Jon Henrik Laake

  • Senior consultant

Research areas and ongoing projects:

Respiratory failure in ICU patients

Guidelines for the management of patients with ARDS

Spontaneous versus controlled mechanical ventilation in patients with acute respiratory distress syndrome (ARDS)

Cooperators:Centre for Research in Intensive Care, Rigshospitalet, Copenhagen, DK, ...........Kommer mer



Publications 2023

Bakkehaug JP, Kåsine T, Romundstad L, Narum J, Laake JH, Svalebjørg M, Fiane AE, Hoel T, Thiara A, Pischke SE, Aasmundstad TA, Barratt-Due A (2023)
[Not Available]
Tidsskr Nor Laegeforen, 143 (2)
DOI 10.4045/tidsskr.22.0545, PubMed 36718886

Fjone KS, Buanes EA, Småstuen MC, Laake JH, Stubberud J, Hofsø K (2023)
Post-traumatic stress symptoms six months after ICU admission with COVID-19: Prospective observational study
J Clin Nurs (in press)
DOI 10.1111/jocn.16665, PubMed 36850042

Laake JH, Møller MH (2023)
A lingua franca for guidelines-or a Tower of Babel?
Acta Anaesthesiol Scand (in press)
DOI 10.1111/aas.14242, PubMed 36967446

Meyhoff TS, Granholm A, Hjortrup PB, Sivapalan P, Lange T, Laake JH, Cronhjort M, Jakob SM, Cecconi M, Nalos M, Ostermann M, Malbrain MLNG, Møller MH, Perner A (2023)
Albumin administration in septic shock-Protocol for post-hoc analyses of data from a multicentre RCT
Acta Anaesthesiol Scand (in press)
DOI 10.1111/aas.14280, PubMed 37246841

Pham T, Heunks L, Bellani G, Madotto F, Aragao I, Beduneau G, Goligher EC, Grasselli G, Laake JH, Mancebo J, Peñuelas O, Piquilloud L, Pesenti A, Wunsch H, van Haren F, Brochard L, Laffey JG, WEAN SAFE Investigators (2023)
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study
Lancet Respir Med, 11 (5), 465-476
DOI 10.1016/S2213-2600(22)00449-0, PubMed 36693401

Publications 2022

Laake JH, Småstuen MC, Møller MH, Larsson A, Aslam TN, Hofsø K, Pham T, Fan E, Bellani G, Laffey JG, LUNG SAFE Investigators (2022)
Patient characteristics, management and outcomes in a Nordic subset of the "large observational study to understand the global impact of severe acute respiratory failure" (LUNG SAFE) study
Acta Anaesthesiol Scand, 66 (6), 684-695
DOI 10.1111/aas.14069, PubMed 35398892

Meyhoff TS, Hjortrup PB, Wetterslev J, Sivapalan P, Laake JH, Cronhjort M, Jakob SM, Cecconi M, Nalos M, Ostermann M, Malbrain M, Pettilä V, Møller MH, Kjær MN, Lange T, Overgaard-Steensen C, Brand BA, Winther-Olesen M, White JO, Quist L, Westergaard B, Jonsson AB, Hjortsø CJS, Meier N, Jensen TS et al. (2022)
Restriction of Intravenous Fluid in ICU Patients with Septic Shock
N Engl J Med, 386 (26), 2459-2470
DOI 10.1056/NEJMoa2202707, PubMed 35709019

Publications 2021

Aslam TN, Klitgaard TL, Hofsø K, Rasmussen BS, Laake JH (2021)
Spontaneous Versus Controlled Mechanical Ventilation in Patients with Acute Respiratory Distress Syndrome
Curr Anesthesiol Rep, 11 (2), 85-91
DOI 10.1007/s40140-021-00443-8, PubMed 33679255

Chew MS, Kattainen S, Haase N, Buanes EA, Kristinsdottir LB, Hofsø K, Laake JH, Kvåle R, Hästbacka J, Reinikainen M, Bendel S, Varpula T, Walther S, Perner A, Flaatten HK, Sigurdsson MI (2021)
A descriptive study of the surge response and outcomes of ICU patients with COVID-19 during first wave in Nordic countries
Acta Anaesthesiol Scand, 66 (1), 56-64
DOI 10.1111/aas.13983, PubMed 34570897

Laake JH (2021)
Numbers that reveal and numbers that conceal
Tidsskr Nor Laegeforen, 141 (3)
DOI 10.4045/tidsskr.21.0088, PubMed 33624969

Laake JH, Astvad M, Bentsen G, Escher C, Haney M, Hoffmann-Petersen J, Hyllested M, Junttila E, Møller MH, Nellgård P, Nyberg A, Olkkola K, Pedersen SKA, Pischke SE, Reinikainen M, Strand K, Thorarensen G, Thormar K, Tønnessen TI (2021)
A policy for diversity, equity, inclusion and anti-racism in the Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI)
Acta Anaesthesiol Scand, 66 (1), 141-144
DOI 10.1111/aas.13978, PubMed 34462910

