Research projects:

  • Identification of the hidden heritability of severe mental disorders
  • Identifying the polygenic basis of the human brain and neurodevelopmental disorders
  • Identifying causal variants in candidate regions
  • Human induced pluripotent stem cell (hiPSC) technologies in psychiatric molecular genetics
  • Prediction of longitudinal outcome and brain phenotype by polygenic scores
  • Identification of genetic loci associated with neurocognitive and MR phenotypes and implications for disease mechanisms in severe mental disorders
  • Biobanking, database, sample prep, QC

Cooperation

It is of vital importance to base genetic discovery on large samples, which is difficult to obtain without international collaboration. The Psychiatric Molecular Genetics Group participates in several large European studies of schizophrenia genetics, the SGENE-plus group (coordinated by deCODE, and including research groups as well as samples from England, Germany, Finland, Denmark, Iceland, Scotland) and Scandinavian Collaboration on Psychiatric Etiology (SCOPE).

Further, the Psychiatric Molecular Genetics Group is a member of the Psychiatric Genetics Consortium (PGC) which includes all GWAS studies in psychiatric genetics, as well as European IPSC Consortium for Neuropsychiatric Disorders  (EURICND)

Challenges and projects

Challenges

The goal of The Psychiatric Molecular Genetics Group is to develop a strong research environment in molecular genetics of psychiatric disorders. The group is part of the SFF NORMENT and KG Jebsen Centre for Psychosis Research, which is a major collaborative effort studying clinical characteristics, neurocognitive functioning and brain biology of psychotic disorders. The group's current research aims are to perform molecular genetic analysis to increase the knowledge and expertise in psychiatric genetics and identify the molecular networks underlying psychiatric disease as well as to continually develop an organization to support psychiatric genetic studies with design and planning.

Our group has several ongoing research projects focused on the following areas:

1. Identification of the hidden heritability of schizophrenia 

  • Identifying causal variants in candidate regions 
  • Prediction of longitudinal outcome and brain phenotype by polygenic scores, constructed using the results from GWAS and polygenic score analyses from Psychiatric Genetics Consortium
  • Does rare variants explain the "hidden" heritability in psychotic disorders - a miRNA study

2. Genetics of brain phenotypes - Identification of genetic loci associated with neurocognitive and MR phenotypes and implications for disease mechanisms in severe mental disorders

3. BUPGEN Network - From genes to phenotypes of neurodevelopmental disorders in children

4. Identification of genetic loci associated with metabolic and cardiovascular side effects in patients on psychopharmacological treatment