
Per Olaf Ekstrøm
- Researcher; Dr. philos.
- +47 2278 1847
Publications 2020
Somatic Mitochondrial DNA Point Mutations Used as Biomarkers to Demonstrate Genomic Heterogeneity in Primary Prostate Cancer
Prostate Cancer, 2020, 7673684
DOI 10.1155/2020/7673684, PubMed 32908706
Tracing of Human Tumor Cell Lineages by Mitochondrial Mutations
Front Oncol, 10, 523860
DOI 10.3389/fonc.2020.523860, PubMed 33344219
Publications 2019
Results of multigene panel testing in familial cancer cases without genetic cause demonstrated by single gene testing
Sci Rep, 9 (1), 18555
DOI 10.1038/s41598-019-54517-z, PubMed 31811167
Publications 2018
Genetic variants of prospectively demonstrated phenocopies in BRCA1/2 kindreds
Hered Cancer Clin Pract, 16, 4
DOI 10.1186/s13053-018-0086-0, PubMed 29371908
Potentially pathogenic germline CHEK2 c.319+2T>A among multiple early-onset cancer families
Fam Cancer, 17 (1), 141-153
DOI 10.1007/s10689-017-0011-0, PubMed 28608266
Identification of genetic variants for clinical management of familial colorectal tumors
BMC Med Genet, 19 (1), 26
DOI 10.1186/s12881-018-0533-9, PubMed 29458332
Publications 2017
Is detection of intraperitoneal exfoliated tumor cells after surgical resection of rectal cancer a prognostic factor of survival?
BMC Cancer, 17 (1), 406
DOI 10.1186/s12885-017-3365-7, PubMed 28592327
Mapping mitochondrial heteroplasmy in a Leydig tumor by laser capture micro-dissection and cycling temperature capillary electrophoresis
BMC Clin Pathol, 17, 6
DOI 10.1186/s12907-017-0042-3, PubMed 28405177
Quantifying mitochondrial DNA copy number using robust regression to interpret real time PCR results
BMC Res Notes, 10 (1), 593
DOI 10.1186/s13104-017-2913-1, PubMed 29132417
Publications 2016
Scanning the mitochondrial genome for mutations by cycling temperature capillary electrophoresis
Mitochondrial DNA A DNA Mapp Seq Anal, 29 (1), 19-30
DOI 10.1080/24701394.2016.1233532, PubMed 27728990
Tp53/p53 status in keratoacanthomas
J Cutan Pathol, 43 (7), 571-8
DOI 10.1111/cup.12713, PubMed 27020606
Cycling temperature capillary electrophoresis: A quantitative, fast and inexpensive method to detect mutations in mixed populations of human mitochondrial DNA
Mitochondrion, 29, 65-74
DOI 10.1016/j.mito.2016.04.006, PubMed 27166160
Publications 2015
Automated amplicon design suitable for analysis of DNA variants by melting techniques
BMC Res Notes, 8, 667
DOI 10.1186/s13104-015-1624-8, PubMed 26559640
Ten modifiers of BRCA1 penetrance validated in a Norwegian series
Hered Cancer Clin Pract, 13 (1), 14
DOI 10.1186/s13053-015-0035-0, PubMed 26052370
Publications 2014
TP53/p53 alterations and Aurora A expression in progressor and non-progressor colectomies from patients with longstanding ulcerative colitis
Int J Mol Med, 35 (1), 24-30
DOI 10.3892/ijmm.2014.1974, PubMed 25333414
Publications 2013
Influence of polymorphisms in genes encoding immunoregulatory proteins and metabolizing enzymes on susceptibility and outcome in patients with diffuse large B-cell lymphoma treated with rituximab
Leuk Lymphoma, 54 (10), 2205-14
DOI 10.3109/10428194.2013.774392, PubMed 23391141
Publications 2012
Separation principles of cycling temperature capillary electrophoresis
Electrophoresis, 33 (7), 1162-8
DOI 10.1002/elps.201100550, PubMed 22539319
Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma
Leuk Lymphoma, 53 (10), 1934-44
DOI 10.3109/10428194.2012.682307, PubMed 22475179
Publications 2010
Validation and use of microdialysis for determination of pharmacokinetic properties of the chemotherapeutic agent mitomycin C - an experimental study
BMC Cancer, 10, 469
DOI 10.1186/1471-2407-10-469, PubMed 20809961
Publications 2008
Scanning for DNA variants by denaturant capillary electrophoresis
Methods Mol Biol, 439, 19-34
DOI 10.1007/978-1-59745-188-8_2, PubMed 18370093
Analysis of mutational spectra by denaturing capillary electrophoresis
Nat Protoc, 3 (7), 1153-66
DOI 10.1038/nprot.2008.79, PubMed 18600220
Molecular detection (k-ras) of exfoliated tumour cells in the pelvis is a prognostic factor after resection of rectal cancer?