Laake JH, Buanes EA, Småstuen MC, Kvåle R, Olsen BF, Rustøen T, Strand K, Sørensen V, Hofsø K (2021)
Characteristics, management and survival of ICU patients with coronavirus disease-19 in Norway, March-June 2020. A prospective observational study
Acta Anaesthesiol Scand, 65 (5), 618-628
DOI 10.1111/aas.13785, PubMed 33501998

Laake JH, Hofsø K (2021)
Intensive care: what should we measure?
Tidsskr Nor Laegeforen, 141 (8)
DOI 10.4045/tidsskr.21.0266, PubMed 34047157

Mølgaard Nielsen F, Lass Klitgaard T, Crescioli E, Rosborg Aagaard S, Andreasen AS, Musaeus Poulsen L, Siegemund M, Craveiro Brøchner A, Bestle MH, Andi Iversen S, Brand BA, Laake JH, Grøfte T, Hildebrandt T, Lange T, Perner A, Lilleholt Schjørring O, Steen Rasmussen B (2021)
Handling oxygenation targets in ICU patients with COVID-19-Protocol and statistical analysis plan in the HOT-COVID trial
Acta Anaesthesiol Scand, 65 (10), 1497-1504
DOI 10.1111/aas.13956, PubMed 34310694

Rasmussen BS, Klitgaard TL, Perner A, Brand BA, Hildebrandt T, Siegemund M, Hollinger A, Aagaard SR, Bestle MH, Marcussen KV, Brøchner AC, Sølling CG, Poulsen LM, Laake JH, Aslam TN, Bäcklund M, Okkonen M, Morgan M, Sharman M, Lange T, Wetterslev J, Schjørring OL (2021)
Oxygenation targets in ICU patients with COVID-19: A post hoc subgroup analysis of the HOT-ICU trial
Acta Anaesthesiol Scand, 66 (1), 76-84
DOI 10.1111/aas.13977, PubMed 34425016

Schjørring OL, Klitgaard TL, Perner A, Wetterslev J, Lange T, Siegemund M, Bäcklund M, Keus F, Laake JH, Morgan M, Thormar KM, Rosborg SA, Bisgaard J, Erntgaard AES, Lynnerup AH, Pedersen RL, Crescioli E, Gielstrup TC, Behzadi MT, Poulsen LM, Estrup S, Laigaard JP, Andersen C, Mortensen CB, Brand BA et al. (2021)
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
N Engl J Med, 384 (14), 1301-1311
DOI 10.1056/NEJMoa2032510, PubMed 33471452

Publications 2020

Alhazzani W, Belley-Cote E, Møller MH, Angus DC, Papazian L, Arabi YM, Citerio G, Connolly B, Denehy L, Fox-Robichaud A, Hough CL, Laake JH, Machado FR, Ostermann M, Piraino T, Sharif S, Szczeklik W, Young PJ, Gouskos A, Kiedrowski K, Burns KEA (2020)
Neuromuscular blockade in patients with ARDS: a rapid practice guideline
Intensive Care Med, 46 (11), 1977-1986
DOI 10.1007/s00134-020-06227-8, PubMed 33104824

Aslam TN, Klitgaard TL, Møller MH, Perner A, Hofsø K, Skrubbeltrang C, Flaatten HI, Rasmussen BS, Laake JH (2020)
Spontaneous versus controlled mechanical ventilation in patients with acute respiratory distress syndrome - Protocol for a scoping review
Acta Anaesthesiol Scand, 64 (6), 857-860
DOI 10.1111/aas.13570, PubMed 32157683

Becker F, Laake JH, Hofso K (2020)
Rehabilitation after Covid-19
Tidsskr. Nor. Laegeforen., 140 (9), 880-883

Becker F, Laake JH, Hofsø K (2020)
[Rehabilitation after COVID-19]
Tidsskr Nor Laegeforen, 140 (9)
DOI 10.4045/tidsskr.20.0352, PubMed 32549011

Laake JH, Hansen M, Mo S, Brathen CC, Adolfsen E, Overland G (2020)
Ethics experts on the wrong track
Tidsskr. Nor. Laegeforen., 140 (18), 1829-1830

Laake JH, Hansen M, Mo S, Bråthen CC, Adolfsen E, Øverland G (2020)
[Ethics experts on the wrong track]
Tidsskr Nor Laegeforen, 140 (18)
DOI 10.4045/tidsskr.20.0952, PubMed 33322871

Laake JH, Aasmundstad TA, Kåsine T, Pischke SE, Barratt-Due A (2020)
[COVID-19: evidence, eminence, or experience- based treatment?]
Tidsskr Nor Laegeforen, 140 (12)
DOI 10.4045/tidsskr.20.0649, PubMed 32900165

