Improvement of interpretation of DNA traces at activity level
This PhD project focuses on increasing knowledge about DNA and body fluids transfer and persistence in criminal cases. The aim of the project is to develop tools that will aid in the interpretation of DNA traces at activity level in criminal cases and to deliver an unbiased framework for reliable statistical interpretation of opposing hypotheses put forward by prosecution and defense lawyers. The work involves experiments to improve the understanding of background DNA and body fluids, investigate the feasibility of aerosol DNA for forensic applications and characterize DNA transfer rates at different scenarios. The results of this project will be incorporated in a large dataset that will be made available to the forensic community to facilitate the interpretation of evidence in criminal cases.
A new probabilistic genotyping software aimed for MPS data
In this work, different kinds of artefacts are quantified for informing models used to handle low-level DNA. This will be used for building a model calibration framework, used to inform part of the model before MPS evidences are evaluated. A new population database for MPS data will also be created and integrated into the tool.
Increasing the efficiency of rape investigation by using advances in forensic evidence analysis
In criminal cases, a DNA profile recovered from an item can link a suspect to the crime scene. However, the DNA profile itself can only provide information to help identify the donor of cellular material and does not explain how (direct or indirect transfer) or when (before, during or after the crime event) the cellular material was deposited. In this PhD project we will investigate transfer, persistence and recovery of DNA and body fluids (gene expression markers) in samples collected from body and clothing after social contact and sexual contact. This knowledge is essential to evaluate the findings in cases related to sexual assault cases. In addition a method that can link a body fluid to a specific contributor to a crime stain, containing DNA from two or more individuals, will be attempted.
The aim of this project is to develop tools that will aid interpretation and understanding of DNA traces at activity level in sexual assault cases. The study will comprise a large dataset that will be made available for other scientists and police to aid in sampling and interpretation of evidence under different case circumstances.
Improving kinship analysis in multi-generation pedigrees
With recent developments and interests in forensic genealogy, it is more important than ever to understand the limits of kinship analysis.
The aim of this project is to improve and develop methods for kinship analysis combining developments in whole genome sequencing (WGS) and the evaluation of a new massive parallel sequencing (MPS) panel. As a start-up project, a set of old bones assumed to date back to 1742, will be used to determine the genealogical relation between ten living assumed relatives of the bones, with relations spanning 6-12 generations.