New books on drug target discovery and validation edited by Mouldy Sioud
Target Discovery and Validation Reviews and Protocols" Volumes 1 and 2 - edited by Mouldy Sioud from the Department of Immunology at the Norwegian Radium Hospital- are recently published by Humana Press - a leading publisher of medical and scientific books.
The books review the most progressive and current methods for drug target discovery and validation. Also, they explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders.
Meriranta L, Sorri S, Huse K, Liu X, Spasevska I, Zafar S, Chowdhury I, Dufva O, Sahlberg E, Tandaric L, Karjalainen-Lindsberg ML, Hyytiainen M, Varjosalo M, Myklebust JH, Leppa S(2024) Disruption of KLHL6 Fuels Oncogenic Antigen Receptor Signaling in B-cell Lymphoma Blood Cancer Discov(in press) DOI 10.1158/2643-3230.BCD-23-0182, PubMed 38630892
Grindedal EM, Zucknick M, Stormorken A, Rønne E, Tandstad NM, Isaacs WB, Axcrona K, Mæhle L(2024) Outcomes of 10 years of PSA screening for prostate cancer in Norwegian men with Lynch syndrome Prostate(in press) DOI 10.1002/pros.24711, PubMed 38629217
Suske T, Sorger H, Manhart G, Ruge F, Prutsch N, Zimmerman MW, Eder T, Abdallah DI, Maurer B, Wagner C, Schönefeldt S, Spirk K, Pichler A, Pemovska T, Schweicker C, Pölöske D, Hubanic E, Jungherz D, Müller TA, Aung MMK, Orlova A, Pham HTT, Zimmel K, Krausgruber T, Bock Cet al.(2024) Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia J Clin Invest, 134(8) DOI 10.1172/JCI168536, PubMed 38618957