Schjørring OL, Klitgaard TL, Perner A, Wetterslev J, Lange T, Keus F, Laake JH, Morgan M, Bäcklund M, Siegemund M, Thormar KM, Rasmussen BS (2020)
The handling oxygenation targets in the intensive care unit (HOT-ICU) trial: Detailed statistical analysis plan
Acta Anaesthesiol Scand, 64 (6), 847-856
DOI 10.1111/aas.13569, PubMed 32068884

Publications 2019

Anthon CT, Granholm A, Perner A, Laake JH, Møller MH (2019)
Overall bias and sample sizes were unchanged in ICU trials over time: a meta-epidemiological study
J Clin Epidemiol, 113, 189-199
DOI 10.1016/j.jclinepi.2019.05.021, PubMed 31150836

Granholm A, Anthon CT, Perner A, Laake JH, Møller MH (2019)
Transparent and systematic reporting of meta-epidemiological studies
J Clin Epidemiol, 112, 93-95
DOI 10.1016/j.jclinepi.2019.04.014, PubMed 31048022

Kjaer MN, Meyhoff TS, Madsen MB, Hjortrup PB, Møller MH, Egerod I, Wetterslev J, Lange T, Cronhjort M, Laake JH, Jakob SM, Nalos M, Pettilä V, van der Horst ICC, Ostermann M, Mouncey P, Cecconi M, Ferrer R, Malbrain MLNG, Ahlstedt C, Hoffmann S, Bestle MH, Gyldensted L, Nebrich L, Russell L et al. (2019)
Long-term patient-important outcomes after septic shock: A protocol for 1-year follow-up of the CLASSIC trial
Acta Anaesthesiol Scand, 64 (3), 410-416
DOI 10.1111/aas.13519, PubMed 31828753

Marker S, Krag M, Perner A, Wetterslev J, Lange T, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Schefold JC, Rasmussen BS, Elkmann T, Bestle M, Arenkiel B, Laake JH, Kamper MK, Lång M, Pawlowicz-Dworzanska MB, Karlsson S, Liisanantti J, Dey N, Knudsen H, Granholm A, Møller MH et al. (2019)
Pantoprazole in ICU patients at risk for gastrointestinal bleeding-1-year mortality in the SUP-ICU trial
Acta Anaesthesiol Scand, 63 (9), 1184-1190
DOI 10.1111/aas.13436, PubMed 31282567

Meyhoff TS, Hjortrup PB, Møller MH, Wetterslev J, Lange T, Kjaer MN, Jonsson AB, Hjortsø CJS, Cronhjort M, Laake JH, Jakob SM, Nalos M, Pettilä V, van der Horst I, Ostermann M, Mouncey P, Rowan K, Cecconi M, Ferrer R, Malbrain MLNG, Ahlstedt C, Hoffmann S, Bestle MH, Nebrich L, Russell L et al. (2019)
Conservative vs liberal fluid therapy in septic shock (CLASSIC) trial-Protocol and statistical analysis plan
Acta Anaesthesiol Scand, 63 (9), 1262-1271
DOI 10.1111/aas.13434, PubMed 31276193

Robertsen A, Helseth E, Laake JH, Førde R (2019)
Neurocritical care physicians' doubt about whether to withdraw life-sustaining treatment the first days after devastating brain injury: an interview study
Scand J Trauma Resusc Emerg Med, 27 (1), 81
DOI 10.1186/s13049-019-0648-9, PubMed 31462245

Schjørring OL, Perner A, Wetterslev J, Lange T, Keus F, Laake JH, Okkonen M, Siegemund M, Morgan M, Thormar KM, Rasmussen BS, HOT-ICU Investigators (2019)
Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure
Acta Anaesthesiol Scand, 63 (7), 956-965
DOI 10.1111/aas.13356, PubMed 30883686

Publications 2018

Anthon CT, Granholm A, Perner A, Laake JH, Møller MH (2018)
No firm evidence that lack of blinding affects estimates of mortality in randomized clinical trials of intensive care interventions: a systematic review and meta-analysis
J Clin Epidemiol, 100, 71-81
DOI 10.1016/j.jclinepi.2018.04.016, PubMed 29705093

Anthon CT, Granholm A, Perner A, Laake JH, Møller MH (2018)
Bias and sample size in intensive care unit trials: Protocol for a meta-epidemiological study
Acta Anaesthesiol Scand, 63 (1), 117-121
DOI 10.1111/aas.13258, PubMed 30203472

Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Schefold JC, Keus F, Guttormsen AB, Bendel S, Borthwick M, Lange T, Rasmussen BS, Siegemund M, Bundgaard H, Elkmann T, Jensen JV, Nielsen RD, Liboriussen L, Bestle MH, Elkjær JM, Palmqvist DF, Bäcklund M, Laake JH, Bådstøløkken PM, Grönlund J et al. (2018)
Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU
N Engl J Med, 379 (23), 2199-2208
DOI 10.1056/NEJMoa1714919, PubMed 30354950

