Lars O. Baumbusch

  • Senior scientist and group leader; MSc, PhD (Dr.)
  • +47 23 07 33 72

Professional experience

10.2022 - present     Dep. of Nursing, Health and Laboratory Science,
                                  Østfold University College (HiØ), Fredrikstad, Norway
                                  Adjunt professor (professor II)

04.2021 - present     Dep. of Pediatric Research (PFI), Division of Pediatric and Adolescent Medicine,
                                  Oslo University Hospital (OUS) Rikshospitalet, Oslo, Norway
                                  Senior scientist and project group leader

01.-05. 2018 - 2021  Dep. of Mechanical, Electronics and Chemical Engineering,
                                  Oslo Metropolitan University (OsloMet), Oslo, Norway
                                  Professor / associate professor (førsteamanuensis)

11.2012 - 03.2021     Dep. of Pediatric Research, Division of Pediatric and Adolescent Medicine,
                                  Oslo University Hospital Rikshospitalet, Oslo, Norway
                                  Scientist and project manager

05.2007 - 10.2012     Dep. of Genetics, Institute for Cancer Research and Dep. of Pathology,
                                  Oslo University Hospital Radiumhospitalet, Oslo, Norway
                                  Scientist and project group leader

09.2006 - 06.2010     Biomedical Research group, Dep. of Informatics, University of Oslo, Norway
                                   Adjunct associate professor (førsteamanuensis-II)

12.2001 - 04.2007     Dep. of Genetics, Institute for Cancer Research and Dep. of Pathology,
                                  Oslo University Hospital Radiumhospitalet, Oslo, Norway
                                  Post-doc

Education

01.2020 - 06.2020     Oslo Metropolitan University, Oslo, Norway
                                    Evaluated for full professor competence
01.1997 - 11.2001     Div. of Molecular Biology, Dep. of Biology, University of Oslo, Norway
                                    Dr. scient. (Ph.D.)
10.1993 - 06.1996     Dep. of Biology, Albert-Ludwig University of Freiburg, Germany
                                    Diploma in Biology (M.Sc. or cand. scient.)
10.1992 - 09.1993     Dep. of Botany, Trinity College Dublin, Ireland
                                    Studies abroad and student project
10.1989 - 09.1992     Dep. of Biology, Albert-Ludwig University of Freiburg, Germany
                                    Intermediate diploma in biology
04.1989 - 09.1989     Philosophical faculty, Albert-Ludwig University of Freiburg, Germany
                                    Philosophical studies
08.1987 - 03.1989     St. Fidelius Parish, Offenburg, Germany
                                    Civilian service
08.1978 - 05.1987     Max-Planck Gymnasium Lahr, Germany
                                    Abitur (university-entrance diploma or examen artium)


Research projects:

visit to the Baumbusch project group home page - Molecular biology of oxidative stress and cancer

 

 

Publications 2021

Hermansen JU, Wojcik DM, Robinson N, Pahnke J, Haugland HK, Jamtoy AH, Flaegstad T, Halvorsen H, Lund B, Baumbusch LO, Munthe-Kaas MC (2021)
The Norwegian childhood cancer biobank
Cancer Rep.-US, e1555
DOI 10.1002/cnr2.1555

Publications 2020

Revhaug C, Zasada M, Rognlien AGW, Gunther CC, Grabowska A, Ksiazek T, Madetko-Talowska A, Szewczyk K, Bik-Multanowski M, Kwinta P, Pietrzyk JJ, Baumbusch LO, Saugstad OD (2020)
Pulmonary vascular disease is evident in gene regulation of experimental bronchopulmonary dysplasia
J. Matern.-Fetal Neonatal Med., 33 (12), 2122-2130
DOI 10.1080/14767058.2018.1541081

Zasada M, Madetko-Talowska A, Revhaug C, Rognlien AGW, Baumbusch LO, Dotek TKO, Szewczyk K, Grabowska A, Bik-Multanowski M, Pietrzyk JJ, Kwinta P, Saugstad OD (2020)
Short- and long-term impact of hyperoxia on the blood and retinal cells' transcriptome in a mouse model of oxygen-induced retinopathy
Pediatr. Res., 87 (3), 485-493
DOI 10.1038/s41390-019-0598-y

