Publications 2022

Chew MS, Kattainen S, Haase N, Buanes EA, Kristinsdottir LB, Hofso K, Laake JH, Kvale R, Hastbacka J, Reinikainen M, Bendel S, Varpula T, Walther S, Perner A, Flaatten HK, Sigurdsson MI (2022)
A descriptive study of the surge response and outcomes of ICU patients with COVID-19 during first wave in Nordic countries
Acta Anaesthesiol. Scand., 66 (1), 56-64
DOI 10.1111/aas.13983

Laake JH, Astvad M, Bentsen G, Escher C, Haney M, Hoffmann-Petersen J, Hyllested M, Junttila E, Moller MH, Nellgard P, Nyberg A, Olkkola K, Pedersen SKA, Pischke SE, Reinikainen M, Strand K, Thorarensen G, Thormar K, Tonnessen TI (2022)
A policy for diversity, equity, inclusion and anti-racism in the Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI)
Acta Anaesthesiol. Scand., 66 (1), 141-144
DOI 10.1111/aas.13978

Rasmussen BS, Klitgaard TL, Perner A, Brand BA, Hildebrandt T, Siegemund M, Hollinger A, Aagaard SR, Bestle MH, Marcussen KV, Brochner AC, Solling CG, Poulsen LM, Laake JH, Aslam TN, Backlund M, Okkonen M, Morgan M, Sharman M, Lange T, Wetterslev J, Schjorring OL (2022)
Oxygenation targets in ICU patients with COVID-19: A post hoc subgroup analysis of the HOT-ICU trial
Acta Anaesthesiol. Scand., 66 (1), 76-84
DOI 10.1111/aas.13977

Publications 2021

Aslam TN, Klitgaard TL, Hofso K, Rasmussen BS, Laake JH (2021)
Spontaneous Versus Controlled Mechanical Ventilation in Patients with Acute Respiratory Distress Syndrome
Curr. Anesthesiol. Rep., 11 (2), 85-91
DOI 10.1007/s40140-021-00443-8

Laake JH, Buanes EA, Smastuen MC, Kvale R, Olsen BF, Rustoen T, Strand K, Sorensen V, Hofso K (2021)
Characteristics, management and survival of ICU patients with coronavirus disease-19 in Norway, March-June 2020. A prospective observational study
Acta Anaesthesiol. Scand., 65 (5), 618-628
DOI 10.1111/aas.13785

Nielsen FM, Klitgaard TL, Crescioli E, Aagaard SR, Andreasen AS, Poulsen LM, Siegemund M, Brochner AC, Bestle MH, Iversen SA, Brand BA, Laake JH, Grofte T, Hildebrandt T, Lange T, Perner A, Schjorring OL, Rasmussen BS (2021)
Handling oxygenation targets in ICU patients with COVID-19-Protocol and statistical analysis plan in the HOT-COVID trial
Acta Anaesthesiol. Scand., 65 (10), 1497-1504
DOI 10.1111/aas.13956

Schjorring OL, Klitgaard TL, Perner A, Wetterslev J, Lange T, Siegemund M, Backlund M, Keus F, Laake JH, Morgan M, Thormar KM, Rosborg SA, Bisgaard J, Erntgaard AES, Lynnerup ASH, Pedersen RL, Crescioli E, Gielstrup TC, Behzadi MT, Poulsen LM, Estrup S, Laigaard JP, Andersen C, Mortensen CB, Brand BA et al. (2021)
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
N. Engl. J. Med., 384 (14), 1301-1311
DOI 10.1056/NEJMoa2032510

Publications 2020

Alhazzani W, Belley-Cote E, Moller MH, Angus DC, Papazian L, Arabi YM, Citerio G, Connolly B, Denehy L, Fox-Robichaud A, Hough CL, Laake JH, Machado FR, Ostermann M, Piraino T, Sharif S, Szczeklik W, Young PJ, Gouskos A, Kiedrowski K, Burns KEA (2020)
Neuromuscular blockade in patients with ARDS: a rapid practice guideline
Intensive Care Med., 46 (11), 1977-1986
DOI 10.1007/s00134-020-06227-8

Aslam TN, Klitgaard TL, Moller MH, Perner A, Hofso K, Skrubbeltrang C, Flaatten HI, Rasmussen BS, Laake JH (2020)
Spontaneous versus controlled mechanical ventilation in patients with acute respiratory distress syndrome - Protocol for a scoping review
Acta Anaesthesiol. Scand., 64 (6), 857-860
DOI 10.1111/aas.13570

