Mazyar Yazdani
- Senior Scientist; PhD
Education
- 2009-2014: PhD in Integrative Biology - Toxicology, Department of Biosciences, University of Oslo, Norway
Thesis: In vitro, in ovo and in vivo models for cytotoxicity, oxidative stress, neurotoxicity and DNA damage
Committee: Ketil Hylland, Ragnhild Paulsen & Tor Gjøen (Collaborator: Gunnar Brunborg, Norwegian Institute of Public Health)
Affiliation
- Metabolomics & Metabolic Molecular Biology Group, Department of Medical Biochemistry, Oslo University Hospital - Rikshospitalet, Norway
– Associated member of:
- The Unit of Regenerative Medicine, Department of Medical Biochemistry, Oslo University Hospital - Ullevål, Norway
- Center for Eye Research, Department of Ophthalmology, Oslo University Hospital - Ullevål, Norway
- Norwegian Dry Eye Clinic, Oslo, Norway
Research Summary
Dr. Yazdani, a toxicologist, began his research career by studying the mechanisms of action of hazardous substances, with emphasis on oxidative stress induction and in vitro (cell culture) method development. He later linked the role of oxidative stress to pathophysiology of dry eye disease and treatment of corneal epithelial (limbal) stem cell deficiency. Currently, as a core member of the Metabolomics & Metabolic Molecular Biology group, he is investigating the role of metabolic changes in health and disease. The main goal is to better understand the mechanisms underlying disease development using mass spectrometry-based metabolomics and lipidomics. Apart from these, Mazyar has always had a keen interest in biological role and effects of oxygen. He is interested in both empirical and conceptual research (Read more here).
Selected projects
Mazyar is involved in several projects (on eye, brain, blood, etc.), but his main fields of interest are ophthalmology and neurology. Some examples:
Dry eye disease (e.g., Yazdani et al 2021a), Kearns–Sayre syndrome (e.g., Salvador et al 2023), Pyridoxine-dependent epilepsy (e.g., Böhm et al 2022) & Neurotoxicity (e.g., Mathisen et al 2013).
Highlights
- Hypothesis-driven article (Vision science): Yazdani (2023)
- Mechanistic articles (Neurology): Yazdani and Elgstøen (2021), Yazdani (2024)
- Methodological articles (In vitro): Yazdani et al (2014), Yazdani (2015), Yazdani (2016), Yazdani (2022)
- Pioneer reviews (Ophthalmology): Yazdani et al (2019a), Yazdani et al (2019b), Yazdani et al (2021b)
- Peer reviewer for several journals published by Nature, Elsevier, Springer & others
- Some contributions: Lecturer (sporadically), Lab Manager (2019-2020), Course Instructor (2018), Lab Instructor (2011 & 2012), Research Assistant (2008 & 2009) and Lab Demonstrator (2007 & 2008)
- Featured in the News (expert opinion on cosmetics): "Eyelash Growth Serums" in VG Newspaper (2021)
Current PhD students
- Fredrik Fineide, Since 2024, Optimization of current dry eye disease treatment regimens through artificial intelligence
- Morten Gundersen, Since 2023, Metabolomic profile in tear film samples of patients with or without dry eye disease before and after cataract surgery
- Madhavi bhandari, Since 2021, Lacritin-incorporated nanoparticles as new and improved treatment of dry eye disease
Work Experience
- 2021-to date: Metabolomics Group, Oslo University Hospital (OUS) - Rikshospitalet, Oslo
- 2017-2020: Regenerative Medicine Group, Oslo University Hospital (OUS) - Ullevål Sykehus, Oslo
- 2016: Health Effects Group, Norwegian Institute for Air Research (NILU), Kjeller + Norwegian Dry Eye Clinic (TØK), Oslo
- 2015: Toxicology Group and Ecotoxicology Group, Norwegian Food Safety Authority (Mattilsynet), Ås
- 2009-2014: Toxicology Group, University of Oslo (UiO), Oslo
Links
NB: Visit our NEWS PAGE for the latest updates and the Galleries (Links: 1, 2, 3 & 4) for social events!
