OUH - Metabolomics and Metabolic Molecular Biology

Sonia Distante

Chief Consultant; MD, PhD
+47 230 71 092

Education

1999-2003: MD PhD, University of Oslo, Norway
1990-1996: Bachelor of Medicine and Chirurgy, University of Aberdeen, UK
1986-1990: BSc, Genetics (Honours), University of Aberdeen, UK

Affiliation

Metabolomics & Metabolic Molecular Biology Group, Department of Medical Biochemistry, Oslo University Hospital - Rikshospitalet, Norway

Research Summary

Hemochromatosis and iron metabolism have been the research interests of Dr. Distante since 1996, when the responsible mutated genes were discovered. During her PhD thesis, she studied the prevalence of such mutations in Norway with main focus on factors regulating their phenotypical expression. Her collaborative studies on the evolution and origin of the mutations have suggested that they are thousands of years old. In this regard, Vikings might have contributed to their spread along the European coastal areas, where the mutations are highest in prevalence. Dr. Distante has been a member of “joint scientific committee” for “Hemochomatosis International” since 2015. Her works with other members have led to several fruitful results such as writing international guidelines for diagnosis and treatment as well as a consensus study on screening of hemochromatosis.

Work Experience

2004-to date: Oslo University Hospital - Rikshospitalet, Norway
2003-2004: Korle-Bu Teaching Hospital, Ghana
1999-2003: University of Oslo, Norway
1996-1998: Aker University Hospital, Norway
1995-1996: Aberdeen Royal Infirmary, UK

Links

NB: Check out our NEWS PAGE for the latest!

Publications 2022

Bowe S, Mitlid-Mork B, Gran JM, Distante S, Redman CWG, Staff AC, Georgieva A, Sugulle M (2022)
Predelivery placenta-associated biomarkers and computerized intrapartum fetal heart rate patterns
AJOG Glob Rep, 3 (1), 100149
DOI 10.1016/j.xagr.2022.100149, PubMed 36647548

Dahlberg D, Rummel J, Distante S, De Souza GA, Stensland ME, Mariussen E, Rootwelt H, Voie Ø, Hassel B (2022)
Glioblastoma microenvironment contains multiple hormonal and non-hormonal growth-stimulating factors
Fluids Barriers CNS, 19 (1), 45
DOI 10.1186/s12987-022-00333-z, PubMed 35659255

Larstorp ACK, Salvador CL, Svensvik BA, Klingenberg O, Distante S (2022)
Neutrophil Gelatinase-Associated Lipocalin (NGAL) and cystatin C are early biomarkers of acute kidney injury associated with cardiac surgery
Scand J Clin Lab Invest, 82 (5), 410-418
DOI 10.1080/00365513.2022.2114105, PubMed 36036280

Yazdani M, Distante S, Mørkrid L, Ulvik RJ, Bolann BJ (2022)
Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations
Biol Trace Elem Res (in press)
DOI 10.1007/s12011-022-03424-y, PubMed 36168081

Publications 2018

Adams P, Altes A, Brissot P, Butzeck B, Cabantchik I, Cançado R, Distante S, Evans P, Evans R, Ganz T, Girelli D, Hultcrantz R, McLaren G, Marris B, Milman N, Nemeth E, Nielsen P, Pineau B, Piperno A, Porto G, Prince D, Ryan J, Sanchez M, Santos P, Swinkels D et al. (2018)
Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype
Hepatol Int, 12 (2), 83-86
DOI 10.1007/s12072-018-9855-0, PubMed 29589198

Skaarud KJ, Hjermstad MJ, Bye A, Veierød MB, Gudmundstuen AM, Lundin KEA, Distante S, Brinch L, Tjønnfjord GE, Iversen PO (2018)
Effects of individualized nutrition after allogeneic hematopoietic stem cell transplantation following myeloablative conditioning; a randomized controlled trial
Clin Nutr ESPEN, 28, 59-66
DOI 10.1016/j.clnesp.2018.08.002, PubMed 30390894

Publications 2016

Distante S, Eikeland J, Pawar T, Skinnes R, Høie K, You P, Mørkrid L, Eide L (2016)
Blood removal therapy in hereditary hemochromatosis induces a stress response resulting in improved genome integrity
Transfusion, 56 (6), 1435-41
DOI 10.1111/trf.13588, PubMed 27045387

Publications 2014

Bolann BJ, Distante S, Mørkrid L, Ulvik RJ (2014)
Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis?
J Trace Elem Med Biol, 31, 225-9
DOI 10.1016/j.jtemb.2014.07.021, PubMed 25175510

Publications 2013

Aakre KM, Hov GG, Skadberg O, Piehler A, Distante S, Hager HB (2013)
Notification of highly abnormal laboratory results to doctors outside hospitals
Tidsskr Nor Laegeforen, 133 (21), E1-6
DOI 10.4045/tidsskr.13.0709, PubMed 24226343

Aakre KM, Hov GG, Skadberg Ø, Piehler A, Distante S, Hager HB (2013)
[Notification of highly deviant biochemical analysis results]
Tidsskr Nor Laegeforen, 133 (21), 2240-1
DOI 10.4045/tidsskr.13.0928, PubMed 24226328

Publications 2012

Bolstad N, Kazaryan AM, Revheim ME, Distante S, Johnsrud K, Warren DJ, Nustad K, Edwin B (2012)
A man with abdominal pain: enough evidence for surgery?
Clin Chem, 58 (8), 1187-90
DOI 10.1373/clinchem.2011.167015, PubMed 22843812