Becker F, Laake JH, Hofso K (2020)
Rehabilitation after Covid-19
Tidsskr. Nor. Laegeforen., 140 (9), 880-883

Kjaer MBN, Meyhoff TS, Madsen MB, Hjortrup PB, Moller MH, Egerod I, Wetterslev J, Lange T, Cronhjort M, Laake JH, Jakob SM, Nalos M, Pettila V, van der Horst ICC, Ostermann M, Mouncey P, Cecconi M, Ferrer R, Malbrain MLNG, Ahlstedt C, Hoffmann S, Bestle MH, Gyldensted L, Nebrich L, Russell L et al. (2020)
Long-term patient-important outcomes after septic shock: A protocol for 1-year follow-up of the CLASSIC trial
Acta Anaesthesiol. Scand., 64 (3), 410-416
DOI 10.1111/aas.13519

Lamontagne F, Agoritsas T, Macdonald H, Leo YS, Diaz J, Agarwal A, Appiah JA, Arabi Y, Blumberg L, Calfee CS, Cao B, Cecconi M, Cooke G, Dunning J, Geduld H, Gee P, Manai H, Hui DS, Kanda S, Kawano-Dourado L, Kim YJ, Kissoon N, Kwizera A, Laake JH, Machado FR et al. (2020)
A living WHO guideline on drugs for covid-19
BMJ-British Medical Journal, 370, m3379
DOI 10.1136/bmj.m3379

Laake JH, Hansen M, Mo S, Brathen CC, Adolfsen E, Overland G (2020)
Ethics experts on the wrong track
Tidsskr. Nor. Laegeforen., 140 (18), 1829-1830

Schjorring OL, Klitgaard TL, Perner A, Wetterslev J, Lange T, Keus F, Laake JH, Morgan M, Backlund M, Siegemund M, Thormar KM, Rasmussen BS (2020)
The handling oxygenation targets in the intensive care unit (HOT-ICU) trial: Detailed statistical analysis plan
Acta Anaesthesiol. Scand., 64 (6), 847-856
DOI 10.1111/aas.13569

Publications 2019

Anthon CT, Granholm A, Perner A, Laake JH, Moller MH (2019)
Bias and sample size in intensive care unit trials: Protocol for a meta-epidemiological study
Acta Anaesthesiol. Scand., 63 (1), 117-121
DOI 10.1111/aas.13258

Anthon CT, Granholm A, Perner A, Laake JH, Moller MH (2019)
Overall bias and sample sizes were unchanged in ICU trials over time: a meta-epidemiological study
J. Clin. Epidemiol., 113, 189-199
DOI 10.1016/j.jclinepi.2019.05.021

Granholm A, Anthon CT, Perner A, Laake JH, Moller MH (2019)
Transparent and systematic reporting of meta-epidemiological studies
J. Clin. Epidemiol., 112, 93-95
DOI 10.1016/j.jclinepi.2019.04.014

Marker S, Krag M, Perner A, Wetterslev J, Lange T, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Schefold JC, Rasmussen BS, Elkmann T, Bestle M, Arenkiel B, Laake JH, Kamper MK, Lng M, Pawlowicz-Dworzanska MB, Karlsson S, Liisanantti J, Dey N, Knudsen H, Granholm A, Moller MH et al. (2019)
Pantoprazole in ICU patients at risk for gastrointestinal bleeding-1-year mortality in the SUP-ICU trial
Acta Anaesthesiol. Scand., 63 (9), 1184-1190
DOI 10.1111/aas.13436

Meyhoff TS, Hjortrup PB, Moller MH, Wetterslev J, Lange T, Kjr MBN, Jonsson AB, Hjortso CJS, Cronhjort M, Laake JH, Jakob SM, Nalos M, Pettil V, van der Horst I, Ostermann M, Mouncey P, Rowan K, Cecconi M, Ferrer R, Malbrain MLNG, Ahlstedt C, Hoffmann S, Bestle MH, Nebrich L, Russell L et al. (2019)
Conservative vs liberal fluid therapy in septic shock (CLASSIC) trial-Protocol and statistical analysis plan
Acta Anaesthesiol. Scand., 63 (9), 1262-1271
DOI 10.1111/aas.13434

