Mazyar Yazdani

  • Senior scientist; PhD

Education

  • 2009-2014: PhD in Integrative Biology - Toxicology, University of Oslo, Norway. [Link]

Affiliation

  • Metabolic Molecular Biology Group, Department of Medical Biochemistry, Oslo University Hospital - Rikshospitalet, Norway. [Link]

– Associated member of:

  • The Unit of Regenerative Medicine, Department of Medical Biochemistry, Oslo University Hospital - Ullevål, Norway. [Link]
  • Center for Eye Research, Department of Ophthalmology, Oslo University Hospital - Ullevål, Norway. [Link]
  • The Norwegian Dry Eye Clinic, Oslo, Norway. [Link]

Research Summary

Dr. Yazdani began his research career with studying the toxic mechanisms of action of hazardous substances, particularly oxidative stress induction. He later linked it to pathophysiology of dry eye disease and treatment of limbal stem cell deficiency. Currently, as a member of Metabolic Molecular Biology group, he is investigating the metabolic changes of rare diseases (e.g., inborn errors of metabolism) and dry eye disease. The main goal is to better understand the underlying mechanisms using mass spectrometry-based metabolomics.

Work Experience

  • 2021-to date: Oslo University Hospital (OUS) - Rikshospitalet, Oslo
  • 2017-2020: Oslo University Hospital (OUS) - Ullevål Sykehus, Oslo
  • 2016: Norwegian Institute for Air Research (NILU), Kjeller + Norwegian Dry Eye Clinic (TØK), Oslo
  • 2015: Norwegian Food Safety Authority (Mattilsynet), Ås
  • 2009-2014: University of Oslo (UIO), Oslo

Links

 

Publications 2020

Gautvik KM, Günther CC, Prijatelj V, Medina-Gomez C, Shevroja E, Rad LH, Yazdani M, Lindalen E, Valland H, Gautvik VT, Olstad OK, Holden M, Rivadeneira F, Utheim TP, Reppe S (2020)
Distinct Subsets of Noncoding RNAs Are Strongly Associated With BMD and Fracture, Studied in Weight-Bearing and Non-Weight-Bearing Human Bone
J Bone Miner Res, 35 (6), 1065-1076
DOI 10.1002/jbmr.3974, PubMed 32017184

Tashbayev B, Utheim TP, Utheim ØA, Ræder S, Jensen JL, Yazdani M, Lagali N, Vitelli V, Dartt DA, Chen X (2020)
Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease
Sci Rep, 10 (1), 5542
DOI 10.1038/s41598-020-62583-x, PubMed 32218518

Tashbayev B, Yazdani M, Arita R, Fineide F, Utheim TP (2020)
Intense pulsed light treatment in meibomian gland dysfunction: A concise review
Ocul Surf, 18 (4), 583-594
DOI 10.1016/j.jtos.2020.06.002, PubMed 32629039

Yazdani M, Shahdadfar A, Reppe S, Sapkota D, Vallenari EM, Lako M, Connon CJ, Figueiredo FC, Utheim TP (2020)
Response of human oral mucosal epithelial cells to different storage temperatures: A structural and transcriptional study
PLoS One, 15 (12), e0243914
DOI 10.1371/journal.pone.0243914, PubMed 33326470

Publications 2019

Yazdani M, Chen X, Tashbayev B, Utheim ØA, Ræder S, Hua Y, Eidet JR, Stojanovic A, Dartt DA, Utheim TP (2019)
Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients
Curr Eye Res, 44 (9), 941-947
DOI 10.1080/02713683.2019.1604972, PubMed 30955380

Yazdani M, Elgstøen KBP, Rootwelt H, Shahdadfar A, Utheim ØA, Utheim TP (2019)
Tear Metabolomics in Dry Eye Disease: A Review
Int J Mol Sci, 20 (15)
DOI 10.3390/ijms20153755, PubMed 31374809

Yazdani M, Shahdadfar A, Jackson CJ, Utheim TP (2019)
Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review
Cells, 8 (3)
DOI 10.3390/cells8030245, PubMed 30875861

