Lars O. Baumbusch
- Senior scientist and group leader; MSc, PhD (Dr.)
- +47 23 07 33 72
Professional experience
10.2022 - present Dep. of Nursing, Health and Laboratory Science,
Østfold University College (HiØ), Fredrikstad, Norway
Adjunt professor (professor II)
04.2021 - present Dep. of Pediatric Research (PFI), Division of Pediatric and Adolescent Medicine,
Oslo University Hospital (OUS) Rikshospitalet, Oslo, Norway
Senior scientist and project group leader
01.-05. 2018 - 2021 Dep. of Mechanical, Electronics and Chemical Engineering,
Oslo Metropolitan University (OsloMet), Oslo, Norway
Professor / associate professor (førsteamanuensis)
11.2012 - 03.2021 Dep. of Pediatric Research, Division of Pediatric and Adolescent Medicine,
Oslo University Hospital Rikshospitalet, Oslo, Norway
Scientist and project manager
05.2007 - 10.2012 Dep. of Genetics, Institute for Cancer Research and Dep. of Pathology,
Oslo University Hospital Radiumhospitalet, Oslo, Norway
Scientist and project group leader
09.2006 - 06.2010 Biomedical Research group, Dep. of Informatics, University of Oslo, Norway
Adjunct associate professor (førsteamanuensis-II)
12.2001 - 04.2007 Dep. of Genetics, Institute for Cancer Research and Dep. of Pathology,
Oslo University Hospital Radiumhospitalet, Oslo, Norway
Post-doc
Education
01.2020 - 06.2020 Oslo Metropolitan University, Oslo, Norway
Evaluated for full professor competence
01.1997 - 11.2001 Div. of Molecular Biology, Dep. of Biology, University of Oslo, Norway
Dr. scient. (Ph.D.)
10.1993 - 06.1996 Dep. of Biology, Albert-Ludwig University of Freiburg, Germany
Diploma in Biology (M.Sc. or cand. scient.)
10.1992 - 09.1993 Dep. of Botany, Trinity College Dublin, Ireland
Studies abroad and student project
10.1989 - 09.1992 Dep. of Biology, Albert-Ludwig University of Freiburg, Germany
Intermediate diploma in biology
04.1989 - 09.1989 Philosophical faculty, Albert-Ludwig University of Freiburg, Germany
Philosophical studies
08.1987 - 03.1989 St. Fidelius Parish, Offenburg, Germany
Civilian service
08.1978 - 05.1987 Max-Planck Gymnasium Lahr, Germany
Abitur (university-entrance diploma or examen artium)
Research projects:
visit to the Baumbusch project group home page - Molecular biology of oxidative stress and cancer
Publications 2021
The Norwegian childhood cancer biobank
Cancer Rep.-US, e1555
DOI 10.1002/cnr2.1555
Publications 2020
Pulmonary vascular disease is evident in gene regulation of experimental bronchopulmonary dysplasia
J. Matern.-Fetal Neonatal Med., 33 (12), 2122-2130
DOI 10.1080/14767058.2018.1541081
Short- and long-term impact of hyperoxia on the blood and retinal cells' transcriptome in a mouse model of oxygen-induced retinopathy
Pediatr. Res., 87 (3), 485-493
DOI 10.1038/s41390-019-0598-y
Transcriptome analysis reveals dysregulation of genes involved in oxidative phosphorylation in a murine model of retinopathy of prematurity
Pediatr. Res., 88 (3), 391-397
DOI 10.1038/s41390-020-0793-x
Publications 2019
Quantification of circulating cell-free DNA (cfDNA) in urine using a newborn piglet model of asphyxia
PLoS One, 14 (12), e0227066
DOI 10.1371/journal.pone.0227066
Immune System Regulation Affected by a Murine Experimental Model of Bronchopulmonary Dysplasia: Genomic and Epigenetic Findings
Neonatology, 116 (3), 269-277
DOI 10.1159/000501461
Comparative two time-point proteome analysis of the plasma from preterm infants with and without bronchopulmonary dysplasia
Ital. J. Pediatr., 45 (1), 112
DOI 10.1186/s13052-019-0676-0
Publications 2018
Cerebellum Susceptibility to Neonatal Asphyxia: Possible Protective Effects of N-Acetylcysteine Amide
Dis. Markers, 2018, 5046372
DOI 10.1155/2018/5046372
A systematic comparison of copy number alterations in four types of female cancer (vol 16, 913, 2016)
BMC Cancer, 18
DOI 10.1186/s12885-017-3766-7
Temporal patterns of circulating cell-free DNA (cfDNA) in a newborn piglet model of perinatal asphyxia
PLoS One, 13 (11), e0206601