BMC Cancer, 8, 213
DOI 10.1186/1471-2407-8-213, PubMed 18655729
Fetal-juvenile origins of point mutations in the adult human tracheal-bronchial epithelium: absence of detectable effects of age, gender or smoking status
Mutat Res, 646 (1-2), 25-40
DOI 10.1016/j.mrfmmm.2008.08.016, PubMed 18824180
Publications 2007
Technology to accelerate pangenomic scanning for unknown point mutations in exonic sequences: cycling temperature capillary electrophoresis (CTCE)
BMC Genet, 8, 54
DOI 10.1186/1471-2156-8-54, PubMed 17697348
Frequency of TP53 mutations in relation to Arg72Pro genotypes in non small cell lung cancer
Cancer Epidemiol Biomarkers Prev, 16 (10), 2077-81
DOI 10.1158/1055-9965.EPI-07-0153, PubMed 17932356
Publications 2006
Evaluation of sieving matrices used to separate alleles by cycling temperature capillary electrophoresis
Electrophoresis, 27 (10), 1878-85
DOI 10.1002/elps.200500642, PubMed 16619298
Coding region polymorphisms in T cell signal transduction genes. Prevalence and association to development of multiple sclerosis
J Neuroimmunol, 177 (1-2), 40-5
DOI 10.1016/j.jneuroim.2006.04.021, PubMed 16764945
Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer
Int J Cancer, 119 (3), 718-21
DOI 10.1002/ijc.21872, PubMed 16496380
Publications 2005
Review of denaturant capillary electrophoresis in DNA variation analysis
Electrophoresis, 26 (13), 2520-30
DOI 10.1002/elps.200410403, PubMed 15934053
BRAF mutation detection and identification by cycling temperature capillary electrophoresis
Electrophoresis, 26 (13), 2553-61
DOI 10.1002/elps.200410427, PubMed 15948220
High-throughput gender determination using automated denaturant gel capillary electrophoresis
Electrophoresis, 26 (13), 2562-6
DOI 10.1002/elps.200410392, PubMed 15934052
Detection and frequency estimation of rare variants in pools of genomic DNA from large populations using mutational spectrometry
Mutat Res, 570 (2), 267-80
DOI 10.1016/j.mrfmmm.2004.11.004, PubMed 15708585
Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients
J Neuroimmunol, 166 (1-2), 197-201
DOI 10.1016/j.jneuroim.2005.06.002, PubMed 16005527
Publications 2004
Determination of hereditary mutations in the BRCA1 gene using archived serum samples and capillary electrophoresis
Anal Chem, 76 (15), 4406-9
DOI 10.1021/ac049788k, PubMed 15283579
Publications 2003
Approach to analysis of single nucleotide polymorphisms by automated constant denaturant capillary electrophoresis
Mutat Res, 526 (1-2), 75-83
DOI 10.1016/s0027-5107(03)00033-2, PubMed 12714185
Direct identification of all oncogenic mutants in KRAS exon 1 by cycling temperature capillary electrophoresis
Electrophoresis, 24 (1-2), 63-9
DOI 10.1002/elps.200390032, PubMed 12652573
DNA variants in the ATM gene are not associated with sporadic rectal cancer in a Norwegian population-based study
Int J Colorectal Dis, 19 (1), 49-54
DOI 10.1007/s00384-003-0519-7, PubMed 12827413
