920, PubMed 29789372

Schjørring OL, Toft-Petersen AP, Kusk KH, Mouncey P, Sørensen EE, Berezowicz P, Bestle MH, Bülow HH, Bundgaard H, Christensen S, Iversen SA, Kirkeby-Garstad I, Krarup KB, Kruse M, Laake JH, Liboriussen L, Laebel RL, Okkonen M, Poulsen LM, Russell L, Sjövall F, Sunde K, Søreide E, Waldau T, Walli AR et al. (2018)
Intensive care doctors' preferences for arterial oxygen tension levels in mechanically ventilated patients
Acta Anaesthesiol Scand, 62 (10), 1443-1451
DOI 10.1111/aas.13171, PubMed 29926908

Publications 2017

Anthon CT, Granholm A, Perner A, Laake JH, Møller MH (2017)
The effect of blinding on estimates of mortality in randomised clinical trials of intensive care interventions: protocol for a systematic review and meta-analysis
BMJ Open, 7 (7), e016187
DOI 10.1136/bmjopen-2017-016187, PubMed 28701412

Hylands M, Moller MH, Asfar P, Toma A, Frenette AJ, Beaudoin N, Belley-Côté É, D'Aragon F, Laake JH, Siemieniuk RA, Charbonney E, Lauzier F, Kwong J, Rochwerg B, Vandvik PO, Guyatt G, Lamontagne F (2017)
A systematic review of vasopressor blood pressure targets in critically ill adults with hypotension
Can J Anaesth, 64 (7), 703-715
DOI 10.1007/s12630-017-0877-1, PubMed 28497426

Hylands M, Toma A, Beaudoin N, Frenette AJ, D'Aragon F, Belley-Côté É, Charbonney E, Møller MH, Laake JH, Vandvik PO, Siemieniuk RA, Rochwerg B, Lauzier F, Green RS, Ball I, Scales D, Murthy S, Kwong JSW, Guyatt G, Rizoli S, Asfar P, Lamontagne F (2017)
Early vasopressor use following traumatic injury: a systematic review
BMJ Open, 7 (11), e017559
DOI 10.1136/bmjopen-2017-017559, PubMed 29151048

Hylands M, Toma A, Beaudoin N, Frenette AJ, D'Aragon F, Belley-Côté E, Hylander M, Lauzier F, Siemieniuk RA, Charbonney E, Kwong J, Laake JH, Guyatt G, Vandvik PO, Rochwerg B, Green R, Ball I, Scales D, Murthy S, Rizoli S, Asfar P, Lamontagne F (2017)
Vasopressor use following traumatic injury: protocol for a systematic review
BMJ Open, 7 (2), e014166
DOI 10.1136/bmjopen-2016-014166, PubMed 28246141

Laffey JG, Madotto F, Bellani G, Pham T, Fan E, Brochard L, Amin P, Arabi Y, Bajwa EK, Bruhn A, Cerny V, Clarkson K, Heunks L, Kurahashi K, Laake JH, Lorente JA, McNamee L, Nin N, Palo JE, Piquilloud L, Qiu H, Jiménez JIS, Esteban A, McAuley DF, van Haren F et al. (2017)
Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study
Lancet Respir Med, 5 (8), 627-638
DOI 10.1016/S2213-2600(17)30213-8, PubMed 28624388

Laake JH (2017)
[Big brother sees my antibiotic prescriptions!]
Tidsskr Nor Laegeforen, 137 (14-15)
DOI 10.4045/tidsskr.17.0491, PubMed 28828818

Laake JH (2017)
Big Brother sees my antibiotics use!
Tidsskr. Nor. Laegeforen., 137 (14-15), 993-994

Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS (2017)
Gender Parity in Critical Care Medicine
Am J Respir Crit Care Med, 196 (4), 425-429
DOI 10.1164/rccm.201701-0076CP, PubMed 28240961

Møller MH, Laake JH, Myburgh JA, Alhazzani W, Perner A (2017)
The Magic Bullet in Sepsis or the Inflation of Chance Findings?
Chest, 152 (1), 222-223
DOI 10.1016/j.chest.2017.04.181, PubMed 28693775

