Alexandre Corthay
- Associate Professor, group leader; PhD
- +47 23 07 41 09
Office: RH A3.3018
Publications 2024
High production of IL-12 by human dendritic cells stimulated with combinations of pattern-recognition receptor agonists
NPJ Vaccines, 9 (1), 83
DOI 10.1038/s41541-024-00869-1, PubMed 38702320
Fungal polysaccharides from Inonotus obliquus are agonists for Toll-like receptors and induce macrophage anti-cancer activity
Commun Biol, 7 (1), 222
DOI 10.1038/s42003-024-05853-y, PubMed 38396285
Publications 2023
On antigen-specific signals, immune class regulation and energetics: Report III from the workshops on foundational concepts of immune regulation
Scand J Immunol, 98 (3), e13311
DOI 10.1111/sji.13311, PubMed 38112131
Publications 2022
Immunology according to Dembic: Preserving integrity is key
Scand J Immunol, 95 (5), e13173
DOI 10.1111/sji.13173, PubMed 35474516
Caspase activation counteracts interferon signaling after G2 checkpoint abrogation by ATR inhibition in irradiated human cancer cells
Front Oncol, 12, 981332
DOI 10.3389/fonc.2022.981332, PubMed 36387237
Publications 2021
Obituary: Dr Zoltan A. Nagy (1941-2020)
Scand. J. Immunol., 93 (5), e13027
DOI 10.1111/sji.13027
Reactive Species from Two-Signal Activated Macrophages Interfere with Their Oxygen Consumption Measurements
Antioxidants (Basel), 10 (7)
DOI 10.3390/antiox10071149, PubMed 34356382
Tackling cancer cell dormancy: Insights from immune models, and transplantation
Semin Cancer Biol, 78, 5-16
DOI 10.1016/j.semcancer.2021.02.002, PubMed 33582171
The Immune Landscape of Human Primary Lung Tumors Is Th2 Skewed
Front Immunol, 12, 764596
DOI 10.3389/fimmu.2021.764596, PubMed 34868011
Publications 2020
Antibody combinations for optimized staining of macrophages in human lung tumours
Scand J Immunol, 92 (1), e12889
DOI 10.1111/sji.12889, PubMed 32299134
The immune microenvironment in typical carcinoid lung tumour, a brief report of four cases
Scand J Immunol, 92 (2), e12893
DOI 10.1111/sji.12893, PubMed 32433774
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models
Commun Biol, 3 (1), 196
DOI 10.1038/s42003-020-0916-2, PubMed 32332858
Publications 2019
Immune Cell Composition in Human Non-small Cell Lung Cancer
Front Immunol, 9, 3101
DOI 10.3389/fimmu.2018.03101, PubMed 30774636
Publications 2018
CD4+ T-cell-Mediated Rejection of MHC Class II-Positive Tumor Cells Is Dependent on Antigen Secretion and Indirect Presentation on Host APCs
Cancer Res, 78 (16), 4573-4585
DOI 10.1158/0008-5472.CAN-17-2426, PubMed 29752262
Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation
Front Immunol, 9, 2520
DOI 10.3389/fimmu.2018.02520, PubMed 30450098
Publications 2017
Immunological Tolerance. Part I of a Report of a Workshop on Foundational Concepts of Immune Regulation
Scand J Immunol, 85 (2), 84-94
DOI 10.1111/sji.12500, PubMed 27885703
Immune Class Regulation and Its Medical Significance Part II of a Report of a Workshop on Foundational Concepts of Immune Regulation
Scand J Immunol, 85 (4), 242-250
DOI 10.1111/sji.12525, PubMed 28236642
Aiming for the Insulin-like Growth Factor-1 system in breast cancer therapeutics
Cancer Treat Rev, 63, 79-95
DOI 10.1016/j.ctrv.2017.11.010, PubMed 29253837
Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ
Front Immunol, 8, 1667
DOI 10.3389/fimmu.2017.01667, PubMed 29276511
Toll-Like Receptor Ligands and Interferon-γ Synergize for Induction of Antitumor M1 Macrophages
Front Immunol, 8, 1383
DOI 10.3389/fimmu.2017.01383, PubMed 29123526
MULTI-STAINING REGISTRATION OF LARGE HISTOLOGY IMAGES
2017 IEEE 14TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2017), 345-348
Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette-Guérin (BCG) via Synergistic Activation of Innate Immune Receptors
Mol Pharm, 14 (11), 4098-4112
DOI 10.1021/acs.molpharmaceut.7b00795, PubMed 28974092
Structural characterization of bioactive heteropolysaccharides from the medicinal fungus Inonotus obliquus (Chaga)
Carbohydr Polym, 185, 27-40
DOI 10.1016/j.carbpol.2017.12.041, PubMed 29421057
Publications 2016
Coupling of HIV-1 Antigen to the Selective Autophagy Receptor SQSTM1/p62 Promotes T-Cell-Mediated Immunity
Front Immunol, 7, 167
DOI 10.3389/fimmu.2016.00167, PubMed 27242780
Rituximab efficiently depletes B cells in lung tumors and normal lung tissue
F1000Res, 5, 38
DOI 10.12688/f1000research.7599.1, PubMed 27081474
Adoptive Transfer of Tumor-Specific Th2 Cells Eradicates Tumors by Triggering an In Situ Inflammatory Immune Response
Cancer Res, 76 (23), 6864-6876
DOI 10.1158/0008-5472.CAN-16-1219, PubMed 27634753
Publications 2015
Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells
Oncoimmunology, 5 (1), e1039763
DOI 10.1080/2162402X.2015.1039763, PubMed 26942052
Publications 2014
Does the immune system naturally protect against cancer?