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A et al. (2018)
Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study
Intensive Care Med, 44 (1), 157-165
DOI 10.1007/s00134-017-4981-z, PubMed 29138899

Laake JH, Møller MH (2018)
Continued licensing of hydroxyethyl starch despite high-quality data documenting harm in vulnerable patient populations: A sad day for patient safety
Acta Anaesthesiol Scand, 63 (1), 131-132
DOI 10.1111/aas.13261, PubMed 30203537

Laake JH, Tønnessen TI, Chew MS, Lipcsey M, Hjelmqvist H, Wilkman E, Pettilä V, Hoffmann-Petersen J, Møller MH, Board of the Scandinavian Society of Anaesthesiology Intensive Care Medicine (SSAI) (2018)
The SSAI fully supports the suspension of hydroxyethyl-starch solutions commissioned by the European Medicines Agency
Acta Anaesthesiol Scand, 62 (6), 874-875
DOI 10.1111/aas.13120, PubMed 29658984

Møller MH, Granholm A, Junttila E, Haney M, Oscarsson-Tibblin A, Haavind A, Laake JH, Wilkman E, Sverrisson KÖ, Perner A (2018)
Scandinavian SSAI clinical practice guideline on choice of inotropic agent for patients with acute circulatory failure
Acta Anaesthesiol Scand, 62 (4), 420-450
DOI 10.1111/aas.13089, PubMed 29479665

Perner A, Laake JH, van der Horst ICC (2018)
Innovation and safety in critical care: should we collaborate with the industry? Con
Intensive Care Med, 44 (12), 2279-2281
DOI 10.1007/s00134-018-5295-5, PubMed 30406807

Rochwerg B, Almenawer SA, Siemieniuk RAC, Vandvik PO, Agoritsas T, Lytvyn L, Alhazzani W, Archambault P, D'Aragon F, Farhoumand PD, Guyatt G, Laake JH, Beltrán-Arroyave C, McCredie V, Price A, Chabot C, Zervakis T, Badhiwala J, St-Onge M, Szczeklik W, Møller MH, Lamontagne F (2018)
Atraumatic (pencil-point) versus conventional needles for lumbar puncture: a clinical practice guideline
BMJ, 361, k1920
DOI 10.1136/bmj.k1920, PubMed 29789372

Schjørring OL, Toft-Petersen AP, Kusk KH, Mouncey P, Sørensen EE, Berezowicz P, Bestle MH, Bülow HH, Bundgaard H, Christensen S, Iversen SA, Kirkeby-Garstad I, Krarup KB, Kruse M, Laake JH, Liboriussen L, Laebel RL, Okkonen M, Poulsen LM, Russell L, Sjövall F, Sunde K, Søreide E, Waldau T, Walli AR et al. (2018)
Intensive care doctors' preferences for arterial oxygen tension levels in mechanically ventilated patients
Acta Anaesthesiol Scand, 62 (10), 1443-1451
DOI 10.1111/aas.13171, PubMed 29926908

Publications 2017

Anthon CT, Granholm A, Perner A, Laake JH, Møller MH (2017)
The effect of blinding on estimates of mortality in randomised clinical trials of intensive care interventions: protocol for a systematic review and meta-analysis
BMJ Open, 7 (7), e016187
DOI 10.1136/bmjopen-2017-016187, PubMed 28701412

Hylands M, Moller MH, Asfar P, Toma A, Frenette AJ, Beaudoin N, Belley-Côté É, D'Aragon F, Laake JH, Siemieniuk RA, Charbonney E, Lauzier F, Kwong J, Rochwerg B, Vandvik PO, Guyatt G, Lamontagne F (2017)
A systematic review of vasopressor blood pressure targets in critically ill adults with hypotension
Can J Anaesth, 64 (7), 703-715
DOI 10.1007/s12630-017-0877-1, PubMed 28497426

Hylands M, Toma A, Beaudoin N, Frenette AJ, D'Aragon F, Belley-Côté É, Charbonney E, Møller MH, Laake JH, Vandvik PO, Siemieniuk RA, Rochwerg B, Lauzier F, Green RS, Ball I, Scales D, Murthy S, Kwong JSW, Guyatt G, Rizoli S, Asfar P, Lamontagne F (2017)
Early vasopressor use following traumatic injury: a systematic review
BMJ Open, 7 (11), e017559
DOI 10.1136/bmjopen-2017-017559, PubMed 29151048

Hylands M, Toma A, Beaudoin N, Frenette AJ, D'Aragon F, Belley-Côté E, Hylander M, Lauzier F, Siemieniuk RA, Charbonney E, Kwong J, Laake JH, Guyatt G, Vandvik PO, Rochwerg B, Green R, Ball I, Scales D, Murthy S, Rizoli S, Asfar P, Lamontagne F (2017)
Vasopressor use following traumatic injury: protocol for a systematic review
BMJ Open, 7 (2), e014166
DOI 10.1136/bmjopen-2016-014166, PubMed 28246141

