Dysfunctional autophagy is linked to several pathophysiological conditions, including cancer and neurodegenerative disorders.⁠ The main focus of the “Simonsen Lab” is to characterize of the molecular mechanisms involved in cargo sequestration and autophagosome biogenesis during non-selective and selective types of autophagy with a long-term goal to identify novel targets for diagnosis or treatment of human disease.

About the group
Work in our laboratory is currently focused on identification of novel lipid-binding proteins involved in different types of autophagy and elucidation of their function in autophagy and link to disease. To address these challenges, we use a combination of cell biological, biochemical, imaging, genomic and computational approaches, as well as disease-related model systems.

Research Projects

• BEACH proteins
• Lipid-binding proteins in autophagy
• CANCELL - Centre for Cancer Cell Reprogramming

Our research is funded by

• The University of Oslo
• The Research Council of Norway
• The Norwegian Cancer Society
• H-2020 MSC COFUND and ITN actions

Contact information:
Department of Molecular Cell Biology, Institute for Cancer Research
The Norwegian Radium Hospital, Montebello, N-0379 Oslo, Norway
Telephone +47 22 78 19 30 (Simonsen), +47 22 78 12 70 (Dept. Secretary)
Email: a.g.simonsen@medisin.uio.no