Welcome to Srdjan Djurovic's research group: Psychiatric Molecular Genetics Group

Srdjan DjurovicGroup leader
Srdjan Djurovic
Group leader

The Psychiatric Molecular Genetics Group works to advance knowledge of the molecular genetics of psychiatric disorders through a strong multidisciplinary research environment. The group has multiple active research projects in collaboration with NORMENT2050, a major collaborative effort studying clinical characteristics, neurocognitive functioning, genetics and brain biology of psychotic disorders and with the newly formed Centre for Precision Psychiatry (OUH/UiO).

Aims

Our research aims are to:

  • perform molecular genetic analyses to increase the knowledge and expertise in psychiatric genetics and genomics
  • identify the molecular networks underlying psychiatric disorders
  • continually develop an organization to support psychiatric genomics and stem cell studies with design and planning and experiments.
  • continuously foster new ideas 

 

 

Research projects:

  • Human induced pluripotent stem cell (hiPSC) technologies in psychiatric molecular genetics (Figure 1)
  • Neuro-immune interactions (Figure 2)
  • Identifying the polygenic basis of the human brain and neurodevelopmental disorders 
  • Understanding the function of ANK3 in psychotic disorders
  • Identifying mechanisms of rare genetic variants in population level brain imaging genetics for clinical subtyping in neurodevelopmental disorders
  • Prediction of longitudinal outcome and brain phenotype by polygenic risk scores
  • Genetics of neuropsychopharmaceutics
  • Cooperation and biobanking with large-scale studies including the national cohorts and further collaboration with other large-scale studies for validation and QC steps

 

Figure 1 A) Representative image of control human induced pluripotent stem cell (iPSC)-derived brain cortical spheroids (hCS) at day 150 of differentiation. B) MAP2/VGLUT1/DAPI immunohistochemistry staining of human iPSC-derived mature cortical spheroid. C) UMAP clustering of single cell RNA sequencing of a healthy donor iPSC-derived cortical spheroid. Provided by Jordi R. Osete

 

Figure 2. Characterization of iPSC-derived astrocytes from CTRL and SCZ donors . Cells from day 40 cultures stained positive for the key astrocyte markers GFAP, S100B, and AQP4. Scale bar: 200 μm. Provided by Attila Szabo

 

Contact information:
Group Leader Srdjan Djurovic, Department of Medical Genetics, Tel: +47 22 11 98 90
E-mail: srdjan.djurovic@medisin.uio.no