The HSØ Core Facility for Structural Biology will provide its users with a range of services within structural biology and biophysical characterization, including protein expression and purification, crystallization screening, structural determination of proteins and protein complexes by X-ray crystallography. We have all major methods for quantitative protein-interaction studies, including ITC, MST and SPR, and we can look at both protein-protein and protein-ligand complexes. We also have several methods for protein stability studies; nanoDSF and DLS. We also help with modeling of proteins and their interactions, and a variety of bioinformatics services, with emphasis on interpretation of clinical data with respect to structural bioinformatics. See our Projects page for examples of studies we have assisted.

We serve all users associated to institutions belonging to Helse Sør-Øst and University of Oslo, as well as research groups at external research institutions in the region, including all hospitals, NMBU and university colleges. We can also provide selected services to industrial partners.