Robertsen A, Helseth E, Laake JH, Forde R (2019)
Neurocritical care physicians' doubt about whether to withdraw life-sustaining treatment the first days after devastating brain injury: an interview study
Scand. J. Trauma Resusc. Emerg. Med., 27 (1), 81
DOI 10.1186/s13049-019-0648-9

Schjorring OL, Perner A, Wetterslev J, Lange T, Keus F, Laake JH, Okkonen M, Siegemund M, Morgan M, Thormar KM, Rasmussen BS, HOT-ICU Investigators (2019)
Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure
Acta Anaesthesiol. Scand., 63 (7), 956-965
DOI 10.1111/aas.13356

Weiss B, Prisco L, Boulanger C, Einav S, Gruber P, Laake JH, Mehta S, Ostermann M, Antonelli M, Ben Nun M, Bollen B, Borkowska M, Borthwick M, Cecconi M, Costa-Pinto R, Derde LPG, Forni LG, Galazzi A, Girbes A, Herridge M, Hofso K, Juffermans NP, Kesecioglu J, Lobo-Valbuena B, Machado FR et al. (2019)
Statement paper on diversity for the European Society of Intensive Care Medicine (ESICM)
Intensive Care Med., 45 (7), 1002-1005
DOI 10.1007/s00134-019-05606-0

Publications 2018

Anthon CT, Granholm A, Pemer A, Laake JH, Moller MH (2018)
No firm evidence that lack of blinding affects estimates of mortality in randomized clinical trials of intensive care interventions: a systematic review and meta-analysis
J. Clin. Epidemiol., 100, 71-81
DOI 10.1016/j.jclinepi.2018.04.016

Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Schefold JC, Keus F, Guttormsen AB, Bendel S, Borthwick M, Lange T, Rasmussen BS, Siegemund M, Bundgaard H, Elkmann T, Jensen JV, Nielsen RD, Liboriussen L, Bestle MH, Elkjaer JM, Palmqvist DF, Backlund M, Laake JH, Badstolokken PM, Gronlund J et al. (2018)
Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU
N. Engl. J. Med., 379 (23), 2199-2208
DOI 10.1056/NEJMoa1714919

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu HB, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A et al. (2018)
Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study (vol 42, pg 1865, 2016)
Intensive Care Med., 44 (1), 157-165
DOI 10.1007/s00134-017-4981-z

Laake JH, Tonnessen TI, Chew MS, Lipcsey M, Hjelmqvist H, Wilkman E, Pettila V, Hoffmann-Petersen J, Moller MH, Board Scandinavian Soc Anaesthesio (2018)
The SSAI fully supports the suspension of hydroxyethyl-starch solutions commissioned by the European Medicines Agency
Acta Anaesthesiol. Scand., 62 (6), 874-875
DOI 10.1111/aas.13120

Moller MH, Granholm A, Junttila E, Haney M, Oscarsson-Tibblin A, Haavind A, Laake JH, Wilkman E, Sverrisson KO, Perner A (2018)
Scandinavian SSAI clinical practice guideline on choice of inotropic agent for patients with acute circulatory failure
Acta Anaesthesiol. Scand., 62 (4), 420-450
DOI 10.1111/aas.13089

Perner A, Laake JH, van der Horst ICC (2018)
Innovation and safety in critical care: should we collaborate with the industry? Con
Intensive Care Med., 44 (12), 2279-2281
DOI 10.1007/s00134-018-5295-5

Rochwerg B, Almenawer SA, Siemieniuk RAC, Vandvik PO, Agoritsas T, Lytvyn L, Alhazzani W, Archambault P, D'Aragon F, Farhoumand PD, Guyatt G, Laake JH, Beltran-Arroyave C, McCredie V, Price A, Chabot C, Zervakis T, Badhiwala J, St-Onge M, Szczeklik W, Moller MH, Lamontagne F (2018)
Atraumatic (pencil-point) versus conventional needles for lumbar puncture: a clinical practice guideline
BMJ-British Medical Journal, 361, k1920
DOI 10.1136/bmj.k1920

Schjorring OL, Toft-Petersen AP, Kusk KH, Mouncey P, Sorensen EE, Berezowicz P, Bestle MH, Bulow HH, Bundgaard H, Christensen S, Iversen SA, Kirkeby-Garstad I, Krarup KB, Kruse M, Laake JH, Liboriussen L, Laebel RL, Okkonen M, Poulsen LM, Russell L, Sjovall F, Sunde K, Soreide E, Waldau T, Walli AR et al. (2018)
Intensive care doctors' preferences for arterial oxygen tension levels in mechanically ventilated patients
Acta Anaesthesiol. Scand., 62 (10), 1443-1451
DOI 10.1111/aas.13171