Laffey JG, Madotto F, Bellani G, Pham T, Fan E, Brochard L, Amin P, Arabi Y, Bajwa EK, Bruhn A, Cerny V, Clarkson K, Heunks L, Kurahashi K, Laake JH, Lorente JA, McNamee L, Nin N, Palo JE, Piquilloud L, Qiu H, Jiménez JIS, Esteban A, McAuley DF, van Haren F et al. (2017)
Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study
Lancet Respir Med, 5 (8), 627-638
DOI 10.1016/S2213-2600(17)30213-8, PubMed 28624388

Laake JH (2017)
[Big brother sees my antibiotic prescriptions!]
Tidsskr Nor Laegeforen, 137 (14-15)
DOI 10.4045/tidsskr.17.0491, PubMed 28828818

Laake JH (2017)
Big Brother sees my antibiotics use!
Tidsskr. Nor. Laegeforen., 137 (14-15), 993-994

Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS (2017)
Gender Parity in Critical Care Medicine
Am J Respir Crit Care Med, 196 (4), 425-429
DOI 10.1164/rccm.201701-0076CP, PubMed 28240961

Møller MH, Laake JH, Myburgh JA, Alhazzani W, Perner A (2017)
The Magic Bullet in Sepsis or the Inflation of Chance Findings?
Chest, 152 (1), 222-223
DOI 10.1016/j.chest.2017.04.181, PubMed 28693775

Rochwerg B, Hylands M, Møller MH, Asfar P, Cohen D, Khadaroo RG, Laake JH, Perner A, Tanguay T, Widder S, Vandvik P, Kristiansen A, Lamontagne F (2017)
CCCS-SSAI WikiRecs clinical practice guideline: vasopressor blood pressure targets in critically ill adults with hypotension and vasopressor use in early traumatic shock
Intensive Care Med, 43 (7), 1062-1064
DOI 10.1007/s00134-016-4539-5, PubMed 28497273

Publications 2016

Claesson J, Freundlich M, Gunnarsson I, Laake JH, Møller MH, Vandvik PO, Varpula T, Aasmundstad TA (2016)
Scandinavian clinical practice guideline on fluid and drug therapy in adults with acute respiratory distress syndrome
Acta Anaesthesiol Scand, 60 (6), 697-709
DOI 10.1111/aas.12713, PubMed 26988416

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A et al. (2016)
Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study
Intensive Care Med, 42 (12), 1865-1876
DOI 10.1007/s00134-016-4571-5, PubMed 27757516

Laake JH (2016)
[Not Available]
Tidsskr Nor Laegeforen, 136 (5), 380
DOI 10.4045/tidsskr.16.0158, PubMed 26983124

Laake JH (2016)
[Sepsis-3 - new definition with aftertaste?]
Tidsskr Nor Laegeforen, 136 (11), 982-3
DOI 10.4045/tidsskr.16.0407, PubMed 27325028

Laake JH (2016)
[Not Available]
Tidsskr Nor Laegeforen, 136 (17), 1424
DOI 10.4045/tidsskr.16.0715, PubMed 27686189

Publications 2014

Claesson J, Freundlich M, Gunnarsson I, Laake JH, Vandvik PO, Varpula T, Aasmundstad TA, Scandinavian Society of Anaesthesiology and Intensive Care Medicine (2014)
Scandinavian clinical practice guideline on mechanical ventilation in adults with the acute respiratory distress syndrome
Acta Anaesthesiol Scand, 59 (3), 286-97
DOI 10.1111/aas.12449, PubMed 25524779

Publications 2013

Laake JH, Nordøy I (2013)
[J.H. Laake & I. Nordøy replies]
Tidsskr Nor Laegeforen, 133 (15), 1555
DOI 10.4045/tidsskr.13.0882, PubMed 23970252

Nordøy I, Laake JH (2013)
[Unjustifiable guidelines for antibiotic use in hospitals]
Tidsskr Nor Laegeforen, 133 (10), 1056
DOI 10.4045/tidsskr.13.0376, PubMed 23712164

Publications 2012

Southwell C, Bengtson J, Bester M, Blix AS, Bornemann H, Boveng P, Cameron M, Forcada J, Laake J, Nordoy E, Plotz J, Rogers T, Southwell D, Steinhage D, Stewart BS, Trathan P (2012)
CCAMLR Sci., 19, 49-74

Publications 2011

Berdal JE, Mollnes TE, Wæhre T, Olstad OK, Halvorsen B, Ueland T, Laake JH, Furuseth MT, Maagaard A, Kjekshus H, Aukrust P, Jonassen CM (2011)
Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza
J Infect, 63 (4), 308-16
DOI 10.1016/j.jinf.2011.07.004, PubMed 21781987