Publications 2024
Can endogenous ethylene glycol production occur in humans? A detailed investigation of adult monozygotic twin sisters
Clin Toxicol (Phila), 62 (11), 698-706
DOI 10.1080/15563650.2024.2401076, PubMed 39327950
Method Development for Omics Analyses using Schirmer Strips
Curr Eye Res, 49 (7), 708-716
DOI 10.1080/02713683.2024.2335271, PubMed 38567868
Iron Metabolism, Calcium, Magnesium and Trace Elements: A Review
Biol Trace Elem Res (in press)
DOI 10.1007/s12011-024-04289-z, PubMed 38969940
Cellular and Molecular Responses to Mitochondrial DNA Deletions in Kearns-Sayre Syndrome: Some Underlying Mechanisms
Mol Neurobiol, 61 (8), 5665-5679
DOI 10.1007/s12035-024-03938-7, PubMed 38224444
Publications 2023
Increased Sphingomyelin and Free Sialic Acid in Cerebrospinal Fluid of Kearns-Sayre Syndrome: New Findings Using Untargeted Metabolomics
Pediatr Neurol, 143, 68-76
DOI 10.1016/j.pediatrneurol.2023.02.016, PubMed 37018879
Tear film lipid layer and corneal oxygenation: a new function?
Eye (Lond), 37 (17), 3534-3541
DOI 10.1038/s41433-023-02557-1, PubMed 37138094
Publications 2022
The Therapeutic Benefits of Nanoencapsulation in Drug Delivery to the Anterior Segment of the Eye: A Systematic Review
Front Pharmacol, 13, 903519
DOI 10.3389/fphar.2022.903519, PubMed 35645827
Global Metabolomics Discovers Two Novel Biomarkers in Pyridoxine-Dependent Epilepsy Caused by ALDH7A1 Deficiency
Int J Mol Sci, 23 (24)
DOI 10.3390/ijms232416061, PubMed 36555701
Uncontrolled Oxygen Levels in Cultures of Retinal Pigment Epithelium: Have We Missed the Obvious?
Curr Eye Res, 47 (5), 651-660
DOI 10.1080/02713683.2022.2050264, PubMed 35243933
Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations
Biol Trace Elem Res, 201 (7), 3193-3201
DOI 10.1007/s12011-022-03424-y, PubMed 36168081
Publications 2021
A pioneer study on human 3-nitropropionic acid intoxication: Contributions from metabolomics
J Appl Toxicol, 42 (5), 818-829
DOI 10.1002/jat.4259, PubMed 34725838
Is oxidative stress an overlooked player in pyridoxine-dependent epilepsy? A focused review
Seizure, 91, 369-373
DOI 10.1016/j.seizure.2021.07.014, PubMed 34298455
Eye Make-up Products and Dry Eye Disease: A Mini Review
Curr Eye Res, 47 (1), 1-11
DOI 10.1080/02713683.2021.1966476, PubMed 34365876
Tear Film Break-Up Time and Dry Eye Disease Severity in a Large Norwegian Cohort
J Clin Med, 10 (4)
DOI 10.3390/jcm10040884, PubMed 33671667
Publications 2020
Distinct Subsets of Noncoding RNAs Are Strongly Associated With BMD and Fracture, Studied in Weight-Bearing and Non-Weight-Bearing Human Bone
J Bone Miner Res, 35 (6), 1065-1076
DOI 10.1002/jbmr.3974, PubMed 32017184
Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease
Sci Rep, 10 (1), 5542
DOI 10.1038/s41598-020-62583-x, PubMed 32218518
Intense pulsed light treatment in meibomian gland dysfunction: A concise review
Ocul Surf, 18 (4), 583-594
DOI 10.1016/j.jtos.2020.06.002, PubMed 32629039
Response of human oral mucosal epithelial cells to different storage temperatures: A structural and transcriptional study
PLoS One, 15 (12), e0243914
DOI 10.1371/journal.pone.0243914, PubMed 33326470
Publications 2019
Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients
Curr Eye Res, 44 (9), 941-947
DOI 10.1080/02713683.2019.1604972, PubMed 30955380
Tear Metabolomics in Dry Eye Disease: A Review
Int J Mol Sci, 20 (15)