Zasada M, Madetko-Talowska A, Revhaug C, Rognlien AGW, Baumbusch LO, Ksiazek T, Szewczyk K, Grabowska A, Bik-Multanowski M, Pietrzyk JJ, Kwinta P, Saugstad OD (2020)
Transcriptome analysis reveals dysregulation of genes involved in oxidative phosphorylation in a murine model of retinopathy of prematurity
Pediatr. Res., 88 (3), 391-397
DOI 10.1038/s41390-020-0793-x

Publications 2019

Rajar P, Asegg-Atneosen M, Saugstad OD, Solberg R, Baumbusch LO (2019)
Quantification of circulating cell-free DNA (cfDNA) in urine using a newborn piglet model of asphyxia
PLoS One, 14 (12), e0227066
DOI 10.1371/journal.pone.0227066

Revhaug C, Bik-Multanowski M, Zasada M, Rognlien AGW, Gunther CC, Ksiazek T, Madetko-Talowska A, Szewczyk K, Grabowska A, Kwinta P, Pietrzyk JJ, Baumbusch LO, Saugstad OD (2019)
Immune System Regulation Affected by a Murine Experimental Model of Bronchopulmonary Dysplasia: Genomic and Epigenetic Findings
Neonatology, 116 (3), 269-277
DOI 10.1159/000501461

Zasada M, Suski M, Bokiniec R, Szwarc-Duma M, Borszewska-Kornacka MK, Madej J, Bujak-Gizycka B, Madetko-Talowska A, Revhaug C, Baumbusch LO, Saugstad OD, Pietrzyk JJ, Kwinta P (2019)
Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
Ital. J. Pediatr., 45 (1), 112
DOI 10.1186/s13052-019-0676-0

Publications 2018

Benterud T, Manueldas S, Rivera S, Henckel E, Loberg EM, Norgren S, Baumbusch LO, Solberg R, Saugstad OD (2018)
Cerebellum Susceptibility to Neonatal Asphyxia: Possible Protective Effects of N-Acetylcysteine Amide
Dis. Markers, 2018, 5046372
DOI 10.1155/2018/5046372

Kaveh F, Baumbusch LO, Nebdal D, Borresen-Dale AL, Lingjaerde OC, Edvardsen H, Kristensen VN, Solvang HK (2018)
A systematic comparison of copy number alterations in four types of female cancer (vol 16, 913, 2016)
BMC Cancer, 18
DOI 10.1186/s12885-017-3766-7

Manueldas S, Benterud T, Rueegg CS, Garberg HT, Huun MU, Pankratov L, Asegg-Atneosen M, Solberg R, Escobar J, Saugstad OD, Baumbusch LO (2018)
Temporal patterns of circulating cell-free DNA (cfDNA) in a newborn piglet model of perinatal asphyxia
PLoS One, 13 (11), e0206601
DOI 10.1371/journal.pone.0206601

Suski M, Bokiniec R, Szwarc-Duma M, Madej J, Bujak-Gizycka B, Borszewska-Kornacka MK, Ksiazek T, Grabowska A, Revhaug C, Baumbusch LO, Saugstad OD, Pietrzyk JJ, Kwinta P (2018)
Plasma proteome changes in cord blood samples from preterm infants
J. Perinatol., 38 (9), 1182-1189
DOI 10.1038/s41372-018-0150-7

Suski M, Bokiniec R, Szwarc-Duma M, Madej J, Bujak-Gizycka B, Kwinta P, Borszewska-Kornacka MK, Revhaug C, Baumbusch LO, Saugstad OD, Pietrzyk JJ (2018)
Prospective plasma proteome changes in preterm infants with different gestational ages
Pediatr. Res., 84 (1), 104-111
DOI 10.1038/s41390-018-0003-2

Zasada M, Suski M, Bokiniec R, Szwarc-Duma M, Borszewska-Kornacka MK, Madej J, Bujak-Gizycka B, Madetko-Talowska A, Revhaug C, Baumbusch LO, Saugstad OD, Pietrzyk JJ, Kwinta P (2018)
An iTRAQ-Based Quantitative Proteomic Analysis of Plasma Proteins in Preterm Newborns With Retinopathy of Prematurity
Invest. Ophthalmol. Vis. Sci., 59 (13), 5312-5319
DOI 10.1167/iovs.18-24914

Publications 2017

Benterud T, Ystgaard MB, Manueldas S, Pankratov L, Alfaro-Cervello C, Florholnnen G, Ahmed MS, Sandvik L, Norgren S, Bjoras M, Baumbusch LO, Solberg R, Saugstad OD (2017)
N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia
Neonatology, 111 (1), 12-21
DOI 10.1159/000447255