Rochwerg B, Hylands M, Møller MH, Asfar P, Cohen D, Khadaroo RG, Laake JH, Perner A, Tanguay T, Widder S, Vandvik P, Kristiansen A, Lamontagne F (2017)
CCCS-SSAI WikiRecs clinical practice guideline: vasopressor blood pressure targets in critically ill adults with hypotension and vasopressor use in early traumatic shock
Intensive Care Med, 43 (7), 1062-1064
DOI 10.1007/s00134-016-4539-5, PubMed 28497273

Publications 2016

Claesson J, Freundlich M, Gunnarsson I, Laake JH, Møller MH, Vandvik PO, Varpula T, Aasmundstad TA (2016)
Scandinavian clinical practice guideline on fluid and drug therapy in adults with acute respiratory distress syndrome
Acta Anaesthesiol Scand, 60 (6), 697-709
DOI 10.1111/aas.12713, PubMed 26988416

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A et al. (2016)
Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study
Intensive Care Med, 42 (12), 1865-1876
DOI 10.1007/s00134-016-4571-5, PubMed 27757516

Laake JH (2016)
[Not Available]
Tidsskr Nor Laegeforen, 136 (5), 380
DOI 10.4045/tidsskr.16.0158, PubMed 26983124

Laake JH (2016)
[Sepsis-3 - new definition with aftertaste?]
Tidsskr Nor Laegeforen, 136 (11), 982-3
DOI 10.4045/tidsskr.16.0407, PubMed 27325028

Laake JH (2016)
[Not Available]
Tidsskr Nor Laegeforen, 136 (17), 1424
DOI 10.4045/tidsskr.16.0715, PubMed 27686189

Publications 2014

Claesson J, Freundlich M, Gunnarsson I, Laake JH, Vandvik PO, Varpula T, Aasmundstad TA, Scandinavian Society of Anaesthesiology and Intensive Care Medicine (2014)
Scandinavian clinical practice guideline on mechanical ventilation in adults with the acute respiratory distress syndrome
Acta Anaesthesiol Scand, 59 (3), 286-97
DOI 10.1111/aas.12449, PubMed 25524779

Publications 2013

Laake JH, Nordøy I (2013)
[J.H. Laake & I. Nordøy replies]
Tidsskr Nor Laegeforen, 133 (15), 1555
DOI 10.4045/tidsskr.13.0882, PubMed 23970252

Nordøy I, Laake JH (2013)
[Unjustifiable guidelines for antibiotic use in hospitals]
Tidsskr Nor Laegeforen, 133 (10), 1056
DOI 10.4045/tidsskr.13.0376, PubMed 23712164

Publications 2012

Southwell C, Bengtson J, Bester M, Blix AS, Bornemann H, Boveng P, Cameron M, Forcada J, Laake J, Nordoy E, Plotz J, Rogers T, Southwell D, Steinhage D, Stewart BS, Trathan P (2012)
A REVIEW OF DATA ON ABUNDANCE, TRENDS IN ABUNDANCE, HABITAT USE AND DIET OF ICE-BREEDING SEALS IN THE SOUTHERN OCEAN
CCAMLR Sci., 19, 49-74

Publications 2011

Berdal JE, Mollnes TE, Wæhre T, Olstad OK, Halvorsen B, Ueland T, Laake JH, Furuseth MT, Maagaard A, Kjekshus H, Aukrust P, Jonassen CM (2011)
Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza
J Infect, 63 (4), 308-16
DOI 10.1016/j.jinf.2011.07.004, PubMed 21781987

Rosseland LA, Laake JH, Stubhaug A (2011)
Percutaneous dilatational tracheotomy in intensive care unit patients with increased bleeding risk or obesity. A prospective analysis of 1000 procedures
Acta Anaesthesiol Scand, 55 (7), 835-41
DOI 10.1111/j.1399-6576.2011.02458.x, PubMed 21615346

Publications 2010

Laake JH (2010)
[Surgical reflections]
Tidsskr Nor Laegeforen, 130 (10), 1015
DOI 10.4045/tidsskr.10.0439, PubMed 20489798

Laake JH (2010)
[Thor Heyerdahl was completely wrong]
Tidsskr Nor Laegeforen, 130 (13), 1328; author reply 1328
DOI 10.4045/tidsskr.10.0589, PubMed 20596101

Laake JH, Bugge JF (2010)
[Acute renal failure in critically ill patients]
Tidsskr Nor Laegeforen, 130 (2), 158-61
DOI 10.4045/tidsskr.10.34549, PubMed 20125208

