Mazyar Yazdani
- Senior Scientist; PhD
Education
- 2009-2014: PhD in Integrative Biology - Toxicology, University of Oslo, Norway.
PhD thesis: In vitro, in ovo and in vivo models for cytotoxicity, oxidative stress, neurotoxicity and DNA damage.
Affiliation
- Metabolomics & Metabolic Molecular Biology Group, Department of Medical Biochemistry, Oslo University Hospital - Rikshospitalet, Norway.
– Associated member of:
- The Unit of Regenerative Medicine, Department of Medical Biochemistry, Oslo University Hospital - Ullevål, Norway.
- Center for Eye Research, Department of Ophthalmology, Oslo University Hospital - Ullevål, Norway.
- The Norwegian Dry Eye Clinic, Oslo, Norway.
Research Summary
Dr. Yazdani, a toxicologist, began his research career with studying the toxic mechanisms of action of hazardous substances, particularly oxidative stress induction, using in vitro and in vivo systems. During that period, a concern has been given to the in vitro (cell culture) method development. He later linked the role of oxidative stress to pathophysiology of dry eye disease and treatment of corneal epithelial (limbal) stem cell deficiency. Currently, as one of core members of Metabolomics & Metabolic Molecular Biology group, he is investigating the metabolic changes of rare diseases (e.g., inborn errors of metabolism) and eye diseases (e.g., dry eye). The main goal is to better understand the underlying mechanisms using mass spectrometry-based metabolomics.
Selected Projects: Dry eye (keratoconjunctivitis sicca), Pyridoxine-dependent epilepsy, Kearns-Sayre syndrome, Iron overload (haemochromatosis).
On the News: "Eyelash Growth Serums" in VG Newspaper (March 2021).
Work Experience
- 2021-to date: Oslo University Hospital (OUS) - Rikshospitalet, Oslo
- 2017-2020: Oslo University Hospital (OUS) - Ullevål Sykehus, Oslo
- 2016: Norwegian Institute for Air Research (NILU), Kjeller + Norwegian Dry Eye Clinic (TØK), Oslo
- 2015: Norwegian Food Safety Authority (Mattilsynet), Ås
- 2009-2014: University of Oslo (UIO), Oslo
Links
NB: Check out our NEWS PAGE for the latest!
Publications 2022
Uncontrolled Oxygen Levels in Cultures of Retinal Pigment Epithelium: Have We Missed the Obvious?
Curr Eye Res, 1-10 (in press)
DOI 10.1080/02713683.2022.2050264, PubMed 35243933
Publications 2021
A pioneer study on human 3-nitropropionic acid intoxication: Contributions from metabolomics
J Appl Toxicol, 42 (5), 818-829
DOI 10.1002/jat.4259, PubMed 34725838
Is oxidative stress an overlooked player in pyridoxine-dependent epilepsy? A focused review
Seizure, 91, 369-373
DOI 10.1016/j.seizure.2021.07.014, PubMed 34298455
Eye Make-up Products and Dry Eye Disease: A Mini Review
Curr Eye Res, 47 (1), 1-11
DOI 10.1080/02713683.2021.1966476, PubMed 34365876
Tear Film Break-Up Time and Dry Eye Disease Severity in a Large Norwegian Cohort
J Clin Med, 10 (4)
DOI 10.3390/jcm10040884, PubMed 33671667
Publications 2020
Distinct Subsets of Noncoding RNAs Are Strongly Associated With BMD and Fracture, Studied in Weight-Bearing and Non-Weight-Bearing Human Bone
J Bone Miner Res, 35 (6), 1065-1076
DOI 10.1002/jbmr.3974, PubMed 32017184
Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease
Sci Rep, 10 (1), 5542
DOI 10.1038/s41598-020-62583-x, PubMed 32218518
Intense pulsed light treatment in meibomian gland dysfunction: A concise review
Ocul Surf, 18 (4), 583-594
DOI 10.1016/j.jtos.2020.06.002, PubMed 32629039
Response of human oral mucosal epithelial cells to different storage temperatures: A structural and transcriptional study
PLoS One, 15 (12), e0243914
DOI 10.1371/journal.pone.0243914, PubMed 33326470