DOI 10.1371/journal.pone.0206601
Plasma proteome changes in cord blood samples from preterm infants
J. Perinatol., 38 (9), 1182-1189
DOI 10.1038/s41372-018-0150-7
Prospective plasma proteome changes in preterm infants with different gestational ages
Pediatr. Res., 84 (1), 104-111
DOI 10.1038/s41390-018-0003-2
An iTRAQ-Based Quantitative Proteomic Analysis of Plasma Proteins in Preterm Newborns With Retinopathy of Prematurity
Invest. Ophthalmol. Vis. Sci., 59 (13), 5312-5319
DOI 10.1167/iovs.18-24914
Publications 2017
N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia
Neonatology, 111 (1), 12-21
DOI 10.1159/000447255
Temporal Profile of Circulating microRNAs after Global Hypoxia-Ischemia in Newborn Piglets
Neonatology, 111 (2), 133-139
DOI 10.1159/000449032
Comparison of whole genome expression profile between preterm and full-term newborns
Ginekol. Pol., 88 (8), 434-441
DOI 10.5603/GP.a2017.0080
Publications 2016
Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing
Genome Biol., 17, 250
DOI 10.1186/s13059-016-1109-7
A systematic comparison of copy number alterations in four types of female cancer
BMC Cancer, 16, 913
DOI 10.1186/s12885-016-2899-4
Publications 2015
Perinatal Asphyxia May Influence the Level of Beta-Amyloid (1-42) in Cerebrospinal Fluid: An Experimental Study on Newborn Pigs
PLoS One, 10 (10), e0140966
DOI 10.1371/journal.pone.0140966
Neonatal Levels of T-cell Receptor Excision Circles (TREC) in Patients with 22q11.2 Deletion Syndrome and Later Disease Features
J. Clin. Immunol., 35 (4), 408-415
DOI 10.1007/s10875-015-0153-5
Publications 2014
Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer
Breast Cancer Res. Treat., 143 (1), 189-201
DOI 10.1007/s10549-013-2796-3
Long Non-Coding RNAs Differentially Expressed between Normal versus Primary Breast Tumor Tissues Disclose Converse Changes to Breast Cancer-Related Protein-Coding Genes
PLoS One, 9 (9), e106076
DOI 10.1371/journal.pone.0106076
Publications 2013
Identifying In-Trans Process Associated Genes in Breast Cancer by Integrated Analysis of Copy Number and Expression Data
PLoS One, 8 (1), e53014
DOI 10.1371/journal.pone.0053014
High Levels of Genomic Aberrations in Serous Ovarian Cancers Are Associated with Better Survival
PLoS One, 8 (1), e54356
DOI 10.1371/journal.pone.0054356
Next-generation sequencing of disseminated tumor cells
Front. Oncol., 3, 320
DOI 10.3389/fonc.2013.00320
Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expression
Int. J. Cancer, 132 (6), 1300-1310
DOI 10.1002/ijc.27783
Publications 2012
High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer
Int. J. Cancer, 131 (4), E405-E415
DOI 10.1002/ijc.26444
Copynumber: Efficient algorithms for single- and multi-track copy number segmentation
BMC Genomics, 13, 591
DOI 10.1186/1471-2164-13-591
Publications 2011
The prognostic significance of tumour cell detection in the peripheral blood versus the bone marrow in 733 early-stage breast cancer patients
Breast Cancer Res., 13 (3), R61
DOI 10.1186/bcr2898
Publications 2010
Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients
Sci. Transl. Med., 2 (38), 38ra47
DOI 10.1126/scitranslmed.3000611
Publications 2009
Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays
Nucleic Acids Res., 37 (15), e105
DOI 10.1093/nar/gkp526
Publications 2008
Comparison of the Agilent, ROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors
BMC Genomics, 9, 379
DOI 10.1186/1471-2164-9-379
Publications 2006
Expression of full-length p53 and its isoform Delta p53 in breast carcinomas in relation to mutation status and clinical parameters
Mol. Cancer, 5, 47
DOI 10.1186/1476-4598-5-47
Publications 2001
Identification and analysis of genes controlling embryogenesis and embryo dormancy in plants
In Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo, The Faculty, Oslo, no. 181, 1 b. (flere pag.)
BIBSYS 012230200
Efficient protocols for CAPS-based mapping in Arabidopsis
Plant Mol. Biol. Rep., 19 (2), 137-149
DOI 10.1007/BF02772156