Rosseland LA, Laake JH, Stubhaug A (2011)
Percutaneous dilatational tracheotomy in intensive care unit patients with increased bleeding risk or obesity. A prospective analysis of 1000 procedures
Acta Anaesthesiol Scand, 55 (7), 835-41
DOI 10.1111/j.1399-6576.2011.02458.x, PubMed 21615346

Publications 2010

Laake JH (2010)
[Surgical reflections]
Tidsskr Nor Laegeforen, 130 (10), 1015
DOI 10.4045/tidsskr.10.0439, PubMed 20489798

Laake JH (2010)
[Thor Heyerdahl was completely wrong]
Tidsskr Nor Laegeforen, 130 (13), 1328; author reply 1328
DOI 10.4045/tidsskr.10.0589, PubMed 20596101

Laake JH, Bugge JF (2010)
[Acute renal failure in critically ill patients]
Tidsskr Nor Laegeforen, 130 (2), 158-61
DOI 10.4045/tidsskr.10.34549, PubMed 20125208

Laake JH, Flaatten HK (2010)
Influenza and the anaesthesiologist
Acta Anaesthesiol Scand, 54 (1), 3-5
DOI 10.1111/j.1399-6576.2009.02167.x, PubMed 19961438

Publications 2009

Laake JH (2009)
[Do-not-resuscitate orders in a stroke unit]
Tidsskr Nor Laegeforen, 129 (4), 310
DOI 10.4045/tidsskr.08.0718, PubMed 19219101

Laake JH, Dybwik K, Flaatten HK, Fonneland IL, Kvåle R, Strand K (2009)
Impact of the post-World War II generation on intensive care needs in Norway
Acta Anaesthesiol Scand, 54 (4), 479-84
DOI 10.1111/j.1399-6576.2009.02170.x, PubMed 19930244

Publications 2008

Alm-Kruse K, Bull EM, Laake JH (2008)
Nurse-led implementation of an insulin-infusion protocol in a general intensive care unit: improved glycaemic control with increased costs and risk of hypoglycaemia signals need for algorithm revision
BMC Nurs, 7, 1
DOI 10.1186/1472-6955-7-1, PubMed 18205930

Publications 2007

Hovdenes J, Laake JH, Haugaa H, Aaberge L, Bugge JF (2007)
Reply to Systemic vascular resistance with an intra-aortic balloon pump: of practical use, even for a petit-maitre?
Acta Anaesthesiol. Scand., 51 (7)
DOI 10.1111/j.1399-6576.2007.01345.x

Laake JH (2007)
[Training and iron constitution?]
Tidsskr Nor Laegeforen, 127 (3), 322
PubMed 17279121

Laake JH (2007)
[The brain belongs to all]
Tidsskr Nor Laegeforen, 127 (10), 1401; author reply 1401
PubMed 17520005

Laake JH (2007)
[Interdisciplinary about stroke?]
Tidsskr Nor Laegeforen, 127 (13), 1807; author reply 1807
PubMed 17599140

Laake JH (2007)
[End of life at intensive care units]
Tidsskr Nor Laegeforen, 127 (24), 3235
PubMed 18084368

Publications 2006

Hovdenes J, Laake JH, Aaberge L, Haugaa H, Bugge JF (2006)
Therapeutic hypothermia after out-of-hospital cardiac arrest: experiences with patients treated with percutaneous coronary intervention and cardiogenic shock
Acta Anaesthesiol Scand, 51 (2), 137-42
DOI 10.1111/j.1399-6576.2006.01209.x, PubMed 17181536

Laake JH (2006)
[Medical treatment of acute heart failure]
Tidsskr Nor Laegeforen, 126 (12), 1624; author reply 1624
PubMed 16770381

Laake JH, Bugge JF (2006)
Prevention of acute renal failure--first do no harm!
Acta Anaesthesiol Scand, 50 (2), 255-6; author reply 256-8
DOI 10.1111/j.1399-6576.2006.00930.x, PubMed 16430553

Publications 2005

Laake JH (2005)
[Use and misuse of albumin]
Tidsskr Nor Laegeforen, 125 (24), 3430-2
PubMed 16357884

Laake JH, Kvåle R (2005)
[The Baerum issue-again]
Tidsskr Nor Laegeforen, 125 (9), 1224-5; author reply 1225
PubMed 15880171

Publications 2004

Laake JH (2004)
[Conflict of interest and therapy recommendations]
Tidsskr Nor Laegeforen, 124 (20), 2663-4; author reply 2664
PubMed 15534654

Laake JH (2004)
[One man's loss is another man's gain]
Tidsskr Nor Laegeforen, 124 (23), 3095
PubMed 15586198