Publications 2017

Anthon CT, Granholm A, Perner A, Laake JH, Moller MH (2017)
The effect of blinding on estimates of mortality in randomised clinical trials of intensive care interventions: protocol for a systematic review and meta-analysis
BMJ Open, 7 (7), e016187
DOI 10.1136/bmjopen-2017-016187

Hylands M, Moller MH, Asfar P, Toma A, Frenette AJ, Beaudoin N, Belley-Cote E, D'Aragon F, Laake JH, Siemieniuk RA, Charbonney E, Lauzier F, Kwong J, Rochwerg B, Vandvik PO, Guyatt G, Lamontagne F (2017)
A systematic review of vasopressor blood pressure targets in critically ill adults with hypotension
Can. J. Anesth., 64 (7), 703-715
DOI 10.1007/s12630-017-0877-1

Hylands M, Toma A, Beaudoin N, Frenette AJ, D'Aragon F, Belley-Cote E, Charbonney E, Moller MH, Laake JH, Vandvik PO, Siemieniuk RA, Rochwerg B, Lauzier F, Green RS, Ball I, Scales D, Murthy S, Kwong JSW, Guyatt G, Rizoli S, Asfar P, Lamontagne F (2017)
Early vasopressor use following traumatic injury: a systematic review
BMJ Open, 7 (11), e017559
DOI 10.1136/bmjopen-2017-017559

Hylands M, Toma A, Beaudoin N, Frenette AJ, D'Aragon F, Belley-Cote E, Hylander M, Lauzier F, Siemieniuk RA, Charbonney E, Kwong J, Laake JH, Guyatt G, Vandvik PO, Rochwerg B, Green R, Ball I, Scales D, Murthy S, Rizoli S, Asfar P, Lamontagne F (2017)
Vasopressor use following traumatic injury: protocol for a systematic review
BMJ Open, 7 (2), e014166
DOI 10.1136/bmjopen-2016-014166

Laffey JG, Madotto F, Bellani G, Pham T, Fan E, Brochard L, Amin P, Arabi Y, Bajwa EK, Bruhn A, Cerny V, Clarkson K, Heunks L, Kurahashi K, Laake JH, Lorente JA, McNamee L, Nin N, Palo JE, Piquilloud L, Qiu HB, Ignacio J, Jimenez S, Esteban A, McAuley DF et al. (2017)
Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study
Lancet Resp. Med., 5 (8), 627-638
DOI 10.1016/S2213-2600(17)30213-8

Laake JH (2017)
Big Brother sees my antibiotics use!
Tidsskr. Nor. Laegeforen., 137 (14-15), 993-994

Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon I, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS (2017)
Gender Parity in Critical Care Medicine
Am. J. Respir. Crit. Care Med., 196 (4), 425-429
DOI 10.1164/rccm.201701-0076CP

Moller MH, Laake JH, Myburgh JA, Alhazzani W, Perner A (2017)
The Magic Bullet in Sepsis or the Inflation of Chance Findings?
Chest, 152 (1), 222-223
DOI 10.1016/j.chest.2017.04.181

Rochwerg B, Hylands M, Moller MH, Asfar P, Cohen D, Khadaroo RG, Laake JH, Perner A, Tanguay T, Widder S, Vandvik P, Kristiansen A, Lamontagne F (2017)
CCCS-SSAI WikiRecs clinical practice guideline: vasopressor blood pressure targets in critically ill adults with hypotension and vasopressor use in early traumatic shock
Intensive Care Med., 43 (7), 1062-1064
DOI 10.1007/s00134-016-4539-5

Publications 2016

Claesson J, Freundlich M, Gunnarsson I, Laake JH, Moller MH, Vandvik PO, Varpula T, Aasmundstad TA (2016)
Scandinavian clinical practice guideline on fluid and drug therapy in adults with acute respiratory distress syndrome
Acta Anaesthesiol. Scand., 60 (6), 697-709
DOI 10.1111/aas.12713

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu HB, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A et al. (2016)
Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study
Intensive Care Med., 42 (12), 1865-1876
DOI 10.1007/s00134-016-4571-5