Publications 2006

Distante S (2006)
Genetic predisposition to iron overload: prevalence and phenotypic expression of hemochromatosis-associated HFE-C282Y gene mutation
Scand J Clin Lab Invest, 66 (2), 83-100
DOI 10.1080/00365510500495616, PubMed 16537242

Publications 2004

Distante S, Robson KJ, Graham-Campbell J, Arnaiz-Villena A, Brissot P, Worwood M (2004)
The origin and spread of the HFE-C282Y haemochromatosis mutation
Hum Genet, 115 (4), 269-79
DOI 10.1007/s00439-004-1152-4, PubMed 15290237

Distante S, Robson KJH, Graham-Campbell J, Arnaiz-Villena A, Brissot P, Worwood M (2004)
The origin and spread of the HFE-C282Y haemochromatosis mutation
In Human genetics, Springer International, Berlin, 115(2004)4, S. 269-79
BIBSYS 05190831x

Publications 2003

Distante S (2003)
Genetic predisposition to iron overload: prevalence and phenotypic expression of hemochromatosis associated HFE-C282Y gene mutation
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 134, 1 b. (flere pag.)
BIBSYS 040850374, ISBN 82-8080-066-2

Distante S, Elmberg M, Foss Haug KB, Ovstebø R, Berg JP, Kierulf P, Hultcrantz R, Bell H (2003)
Tumour necrosis factor alpha and its promoter polymorphisms' role in the phenotypic expression of hemochromatosis
Scand J Gastroenterol, 38 (8), 871-7
DOI 10.1080/00365520310003444, PubMed 12940442

Distante S, Elmberg M, Foss Haug KB, Øvstebø R, Berg JP, Kierulf P, Hultcrantz R, Bell H (2003)
Tumor necrosis factor alpha and its promoter polymorphisms' role in the phenotypic expression of hemachromatosis
In Scandinavian journal of gastroenterology, Taylor & Francis, Basingstoke, 38(2003)8, s.871-7
BIBSYS 041707850

Publications 2002

Distante S, Bjøro K, Hellum K, Myrvang B, Berg JP, Skaug K, Raknerud N, Bell H (2002)
Raised serum ferritin predicts non-response to interferonand ribavirin treatment in patients with chronic hepatitis C-infection
In Journal of hepatology, Munksgaard, København, 36(2002)Suppl 1, s. 233
BIBSYS 03142631x

Distante S, Bjøro K, Hellum KB, Myrvang B, Berg JP, Skaug K, Raknerud N, Bell H (2002)
Raised serum ferritin predicts non-response to interferon and ribavirin treatment in patients with chronic hepatitis C infection
Liver, 22 (3), 269-75
DOI 10.1046/j.0106-9543.2002.01672.x, PubMed 12100578

Publications 2001

Distante S, Bell H (2001)
Phenotypic expression of the HFE gene mutation (C282Y) among the hospitalised population - Reply
Gut, 49 (1), 156

Publications 2000

Bell H, Berg JP, Undlien DE, Distante S, Raknerud N, Heier HE, Try K, Thomassen Y, Haug E, Raha-Chowdhury R, Thorsby E (2000)
The clinical expression of hemochromatosis in Oslo, Norway. Excessive oral iron intake may lead to secondary hemochromatosis even in HFE C282Y mutation negative subjects
Scand J Gastroenterol, 35 (12), 1301-7
DOI 10.1080/003655200453665, PubMed 11199371

Bell H, Berg JP, Undlien DE, Distante S, Raknerud N, Heier HE, Try K, Thomassen Y, Haug E, Raha-Chowdhury R, Thorsby E (2000)
The clinical expression of hemachromatosis in Oslo, Norway. Excessive oral iron intake may lead to secondary hemachromatosis even in the HFE C282Y mutation negative subjects
In Scandinavian journal of gastroenterology, Taylor & Francis, Basingstoke, 35(2000)nr 12, s. 1301-1307
BIBSYS 010706097

Distante S, Berg JP, Lande K, Haug E, Bell H (2000)
HFE gene mutation (C282Y) and phenotypic expression among a hospitalised population in a high prevalence area of haemochromatosis
Gut, 47 (4), 575-9
DOI 10.1136/gut.47.4.575, PubMed 10986220

Distante S, Berg JP, Lande K, Haug E, Bell H (2000)
HFE gene mutation (C282Y) and phenotypic expression amonga hospitalised population in a high prevalence area of haemochromatosis
In Gut, British Medical Association, London, 47(2000)nr 4, s. 575-579
BIBSYS 010719873

Publications 1999

Distante S, Berg JP, Lande K, Haug E, Bell H (1999)
High prevalence of the hemochromatosis-associated Cys282Tyr HFE gene mutation in a healthy Norwegian population in the city of Oslo, and its phenotypic expression
Scand J Gastroenterol, 34 (5), 529-34
DOI 10.1080/003655299750026290, PubMed 10423072

Publications 1997

Boddie DE, Distante S, Blaiklock CT (1997)
Cranial fasciitis of childhood: an incidental finding of a lytic skull lesion
Br J Neurosurg, 11 (5), 445-7
DOI 10.1080/02688699745989, PubMed 9474280

Saeed WR, Distante S, Holmes JD, Kolhe PS (1997)
Skin injuries afflicting three oil workers following contact with calcium bromide and/or calcium chloride
Burns, 23 (7-8), 634-7
DOI 10.1016/s0305-4179(97)00040-5, PubMed 9568340

Publications 1996

Distante S, Nasioulas S, Somers GR, Cameron DJ, Young MA, Forrest SM, Gardner RJ (1996)
Familial adenomatous polyposis in a 5 year old child: a clinical, pathological, and molecular genetic study
J Med Genet, 33 (2), 157-60
DOI 10.1136/jmg.33.2.157, PubMed 8929955