Welcome to the home page of Anne Simonsen's group Autophagy
Dysfunctional autophagy is linked to several pathophysiological conditions, including cancer and neurodegenerative disorders. The main focus of the “Simonsen Lab” is to characterize of the molecular mechanisms involved in cargo sequestration and autophagosome biogenesis during non-selective and selective types of autophagy with a long-term goal to identify novel targets for diagnosis or treatment of human disease.
About the group
Work in our laboratory is currently focused on identification of novel lipid-binding proteins involved in different types of autophagy and elucidation of their function in autophagy and link to disease. To address these challenges, we use a combination of cell biological, biochemical, imaging, genomic and computational approaches, as well as disease-related model systems.
Our research is funded by
- The University of Oslo
- The Research Council of Norway
- The Norwegian Cancer Society
- H-2020 MSC COFUND and ITN actions