Laake JH, Bergmann JB, Riddervold F, Bjørneklett A, Aukrust P, Frøland SS (2004)
[Should patients with severe sepsis be treated with activated protein C?]
Tidsskr Nor Laegeforen, 124 (6), 782-4
PubMed 15039808

Publications 2003

Laake JH, Stubhaug A (2003)
Medical end-of-life decisions in Norway
Resuscitation, 57 (3), 311-2; author reply 312-3
DOI 10.1016/s0300-9572(03)00120-5, PubMed 12804809

Publications 2002

Rosseland LA, Laake JH, Winnem BM (2002)
[The dying patient's preferences when end-of-life decisions are made]
Tidsskr Nor Laegeforen, 122 (3), 293-5
PubMed 11894600

Publications 2001

Laake JH, Røttingen JA (2001)
Rocuronium and anaphylaxis--a statistical challenge
Acta Anaesthesiol Scand, 45 (10), 1196-203
DOI 10.1034/j.1399-6576.2001.451004.x, PubMed 11736669

Publications 2000

Laake JH (2000)
[Continuing education in anesthesiology]
Tidsskr Nor Laegeforen, 120 (5), 618
PubMed 10833925

Laake JH (2000)
[The limited value of clinical experience]
Tidsskr Nor Laegeforen, 120 (15), 1803
PubMed 10904672

Roberg B, Torgner IA, Laake J, Takumi Y, Ottersen OP, Kvamme E (2000)
Properties and submitochondrial localization of pig and rat renal phosphate-activated glutaminase
Am J Physiol Cell Physiol, 279 (3), C648-57
DOI 10.1152/ajpcell.2000.279.3.C648, PubMed 10942715

Publications 1999

Laake JH (1999)
Glutamate as transmitter and toxin: synthesis, compartmentation and pathophysiology
Department of Anatomy, University of Oslo, [Oslo], 1 b. (flere pag.)
BIBSYS 990855007, ISBN 82-91061-03-3

Laake JH, Haug FM, Wieloch T, Ottersen OP (1999)
A simple in vitro model of ischemia based on hippocampal slice cultures and propidium iodide fluorescence
Brain Res Brain Res Protoc, 4 (2), 173-84
DOI 10.1016/s1385-299x(99)00021-5, PubMed 10446412

Laake JH, Takumi Y, Eidet J, Torgner IA, Roberg B, Kvamme E, Ottersen OP (1999)
Postembedding immunogold labelling reveals subcellular localization and pathway-specific enrichment of phosphate activated glutaminase in rat cerebellum
Neuroscience, 88 (4), 1137-51
DOI 10.1016/s0306-4522(98)00298-x, PubMed 10336125

Takumi Y, Matsubara A, Laake JH, Ramírez-León V, Roberg B, Torgner I, Kvamme E, Usami S, Ottersen OP (1999)
Phosphate activated glutaminase is concentrated in mitochondria of sensory hair cells in rat inner ear: a high resolution immunogold study
J Neurocytol, 28 (3), 223-37
DOI 10.1023/a:1007076007642, PubMed 10617904

Publications 1998

Nagelhus EA, Veruki ML, Torp R, Haug FM, Laake JH, Nielsen S, Agre P, Ottersen OP (1998)
Aquaporin-4 water channel protein in the rat retina and optic nerve: polarized expression in Müller cells and fibrous astrocytes
J Neurosci, 18 (7), 2506-19
DOI 10.1523/JNEUROSCI.18-07-02506.1998, PubMed 9502811

Ottersen OP, Takumi Y, Matsubara A, Landsend AS, Laake JH, Usami S (1998)
Molecular organization of a type of peripheral glutamate synapse: the afferent synapses of hair cells in the inner ear
Prog Neurobiol, 54 (2), 127-48
DOI 10.1016/s0301-0082(97)00054-3, PubMed 9481795

Rundén E, Seglen PO, Haug FM, Ottersen OP, Wieloch T, Shamloo M, Laake JH (1998)
Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism
J Neurosci, 18 (18), 7296-305
DOI 10.1523/JNEUROSCI.18-18-07296.1998, PubMed 9736650

Publications 1997

Laake JH (1997)
[Scholarship holders at the medical faculty in Oslo]
Tidsskr Nor Laegeforen, 117 (12), 1811-2
PubMed 9213997

Laake JH (1997)
[Little on ethics and liberal health policy]
Tidsskr Nor Laegeforen, 117 (17), 2511
PubMed 9265317

Laake JH (1997)
[Recruitment of physicians for research work]
Tidsskr Nor Laegeforen, 117 (30), 4485-6
PubMed 9456601

Ottersen OP, Chaudhry FA, Danbolt NC, Laake JH, Nagelhus EA, Storm-Mathisen J, Torp R (1997)
Molecular organization of cerebellar glutamate synapses
Prog Brain Res, 114, 97-107
DOI 10.1016/s0079-6123(08)63360-9, PubMed 9193140