Laake JH, Flaatten HK (2010)
Influenza and the anaesthesiologist
Acta Anaesthesiol Scand, 54 (1), 3-5
DOI 10.1111/j.1399-6576.2009.02167.x, PubMed 19961438

Publications 2009

Laake JH (2009)
[Do-not-resuscitate orders in a stroke unit]
Tidsskr Nor Laegeforen, 129 (4), 310
DOI 10.4045/tidsskr.08.0718, PubMed 19219101

Laake JH, Dybwik K, Flaatten HK, Fonneland IL, Kvåle R, Strand K (2009)
Impact of the post-World War II generation on intensive care needs in Norway
Acta Anaesthesiol Scand, 54 (4), 479-84
DOI 10.1111/j.1399-6576.2009.02170.x, PubMed 19930244

Publications 2008

Alm-Kruse K, Bull EM, Laake JH (2008)
Nurse-led implementation of an insulin-infusion protocol in a general intensive care unit: improved glycaemic control with increased costs and risk of hypoglycaemia signals need for algorithm revision
BMC Nurs, 7, 1
DOI 10.1186/1472-6955-7-1, PubMed 18205930

Publications 2007

Hovdenes J, Laake JH, Haugaa H, Aaberge L, Bugge JF (2007)
Reply to Systemic vascular resistance with an intra-aortic balloon pump: of practical use, even for a petit-maitre?
Acta Anaesthesiol. Scand., 51 (7)

Laake JH (2007)
[Training and iron constitution?]
Tidsskr Nor Laegeforen, 127 (3), 322
PubMed 17279121

Laake JH (2007)
[The brain belongs to all]
Tidsskr Nor Laegeforen, 127 (10), 1401; author reply 1401
PubMed 17520005

Laake JH (2007)
[Interdisciplinary about stroke?]
Tidsskr Nor Laegeforen, 127 (13), 1807; author reply 1807
PubMed 17599140

Laake JH (2007)
[End of life at intensive care units]
Tidsskr Nor Laegeforen, 127 (24), 3235
PubMed 18084368

Publications 2006

Hovdenes J, Laake JH, Aaberge L, Haugaa H, Bugge JF (2006)
Therapeutic hypothermia after out-of-hospital cardiac arrest: experiences with patients treated with percutaneous coronary intervention and cardiogenic shock
Acta Anaesthesiol Scand, 51 (2), 137-42
DOI 10.1111/j.1399-6576.2006.01209.x, PubMed 17181536

Laake JH (2006)
[Medical treatment of acute heart failure]
Tidsskr Nor Laegeforen, 126 (12), 1624; author reply 1624
PubMed 16770381

Laake JH, Bugge JF (2006)
Prevention of acute renal failure--first do no harm!
Acta Anaesthesiol Scand, 50 (2), 255-6; author reply 256-8
DOI 10.1111/j.1399-6576.2006.00930.x, PubMed 16430553

Publications 2005

Laake JH (2005)
[Use and misuse of albumin]
Tidsskr Nor Laegeforen, 125 (24), 3430-2
PubMed 16357884

Laake JH, Kvåle R (2005)
[The Baerum issue-again]
Tidsskr Nor Laegeforen, 125 (9), 1224-5; author reply 1225
PubMed 15880171

Publications 2004

Laake JH (2004)
[Conflict of interest and therapy recommendations]
Tidsskr Nor Laegeforen, 124 (20), 2663-4; author reply 2664
PubMed 15534654

Laake JH (2004)
[One man's loss is another man's gain]
Tidsskr Nor Laegeforen, 124 (23), 3095
PubMed 15586198

Laake JH, Bergmann JB, Riddervold F, Bjørneklett A, Aukrust P, Frøland SS (2004)
[Should patients with severe sepsis be treated with activated protein C?]
Tidsskr Nor Laegeforen, 124 (6), 782-4
PubMed 15039808

Publications 2003

Laake JH, Stubhaug A (2003)
Medical end-of-life decisions in Norway
Resuscitation, 57 (3), 311-2; author reply 312-3
DOI 10.1016/s0300-9572(03)00120-5, PubMed 12804809

Publications 2002

Rosseland LA, Laake JH, Winnem BM (2002)
[The dying patient's preferences when end-of-life decisions are made]
Tidsskr Nor Laegeforen, 122 (3), 293-5
PubMed 11894600