Garberg HT, Huun MU, Baumbusch LO, Asegg-Atneosen M, Solberg R, Saugstad OD (2017)
Temporal Profile of Circulating microRNAs after Global Hypoxia-Ischemia in Newborn Piglets
Neonatology, 111 (2), 133-139
DOI 10.1159/000449032

Kwinta P, Bokiniec R, Bik-Multanowski M, Gunther CC, Grabowska A, Ksiazek T, Madetko-Talowska A, Szewczyk K, Szwarc-Duma M, Borszewska-Kornacka MK, Baumbusch LO, Revhaug C, Saugstad OD, Pietrzyk JJ (2017)
Comparison of whole genome expression profile between preterm and full-term newborns
Ginekol. Pol., 88 (8), 434-441
DOI 10.5603/GP.a2017.0080

Publications 2016

Demeulemeester J, Kumar P, Moller EK, Nord S, Wedge DC, Peterson A, Mathiesen RR, Fjelldal R, Esteki MZ, Theunis K, Gallardo EF, Grundstad AJ, Borgen E, Baumbusch LO, Borresen-Dale AL, White KP, Kristensen VN, Van Loo P, Voet T, Naume B (2016)
Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing
Genome Biol., 17, 250
DOI 10.1186/s13059-016-1109-7

Kaveh F, Baumbusch LO, Nebdal D, Borresen-Dale AL, Lingjaerde OC, Edvardsen H, Kristensen VN, Solvang HK (2016)
A systematic comparison of copy number alterations in four types of female cancer
BMC Cancer, 16, 913
DOI 10.1186/s12885-016-2899-4

Publications 2015

Benterud T, Pankratov L, Solberg R, Bolstad N, Skinningsrud A, Baumbusch L, Sandvik L, Saugstad OD (2015)
Perinatal Asphyxia May Influence the Level of Beta-Amyloid (1-42) in Cerebrospinal Fluid: An Experimental Study on Newborn Pigs
PLoS One, 10 (10), e0140966
DOI 10.1371/journal.pone.0140966

Gul KA, Overland T, Osnes L, Baumbusch LO, Pettersen RD, Lima K, Abrahamsen TG (2015)
Neonatal Levels of T-cell Receptor Excision Circles (TREC) in Patients with 22q11.2 Deletion Syndrome and Later Disease Features
J. Clin. Immunol., 35 (4), 408-415
DOI 10.1007/s10875-015-0153-5

Publications 2014

Liu YH, Zhou RK, Baumbusch LO, Tsavachidis S, Brewster AM, Do KA, Sahin A, Hortobagyi GN, Taube JH, Mani SA, Aaroe J, Warnberg F, Borresen-Dale AL, Mills GB, Thompson PA, Bondy ML (2014)
Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer
Breast Cancer Res. Treat., 143 (1), 189-201
DOI 10.1007/s10549-013-2796-3

Reiche K, Kasack K, Schreiber S, Luders T, Due EU, Naume B, Riis M, Kristensen VN, Horn F, Borresen-Dale AL, Hackermuller J, Baumbusch LO (2014)
Long Non-Coding RNAs Differentially Expressed between Normal versus Primary Breast Tumor Tissues Disclose Converse Changes to Breast Cancer-Related Protein-Coding Genes
PLoS One, 9 (9), e106076
DOI 10.1371/journal.pone.0106076

Publications 2013

Aure MR, Steinfeld I, Baumbusch LO, Liestol K, Lipson D, Nyberg S, Naume B, Sahlberg KK, Kristensen VN, Borresen-Dale AL, Lingjaerde OC, Yakhini Z (2013)
Identifying In-Trans Process Associated Genes in Breast Cancer by Integrated Analysis of Copy Number and Expression Data
PLoS One, 8 (1), e53014
DOI 10.1371/journal.pone.0053014

Baumbusch LO, Helland A, Wang Y, Liestol K, Schaner ME, Holm R, Etemadmoghadam D, Alsop K, Brown P, Mitchell G, Fereday S, DeFazio A, Bowtell DDL, Kristensen GB, Lingjaerde OC, Borresen-Dale AL, Australian Ovarian Canc Study Grp (2013)
High Levels of Genomic Aberrations in Serous Ovarian Cancers Are Associated with Better Survival
PLoS One, 8 (1), e54356
DOI 10.1371/journal.pone.0054356