Publications 2019
Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients
Curr Eye Res, 44 (9), 941-947
DOI 10.1080/02713683.2019.1604972, PubMed 30955380
Tear Metabolomics in Dry Eye Disease: A Review
Int J Mol Sci, 20 (15)
DOI 10.3390/ijms20153755, PubMed 31374809
Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review
Cells, 8 (3)
DOI 10.3390/cells8030245, PubMed 30875861
A Hyaluronan Hydrogel Scaffold for Culture of Human Oral Mucosal Epithelial Cells in Limbal Stem-Cell Therapy
Bioengineering (Basel), 6 (4)
DOI 10.3390/bioengineering6040097, PubMed 31652804
Publications 2018
Comparative toxicity of selected PAHs in rainbow trout hepatocytes: genotoxicity, oxidative stress and cytotoxicity
Drug Chem Toxicol, 43 (1), 71-78
DOI 10.1080/01480545.2018.1497054, PubMed 30246564
Tear Production Levels and Dry Eye Disease Severity in a Large Norwegian Cohort
Curr Eye Res, 43 (12), 1465-1470
DOI 10.1080/02713683.2018.1514055, PubMed 30183390
Publications 2016
Fibrous shape underlies the mutagenic and carcinogenic potential of nanosilver while surface chemistry affects the biosafety of iron oxide nanoparticles
Mutagenesis, 32 (1), 193-202
DOI 10.1093/mutage/gew045, PubMed 27658822
Technical aspects of oxygen level regulation in primary cell cultures: A review
Interdiscip Toxicol, 9 (3-4), 85-89
DOI 10.1515/intox-2016-0011, PubMed 28652851
Short-term effect of bisphenol-a on oxidative stress responses in Atlantic salmon kidney cell line: a transcriptional study
Toxicol Mech Methods, 26 (4), 295-300
DOI 10.1080/15376516.2016.1177864, PubMed 27117342
A Kinetic Study of Reactive Oxygen Species in Rainbow Trout Hepatocytes by Fluorometry
J Environ Pathol Toxicol Oncol, 35 (4), 291-297
DOI 10.1615/JEnvironPatholToxicolOncol.2016016184, PubMed 27992310
Publications 2015
Concerns in the application of fluorescent probes DCDHF-DA, DHR 123 and DHE to measure reactive oxygen species in vitro
Toxicol In Vitro, 30 (1 Pt B), 578-82
DOI 10.1016/j.tiv.2015.08.010, PubMed 26318276
Publications 2014
Reactive oxygen species and cytotoxicity in rainbow trout hepatocytes: effects of medium and incubation time
Bull Environ Contam Toxicol, 94 (2), 193-8
DOI 10.1007/s00128-014-1433-0, PubMed 25432295
Publications 2013
Prenatal exposure to bisphenol A interferes with the development of cerebellar granule neurons in mice and chicken
Int J Dev Neurosci, 31 (8), 762-9
DOI 10.1016/j.ijdevneu.2013.09.009, PubMed 24091367
Publications 2011
Species-dependent sensitivity to contaminants: an approach using primary hepatocyte cultures with three marine fish species
Mar Environ Res, 72 (4), 216-24
DOI 10.1016/j.marenvres.2011.09.003, PubMed 21963059
Is the high Cu tolerance of Trichoderma atroviride isolated from the Cu-polluted sediment due to adaptation? An in vitro toxicological study
Journal of Sains Malaysiana , 40 (2), 119-124
PublikaID 362
Publications 2010
Effects of the metal contaminated soils on the accumulation of heavy metals in the different parts of Centella asiatica: A laboratory study
Journal of Sains Malaysiana, 39 (3), 347-352
PublikaID 360
An in vitro study on the adsorption, absorption and uptake capacity of Zn by using the bioremediator Trichoderma atroviride
EnvironmentAsia, 3 (1), 53-59
PublikaID 361
Publications 2009
The identification of point sources in a river receiving industrial metal effluents at the Serdang industrial area, Selangor
Sustainability Science and Management, 4 (2), 18-26
PublikaID 358
Trichoderma atroviride as a bioremediator of Cu pollution: An in vitro study
Toxicological & Environmental Chemistry , 91 (7), 1305-1314
DOI 10.1080/02772240802616510, PublikaID 359