
Sonia Distante
- Chief Consultant; MD, PhD
- +47 414 62 160
Education
- 1999-2003: MD PhD, University of Oslo, Norway.
- 1990-1996: Bachelor of Medicine and Chirurgy, University of Aberdeen, UK.
- 1986-1990: BSc, Genetics (Honours), University of Aberdeen, UK.
Affiliation
- Metabolomics & Metabolic Molecular Biology Group, Department of Medical Biochemistry, Oslo University Hospital - Rikshospitalet, Norway.
Research Summary
Hemochromatosis and iron metabolism has been Dr. Distante’s topic of research since gene mutations responsible for this condition were discovered in 1996. Her doctoral thesis focused on the prevalence of these mutations in Norway and on factors regulating their phenotypical expression. Her collaborative studies on the evolution and origin of the mutations, have suggested that they are thousands of years old and that Vikings might have contributed to their spread along the European coastal areas, where the mutations are highest in prevalence. Dr. Distante’s current work with “Hemochomatosis International” has led to international guidelines for diagnosis and treatment and a consensus study on screening of hemochromatosis.
Work Experience
- 2004-to date: Oslo University Hospital - Rikshospitalet, Norway.
- 2003-2004: Korle-Bu Teaching Hospital, Ghana.
- 1999-2003: University of Oslo, Norway.
- 1996-1998: Aker University Hospital, Norway.
- 1995-1996: Aberdeen Royal Infirmary, UK.
Links
NB: Check out our NEWS PAGE for the latest!
Publications 2018
Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype
Hepatol Int, 12 (2), 83-86
DOI 10.1007/s12072-018-9855-0, PubMed 29589198
Effects of individualized nutrition after allogeneic hematopoietic stem cell transplantation following myeloablative conditioning; a randomized controlled trial
Clin Nutr ESPEN, 28, 59-66
DOI 10.1016/j.clnesp.2018.08.002, PubMed 30390894
Publications 2016
Blood removal therapy in hereditary hemochromatosis induces a stress response resulting in improved genome integrity
Transfusion, 56 (6), 1435-41
DOI 10.1111/trf.13588, PubMed 27045387
Publications 2014
Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis?
J Trace Elem Med Biol, 31, 225-9
DOI 10.1016/j.jtemb.2014.07.021, PubMed 25175510
Publications 2013
Notification of highly abnormal laboratory results to doctors outside hospitals
Tidsskr Nor Laegeforen, 133 (21), E1-6
DOI 10.4045/tidsskr.13.0709, PubMed 24226343
[Notification of highly deviant biochemical analysis results]
Tidsskr Nor Laegeforen, 133 (21), 2240-1
DOI 10.4045/tidsskr.13.0928, PubMed 24226328
Publications 2012
A man with abdominal pain: enough evidence for surgery?
Clin Chem, 58 (8), 1187-90
DOI 10.1373/clinchem.2011.167015, PubMed 22843812
Publications 2006
Genetic predisposition to iron overload: prevalence and phenotypic expression of hemochromatosis-associated HFE-C282Y gene mutation
Scand J Clin Lab Invest, 66 (2), 83-100
DOI 10.1080/00365510500495616, PubMed 16537242
Publications 2004
The origin and spread of the HFE-C282Y haemochromatosis mutation
Hum Genet, 115 (4), 269-79
DOI 10.1007/s00439-004-1152-4, PubMed 15290237
The origin and spread of the HFE-C282Y haemochromatosis mutation
In Human genetics, Springer International, Berlin, 115(2004)4, S. 269-79
BIBSYS 05190831x
Publications 2003
Genetic predisposition to iron overload: prevalence and phenotypic expression of hemochromatosis associated HFE-C282Y gene mutation
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 134, 1 b. (flere pag.)
BIBSYS 040850374, ISBN 82-8080-066-2
Tumour necrosis factor alpha and its promoter polymorphisms' role in the phenotypic expression of hemochromatosis
Scand J Gastroenterol, 38 (8), 871-7
DOI 10.1080/00365520310003444, PubMed 12940442
Tumor necrosis factor alpha and its promoter polymorphisms' role in the phenotypic expression of hemachromatosis
In Scandinavian journal of gastroenterology, Taylor & Francis, Basingstoke, 38(2003)8, s.871-7
BIBSYS 041707850
Publications 2002
Raised serum ferritin predicts non-response to interferonand ribavirin treatment in patients with chronic hepatitis C-infection
In Journal of hepatology, Munksgaard, København, 36(2002)Suppl 1, s. 233
BIBSYS 03142631x
Raised serum ferritin predicts non-response to interferon and ribavirin treatment in patients with chronic hepatitis C infection
Liver, 22 (3), 269-75
DOI 10.1046/j.0106-9543.2002.01672.x, PubMed 12100578
Publications 2001
Phenotypic expression of the HFE gene mutation (C282Y) among the hospitalised population - Reply
Gut, 49 (1), 156
Publications 2000
The clinical expression of hemochromatosis in Oslo, Norway. Excessive oral iron intake may lead to secondary hemochromatosis even in HFE C282Y mutation negative subjects
Scand J Gastroenterol, 35 (12), 1301-7
DOI 10.1080/003655200453665, PubMed 11199371
The clinical expression of hemachromatosis in Oslo, Norway. Excessive oral iron intake may lead to secondary hemachromatosis even in the HFE C282Y mutation negative subjects
In Scandinavian journal of gastroenterology, Taylor & Francis, Basingstoke, 35(2000)nr 12, s. 1301-1307
BIBSYS 010706097
HFE gene mutation (C282Y) and phenotypic expression among a hospitalised population in a high prevalence area of haemochromatosis
Gut, 47 (4), 575-9
DOI 10.1136/gut.47.4.575, PubMed 10986220
HFE gene mutation (C282Y) and phenotypic expression amonga hospitalised population in a high prevalence area of haemochromatosis
In Gut, British Medical Association, London, 47(2000)nr 4, s. 575-579
BIBSYS 010719873
Publications 1999
High prevalence of the hemochromatosis-associated Cys282Tyr HFE gene mutation in a healthy Norwegian population in the city of Oslo, and its phenotypic expression
Scand J Gastroenterol, 34 (5), 529-34
DOI 10.1080/003655299750026290, PubMed 10423072
Publications 1997
Cranial fasciitis of childhood: an incidental finding of a lytic skull lesion
Br J Neurosurg, 11 (5), 445-7
DOI 10.1080/02688699745989, PubMed 9474280
Skin injuries afflicting three oil workers following contact with calcium bromide and/or calcium chloride
Burns, 23 (7-8), 634-7
DOI 10.1016/s0305-4179(97)00040-5, PubMed 9568340
Publications 1996
Familial adenomatous polyposis in a 5 year old child: a clinical, pathological, and molecular genetic study
J Med Genet, 33 (2), 157-60
DOI 10.1136/jmg.33.2.157, PubMed 8929955