Moller EK, Kumar P, Voet T, Peterson A, Van Loos P, Mathiesen RR, Fjelldal R, Grundstad J, Borgen E, Baumbusch LO, Naume B, Borresen-Dale AL, White KP, Nord S, Kristensen VN (2013)
Next-generation sequencing of disseminated tumor cells
Front. Oncol., 3, 320
DOI 10.3389/fonc.2013.00320

Otto B, Gruner K, Heinlein C, Wegwitz F, Nollau P, Ylstra B, Pantel K, Schumacher U, Baumbusch LO, Martin-Subero JI, Siebert R, Wagener C, Streichert T, Deppert W, Tolstonog GV (2013)
Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expression
Int. J. Cancer, 132 (6), 1300-1310
DOI 10.1002/ijc.27783

Publications 2012

Mathiesen RR, Fjelldal R, Liestol K, Due EU, Geigl JB, Riethdorf S, Borgen E, Rye IH, Schneider IJ, Obenauf AC, Mauermann O, Nilsen G, Lingjaerde OC, Borresen-Dale AL, Pantel K, Speicher MR, Naume B, Baumbusch LO (2012)
High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer
Int. J. Cancer, 131 (4), E405-E415
DOI 10.1002/ijc.26444

Nilsen G, Liestol K, Van Loo P, Vollan HKM, Eide MB, Rueda OM, Chin SF, Russell R, Baumbusch LO, Caldas C, Borresen-Dale AL, Lingjaerde OC (2012)
Copynumber: Efficient algorithms for single- and multi-track copy number segmentation
BMC Genomics, 13, 591
DOI 10.1186/1471-2164-13-591

Publications 2011

Molloy TJ, Bosma AJ, Baumbusch LO, Synnestvedt M, Borgen E, Russnes HG, Schlichting E, van't Veer LJ, Naume B (2011)
The prognostic significance of tumour cell detection in the peripheral blood versus the bone marrow in 733 early-stage breast cancer patients
Breast Cancer Res., 13 (3), R61
DOI 10.1186/bcr2898

Publications 2010

Russnes HG, Vollan HKM, Lingjaerde OC, Krasnitz A, Lundin P, Naume B, Sorlie T, Borgen E, Rye IH, Langerod A, Chin SF, Teschendorff AE, Stephens PJ, Maner S, Schlichting E, Baumbusch LO, Karesen R, Stratton MP, Wigler M, Caldas C, Zetterberg A, Hicks J, Borresen-Dale AL (2010)
Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients
Sci. Transl. Med., 2 (38), 38ra47
DOI 10.1126/scitranslmed.3000611

Publications 2009

Geigl JB, Obenauf AC, Waldispuehl-Geigl J, Hoffmann EM, Auer M, Hormann M, Fischer M, Trajanoski Z, Schenk MA, Baumbusch LO, Speicher MR (2009)
Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays
Nucleic Acids Res., 37 (15), e105
DOI 10.1093/nar/gkp526

Publications 2008

Baumbusch LO, Aaroe J, Johansen FE, Hicks J, Sun H, Bruhn L, Gunderson K, Naume B, Kristensen VN, Liestol K, Borresen-Dale AL, Lingjaerde OC (2008)
Comparison of the Agilent, ROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors
BMC Genomics, 9, 379
DOI 10.1186/1471-2164-9-379

Publications 2006

Baumbusch LO, Myhre S, Langerod A, Bergamaschi A, Geisler SB, Lonning PE, Deppert W, Dornreiter I, Borresen-Dale AL (2006)
Expression of full-length p53 and its isoform Delta p53 in breast carcinomas in relation to mutation status and clinical parameters
Mol. Cancer, 5, 47
DOI 10.1186/1476-4598-5-47

Publications 2001

Baumbusch LO (2001)
Identification and analysis of genes controlling embryogenesis and embryo dormancy in plants
In Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo, The Faculty, Oslo, no. 181, 1 b. (flere pag.)
BIBSYS 012230200

Baumbusch LO, Sundal IK, Hughes DW, Galau GA, Jakobsen KS (2001)
Efficient protocols for CAPS-based mapping in Arabidopsis
Plant Mol. Biol. Rep., 19 (2), 137-149
DOI 10.1007/BF02772156