Institute for Cancer Research
Institute for Cancer Research has since its foundation in 1954 played a central role within the field of cancer research both in Norway and internationally. The Institute has seven research departments and more than 320 employees, master students included. About 70% of the employees and projects are externally funded.
The Institute has internationally strong research groups within biochemistry, cell and tumor biology, genetics, radiation biology, immunology and cancer prevention. For more than 30 years there has been a close interaction between researchers at the Institute and cancer surgeons, oncologists and pathologists. This emphasis on translational science has resulted in numerous clinical protocols based on in-house research, and the Institute is a key partner in the Comprehensive Cancer Center, organizationally under the Division of Surgery and Cancer Treatment at Oslo University Hospital.
Scientific production - Institute for Cancer Research
Annual report 2015 (pdf format)
Erlend Strønen and Johanna Olweus from the Department of Immunology at the Institute for Cancer Research and the K.G. Jebsen Centre for Cancer Immunotherapy are first and joint last author respectively on a paper recently (May 19th) published in Science (journal impact factor 33.6), entitled "Targeting of cancer neoantigens with donor-derived T cell receptor repertoires".
The international research team - based in Oslo, Amsterdam and Copenhagen - has made a breakthrough methodological development in generating broad and tumour-specific T-cell immune responses based on a novel allogeneic approach. This is a powerful technological advancement which can in the relatively near future be subjected to clinical testing.
Håvard Danielsen and Erik Fosse receive Lighthouse project grants from the Norwegian Research Council
Oslo University Hospital heads projects DoMore! led by Håvard Danielsen from the Institute for Cancer Genetics and Informatics and BIGMED led by Erik Fosse from the Intervention Centre project receive Lighthouse project grant from the Norwegian Research Council's IKTPLUSS area of commitment. The funding for each project is 60 million NOK over a five-year period.
There were 76 research teams competing for the prestigious grant and only three winners- The third project is INTROMAT, led by Tine Nordgreen from UiB.
The DoMore! team is composed of experts within several fields, including digital imaging, processing, robotics, pathology, cell biology, surgery and oncology, both in Norway and abroad.
The vision behind the BIG data MEDical solution (BIGMED) is to lay the foundation for an ICT platform that addresses the analytic bottlenecks for the implementation of precision medicine, and paves the way for novel big data analytics.
"Intelligent needle tracking using ultrasound imaging for improved minimally invasive interventions" supported by EU
Philips, B.Braun and Oslo University Hospital are partnering in the EU funded INTUI-VIEW project to develop, validate, and bring to the market an intelligent needle tracking technology using ultrasound imaging. The aim of this project is to reliably visualize the needle position in relation to the patient’s anatomy, under ultrasound guidance. The INTUI-VIEW project has been granted €2.36 million.
The participants representing OUH in the project are Axel R. Sauter and Leiv-Arne Rosseland (photo) from the Division of Emergencies and Critical Care at Oslo University Hospital. OUH will receive € 75000 for use in this project, which will be running approximately for 3 years.
2015 has been a very good year for ICR, and areas for further improvement include increases in collaboration with clinical researchers, partnerships and coordinator roles in more successful EU grants, and strengthened international visibility.
Read all the details in the recently published annual report.
The most comprehensive analysis to date of somatic (acquired) mutations, across whole-genome sequences for breast cancer, is reported in a paper published in the May 2nd edition of Nature (journal impact factor 41.5).
Miriam R. Aure, Anita Langerød, Ole Christian Lingjærde, and Anne-Lise Børresen-Dale from the "Molecular biology of breast cancer group" at the Department of Cancer Genetics has contributed substantially to the study.
A related paper, published in Nature Communications, explores how these mutations relate to aspects of genome structure. Together, the studies highlight the repertoire of genes and mutational processes involved in breast cancer and move us closer to a more complete account of the genetic basis of the disease.
Same, but different? Genetic analysis of five immune mediated diseases reveals molecular taxonomy of chronic inflammation
A genetic analysis recently published in Nature Genetics (journal impact factor 29.35) sheds new light on the high comorbidity between primary sclerosing cholangitis (PSC) and inflammatory bowel disease.
Researchers from four large disease consortia, encompassing hundreds of researchers from 26 countries, joined forces to combine data from studies of their respective diseases, amounting to 52,262 patients and 34,213 healthy controls.
“This study is important because it creates a platform for understanding the molecular make-up of each disease, in the future enabling more specified treatment of chronic inflammatory disease”, says Tom Hemming Karlsen, coordinator of one of the participating consortia.
May 20, 2016
May 19, 2016
The new WHO classification of pediatric brain tumors
May 18, 2016
Inst. for Cancer Research
Journal Impact Factor > 5, first or last author from the Institute for Cancer Research
Subtype-specific micro-RNA expression signatures in breast cancer progression
Int J Cancer (in press)