Cycling gradient capillary electrophoresis: a low-cost tool for high-throughput analysis of genetic variations
Electrophoresis, 24 (11), 1716-22
DOI 10.1002/elps.200305384, PubMed 12783447
Publications 2002
Mutation detection in KRAS Exon 1 by constant denaturant capillary electrophoresis in 96 parallel capillaries
Anal Biochem, 304 (2), 200-5
DOI 10.1006/abio.2002.5629, PubMed 12009696
Reducing the cost of consumables used for ABI 310 genetic analyzer
Anal Biochem, 306 (1), 148-9
DOI 10.1006/abio.2002.5656, PubMed 12069426
Population screening of single-nucleotide polymorphisms exemplified by analysis of 8000 alleles
J Biomol Screen, 7 (6), 501-6
DOI 10.1177/1087057102238623, PubMed 14599347
Detection of mutations in exon 8 of TP53 by temperature gradient 96-capillary array electrophoresis
Biotechniques, 33 (3), 650-3
DOI 10.2144/02333pf01, PubMed 12238774
Publications 2001
Automated constant denaturant capillary electrophoresis applied for detection of KRAS exon 1 mutations
Biotechniques, 30 (5), 972-5
DOI 10.2144/01305st01, PubMed 11355359
Mutation analysis of TP53 exons 5-8 by automated constant denaturant capillary electrophoresis
Tumour Biol, 22 (5), 323-7
DOI 10.1159/000050634, PubMed 11553863
Publications 2000
Two-point fluorescence detection and automated fraction collection applied to constant denaturant capillary electrophoresis
Biotechniques, 29 (3), 582-4, 586-9
DOI 10.2144/00293rr01, PubMed 10997272
Publications 1999
Detection of low-frequency mutations in exon 8 of the TP53 gene by constant denaturant capillary electrophoresis (CDCE)
Biotechniques, 27 (1), 128-34
DOI 10.2144/99271rr01, PubMed 10407675
Publications 1997
The use of microdialysis to investigate extracellular pharmacokinetics of methotrexate
University of Oslo, Oslo, 1 b. (flere pag.)
BIBSYS 972142363, ISBN 82-7722-076-6
Continuous intratumoral microdialysis during high-dose methotrexate therapy in a patient with malignant fibrous histiocytoma of the femur: a case report
Cancer Chemother Pharmacol, 39 (3), 267-72
DOI 10.1007/s002800050571, PubMed 8996531
Intratumoral differences in methotrexate levels within human osteosarcoma xenografts studied by microdialysis
Life Sci, 61 (19), PL275-80
DOI 10.1016/s0024-3205(97)00839-4, PubMed 9364204
Alterations in methotrexate pharmacokinetics by naproxen in the rat as measured by microdialysis
Life Sci, 60 (24), PL 359-64
DOI 10.1016/s0024-3205(97)00241-5, PubMed 9188769
Publications 1996
Determination of extracellular methotrexate tissue levels by microdialysis in a rat model
Cancer Chemother Pharmacol, 37 (5), 394-400
DOI 10.1007/s002800050403, PubMed 8599860
Publications 1995
Mikrodialyse av metotrexat i en rottemodell: en teknikk for bestemmelse av et cytostatikums vevsdistribusjon
[P.O. Ekstrøm>, Oslo, 1 b. (flere pag.)
BIBSYS 951032674
Pharmacokinetics of different doses of methotrexate at steady state by in situ microdialysis in a rat model
Cancer Chemother Pharmacol, 36 (4), 283-9
DOI 10.1007/BF00689044, PubMed 7628046