Publications 2001

Laake JH, Røttingen JA (2001)
Rocuronium and anaphylaxis--a statistical challenge
Acta Anaesthesiol Scand, 45 (10), 1196-203
DOI 10.1034/j.1399-6576.2001.451004.x, PubMed 11736669

Publications 2000

Laake JH (2000)
[Continuing education in anesthesiology]
Tidsskr Nor Laegeforen, 120 (5), 618
PubMed 10833925

Laake JH (2000)
[The limited value of clinical experience]
Tidsskr Nor Laegeforen, 120 (15), 1803
PubMed 10904672

Roberg B, Torgner IA, Laake J, Takumi Y, Ottersen OP, Kvamme E (2000)
Properties and submitochondrial localization of pig and rat renal phosphate-activated glutaminase
Am J Physiol Cell Physiol, 279 (3), C648-57
DOI 10.1152/ajpcell.2000.279.3.C648, PubMed 10942715

Publications 1999

Laake JH (1999)
Glutamate as transmitter and toxin: synthesis, compartmentation and pathophysiology
Department of Anatomy, University of Oslo, [Oslo], 1 b. (flere pag.)
BIBSYS 990855007, ISBN 82-91061-03-3

Laake JH, Haug FM, Wieloch T, Ottersen OP (1999)
A simple in vitro model of ischemia based on hippocampal slice cultures and propidium iodide fluorescence
Brain Res Brain Res Protoc, 4 (2), 173-84
DOI 10.1016/s1385-299x(99)00021-5, PubMed 10446412

Laake JH, Takumi Y, Eidet J, Torgner IA, Roberg B, Kvamme E, Ottersen OP (1999)
Postembedding immunogold labelling reveals subcellular localization and pathway-specific enrichment of phosphate activated glutaminase in rat cerebellum
Neuroscience, 88 (4), 1137-51
DOI 10.1016/s0306-4522(98)00298-x, PubMed 10336125

Takumi Y, Matsubara A, Laake JH, Ramírez-León V, Roberg B, Torgner I, Kvamme E, Usami S, Ottersen OP (1999)
Phosphate activated glutaminase is concentrated in mitochondria of sensory hair cells in rat inner ear: a high resolution immunogold study
J Neurocytol, 28 (3), 223-37
DOI 10.1023/a:1007076007642, PubMed 10617904

Publications 1998

Nagelhus EA, Veruki ML, Torp R, Haug FM, Laake JH, Nielsen S, Agre P, Ottersen OP (1998)
Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in Müller cells and fibrous astrocytes
J Neurosci, 18 (7), 2506-19
PubMed 9502811

Ottersen OP, Takumi Y, Matsubara A, Landsend AS, Laake JH, Usami S (1998)
Molecular organization of a type of peripheral glutamate synapse: the afferent synapses of hair cells in the inner ear
Prog Neurobiol, 54 (2), 127-48
DOI 10.1016/s0301-0082(97)00054-3, PubMed 9481795

Rundén E, Seglen PO, Haug FM, Ottersen OP, Wieloch T, Shamloo M, Laake JH (1998)
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism
J Neurosci, 18 (18), 7296-305
PubMed 9736650

Publications 1997

Laake JH (1997)
[Scholarship holders at the medical faculty in Oslo]
Tidsskr Nor Laegeforen, 117 (12), 1811-2
PubMed 9213997

Laake JH (1997)
[Little on ethics and liberal health policy]
Tidsskr Nor Laegeforen, 117 (17), 2511
PubMed 9265317

Laake JH (1997)
[Recruitment of physicians for research work]
Tidsskr Nor Laegeforen, 117 (30), 4485-6
PubMed 9456601

Ottersen OP, Chaudhry FA, Danbolt NC, Laake JH, Nagelhus EA, Storm-Mathisen J, Torp R (1997)
Molecular organization of cerebellar glutamate synapses
Prog Brain Res, 114, 97-107
DOI 10.1016/s0079-6123(08)63360-9, PubMed 9193140

Takumi Y, Matsubara A, Danbolt NC, Laake JH, Storm-Mathisen J, Usami S, Shinkawa H, Ottersen OP (1997)
Discrete cellular and subcellular localization of glutamine synthetase and the glutamate transporter GLAST in the rat vestibular end organ
Neuroscience, 79 (4), 1137-44
DOI 10.1016/s0306-4522(97)00025-0, PubMed 9219972