DOI 10.3390/ijms20153755, PubMed 31374809
Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review
Cells, 8 (3)
DOI 10.3390/cells8030245, PubMed 30875861
A Hyaluronan Hydrogel Scaffold for Culture of Human Oral Mucosal Epithelial Cells in Limbal Stem-Cell Therapy
Bioengineering (Basel), 6 (4)
DOI 10.3390/bioengineering6040097, PubMed 31652804
Publications 2018
Comparative toxicity of selected PAHs in rainbow trout hepatocytes: genotoxicity, oxidative stress and cytotoxicity
Drug Chem Toxicol, 43 (1), 71-78
DOI 10.1080/01480545.2018.1497054, PubMed 30246564
Tear Production Levels and Dry Eye Disease Severity in a Large Norwegian Cohort
Curr Eye Res, 43 (12), 1465-1470
DOI 10.1080/02713683.2018.1514055, PubMed 30183390
Publications 2016
Fibrous shape underlies the mutagenic and carcinogenic potential of nanosilver while surface chemistry affects the biosafety of iron oxide nanoparticles
Mutagenesis, 32 (1), 193-202
DOI 10.1093/mutage/gew045, PubMed 27658822
Technical aspects of oxygen level regulation in primary cell cultures: A review
Interdiscip Toxicol, 9 (3-4), 85-89
DOI 10.1515/intox-2016-0011, PubMed 28652851
Short-term effect of bisphenol-a on oxidative stress responses in Atlantic salmon kidney cell line: a transcriptional study
Toxicol Mech Methods, 26 (4), 295-300
DOI 10.1080/15376516.2016.1177864, PubMed 27117342
A Kinetic Study of Reactive Oxygen Species in Rainbow Trout Hepatocytes by Fluorometry
J Environ Pathol Toxicol Oncol, 35 (4), 291-297
DOI 10.1615/JEnvironPatholToxicolOncol.2016016184, PubMed 27992310
Publications 2015
Concerns in the application of fluorescent probes DCDHF-DA, DHR 123 and DHE to measure reactive oxygen species in vitro
Toxicol In Vitro, 30 (1 Pt B), 578-82
DOI 10.1016/j.tiv.2015.08.010, PubMed 26318276
Publications 2014
Reactive oxygen species and cytotoxicity in rainbow trout hepatocytes: effects of medium and incubation time
Bull Environ Contam Toxicol, 94 (2), 193-8
DOI 10.1007/s00128-014-1433-0, PubMed 25432295
Publications 2013
Prenatal exposure to bisphenol A interferes with the development of cerebellar granule neurons in mice and chicken
Int J Dev Neurosci, 31 (8), 762-9
DOI 10.1016/j.ijdevneu.2013.09.009, PubMed 24091367
Publications 2011
Species-dependent sensitivity to contaminants: an approach using primary hepatocyte cultures with three marine fish species
Mar Environ Res, 72 (4), 216-24
DOI 10.1016/j.marenvres.2011.09.003, PubMed 21963059
Is the high Cu tolerance of Trichoderma atroviride isolated from the Cu-polluted sediment due to adaptation? An in vitro toxicological study
Journal of Sains Malaysiana , 40 (2), 119-124
PublikaID 362
Publications 2010
Effects of the metal contaminated soils on the accumulation of heavy metals in the different parts of Centella asiatica: A laboratory study
Journal of Sains Malaysiana, 39 (3), 347-352
PublikaID 360
An in vitro study on the adsorption, absorption and uptake capacity of Zn by using the bioremediator Trichoderma atroviride
EnvironmentAsia, 3 (1), 53-59
PublikaID 361
Publications 2009
The identification of point sources in a river receiving industrial metal effluents at the Serdang industrial area, Selangor
Sustainability Science and Management, 4 (2), 18-26
PublikaID 358
Trichoderma atroviride as a bioremediator of Cu pollution: An in vitro study
Toxicological & Environmental Chemistry , 91 (7), 1305-1314
DOI 10.1080/02772240802616510, PublikaID 359