Yazdani M, Shahdadfar A, Jackson CJ, Utheim TP (2019)
A Hyaluronan Hydrogel Scaffold for Culture of Human Oral Mucosal Epithelial Cells in Limbal Stem-Cell Therapy
Bioengineering (Basel), 6 (4)
DOI 10.3390/bioengineering6040097, PubMed 31652804

Publications 2018

Yazdani M (2018)
Comparative toxicity of selected PAHs in rainbow trout hepatocytes: genotoxicity, oxidative stress and cytotoxicity
Drug Chem Toxicol, 43 (1), 71-78
DOI 10.1080/01480545.2018.1497054, PubMed 30246564

Yazdani M, Chen X, Tashbayev B, Utheim ØA, Ræder S, Lagali N, Stojanovic A, Dartt DA, Utheim TP (2018)
Tear Production Levels and Dry Eye Disease Severity in a Large Norwegian Cohort
Curr Eye Res, 43 (12), 1465-1470
DOI 10.1080/02713683.2018.1514055, PubMed 30183390

Publications 2016

Gábelová A, El Yamani N, Alonso TI, Buliaková B, Srančíková A, Bábelová A, Pran ER, Fjellsbø LM, Elje E, Yazdani M, Silva MJ, Dušinská M (2016)
Fibrous shape underlies the mutagenic and carcinogenic potential of nanosilver while surface chemistry affects the biosafety of iron oxide nanoparticles
Mutagenesis, 32 (1), 193-202
DOI 10.1093/mutage/gew045, PubMed 27658822

Yazdani M (2016)
Technical aspects of oxygen level regulation in primary cell cultures: A review
Interdiscip Toxicol, 9 (3-4), 85-89
DOI 10.1515/intox-2016-0011, PubMed 28652851

Yazdani M, Andresen AM, Gjøen T (2016)
Short-term effect of bisphenol-a on oxidative stress responses in Atlantic salmon kidney cell line: a transcriptional study
Toxicol Mech Methods, 26 (4), 295-300
DOI 10.1080/15376516.2016.1177864, PubMed 27117342

Yazdani M, Hylland K (2016)
A Kinetic Study of Reactive Oxygen Species in Rainbow Trout Hepatocytes by Fluorometry
J Environ Pathol Toxicol Oncol, 35 (4), 291-297
DOI 10.1615/JEnvironPatholToxicolOncol.2016016184, PubMed 27992310

Publications 2015

Yazdani M (2015)
Concerns in the application of fluorescent probes DCDHF-DA, DHR 123 and DHE to measure reactive oxygen species in vitro
Toxicol In Vitro, 30 (1 Pt B), 578-82
DOI 10.1016/j.tiv.2015.08.010, PubMed 26318276

Publications 2014

Yazdani M, Paulsen RE, Gjøen T, Hylland K (2014)
Reactive oxygen species and cytotoxicity in rainbow trout hepatocytes: effects of medium and incubation time
Bull Environ Contam Toxicol, 94 (2), 193-8
DOI 10.1007/s00128-014-1433-0, PubMed 25432295

Publications 2013

Mathisen GH, Yazdani M, Rakkestad KE, Aden PK, Bodin J, Samuelsen M, Nygaard UC, Goverud IL, Gaarder M, Løberg EM, Bølling AK, Becher R, Paulsen RE (2013)
Prenatal exposure to bisphenol A interferes with the development of cerebellar granule neurons in mice and chicken
Int J Dev Neurosci, 31 (8), 762-9
DOI 10.1016/j.ijdevneu.2013.09.009, PubMed 24091367

Publications 2011

Ellesat KS, Yazdani M, Holth TF, Hylland K (2011)
Species-dependent sensitivity to contaminants: an approach using primary hepatocyte cultures with three marine fish species
Mar Environ Res, 72 (4), 216-24
DOI 10.1016/j.marenvres.2011.09.003, PubMed 21963059

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