Publications 1996

Matsubara A, Laake JH, Davanger S, Usami S, Ottersen OP (1996)
Organization of AMPA receptor subunits at a glutamate synapse: a quantitative immunogold analysis of hair cell synapses in the rat organ of Corti
J Neurosci, 16 (14), 4457-67
PubMed 8699256

Ottersen OP, Laake JH, Reichelt W, Haug FM, Torp R (1996)
Ischemic disruption of glutamate homeostasis in brain: quantitative immunocytochemical analyses
J Chem Neuroanat, 12 (1), 1-14
DOI 10.1016/s0891-0618(96)00178-0, PubMed 9001944

Publications 1995

Laake JH, Slyngstad TA, Haug FM, Ottersen OP (1995)
Glutamine from glial cells is essential for the maintenance of the nerve terminal pool of glutamate: immunogold evidence from hippocampal slice cultures
J Neurochem, 65 (2), 871-81
DOI 10.1046/j.1471-4159.1995.65020871.x, PubMed 7616248

Publications 1993

Laake JH, Torp R, Ottersen OP (1993)
Ultrastructural immunocytochemical studies as a means of distinguishing between transmitter and non-transmitter glutamate
Biochem Soc Trans, 21 (1), 45-9
DOI 10.1042/bst0210045, PubMed 8095471

Aas JE, Berg-Johnsen J, Hegstad E, Laake JH, Langmoen IA, Ottersen OP (1993)
Redistribution of glutamate and glutamine in slices of human neocortex exposed to combined hypoxia and glucose deprivation in vitro
J Cereb Blood Flow Metab, 13 (3), 503-15
DOI 10.1038/jcbfm.1993.65, PubMed 8097518

Publications 1992

Laake J (1992)
[Criteria of suitability for medical education]
Tidsskr Nor Laegeforen, 112 (16), 2123
PubMed 1523645

Laake J (1992)
[Criteria of suitability for medical education]
Tidsskr Nor Laegeforen, 112 (11), 1493
PubMed 1631835

Aas JE, Laake JH, Brodal P, Ottersen OP (1992)
Immunocytochemical evidence for in vitro release of glutamate and GABA from separate nerve terminal populations in the rat pontine nuclei
Exp Brain Res, 89 (3), 540-8
DOI 10.1007/BF00229879, PubMed 1353724

Publications 1991

Ji ZQ, Aas JE, Laake J, Walberg F, Ottersen OP (1991)
An electron microscopic, immunogold analysis of glutamate and glutamine in terminals of rat spinocerebellar fibers
J Comp Neurol, 307 (2), 296-310
DOI 10.1002/cne.903070210, PubMed 1677366

Zhang NH, Laake J, Nagelhus E, Storm-Mathisen J, Ottersen OP (1991)
Distribution of glutamine-like immunoreactivity in the cerebellum of rat and baboon (Papio anubis) with reference to the issue of metabolic compartmentation
Anat Embryol (Berl), 184 (3), 213-23
DOI 10.1007/BF01673257, PubMed 1686533

Publications 1990

Ottersen OP, Laake JH, Storm-Mathisen J (1990)
Demonstration of a releasable pool of glutamate in cerebellar mossy and parallel fibre terminals by means of light and electron microscopic immunocytochemistry
Arch Ital Biol, 128 (2-4), 111-25
PubMed 1702606

Ottersen OP, Storm-Mathisen J, Bramham C, Torp R, Laake J, Gundersen V (1990)
A quantitative electron microscopic immunocytochemical study of the distribution and synaptic handling of glutamate in rat hippocampus
Prog Brain Res, 83, 99-114
DOI 10.1016/s0079-6123(08)61244-3, PubMed 1975455

Zhang N, Walberg F, Laake JH, Meldrum BS, Ottersen OP (1990)
Aspartate-like and glutamate-like immunoreactivities in the inferior olive and climbing fibre system: a light microscopic and semiquantitative electron microscopic study in rat and baboon (Papio anubis)
Neuroscience, 38 (1), 61-80
DOI 10.1016/0306-4522(90)90374-d, PubMed 1979432

Publications 1986

Storm-Mathisen J, Ottersen OP, Fu-Long T, Gundersen V, Laake JH, Nordbø G (1986)
Metabolism and transport of amino acids studied by immunocytochemistry
Med Biol, 64 (2-3), 127-32
PubMed 2875229