Laake JH (2016)
Should fever be treated in ICU patients?
Tidsskr. Nor. Laegeforen., 136 (5), 380
DOI 10.4045/tidsskr.16.0158

Laake JH (2016)
Sepsis-3-new definition of bad taste?
Tidsskr. Nor. Laegeforen., 136 (11), 982-984
DOI 10.4045/tidsskr.16.0407

Laake JH (2016)
A patient with sepsis following a burn injury in Pakistan
Tidsskr. Nor. Laegeforen., 136 (17), 1424
DOI 10.4045/tidsskr.16.0715

Publications 2015

Claesson J, Freundlich M, Gunnarsson I, Laake JH, Vandvik PO, Varpula T, Aasmundstad TA (2015)
Scandinavian clinical practice guideline on mechanical ventilation in adults with the acute respiratory distress syndrome
Acta Anaesthesiol. Scand., 59 (3), 286-297
DOI 10.1111/aas.12449

Publications 2012

Southwell C, Bengtson J, Bester M, Blix AS, Bornemann H, Boveng P, Cameron M, Forcada J, Laake J, Nordoy E, Plotz J, Rogers T, Southwell D, Steinhage D, Stewart BS, Trathan P (2012)
A REVIEW OF DATA ON ABUNDANCE, TRENDS IN ABUNDANCE, HABITAT USE AND DIET OF ICE-BREEDING SEALS IN THE SOUTHERN OCEAN
CCAMLR Sci., 19, 49-74

Publications 2011

Berdal JE, Mollnes TE, Waehre T, Olstad OK, Halvorsen B, Ueland T, Laake JH, Furuseth MT, Maagaard A, Kjekshus H, Aukrust P, Jonassen CM (2011)
Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza
J. Infect., 63 (4), 308-316
DOI 10.1016/j.jinf.2011.07.004

Rosseland LA, Laake JH, Stubhaug A (2011)
Percutaneous dilatational tracheotomy in intensive care unit patients with increased bleeding risk or obesity. A prospective analysis of 1000 procedures
Acta Anaesthesiol. Scand., 55 (7), 835-841
DOI 10.1111/j.1399-6576.2011.02458.x

Publications 2010

Laake JH, Dybwik K, Flaatten HK, Fonneland IL, Kvale R, Strand K (2010)
Impact of the post-World War II generation on intensive care needs in Norway
Acta Anaesthesiol. Scand., 54 (4), 479-484
DOI 10.1111/j.1399-6576.2009.02170.x

Laake JH, Flaatten HK (2010)
Influenza and the anaesthesiologist
Acta Anaesthesiol. Scand., 54 (1), 3-5
DOI 10.1111/j.1399-6576.2009.02167.x

Publications 2008

Alm-Kruse K, Bull EM, Laake JH (2008)
Nurse-led implementation of an insulin-infusion protocol in a general intensive care unit: improved glycaemic control with increased costs and risk of hypoglycaemia signals need for algorithm revision
BMC Nurs., 7, 1
DOI 10.1186/1472-6955-7-1

Publications 2007

Hovdenes J, Laake JH, Haugaa H, Aaberge L, Bugge JF (2007)
Reply to Systemic vascular resistance with an intra-aortic balloon pump: of practical use, even for a petit-maitre?
Acta Anaesthesiol. Scand., 51 (7)
DOI 10.1111/j.1399-6576.2007.01345.x

Hovdenes J, Laake JH, Aaberge L, Haugaa H, Bugge JF (2007)
Therapeutic hypothermia after out-of-hospital cardiac arrest: experiences with patients treated with percutaneous coronary intervention and cardiogenic shock
Acta Anaesthesiol. Scand., 51 (2), 137-142
DOI 10.1111/j.1399-6576.2006.01209.x

Publications 2000

Roberg B, Torgner IA, Laake J, Takumi Y, Ottersen OP, Kvamme E (2000)
Properties and submitochondrial localization of pig and rat renal phosphate-activated glutaminase
Am. J. Physiol.-Cell Physiol., 279 (3), C648-C657
DOI 10.1152/ajpcell.2000.279.3.C648

Publications 1999

Laake JH (1999)
Glutamate as transmitter and toxin: synthesis, compartmentation and pathophysiology
Department of Anatomy, University of Oslo, [Oslo], 1 b. (flere pag.)
BIBSYS 990855007, ISBN 82-91061-03-3