Front Immunol, 5, 197
DOI 10.3389/fimmu.2014.00197, PubMed 24860567
How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules?
Front Immunol, 5, 174
DOI 10.3389/fimmu.2014.00174, PubMed 24782871
Publications 2013
Molecular profiling of tumor-specific TH1 cells activated in vivo
Oncoimmunology, 2 (5), e24383
DOI 10.4161/onci.24383, PubMed 23762808
Publications 2012
SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice
PLoS One, 7 (10), e48239
DOI 10.1371/journal.pone.0048239, PubMed 23144743
A model for cancer-suppressive inflammation
Oncoimmunology, 1 (7), 1146-1155
DOI 10.4161/onci.21542, PubMed 23170261
Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice
Blood, 119 (9), 2176-7
DOI 10.1182/blood-2011-10-388892, PubMed 22383793
Publications 2011
Is secretion of tumour-specific antigen important for cancer eradication by CD4(+) T cells?--Implications for cancer immunotherapy by adoptive T cell transfer
Scand J Immunol, 73 (6), 527-30
DOI 10.1111/j.1365-3083.2011.02558.x, PubMed 21388431
Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer
Nat Commun, 2, 240
DOI 10.1038/ncomms1239, PubMed 21407206
Publications 2009
How do regulatory T cells work?
Scand J Immunol, 70 (4), 326-36
DOI 10.1111/j.1365-3083.2009.02308.x, PubMed 19751267
Secretion of tumor-specific antigen by myeloma cells is required for cancer immunosurveillance by CD4+ T cells
Cancer Res, 69 (14), 5901-7
DOI 10.1158/0008-5472.CAN-08-4816, PubMed 19567679
Publications 2008
Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA)
Cell Signal, 21 (2), 274-81
DOI 10.1016/j.cellsig.2008.10.013, PubMed 19000925
Publications 2007
CD4+ T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells
Adv Exp Med Biol, 590, 195-208
DOI 10.1007/978-0-387-34814-8_14, PubMed 17191387
Publications 2006
Idiotype-specific immunotherapy in multiple myeloma: suggestions for future directions of research
Haematologica, 91 (7), 941-8
PubMed 16818282
A three-cell model for activation of naïve T helper cells
Scand J Immunol, 64 (2), 93-6
DOI 10.1111/j.1365-3083.2006.01782.x, PubMed 16867153
Publications 2005
Primary antitumor immune response mediated by CD4+ T cells
Immunity, 22 (3), 371-83
DOI 10.1016/j.immuni.2005.02.003, PubMed 15780993
Systemic autoimmune disease caused by autoreactive B cells that receive chronic help from Ig V region-specific T cells
J Immunol, 175 (4), 2391-400
DOI 10.4049/jimmunol.175.4.2391, PubMed 16081810
Publications 2004
Immunotherapy in multiple myeloma: Id-specific strategies suggested by studies in animal models
Cancer Immunol Immunother, 53 (9), 759-69
DOI 10.1007/s00262-004-0504-1, PubMed 15088126
Monoclonal antibodies produced by muscle after plasmid injection and electroporation
Mol Ther, 9 (3), 328-36
DOI 10.1016/j.ymthe.2003.12.007, PubMed 15006599
Publications 2003
Therapeutic effect of idiotype-specific CD4+ T cells against B-cell lymphoma in the absence of anti-idiotypic antibodies
Blood, 102 (2), 605-12
DOI 10.1182/blood-2002-11-3381, PubMed 12649166
Role of gamma/delta T cell receptor-expressing lymphocytes in cutaneous infection caused by Staphylococcus aureus
Clin Exp Immunol, 132 (2), 209-15
DOI 10.1046/j.1365-2249.2003.02151.x, PubMed 12699407
Publications 2001
Role of glycopeptide-specific T cells in collagen-induced arthritis: an example how post-translational modification of proteins may be involved in autoimmune disease
Ann Med, 33 (7), 456-65
DOI 10.3109/07853890109002094, PubMed 11680793
Evaluation of the percentage of peripheral T cells with two different T cell receptor alpha-chains and of their potential role in autoimmunity
J Autoimmun, 16 (4), 423-9
DOI 10.1006/jaut.2001.0504, PubMed 11437490
Publications 2000
T cells in autoimmunity: studies on murine type II collagen-induced arthritis
Lund university, Lund, 1 b. (flere pag.)
BIBSYS 001433148, ISBN 91-628-4037-1
T lymphocytes are not required for the spontaneous development of entheseal ossification leading to marginal ankylosis in the DBA/1 mouse
Arthritis Rheum, 43 (4), 844-51
DOI 10.1002/1529-0131(200004)43:4<844::AID-ANR15>3.0.CO;2-B, PubMed 10765929
Publications 1999
Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: studies with T cell-deficient (TCR mutant) mice
Int Immunol, 11 (7), 1065-73
DOI 10.1093/intimm/11.7.1065, PubMed 10383939
Publications 1998
Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen-induced arthritis
Eur J Immunol, 28 (8), 2580-90
DOI 10.1002/(SICI)1521-4141(199808)28:08<2580::AID-IMMU2580>3.0.CO;2-X, PubMed 9710235