Tumor Immunology group

A. Corthay
Group leader

The Tumor Immunology group investigates the interplay between the immune system and cancer with a main focus on two types of immune cells, namely tumor-specific T cells and macrophages.

A central function of the immune system is to protect the individual against cancer. Enhancing the natural immune responses against tumors has an immense therapeutic potential. In fact, immunotherapy has now established itself as one of the four pillars of cancer treatment together with surgery, chemo- and radiation therapy. Our research vision is to increase the understanding of how the immune system naturally fights cancer in order to develop novel strategies for cancer immunotherapy. We perform both in vivoand in vitroexperiments with experimental mouse models, cell lines, and tumor tissue from patients with non-small cell lung cancer (NSCLC). On the basis of our previous findings, we focus our research on the mechanisms whereby tumor-specific CD4 T cells and macrophages collaborate to recognize and eliminate malignant cells.

Projects

  • Cancer immunotherapy based on the activation of tumor-associated macrophages
  • Macrophage phenotypes and functions: defining the rules
  • Using tumor-infiltrating immune cells to predict patient’s survival and response to therapy
  • Development of immunotherapy for lung cancer using patient-derived xenografts (PDX)
  • Cancer immunotherapy using viral vectors for cytokine gene delivery in tumors

Back, from left to right: Kari Tvete Inngjerdingen*, Anna Lunde, Alexandre Corthay, Inger Øynebråten, Henrik Aamodt.
Middle: Christian Winther Wold*, Aline Defforges, Panagiotis Christopoulos, Linda Dorp, Justyna Stokowiec, Ashalul Ahmed Nur Gutale.
Front: Baiba Kurena, Elisabeth Müller, Branislava Stankovic, Astri Frafjord, Ajna Avdagic, Renate Skarshaug.
* Associate group members.
Photographer: Kathrine Rehder


Contact information:

Alexandre Corthay, PhD
Head of Tumor immunology group
Mail address: Department of Pathology, Oslo University Hospital Rikshospitalet, P.O. Box 4950 Nydalen, NO-0424 Oslo, Norway. 
Visitor address: Institute of Pathology, Oslo University Hospital Rikshospitalet, Sognsvannsveien 20, Oslo, Norway. Office: room A3.M018.