Takumi Y, Matsubara A, Danbolt NC, Laake JH, Storm-Mathisen J, Usami S, Shinkawa H, Ottersen OP (1997)
Discrete cellular and subcellular localization of glutamine synthetase and the glutamate transporter GLAST in the rat vestibular end organ
Neuroscience, 79 (4), 1137-44
DOI 10.1016/s0306-4522(97)00025-0, PubMed 9219972

Publications 1996

Matsubara A, Laake JH, Davanger S, Usami S, Ottersen OP (1996)
Organization of AMPA receptor subunits at a glutamate synapse: a quantitative immunogold analysis of hair cell synapses in the rat organ of Corti
J Neurosci, 16 (14), 4457-67
DOI 10.1523/JNEUROSCI.16-14-04457.1996, PubMed 8699256

Ottersen OP, Laake JH, Reichelt W, Haug FM, Torp R (1996)
Ischemic disruption of glutamate homeostasis in brain: quantitative immunocytochemical analyses
J Chem Neuroanat, 12 (1), 1-14
DOI 10.1016/s0891-0618(96)00178-0, PubMed 9001944

Publications 1995

Laake JH, Slyngstad TA, Haug FM, Ottersen OP (1995)
Glutamine from glial cells is essential for the maintenance of the nerve terminal pool of glutamate: immunogold evidence from hippocampal slice cultures
J Neurochem, 65 (2), 871-81
DOI 10.1046/j.1471-4159.1995.65020871.x, PubMed 7616248

Publications 1993

Laake JH, Torp R, Ottersen OP (1993)
Ultrastructural immunocytochemical studies as a means of distinguishing between transmitter and non-transmitter glutamate
Biochem Soc Trans, 21 (1), 45-9
DOI 10.1042/bst0210045, PubMed 8095471

Aas JE, Berg-Johnsen J, Hegstad E, Laake JH, Langmoen IA, Ottersen OP (1993)
Redistribution of glutamate and glutamine in slices of human neocortex exposed to combined hypoxia and glucose deprivation in vitro
J Cereb Blood Flow Metab, 13 (3), 503-15
DOI 10.1038/jcbfm.1993.65, PubMed 8097518

Publications 1992

Laake J (1992)
[Criteria of suitability for medical education]
Tidsskr Nor Laegeforen, 112 (16), 2123
PubMed 1523645

Laake J (1992)
[Criteria of suitability for medical education]
Tidsskr Nor Laegeforen, 112 (11), 1493
PubMed 1631835

Aas JE, Laake JH, Brodal P, Ottersen OP (1992)
Immunocytochemical evidence for in vitro release of glutamate and GABA from separate nerve terminal populations in the rat pontine nuclei
Exp Brain Res, 89 (3), 540-8
DOI 10.1007/BF00229879, PubMed 1353724

Publications 1991

Ji ZQ, Aas JE, Laake J, Walberg F, Ottersen OP (1991)
An electron microscopic, immunogold analysis of glutamate and glutamine in terminals of rat spinocerebellar fibers
J Comp Neurol, 307 (2), 296-310
DOI 10.1002/cne.903070210, PubMed 1677366

Zhang NH, Laake J, Nagelhus E, Storm-Mathisen J, Ottersen OP (1991)
Distribution of glutamine-like immunoreactivity in the cerebellum of rat and baboon (Papio anubis) with reference to the issue of metabolic compartmentation
Anat Embryol (Berl), 184 (3), 213-23
DOI 10.1007/BF01673257, PubMed 1686533

Publications 1990

Ottersen OP, Laake JH, Storm-Mathisen J (1990)
Demonstration of a releasable pool of glutamate in cerebellar mossy and parallel fibre terminals by means of light and electron microscopic immunocytochemistry
Arch Ital Biol, 128 (2-4), 111-25
PubMed 1702606

Ottersen OP, Storm-Mathisen J, Bramham C, Torp R, Laake J, Gundersen V (1990)
A quantitative electron microscopic immunocytochemical study of the distribution and synaptic handling of glutamate in rat hippocampus
Prog Brain Res, 83, 99-114
DOI 10.1016/s0079-6123(08)61244-3, PubMed 1975455

Zhang N, Walberg F, Laake JH, Meldrum BS, Ottersen OP (1990)
Aspartate-like and glutamate-like immunoreactivities in the inferior olive and climbing fibre system: a light microscopic and semiquantitative electron microscopic study in rat and baboon (Papio anubis)
Neuroscience, 38 (1), 61-80
DOI 10.1016/0306-4522(90)90374-d, PubMed 1979432

Publications 1986

Storm-Mathisen J, Ottersen OP, Fu-Long T, Gundersen V, Laake JH, Nordbø G (1986)
Metabolism and transport of amino acids studied by immunocytochemistry
Med Biol, 64 (2-3), 127-32
PubMed 2875229

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